cd33 mdsc are induced by tumor derived il 1β il 6 tnfα vegf and gm csf
Báo cáo sinh học: " Transcription and translation of human F11R gene are required for an initial step of atherogenesis induced by inflammatory cytokines" doc
... HAEC HAEC TNFα& IFNγ α γ * IFNγ γ TNFα α Untreated IFNγ γ * HUVEC TNFα& IFNγ α γ IFNγ γ * * TNFα α Untreated TNFα& IFNγ α γ IFNγ γ TNFα α * * TNFα& IFNγ α γ * * * TNFα α * b Untreated F11R arbitrary ... aortic (HAEC) and human umbilical endothelial vein endothelial cells (HUVEC) by F11R siRNA: inhibition by silencing of the F11R gene Transfection of HUVEC and HAEC was conducted by using either ... lesion formation and infiltration in atherosclerosis-prone mice Arterioscler Thromb Vasc Biol 20 06, 26: 10-13 doi:10.11 86/ 1479-58 76- 9-98 Cite this article as: Azari et al.: Transcription and translation...
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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" doc
... osteoblasts and osteoclasts [12,13] RANKL and OPG are members of a ligand-receptor system that directly regulates osteoclast differentiation and bone resorption, and both are produced and secreted by ... dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG -63 human osteosarcoma cells Clin Exp Rheumatol 20 06, 24: 366 -372 39 Clover J, Gowen M: Are MG -63 and HOS ... Tissue Int 19 86, 38:339-341 11 Brain SD, Williams TJ: Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability Br J...
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báo cáo hóa học:" Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-B ligand expression in MG-63 osteoblastlike cells exposed to polyethylene particles" pot
... osteoblasts and osteoclasts [12,13] RANKL and OPG are members of a ligand-receptor system that directly regulates osteoclast differentiation and bone resorption, and both are produced and secreted by ... dexamethasone and celecoxib on calcium homeostasis and expression of cyclooxygenase-2 mRNA in MG -63 human osteosarcoma cells Clin Exp Rheumatol 20 06, 24: 366 -372 39 Clover J, Gowen M: Are MG -63 and HOS ... Tissue Int 19 86, 38:339-341 11 Brain SD, Williams TJ: Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability Br J...
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báo cáo hóa học: " Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis" pdf
... Wiendl H: CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability FASEB J 2009, 23: 365 9- 367 3 Hauser SL, Bhan AK, Gilles F, Kemp M, Kerr ... death-ligand [corrected] and programmed death-ligand [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis J Immunol 20 06, 1 76: 3480-3489 ... human dendritic and tumor cells [44] via a STAT6-mediated mechanism Therefore, a more detailed dissection of the mechanisms regulating PD-L1 and PD-L2 expression under physiological and disease conditions...
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Báo cáo khoa học: " Effect of dihydrotestosterone on mouse embryonic stem cells exposed to H2O2-induced oxidative stress" pdf
... cell toxicity induced by oxidative stress ES cell lines are pluripotent cells derived from the blastocyst-stage of mammalian embryos [12, 16] These unique cells are characterized by their capacity ... event and is regulated by the availability of substrates in the form of polyunsaturated fatty acids, pro-oxidants which promote peroxidation, and inhibited by antioxidants such as β-carotene and ... against H2O2 -induced ES cell injury Acknowledgments This work was supported by Stem Cell Research Program (M1 064 1450001-06N4145-00110), Ministry of Education, Science and Technology, and Korea Research...
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Báo cáo y học: " Effect of recombinant IL-10 on cultured fetal rat alveolar type II cells exposed to 65%-hyperoxia" pps
... experiments compared to untreated cells (Figure 6B), and the percentage of cellular necrosis [PI-positive and AV-negative] significantly decreased in rIL-10-treated cells by 66 % after 24 h and 36 h of ... decreased by 22% after 36 h when compared to hyperoxic cells without rIL-10 ( 36 h-untreated = 3.7 ± 0. 06 vs 36 h- treated = 2.9 ± 0.17; p < 0.01) (Figure 6F) As shown in Figure 6G, IL- 8-release ... of 65 %-hyperoxia on VEGF and cytokine genes expression Graphical depiction showing that 65 %-hyperoxia upregulates VEGF (A) and IL- 8 genes (B) and downregulates IL- 10 (C) gene The results of IL- 8...
