cd4 cd25 regulatory t cells in hematopoietic stem cell transplantation
Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... for the induction of CD4+ CD25+ regulatory T cells by conversion of CD4+ CD2 5T cells after antigen stimulation [41] We found that CD4+ CD25+ T cells obtained after coculture of CD4+ CD25- T cells ... examined Foxp3 transcripts involved in the conversion of CD4+ CD25- T cells into CD4+ CD25+ T cells (Figure 5d) Our findings show that highly purified CD4+ CD25- T cells can be converted into CD4+ CD25+ ... thought to be regulatory T cells, inhibited the proliferation of CII-reactive CD4+ T cells in a dose-dependent manner CD4+ CD25+ regulatory T cells converted from peripheral CD4+ CD25- naïve T cells...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... abrogating the suppressive effect of Treg cells [37] With this in mind, it could be interesting to investigate whether the accumulated Treg cells in patients with arthritis function properly in ... hand, transfer of Treg cells 24 hours after intra-articular antigen challenge might be too late to inhibit activation of effector T cells and their migration to the joint Indeed, T- cell activation ... disease Using depletion of CD25- expressing cells or transfer of CD4+ CD25+ cells, in the present study we demonstrated that Treg cells modulate the onset of AIA but are ineffective at later stages,...
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Báo cáo y học: " Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD" potx
... at 4°C for 10 minutes, 300 g and 300 μl of PBS was added To identify CD3+, CD4+ and CD25+ cells, the cells were stained with same antibodies as in the extracellular staining To obtain FoxP3+ cells, ... of T cells into a cytotoxic phenotype This further supports a potential involvement of the acquired immune response in the pathogenesis of COPD To further evaluate the role of regulatory T cells ... [6] In addition, CD4+ cells express high levels of CD25 in COPD and smokers, suggesting the presence of regulatory T- cells [6] It is of importance to verify and evaluate regulatory T cells in...
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Báo cáo y học: "CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis" ppsx
... report that the effective function of the CD4+ CD25+ regulatory T cells is T- cell receptor (TCR) specific [28] Collectively, our data suggest that the CD4+ CD25+ regulatory T cells may not be involved ... deficient for CD4+ CD25+ T cells, are resistant to PGIA Our data suggest that the CD4+ CD25+ regulatory T cells may not be essential for controlling experimentally induced autoimmune arthritis Competing ... CD4+ CD25+ regulatory T cells from BALB/c mice with PGIA may mediate the induction of the disease CD4+ CD25+ regulatory T cells may not control autoimmune arthritis To further investigate whether the...
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Báo cáo y học: "Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ" potx
... (Radioactivity in condition without Treg cells – Radioactivity in condition with Treg cells) /Radioactivity in condition without Treg cells) against the number of Treg cells R404 Arthritis Research ... of wild-type Treg cells against wild-type or IFN-γR KO (data not shown) Teff cells These data demonstrate that the defect in inhibiting CD4+ CD25- Teff cells acquired the presence of Treg cells ... indicated number of CD4+ CD25+ Treg cells The percentage inhibition (100 × (Radioactivity in condition without Treg cells – Radioactivity in condition with Treg cells) /Radioactivity in condition without...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... constitutive Treg cells, account for to 10% of peripheral CD4+ T cells and inhibit the activation of effector T cells in the periphery.38,39 FOXP3, the transcriptional regulator expressed on Treg cells, ... et al, Regulatory T Cells in the Context of Allergic Disease thus preventing the activation of mast cells and basophils IgG4 has been shown to reduce the IgE-mediated degranulation of these cells ... mucosa represents a unique immunologic unit with the first contact with the allergen within the gastrointestinal tract, where immune tolerance is the natural outcome Freshly isolated oral LCs expressed...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... selection, but also in the periphery Those autoreactive cells that escape negative selection must be restrained in the periphery, and it is thought that CD4+ CD25+ TR cells generated in the thymus ... Tr1 cells [74], extends this paradigm The fate of the TR cells induced at the site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, ... proceed It is not yet known whether the CD4+ CD25 T cells capable of differentiating into TR cells following activation are derived from a separate lineage of CD4+ T cells, and whether their induction...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... colleagues, that therapeutic use of CD4+ CD25 Treg might not be a feasible option treatment decreases the infiltrate in joints Furthermore, RA patients relapse shortly after withdrawal of anti-TNF-α ... function of CD4+ CD25+ Treg [18] The crucial point of that study was that Treg isolated from patients with active RA before treatment with anti-TNF-α were unable to suppress proinflammatory cytokine secretion ... context, recent studies on RA have indicated that antigen-specific (HC-gp39) CD4+ CD25+ Treg might be deficient in patients in comparison with controls [23] A more recent study indicated that in...
