cell cell signaling in the testis and ovary
báo cáo khoa học: " Predictive biomarker discovery through the parallel integration of clinical trial and functional genomics datasets" potx
... and resistance in RCC The rapamycin-like (rapalog) drug everolimus inhibits the serine/threonine protein kinase mTOR after forming a complex with the intracellular protein FKBP12 (FK506 binding ... mTORC1 increases protein translation and promotes entry into the G1 phase of the cell cycle by phosphorylation of downstream substrates, including ribosomal S6 kinase (S6K) and 4EIF binding protein ... these tumors The multitargeted tyrosine kinase inhibitor sunitinib targets the VEGFR, PDGFR, cKIT, FLT3 (FMS-like tyrosine kinase 3), RET and the CSF1 (colony stimulating factor 1) receptor and...
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The integration of lean man and 6 sigma
... forgings might move in a single-piece flow through a U-shaped machining cell, but then accumulate into a large batch at the end of the cell before being moved to a chrome plating station In fact, ... is producing to stock will gain from reduced lead times by decreasing the horizon of their forecasts and by replenishing stocks more often, thereby increasing the company’s revenues and inventory ... batch -and- queue mode, processing is done in batches since machine setup times and the reluctance to risk idle machinery cause the company to accumulate large WIP inventories on the shop floor In the...
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Báo cáo khoa học: "Diagram Understanding Using Integration of Layout Information and Textual Information" ppt
... relationship with the corresponding sketch These words have the same Kanji character at the end of the writing Some of these words are found in the expression pattern (a), (b), and (c) described in Section ... plant readably and accurately The features represented by sketches are explained by words in the diagram Observing the PBF diagrams, the information explained by words is classified into five categories, ... framework for the semantic interpretation of words in the PBF diagrams by using not only the pattern (layout) information but also the natural language information The reason is as follows: there is...
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Báo cáo hóa học: " Research Article Binocular Image Sequence Analysis: Integration of Stereo Disparity and Optic Flow for Improved Obstacle Detection and Tracking" pptx
... epipolar line constraint, we can search the correspondence point in the same row For a seed point at position (il , j) in the left edge image and a candidate point at position (ir , j) in the right ... ], which requires knowing the longitudinal distance Z Therefore, in practice, we first calculate the third group of the variables and then use the obtained results for the other two groups of variables ... speed are shown in Figures 5(a) and 5(b) The lateral and vertical relative speeds are shown in Figures 5(c) and 5(d) In the figures, the red line is the true state of the system, the green curve...
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INTERNATIONAL ASSIGNMENTS An Integration of Strategy, Research, and Practice ppt
... families for their support and understanding We thank them for their willingness to live in such places as Japan, Finland, Switzerland, and Canada We also thank them for making international ... they send there or on the people they hire there They cannot compromise on the thoroughness of their planning, either—or on the resources they are willing to commit to the development of the market ... Appraising: Determining if People Are Doing the Right Things 144 Rewarding: Compensation and Pay 171 IV AFTER THE ASSIGNMENT 187 Repatriating: Helping People Readjust and Perform 189 10 Retaining:...
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Báo cáo sinh học: "Dishevelled and Wnt signaling: is the nucleus the final frontier" potx
... proteins including Axin, glycogen synthase kinase (GSK3), GSK3-binding protein (GBP) and casein kinase (CK1) In the absence of Wnt stimulation, -catenin is targeted for degradation through the ... Wnt signaling through Frizzled receptors leads to the release of intra-cellular Ca2+ in a process mediated through heterotrimeric G-proteins and involving numerous other molecules, including ... receptor-related  proteins and in Wnt/-catenin signaling: arrows point the way Development 2004, 131:1663-1677 Wharton KA Jr: Runnin’ with the Dvl: proteins that associate with Dsh/Dvl and their significance...
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báo cáo khoa học: "Different patterns of NF-B and Notch1 signaling contribute to tumor-induced lymphangiogenesis of esophageal squamous cell carcinoma" ppt
... carcinomas These highly conserved proteins regulate “decisions” involved in cell- fate determination, including those involved in mammalian vascular development [15] The finding that genes of the ... presumed oncogenic role of Notch signaling during tumorigenesis, the finding that Notch signaling is diminished in epithelial squamous cell carcinoma of the skin would seem to suggest that Notch ... immunohistochemical staining Nuclear staining of NF-B and cytoplasmic staining of Notch1 and VEGF-C were scored in this study The intensity of NF-B, Notch1, podoplanin, and/ or VEGFC staining was score...
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Báo cáo y học: " Bringing metabolic networks to life: integration of kinetic, metabolic, and proteomic data" pptx
... Original value Figure Posterior distributions in the threonine model Posterior distributions in the threonine model Left: prior and kinetics-based posterior in the threonine model All sysG tem kinetic ... combining both kinds of information, we can obtain a posterior distribution, which describes how plausible certain parameter sets appear, taking into account both the prior information and the ... solving the steady state equations Computing the posterior distribution Theoretically, we can obtain the posterior distribution p(θ|x*, y*) by inserting the distributions (5), (6), and (7) into...
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integration of fracture, reservoir and geomechanic Modeling for shale gas reservoir development
... Production Injection Injection Production Shut -in Injection Injection Shut -in Shut -in No activitiy No activity Shut -in Table 1: Options explored for steering fractures in Wells and The wells in the ... minimizing production impacts on the primary wells (Wells and 2) was to shut -in Wells and while fracturing all of the infill wells Wells and were shut -in while Wells and were fractured For the ... during their fracturing Figure 13 highlights one of the chemical tracers injected into Wells and While not shown, similar plots were obtained for the other chemical tracers used in these wells The...