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Báo cáo y học: " Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions" pps
... - 62 7 79 Prostate BPH - 66 2 66 Prostate BPH - 66 5 53 Prostate 63 ± 18.4 66 7 47 Prostate 61 ± 4.2 68 7 63 Prostate 74 69 0 79 Prostate BPH - 69 3 75 Prostate BPH - 704 64 Prostate (HR) - 003/ 06 52 ... 99 ± 56 484 69 Prostate 105 ± 29 512 74 Prostate BPH - 561 72 Prostate BPH - 563 64 Prostate 35 ± 9.5 75 ± 569 64 Prostate 574 74 Prostate BPH/G6 (5%) - 60 5 56 LN metastasis 119 ± 21 66 1 78 Prostate ... prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells Cancer Res 2002, 62 :66 59 -66 66 Patterson SG, Wei S, Chen X, Sallman DA, Gilvary DL,...
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báo cáo hóa học: " Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures" pot
... IL- 6 (B), IL- 1b and TNF-a (C), and IL- 6 and TNF-a (D) in febrile patients (N = 82) IL- 1b levels are significantly correlated with HMGB1, IL- 6, and TNF-a levels (all, p < 0.05, r = 0.28, 0.25, and ... 84.2 ± 38 .6 5 .6 ± 2.9 8.3 ± 2 .6 Febrile seizures (41) 12.0 ± 5.3* 247.1 ± 43.0 32 .6 ± 3.0* 73.5 ± 20.9 5.0 ± 1.8 23 .6 ± 13.4 Typical FS (27) 12.9 ± 7 .6* 260 .1 ± 50.4* 30.5 ± 3.8 66 .5 ± 21 .6 3.0 ± ... Comparisons of IL- 1b levels among afebrile and febrile controls and the four seizure groups (first and recurrent febrile seizures, afebrile seizures in GEFSP and afebrile status epilepticus in...
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Motility and alignment of human umbilical vein endothelial cells (HUVEC) on 3d scaffolds
... 0.0127 0.01 86 0.0 065 0.0210 0.0135 0.0054 0.01 56 0.0138 0.0030 0.0147 0.0217 0.00 56 0.02 36 0.0185 0.00 46 0.0200 0.0 160 0.0033 0.0179 Table 3.3: Average speed on 15µm wide grooves and ridges Cell ... to the code Another software package, named as Ionutils, is used to support file conversion to and from monochromatic bitmap, ascii and epl, the native file format used by Ionscan [12] Figure 2.4: ... cells are similar for different ridge widths, and range from 0.0171 ∼ 0.0203 (µm/s) 36 Cell Number Total Average Vx (µm/s) Vy (µm/s) V (µm/s) 0.0252 0.00 36 0.0258 0.0200 0.0024 0.02 06 0.01 86 0.0031...
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Tài liệu Báo cáo khoa học: Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse pdf
... C (VEGF- A or VEGF- C) (Fig 4C) Phosphorylation of VEGFR-2 and mitogenactivated protein kinases (MAPKs), but not of VEGFR-3, was induced by VEGF- A, whereas phosphorylation of VEGFR-2, VEGFR-3 and ... Mesenteric BECs and LECs (Fig 5A,B) were also obtained by the same strategy as illustrated in Figs and 4, and were treated with VEGF- A or VEGF- C (Fig 5C) MAPK and Akt phosphorylation were induced in ... VEGFR-3 Lyve-1 SV40T VEGF- C VEGF- A No treatment VEGF- C VEGF- A C No treatment Lyve-1 The early mortality of the T 26 ⁄ Tie2–Cre doubletransgenic mice is a disadvantage for the generation of T26...
