cd25 cd127 t cells by ido cho cells in the peripheral blood of breast cancer patients
báo cáo khoa học: "Upregulated expression of indoleamine 2, 3-dioxygenase in CHO cells induces apoptosis of competent T cells and increases proportion of Treg cells" pptx
... + CD127- T cells by IDO+ CHO cells in the peripheral blood of breast cancer patients Mononuclear cells isolated from the peripheral blood of breast cancer patients were incubated with IDO+ CHO ... suggested that Vav1 is a target molecule involved in the regulatory effect of IDO on T- cells Whether IDO can induce the maturation and differentiation of Tregs is unclear Investigation into the ... exist that can increase the proportion of Tregs We also added 1MT, the specific inhibitor of IDO in the co-culture system composing of CHO /IDO cells and CD3 +T cells to elucidate the regulatory...
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Pulmonary tuberculosis associated with increased number and percentage of natural killer and B cells in the peripheral blood pot
... diseases The study was limited by lack of access to the patient records therefore it was not possible to correlate the laboratory data with the clinical findings Peripheral blood subset data of the patients ... significantly lower in patients with PTB in the present study It is possible that the depletion of CD4 + cells may have mostly contributed to the decreased of CD3 + cell percentage and counts in patients ... counts observed in the present study may therefore indicate a better immune status of the patients in this study Immunity against MTB comprises of a predominant cellular response and majority of...
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Báo cáo y học: "Indoleamine 2,3-dioxygenase-expressing dendritic cells are involved in the generation of CD4+CD25+ regulatory T cells in Peyer''''s patches in an orally tolerized, collagen-induced arthritis mouse model" ppt
... 1-MT, an IDO inhibitor These findings suggest that the functional activities of IDO from tolerized mice could affect the T- cell response In the resting state, autoreactive T cells residing in the ... determining immunity or immune tolerance; this determination is based on the maturation or activation state and the subset of DCs, and cytokine profiles in the microenvironment at the time of antigen ... slight edema and erythema from the ankle to the tarsal bone, = moderate edema and erythema from the ankle to the tarsal bone, and = edema and erythema from the ankle to the entire leg The sum of the...
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Báo cáo khoa học: Effect of 5-lipoxygenase inhibitor MK591 on early molecular and signaling events induced by staphylococcal enterotoxin B in human peripheral blood mononuclear cells doc
... thymidine incorporation (in cpm) The investigation then focused on analyzing the effect of the same set of inhibitors on TNF-a induction (Table 1) The observed induction in SEB treated cells (22-fold) ... It is possible that the ability of the target to inter-connect multiple signal pathways allowed it to in uence cellular activity in the two crucial cell types that are most effected by SEB stimulation ... due to a number of reasons, including the inability of the targets to completely block the signaling cascades due to the leaking effect or the ability of the signal to use alternative signaling...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... Hence, the oral mucosa represents a unique immunologic unit with the first contact with the allergen within the gastrointestinal tract, where immune tolerance is the natural outcome Freshly isolated ... amounts of IL-4 and IL-10.35 Further studies are required to elucidate the in vivo role of these cells and their subsets Effects of SIT on Dendritic Cells To understand the mechanisms of action of ... et al, Regulatory T Cells in the Context of Allergic Disease thus preventing the activation of mast cells and basophils IgG4 has been shown to reduce the IgE-mediated degranulation of these cells...
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Báo cáo y học: "Decreased effector memory CD45RA+CD62L– CD8+ T cells and increased central memory CD45RA–CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients" ppt
... differences in the differentiation of T cells in RA patients Decreases in some of the subpopulations in peripheral blood may indicate that there is a selective migration of these cells out of the peripheral ... between the age of the RA patient group and the corresponding healthy control group (P > 0.9, by Student’s t- test), between the age of the SLE patient group and the corresponding healthy control ... suggested that the differentiation may not be linear at all The central and effector memory phenotypes of CD4+ and CD8+ T cells in peripheral blood of RA patients are unknown Determination of these...