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Báo cáo y học: "Regulatory T cells in systemic lupus erythematosus: past, present and future" pot
... activated T cells, continuously stimulate immature DC to become immunogenic antigen-presenting cells These cells, in turn, activate more self-reactive T cells to produce proinflammatory cytokines ... T- cell/ dendritic cell interactions in health and in systemic lupus erythematosus Regulatory T cells (Tregs) (red) and effector T cells, shown as potentially pathogenic anti-self T cells (blue), can affect ... antigen-presenting cells strongly contributed to the defective function These findings are consistent with the evidence of the important role of type I interferons in the pathogenesis of SLE The...
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Báo cáo y học: "Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation" pot
... sjTRECs and TRBV-BD sjTRECs to evaluate not only the recent total naïve T- cell output but also the specific TRBV subfamily naïve T- cell output from the thymus in patients after HSCT The sjTRECs ... important factor determining the success of immune reconstitution post-HSCT and whether thymicdependent or -independent pathways contribute to Tcell reconstitution post-HSCT Thymic function and ... evaluating Tcell reconstitution in acute leukemia patients after alloHSCT and may further support and explain reconstitution of RTEs measured by quantitative detection of total sjTRECs Materials...
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Báo cáo y học: "haracterization of regulatory T cells in urban newborns" pptx
... regulatory T cells, [26] we compared the proportion of CD4+ CD25+ and CD4+ CD25+ bright T cells in CB and maternal PB (Table 3) We found that CB contained fewer CD4+ CD25+ and CD4+ CD25+ bright T- cells ... and PB CD4+ CD25+ T cell populations were statistically significant (p < 0.02) Proportion of CD4+ CD25+ bright and CD4+ CD25+ FOXP3 T cells in CB and maternal PB Considering CD4+ CD25+ brightT -cells ... numbers of CD25+ bright cells present in CB and PB, we next sought to establish whether or not these CD25+ bright cells expressed distinct patterns of differentiation/activation markers (C45RO, CD45 RA,...
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Báo cáo y học: "The relationship between CD4+CD25+CD127regulatory T cells and inflammatory response and outcome during shock states" potx
... different between patients and healthy volunteers throughout the study period, patients with shock presented with constantly decreased NK absolute To get further insight in to the role of Tregs during ... leads to the depletion of other important cells (activated T cells) Moreover, anti -CD25 antibody may not have completely eliminated CD25low Tregs Conclusions Taken together, these data argue against ... in septic as well as in non-septic patients As NK cells have recently been advocated to play a role in sepsis outcome, we also investigated the kinetics of this cell s subset In contrast to the...
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Báo cáo sinh học: " Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice" docx
... and mature DCs, resulting in tolerogenic interaction with T cells in SIT We found that the combination of DNA vaccination with Fc and OVA had better effects onOVAinduced alterations in the spleen ... regulation of type immunity in asthma Competing interests The authors declare that they have no competing interests Authors' contributions YL performed all analyses and wrote the initial draft of the ... stimulating the production of TH1 cytokine synthesis in naïve and memory T cells As an alternative to the administration of allergens or allergen derivatives, vaccination with allergen-encoding...
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ADVANCES IN HEMATOPOIETIC STEM CELL RESEARCH pot
... 1) Hematopoietic stem cell properties, 2) Regulation of hematopoietic stem cells, 3) Hematopoietic stem cells in aging and disease, and 4) Hematopoietic stem cell therapy The first section provides ... Part Hematopoietic Stem Cell Therapy 345 Chapter 16 Hematopoietic Stem Cells Therapeutic Applications 347 Carla McCrave Chapter 17 Hematopoietic Stem Cell Potency for Cellular Therapeutic Transplantation ... IL3) that interact with receptors and initiate signal transduction processes that culminate in the activation of new genetic programs These external stimuli trigger intrinsic determinants of cell...