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Tài liệu Báo cáo khoa học: Gene transcription of fgl2 in endothelial cells is controlled by Ets-1 and Oct-1 and requires the presence of both Sp1 and Sp3 pdf
... fgl2 fgl2 fgl2 fgl2 fgl2 fgl2 fgl2 fgl2 fgl2 )82/)55 )98/ )69 )57/)32 )85/ )66 m)85/ )66 )97/)77 m)97/)77 ) 76/ ) 56 m) 76/ ) 56 Electrophoretic mobility shift assays (EMSA) Nuclear extracts from endothelial ... pGL2-Basic using the SmaI and XhoI sites in this vector to construct the plasmid pfgl2()3500/+9)Luc A 1.3-kb fragment was also released from pM 166 by digestion with SalI and EcoRV and subcloned into ... determined by morphology and viability exceeded 98% by trypan blue exclusion MHV-3 was grown and titrated as described previously [8] The murine SVE-10 endothelial cell line and Schneider’s Drosophila...
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Báo cáo khoa học: Cytosolic phospholipase A2-a and cyclooxygenase-2 localize to intracellular membranes of EA.hy.926 endothelial cells that are distinct from the endoplasmic reticulum and the Golgi apparatus pdf
... cPLA2-a in EA.hy.9 26 cells and HUVECs were compared Equivalent amounts of protein were separated by SDS ⁄ PAGE and immunoblotted for cPLA2-a Lysates from the parental A549 cell line and HeLa cells ... cPLA2-a expression levels and subcellular distribution in EA.hy.9 26, HUVEC, A549 and HeLa cells (A) Total cell lysates from EA.hy.9 26, HUVEC, A549 and HeLa cells were prepared and 20 lg protein of ... EA.hy9 26 In Vitro Cell Dev Biol 26, 1 167 –1172 Suggs JE, Madden MC, Friedman M & Edgell CJ (19 86) Prostacyclin expression by a continuous human cell line derived from vascular endothelium Blood 68 ,...
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Báo cáo khoa học: Biochemical characterization of human umbilical vein endothelial cell membrane bound acetylcholinesterase ppt
... acetylcholinesterase variants in biology and pathology Eur J Biochem 264 , 67 2 68 6 Scoumanne A, Kalamati T, Moss J, Powell JT, Gosling M & Carey N (2002) Generation and characterisation of human saphenous ... (C-terminal, 94. 56% and N-terminal, 99.95%), reaching its maximum with incubation with IL1 -b 500 pgÆmL)1 (C-terminal, 99.72%) The stimulation with IL1 -b slightly increased the von Willebrand factor ... (vWf) expression (64 .99% to 68 .04%) F A Carvalho et al Isolation and solubilization of plasma membranes from cultured HUVECs Membranes from HUVECs were isolated and further solubilized At different...
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Báo cáo khoa học: Lithium increases PGC-1a expression and mitochondrial biogenesis in primary bovine aortic endothelial cells ppt
... cocktail inhibitors (Sigma-Aldrich) Equal amounts of the proteins were denaturated by boiling in Laemmli buffer, fractionated on SDS–PAGE and transferred onto Immobilon P membrane (Millipore, Billerica, ... (complex IV), and ATPsynthase subunit-b by 2 .66 ± 0.57-fold (complex V), whereas the mRNA levels of cytochrome c and mitochondria DNA polymerase were increased slightly, by 1.3 ± 0.04 and 1.33 ± ... 0.7-fold at 36 h treatment (Fig 8A) Indeed, these results, although novel for valproate, are consistent with the regulation of PGC-1a expression by nutrient availability and, in particular, by various...