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The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
... C-terminus domain, to expose binding sites for Src-homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain ... ligands bind to the extracellular domains of two receptor subunits and form a 2:2 complex (42), resulting in activation of the intracellular kinases of the receptors Upon ligand binding, the ... hemagglutinin epitope tag heparin-binding epidermal growth factor protein kinase C-related kinase homology region IQ motif containing GTPase activating protein infrared insulin receptor tyrosine kinase...
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The convergence challenge global survey into the integration of governance, risk and compliance
... understand and respond to the risks facing the business, as well as anticipating and meeting changing stakeholder and regulatory demands The result is an increasingly resilient, informed and performance-oriented ... across the world, such as the US Food and Drug Administration and the Medicines and Healthcare products Regulatory Agency in the UK Since the merger of Glaxo Wellcome and SmithKline Beecham in 2001, ... and KPMG Final Thought sections, the views and opinions expressed herein are those of the Economist Intelligence Unit and the entities surveyed and not necessarily represent the views and opinions...
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The convergence evolution global survey into the integration of governance, risk and compliance
... revenues The vast majority have seen an increase in this expense over the past two years, and expect it to increase even further in the next two years And the proportion that thinks the cost is increasing ... focused on where the company is going in terms of its strategy, and then optimizing the strategy as new risks emerge, it is spending time addressing the wrong things.” By co-ordinating their GRC activities ... risk into how they run the business.” The link between risk and compliance, and strategic decision-making remains relatively weak in many organizations For example, only 40 percent involve their...
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Tài liệu Transformation through Integration An Activity Theoretical Analysis of School Development as Integration of Child Care Institutions and the Elementary School ppt
... them from begging on the streets and disturbing the peace (Sandin, 1986) At this time the population was growing, poverty was huge, and criminality was widespread In the beginning the elementary ... were mainly directed toward the 5thD even though I also intervened in the VT process Today, in the spring of 2003, the 5thD is still operating in the school I will in this thesis account for the ... to the intra dimensional learning contexts three inter-dimensional learning contexts, which I call the intercultural learning context, the intergenerational learning context, and the interinstitutional...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... equal protein loading is shown by probing the same blot with GAPDH Ig mediated through various protein kinase and monomeric GTP-binding protein signaling pathways including MAP kinases and Rho GTPases ... determine and characterize the kinetic parameters of its induction by the lysolipid S1P, which has been shown to form in the cells in response to and mimic the effects of diverse stimuli including ... level We investigated the nature of the intracellular signaling pathways that link S1P signaling to Cyr61/CCN1 gene expression and showed that the activation of RhoA GTPase and p38 MAP kinase pathways...
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Báo cáo sinh học: "Wnt signaling and the developmental fate of lung cells" ppsx
... lack definitive markers for stem cells.” The findings also reveal something of the delicate interplay between the timing and nature of signaling in determining cell fate For example, the absolute ... local injury and inflammation there is local up-regulation of Wnt signaling and the activity of -catenin, and that this is then switching some of the cells to become progenitors of intestine.” ... example, the endodermal lineage derives from the innermost of the three layers of cells in the very early embryo, and cells within the endodermal lineage can have various fates, including becoming...
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Báo cáo y học: "Eotaxin and FGF enhance signaling through an Extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic Esophagitis" doc
... JK, JP, and LN and KN aiding in obtaining biopsy and blood samples NR and LH were involved in enrolling and consenting patients JH drafted the manuscript All authors read and approved the final ... found in a variety of tissues, including epithelial and mesenchymal tissue [20] bFGF increases the half-life of cells and could possibly increase the overall lifetime of the eosinophil in the esophagus ... increase in FGF and ERK pathways was closely associated with the severity of the disease and endoscopic findings in the EoE patients; further patients will help determine if FGF and other immune indicators...
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Báo cáo y học: " Examination of effects of GSK3β phosphorylation, β-catenin phosphorylation, and β-catenin degradation on kinetics of Wnt signaling pathway using computational method" pdf
... experimentally and computationally, much of its role in cell signaling and the means by which it interacts with other pathways remain to be explored In the present study, in the light of the recent ... β-catenin and axin with transient wnt signaling Solid line: the original Lee-Heinrich model Other lines: kG parameter was varied Long dashed line: kG = 0.1 min-1 Short dashed line: kG = 0.5 min-1 ... constants k4 and k5 and the influx rate, v12 It does significantly change in the case of kG in reaction step 18 Effect of wnt signal In examining the wnt signaling effect, computations for the present...
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WNT signaling in the early development of zebrfish swimbladder and xenopus lung
... Hh signaling and is negatively regulated by Hh signaling 4.7.2 Hh signaling might be required to maintain wif1 expression 133 4.8 Crosstalk between Wnt signaling and tbx2a signaling regulated the ... proteins also inhibit fibroblast growth factor (FGF) signaling by trapping FGF receptors in the ER Finally, insulin-like growthfactor (IGF) binding protein-4 (IGFBP-4) antagonizes Wnt signaling ... understand a comprehensive map of the combinations of Wnt ligands and their receptors in a cell- specific manner 1.7.4 Mechanism of Wnt signaling The complete process for Wnt signaling includes...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008