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Báo cáo y học: "Marked increase of procalcitonin after the administration of anti-thymocyte globulin in patients before hematopoietic stem cell transplantation does not indicate sepsis: a prospective study" pptx
... prior to hematopoietic stem cell transplantation The patients were treated at the Institute of Hematology and Blood Transfusion in Prague, Czech Republic The study was approved by the institutional ... filtration rate; GGT, gamma-glutamyl transferase infection in this population Patients undergoing conditioning before hematopoietic stem cell transplantation represent a distinct population with ... AV participated in the transplantation and contributed to the study design AK and TZ participated in the study design and helped to draft the manuscript TD intellectually contributed to the preparation...
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Báo cáo y học: "Hematopoietic stem cell transplantation for systemic lupus erythematosus" ppsx
... maintains steady state by constantly fluctuating between tolerance and immunity This dynamic state is best demonstrated by the intermittent clinical course of some autoimmune diseases such as relapsing-remitting ... transplant neutropenic interval by 4–6 days compared with the same dose of cyclophosphamide without hematopoietic stem cell support, and also to hasten stem cell regeneration of the immune system ... with normally intact third-party responses Autologous HSCT appears to be reintroducing self-tolerance accompanied with a restoration of immune diversity, although the exact pathway(s) (e.g T regulatory...
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Báo cáo y học: "Allogeneic hematopoietic stem cell transplantation for acute leukemia with Gilbert’s syndrome" pptx
... possible that phenytoin, an inducer of UGT1A1 activity used during the conditioning, prevented hyperbilirubinemia [8] It has been reported that UGT1A1 inducers, including phenobarbital, rifampin and ... of Chinese Anti-Cancer Association of Professional Committee of Hematology Branch; editor of more than 10 journals Competing interests The authors declare that they have no competing interests ... and phenytoin, were used in the diagnosis and treatment of GS [8,9] List of abbreviations GS: Gilbert’s syndrome; allo-HSCT: Allogeneic hematopoietic stem cell transplantation; AML: acute myeloid...
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Báo cáo y học: "Are CD4+CD25-Foxp3+ cells in untreated new-onset lupus patients regulatory T cells" doc
... on CD4+ CD25- , CD4+ CD25low, and CD4+ CD25high T cells, we found that, unlike in CD4+ CD25high T cells, CD127low/- was not a perfect surface marker for intracellular Foxp3 in CD4+ CD2 5T cells; therefore, ... Foxp3 in CD4+ CD25- T cells It is also important to note that, although the CD25low population lies adjacent to CD25- on a FACS plot (as shown in Figure 2), they belong to two different cell entities ... intracellular Foxp3 in CD4+ CD25- T cells and that CD4+ CD25- CD127low/- T cells could not be used as a live substitute for CD4+ CD25- Foxp3+ T cells to perform functional assay Expressions of GITR,...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
... Unfractionated CD4+ cells (which contain CD5high-expressing cells) prevented the induction of autoimmunity when transferred together with the CD5low cells, implying that the TR cells were contained specifically ... Antigen-presenting cell (APC)-activated TR cells transduce an unidentified active negative signal to nearby effector T (TE) cells located on the same APC or an adjacent one (b) TR cells outcompete TE cells ... D: Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin in the prevention of autoimmune thyroiditis in rats by peripheral CD4+ CD45RC–...
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Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen" pptx
... elevated production of TGF-β from tolerized lymphocytes as well, and it would therefore be very interesting to investigate the role of Th3 cells In order to further define the characteristics of cells ... spleen % CD4+ CD25+ IL-10-positive cells Site Induction of IL-10-producing CD4+ CD25+ T cells in the spleen of tolerized mice The proportion of IL-10-producing CD4+ CD25+ T cells was analyzed by triple-colour ... and the spleen That in vitro restimulation with CII generated significant enrichment in IL-10-producing CD4+ CD25+ T cells among lymphocytes from tolerized spleen is particularly interesting We...
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