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Báo cáo khoa học: Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine⁄chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-jB pdf
... significantly induced IFN-c, IP-10 and GM- CSF expression in HUVECs (data not shown) However, neither LPS, nor AGE-HSA stimulated HUVECs to produce tumor necrosis factor-a, IL- 1b, IL- 2, IL- 4, IL- 10 and IL- 12 ... (A) IL- 6, IL- 8 and MCP-1 release from HUVECs 24 h after stimulation was measured and (B) gene expression of IL- 6, IL- 8 and MCP-1 in HUVECs h after stimulation was assessed by RT-PCR Data are ... by AGE-HSA and LPS in HUVECs is highly selective 460 0 We further performed RT-PCR and found that either AGE-HSA alone or LPS alone increased the mRNA transcripts of IL- 6, IL- 8 and MCP-1 compared...
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Báo cáo khóa học: Ouabain stimulates endothelin release and expression in human endothelial cells without inhibiting the sodium pump Robert Saunders and Georgios Scheiner-Bobis pptx
... intracellular 86Rb+, and the radioactivity in the lysate was measured by liquid-scintillation counting The 86Rb+ activity was normalized against the amount of protein [13] per well 86 Rb+ uptake ... uptake of 86Rb+ into endothelial cells was determined as a function of the ouabain concentration Rubidium is recognized by the sodium pump and its uptake can easily be inhibited by ouabain and several ... Fig are consistent with these results 86Rb+ uptake by HUAECs was not inhibited by ouabain, but at nM or 10 nM concentrations of the steroid, the uptake was stimulated by at least 15% (Fig 3B) and...
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báo cáo hóa học:"Interdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells" pdf
... mAb, CD66b mAb, and CD66c mAb (panel B), the CD66ae mAb, CD66b mAb, and CD66de mAb (panel C), the CD66ae mAb, CD66c mAb, and CD66de mAb (panel D), or the CD66b mAb, CD66c mAb, and CD66de mAb ... the CD66ae mAb and CD66c mAb (panel C), the CD66ae mAb and CD66de mAb (panel D), the CD66b mAb and CD66c mAb (panel E), the CD66b mAb and CD66de mAb (panel F), or the CD66c mAb and CD66de mAb ... CD66ae, CD66b, CD66c, and CD66de mAbs, but not to CD63 mAbs (Fig 2, panel D) In contrast, desensitization to the CD66b, CD66c, and CD66de mAbs left the cells unresponsive to CD66b, CD66c, and...
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báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... animal care set by the European Union ( 86/ 609/ EEC) and the Spanish regulations (BOE67/8509-12; BOE1201/2005) on the use and care of laboratory animals, and approved by the local Animal Care and ... enhances IL- 6 production in astrocytes infected with TMEV by a CB1 receptor-mediated pathway [58] and in a more recent work AEA modulates TMEVinduced IL- 12, IL- 23 and IL- 10 in microglia by activating ... 15,909 2,327 15 909 ± 327 Ipsilateral 20,028 ± 1,257## 21,341 ± 0,958## 19 ,65 7 1,120 19 65 7 ± 120# contralateral 16, 9 56 ± 0,913 17,151 ± 1,007 16, 320 0,7 96 16 320 ± 7 96 Figure CB1 deletion exacerbates...
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báo cáo hóa học:" Biocompatibility of Poly-ε-caprolactone-hydroxyapatite composite on mouse bone marrow-derived osteoblasts and endothelial cells" doc
... endothelial cell viability and functions J Biomed Mater Res (part A) 20 06, 76: 6 56- 663 Groessner-Schreiber B, Tuan RS: Enhanced extracellular matrix production and mineralization by osteoblasts cultured ... for cell process and spreading, adhesion and orientation Therefore, osteoblasts and endothelial cells were inclined to attach to the rougher surface and appeared better viability and strong cellular ... of osteoblasts viability (Figure 6A) Compared to the HA-free PCL material, osteoblasts viability was increased by 740% (p < 0.001) in high HA ratio (HA: PCL = 1:1) group and by 570% (p < 0.001)...
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