cd4 cd25 regulatory t cells
Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... converted CD4+ CD25+ T cells Plots were gated on CD4+ CD25+ DCs Dotted histogram lines represent cells stained with isotype-matched control monoclonal antibodies Data represent the mean ± standard ... increase the proportion of antigen-specific CD4+ CD25+ regulatory T cells in tolerized mice Figure shows that the percentage of CD4+ CD25+ cells increased significantly after coculture of CD4+ CD25- T cells ... similar to that in cells cocultured with CD11c+ DCs from CIA mice This result suggests that the conversion into CD4+ CD25+ T cells without CII stimulation result from the IDO-independent expansion...
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Báo cáo y học: " Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD" potx
... confirmed in longitudinal studies These data therefore indicate the expansion of a T cell population without a regulatory function, which may contribute to the persistent cytotoxic T cells responses ... supports a potential involvement of the acquired immune response in the pathogenesis of COPD To further evaluate the role of regulatory T cells in COPD and to clarify whether CD4 + CD25 bright cells ... the upregulation of regulatory T cells would restrain cigarette smoke-induced inflammatory activation and, thus, the development of COPD [10] In contrast, in smokers who develop COPD, the T regulatory...
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Báo cáo y học: "CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis" ppsx
... immunization (Fig 2a) This observation suggests that the CD4+ CD25+ regulatory T cells might not be involved in the development of PGIA Although it has been shown that the CD4+ CD25+ regulatory T cells ... report that the effective function of the CD4+ CD25+ regulatory T cells is T- cell receptor (TCR) specific [28] Collectively, our data suggest that the CD4+ CD25+ regulatory T cells may not be involved ... mediate the induction of the disease CD4+ CD25+ regulatory T cells may not control autoimmune arthritis To further investigate whether the CD4+ CD25+ T cells play a role in PGIA, we performed adoptive...
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Báo cáo y học: "Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ" potx
... AAC CTT; Foxp3-RV, TTC TCA CAA CCA GGC CAC TTG; Foxp3-TP, ATC CTA CCC ACT GCT GGC AAA TGG AGT C; TGF-β-FW, TGA CGT CAC TGG AGT TGT ACG G; TGF-β-RV, GGT TCA TGT CAT GGA TGG TGC; TGFβ-TP, TTC AGC ... condition without Treg cells – Radioactivity in condition with Treg cells) /Radioactivity in condition without Treg cells) of the proliferation of Teff cells (CD4+ CD25- ) by increasing numbers of CD4+ CD25+ ... unable to reduce the suppressive effect of wild-type Treg cells against wild-type or IFN-γR KO (data not shown) Teff cells These data demonstrate that the defect in inhibiting CD4+ CD25- Teff cells...
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Báo cáo y học: "The relationship between CD4+CD25+CD127regulatory T cells and inflammatory response and outcome during shock states" potx
... between patients and healthy volunteers throughout the study period, patients with shock presented with constantly decreased NK absolute To get further insight in to the role of Tregs during septic ... to deplete Tregs, we must acknowledge that anti -CD25 is not specific for Tregs and leads to the depletion of other important cells (activated T cells) Moreover, anti -CD25 antibody may not have ... severity and cytokines plasma concentrations Considering the correlation between Tregs and outcome, at least in septic patients, we evaluated the relation between these cells and severity Indeed, there...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
... that the adoptive transfer of CD25- depleted thymocytes to syngeneic nude mice recipients led to a similar spectrum of autoimmune disease to that with CD25 CD4+ peripheral cells [14] CD25 +CD4+ thymocytes ... doubly transgenic mouse have also demonstrated that the CD25 +CD4+ TR cells show a high self-reactivity and differentiate on thymic epithelial cells [41,42] Thus, the central generation of CD25 +CD4+ ... distinctions still remain between the surface phenotype of TR and primed T cells, but they are more relative than absolute For example, although both primed T cells and TR cells express CD25, the latter...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... against the foreign antigen mBSA clearly demonstrates that their suppressive effect is not strictly limited to autoreactive T cells Taking into consideration that Treg cells are also critically ... injected with rat IgG (Fig 1) Of note, the antiCD25 treatment almost completely depleted cells with high expression of CD25, which are considered Treg cells, in contrast to CD4+ T cells with low ... online http://arthritis-research.com/content/7/2/R291 Figure Transfer of regulatory T cells (Treg cells) cannot cure established arthriarthritis tis Pre-activated CD4+ CD25+ cells (1 × 106) were transferred...