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Báo cáo y học: "Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease" ppsx
... GTT GTT CTC GT-3' mTLR4 upper 5'-AGC CGG AAG GTT ATT GTG GTA GT-3' mTLR4 lower 5'-TGC CGT TTC TTG TTC TTC CTC T- 3' mTLR6 upper 5'-ATA CCA CCG TTC TCC ATT T- 3' mTLR6 lower 5'-GAC GTG CTC TAT CAT ... The amount of the secreted interferon-γ in the supernatant was then tested in duplicate using the enzyme-linked immunosorbent assay technique One representative experiment is shown The detection ... that bacterial lipoproteins directly stimulate alloreactive CTLs to proliferate and to secrete IFN-γ via TLR-2 adds another facet to the functional potential of T effector cells The fact that...
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Báo cáo y học: "Regulating the immune system: the induction of regulatory T cells in the periphery Jane H Buckner1 and Steven F Ziegler2" pot
... 1) In addition, CD4 +CD25+ TR cells leading to ‘infectious tolerance’, thus inducing the local induction of Th3 or Tr1 cells [74], extends this paradigm The fate of the TR cells induced at the ... site is not known — whether these cells exist only transiently then die, whether they persist in the body as TR cells, or whether they return to their previous role as nonregulatory resting T cells ... question: Do TR cells represent a lineage of T cells or a state of activation that may be achieved by any T cell under the appropriate conditions of activation? The induction of TR cells in the...
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The role of CD8 t cells in the differentiation of TNF iNOS producing dendritic cells and TH1 responses
... suggesting that CD8 T cells were vital for the polarization of Th1 cells This was also supported by studies demonstrating the involvement of CD8 T cells in the generation of protective CD4 Th1 ... by inhibiting the differentiation of bystander non-infected monocytes into DCs through the release of interleukin-10 (Remoli et al., 2011) Therefore, the 41 Chapter 1: Introduction presence of ... types of lymphocytes T cells provide important cell mediated immunity by participating in the cytolysis of infected cells through the recognition of antigen presented on MHC class I They so through...
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Báo cáo khoa học: " An immunohistochemical study of chromogranin A and Sp-1 immunoreactive cells in the gastrointestinal tract of ovariectomized rats" pdf
... noitprosba lanitsetni ni esaerced citamard eht yb detrexe sdnamed wen eht teem ot ssecorp evitceles a era sllec enircodne IG eht ni segnahc eht taht detalutsop neeb sah tI ]51[ sitirtsag cihporta ... eht ni sllec RI-GC eseht fo snrettap lanoitubirtsid eht ,hguohtlA ]8,3[ sllec enircodneoruen lla fo ”srekram“ nommoc yltnacifingis a ,stneitap aitreni cinoloc nI slamina fo sutats evitsegid ot ... 9611-2611 ,63 ,1002 loretneortsaG J dnacS ytivitca lacirtceleoym dna gniytpme cirtsag ot pihsnoitaler :I epyt setebaid htiw stneitap ni sllec enircodne lanitsetniortsag lamronbA B yhotiS ,M yhlaS-lE...
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Báo cáo y học: "Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients" doc
... importance of these cells in the inflammatory process would be to assess their numbers and function within the airways Therefore, in this study we have extended the findings of our previous study to investigate, ... what was observed in the peripheral blood of the same group [12] This raises the possibility that the cells are being selectively recruited to the lung The increased proportion of cells expressing ... spontaneous target LDH release)}x100 The biological lytic ability was then calculated by multiplying the lytic activity per cell by the total number of CD56+ cells per gram of induced sputum Statistical...
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Báo cáo y học: " Aberrant splicing of the hRasGRP4 transcript and decreased levels of this signaling protein in the peripheral blood mononuclear cells in a subset of patients with rheumatoid arthritis" pdf
... range of ∆∆-CT value as the mean ± SD of the healthy volunteers The levels of the hRasGRP4 transcript in the RA patients were then quantitated The expression of hRasGRP4 transcripts in control individuals ... cycle threshold (CT) method in which ∆CT is the level of the hRasGRP4 transcript in the RNA sample relative to that of the hGAPDH transcript The difference in the expression of the hRasGRP4 transcripts ... production of defective transcripts in an attempt to compensate for the defective isoform In support of this hypothesis, the peripheral blood cells from RA patients fail to express substantial amount of...