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Báo cáo y học: "Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells" doc
... in CD4+ CD25- T cells It is also important to note that, although the CD25low population lies adjacent to CD25- on a FACS plot (as shown in Figure 2), they belong to two different cell entities ... patients correlated with disease activity and that the cell number significantly decreased after glucocorticoid treatment [2] Whether these cells are Tregs or activated Teffs remains to be determined ... with untreated new-onset lupus (UNOL) (UNOL) intracellular Foxp3 in CD4+ CD25- T cells and that CD4+ CD25- CD127low/- T cells could not be used as a live substitute for CD4+ CD25- Foxp3+ T cells to...
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báo cáo hóa học:" In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells" docx
... of CD8+ T cells to WT1 or CEA or both are shown as the percentage of the total population of CD8+ T cells that were double positive (CD8+pentamer+) Cytotoxicity assays The cytotoxicity assays ... factors in the supernatant inhibit the maturation of fusion cells and have a negative impact in the stimulation of T cells To determine the induction of WT1-specitic CD8+ T cells, a pentameric assay ... http://www.translational-medicine.com/content/6/1/51 Figure The ability of vaccination with autologous FCs to stimulate T cells The ability of vaccination with autologous FCs to stimulate T cells A, Nonadherent PBMCs obtained...
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báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot
... Cytotoxicity of In Vivo Generated T Cells T2 -cytotoxicity Cumulative cytotoxicity results for all patient samples show that after two cycles of vaccination (the time point associated with the ... substantial generation of tetramer+, CD8+, T cells In fact, the responses generated to the two DC preparations were atypical only in this particular patient The remaining patients showed the pattern ... that hTERT p540 is not expressed or is cryptic on the surface of tumour cells and that immunization of cancer patients with hTERT p540 leads to the production of T cells that not recognize tumour...
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Báo cáo hóa học: " Decreased level of recent thymic emigrants in CD4+ and CD8+T cells from CML patients" pdf
... exported from thymus to the periphery within recent thymic emigrants (RTEs), therefore, the frequency of sjTRECs is considered to be the most accurate marker of T- cell neogenesis Quantitative detection ... doesn 't allow the evaluation of the complexity of thymic output in different TRBV subfamily naïve T cells, which is an important factor in immune competence In this study, we analyzed the total ... Germany) After CD4+ and CD8+ T cells sorting, the purity was determined by indirect immune fluorescent analysis The positive cells were around 95% to 97% DNA extraction Total DNA from distinct cell...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... mucosa represents a unique immunologic unit with the first contact with the allergen within the gastrointestinal tract, where immune tolerance is the natural outcome Freshly isolated oral LCs expressed ... Treg cells, account for to 10% of peripheral CD4+ T cells and inhibit the activation of effector T cells in the periphery.38,39 FOXP3, the transcriptional regulator expressed on Treg cells, acts ... et al, Regulatory T Cells in the Context of Allergic Disease thus preventing the activation of mast cells and basophils IgG4 has been shown to reduce the IgE-mediated degranulation of these cells...
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Báo cáo y học: "CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease" potx
... joint These features were apparent in the vast majority of the patients despite the different treatments they received, indicating that the anti-rheumatic drugs that patients receive not affect the ... enrichment of regulatory T cells was seen Thus, the simple extrapolation of the animal data into future therapeutic strategies that aim at reconstituting this population does not seem to hold true ... referred to as responder cells (RSF) The sorting gate for CD25brightCD4+ T cells was adjusted to contain CD4+ T cells that expressed CD25 more brightly than activated CD25+ CD8+ T cells SFMC not expressing...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... effectors Activation also induces a subset of CD4+ CD25 T cells to upregulate CD25 and FoxP3 and acquire CD25 +CD4+ (TR) cell function These cells may result from activation at the initiation of the ... It is thought that TR cells in mice represent those thymocytes with the highest affinity for self-peptide but that are below the threshold of negative selection [50] Only a small number of TR ... activation of CD4+ CD25 T cells with mature, allogeneic dendritic cells, and these T cells also expressed FoxP3 The specificity of the TR cells was determined by the type of mature dendritic cells...
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Báo cáo y học: "The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases" pot
... Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes Characterization of the CD4+ T cell subset that inhibits this autoimmune potential J Exp ... activation of CD4+ CD25+ cells is antigen specific, once these cells are activated they not only suppress T cells stimulated by the same antigen, but they also inhibit T cells stimulated by other ... death of some T cells [48,49], while others observed that this cytokine protected T cells from apoptosis [50,51] We favor the hypothesis that TGF-β promotes the death of mature Th1 and Th2 cells...
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Báo cáo y học: "β Transforming growth factor-β-induced regulatory T cells referee inflammatory and autoimmune diseases" potx
... population of Treg and documentation of their in vivo potential was an important next step In pursuit of this goal, recent studies demonstrated for the first time that the transfer of in vitro ... in the absence of TGF-β and/or if TGF-β is dysregulated The identification and intersection points of such pathways await further study Among the factors that contribute to the regulation of TGF-β ... abnormalities have been attributed, at least partly, to defective production and function of TGF-β [12,66] In contrast to strong suspicions, few data yet exist as to whether the uncontrolled T and...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... before treatment with anti-TNF-α were unable to suppress proinflammatory cytokine secretion from activated T cells and monocytes After anti-TNF-α treatment the ‘hibernated’ peripheral blood CD4+ CD25+ ... all these studies CD4+ CD25+ Treg were detected in the joints or synovial fluid of the patients In these reports it was also shown that the identified CD4+ CD25+ Treg had a suppressive function ... might not be a feasible option treatment decreases the infiltrate in joints Furthermore, RA patients relapse shortly after withdrawal of anti-TNF-α [19] and thus, despite the dampening of joint...
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Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... groups attributed the defects to the Tregs, but one group reported increased resistance to suppression [57] This resistance positively correlated with disease activity Although this group attributed ... erythematosus Regulatory T cells (Tregs) (red) and effector T cells, shown as potentially pathogenic anti-self T cells (blue), can affect the maturation of immature dendritic cells (DCs) to immunogenic ... documenting that CD4+ CD25high cells in SLE are similar to those of healthy donors [57,58] A third group reported that although the percentage of CD4+ CD25high cells in SLE in patients with active...
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Báo cáo y học: "Japanese Encephalitis Virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells" doc
... replication DCs infected with P3 attenuated allostimulatory activities to T cells To test whether P3 infection will impair the ability of DCs to activate allogeneic naïve T cells, the direct effect ... and activate T lymphocytes through up-regulating the expression of costimulatory and antigen presentation-associtated molecules at the mature stage [17] To examine whether the characteristics ... T cells, the number of spot forming units/106 purified T cells was counted after twenty four hour incubation with differently treated bmDCs or spDCs The results in vitro showed that P3-infected...
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Báo cáo y học: " CD39+ Regulatory T cells suppress generation and differentiation of Th17 cells in human malignant pleural effusion via a LAP-dependent mechanism" pps
... found that the purified CD39 + CD4 + CD25 high T cells were almost FOXP3 positive and were almost CD127 negative, indicating that these T cells were Tregs The most important finding in the present ... of activation status [34] Furthermore, these markers cannot be used to identify Treg poststimulation in vitro, since their expression patterns change toward the Treg phenotype upon activation ... representative dot plots of CD39+Tregs and Th17 cells detected in naïve CD4+ T cells after culturing in presence both IL-1b and IL-6 (C) The representative dot plots of CD39+Tregs and Th17 cells detected...
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