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Báo cáo y học: " In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques" pptx
... with the FLP Qdot 655 multimer (data not shown); no positive cells were detected We found that the intraepithelial cells in the ileum and in the colon showed higher autoflorescence than cells in ... of interest to further explore the role of these virus specific CD8 +cells located near or within the B cell follicle, to understand both the immunological interactions between the different cells ... CM9 peptide stimulation and between 0.32-3.94% of CD8 + CD69 + T cells secreted TNF-a after SEB stimulation (data not shown) Next, we tested the ability of the Qdot 655 multimer to detect the Gag...
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Báo cáo khoa học: " Water extraction by tree fine roots in the forest floor of a temperate Fagus-Quercus forest" pdf
... following infiltration (wetting characteristics) They allow the calculation of the saturating water content &s; (i.e thetas the water content immediately after a saturating infiltration) and the water ... directly after a saturating infiltration is taken as the ’saturated water content’ &s; of the humus material This thetas is lower than the maximum water content &thetas; max (= porosity) of the organic ... storage in the forest floor on I ) the water retention curve of the humus material, 2) the water conductivity of the material, and 3) the profile depth The water content-soil water matric potential...
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Báo cáo y học: " Induction of IL-10-producing CD4+CD25+ T cells in animal model of collagen-induced arthritis by oral administration of type II collagen" pptx
... excluding the hind leg into which CII/incomplete Freund’s adjuvant was injected, was determined at the time of the second injection The final values presented in the Results section represent an ... attempted to improve our basic understanding of the immune cell functions that participate in the process of induction of oral tolerance Because most of the previous studies that addressed the ... function that are involved in the induction of peripheral tolerance in an orally tolerized mouse model of arthritis R218 Our findings indicate that the serum levels of proinflammatory and anti-inflammatory...
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Báo cáo y học: "CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis" ppsx
... either depleted of CD25+ cells or without depletion, were injected into SCID mice together with proteoglycan The incidence and severity of arthritis in SCID mice receiving spleen cells containing ... regulatory T cells to suppress PGIA was not due to loss of their suppression activity, because in vitro the CD4 +CD25+ T cells could effectively inhibit the proliferation of the CD4 +CD25 T cells ... essential for the homeostasis of the CD4 +CD25+ regulatory T cells that control autoimmune diabetes [6] Consistent with that report, the expression of CD4 +CD25+ regulatory T cells was found to be...
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Báo cáo y học: "A paragon of self-tolerance: CD25+CD4+ regulatory T cells and the control of immune responses" pps
... Mason D: Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin in the prevention of autoimmune thyroiditis in rats by peripheral ... to maintain tolerance is also uncertain, but it might be through the inhibition of APCs or pathogenic T cells, by maintenance of the TR cell population and/or by enhancement of their function (reviewed ... suppressive stimulators of TE cells (d) CD25 expression by the TR cells acts as an interleukin-2 sink and hinders the autocrine/paracrine stimulation of TE cells 23 Arthritis Research & Therapy Vol...
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Báo cáo y học: "The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells" doc
... of the T- cell compartment is still activated 14 days after intra-articular antigen challenge in the absence of Treg cells Compatible with these findings is that the production of cytokines in ... prevent autoimmunity but also to control the extent of inflammatory reactions in order to prevent tissue damage to the host Further support for the influence of CD4 +CD25+ Treg cells on arthritis ... 7b) The migration behaviour of CD4 +CD25+ Treg cells does reflect their more activated phenotype, and their ability to enter inflamed joints makes it possible that they act directly at the site of...
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Báo cáo y học: " Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPD" potx
... of T cells into a cytotoxic phenotype This further supports a potential involvement of the acquired immune response in the pathogenesis of COPD To further evaluate the role of regulatory T cells ... proportions of CD127+ helper T cells in the airways Smoking cessation may reduce the proportion of these cells but this has to be confirmed in longitudinal studies These data therefore indicate the ... fluorescence intensity, is associated to both current smoking and COPD (Figure 2b) Even though the number of patients in the present study is rather small, the data are consistent with previously...
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