cd147 mmp 1 and timp 1 on synovium from ra patients and control
Báo cáo y học: "The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanase" docx
Ngày tải lên :
09/08/2014, 06:23
... articular chondrocytes in vivo R 110 1 Arthritis Research & Therapy 32 33 34 35 36 R 110 2 Vol No Pelletier et al and in vitro, is downregulated by interleukin 1beta J Rheumatol 2004, 31: 315 -320 Glasson SS, ... published [18 ] and showed only background staining Immunohistomorphometric analysis Several sections were made from each block of cartilage, and three non-consecutive representative sections from each ... Cartilage from normal controls had normal microscopic appearance Specimens from the OA group presented typical OA changes with a Mankin score of 5 .1 (3 11 ) and a safraninO score of (0–4) Specimens from...
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Senescence and Cell Cycle Control
Ngày tải lên :
25/10/2013, 21:20
... senescence and are resistant to transformation by oncogenic Ras Oncogene 18 :4974–4982 Park IK, Morrison SJ, Clarke MF (2004) Bmi1, stem cells, and senescence regulation J Clin Invest 11 3 :17 5 17 9 Parrinello ... Biol Chem 278 :11 7 31 11 734 Drayton S, Peters G (2002) Immortalisation and transformation revisited Curr Opin Genet Dev 12 :98 10 4 El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent ... ubiquitin-dependent degradation by the ring-finger protein MDM2 (Pomerantz et al 19 98; Stott et al 19 98; Zhang et al 19 98) p53 stabilization leads to induction of p21Cip1 expression Therefore, p16INK4a and p14ARF...
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Tài liệu Báo cáo khoa học: Inhibition of pneumococcal choline-binding proteins and cell growth by esters of bicyclic amines pptx
Ngày tải lên :
19/02/2014, 05:20
... triplicate Conditions are as described in the text Elution at 10 mM (%) Elution at 14 0 mM (%) Choline < 0 .1 > 80 Tetramethylamonium < 0 .1 > 80 Tetramethylphosphonium < 0 .1 > 80 2,2-Dimethyl -1- propanol ... in the elution profile, corresponding to partial accumulation of dimers in these conditions [ 21] On the other hand, addition of 1. 5 mm ipratropium generated a new peak with an elution volume close ... protein concentration of 19 lm Tryptophan emission spectra were obtained using an excitation wavelength of 280 nm, with excitation and emission slits of nm, and a scan rate of 60 nmÆmin )1 Size-exclusion...
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Báo cáo khoa học: The dipeptidyl peptidase IV family in cancer and cell biology pot
Ngày tải lên :
06/03/2014, 09:22
... (19 89) 1F7, a novel cell surface molecule involved in FEBS Journal 277 (2 010 ) 11 26 11 44 ª 2 010 The Authors Journal compilation ª 2 010 FEBS Denise M T Yu et al 10 3 10 4 10 5 10 6 10 7 10 8 10 9 11 0 11 1 ... transduction function, but not proteolytic activity, is directly related to its expression level on human Th1 and Th2 cell lines DPIV family in cancer and cell biology 11 4 11 5 11 6 11 7 11 8 11 9 ... Alpaugh RK & Weiner LM (2002) Promotion of tumor growth by murine fibroblast activation protein, 11 42 13 8 13 9 14 0 14 1 14 2 14 3 14 4 14 5 14 6 14 7 14 8 14 9 15 0 15 1 a serine protease, in an animal model...
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Understanding the participatory news consumer - How internet and cell phone users have turned news into a social experience pdf
Ngày tải lên :
06/03/2014, 21:20
... 1: Sample Disposition Landline Cell 21, 854 9,000 1, 2 31 162 Non-residential 1, 0 91 11 Computer/Fax - Cell phone 9 ,10 5 3,463 1, 466 19 1 8,957 5 ,17 4 41. 0% 57.5% 489 64 1, 477 1, 218 Total Numbers Dialed ... Cooperation Rate 300 16 8 Language Barrier Contacted numbers Contact Rate Callback - 320 Child's cell phone 1, 748 580 Eligible numbers 85.4% 54.3% 51 18 1, 697 562 97 .1% 96.9% Eligibility Rate ... occasional online news consumers were asked if, on a typical day, they get news from any one of 14 different online sources, ranging from the website of a national newspaper or television news...
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Báo cáo khoa học: Linking pseudouridine synthases to growth, development and cell competition potx
Ngày tải lên :
06/03/2014, 22:21
... derived from snoRNAs RNA 15 , 12 33 12 40 12 Politz JC, Hogan EM & Pederson T (2009) MicroRNAs with a nucleolar location RNA 15 , 17 05 17 15 13 Scott MS, Avolio F, Ono M, Lamond AI & Barton GJ (2009) ... Johnston LA (2004) Drosophila myc regulates organ size by inducing cell competition Cell 11 7, 10 7 11 6 44 Moreno E & Basler K (2004) dMyc transforms cells into super-competitors Cell 11 7, 11 7 12 9 ... AcademicPress Watson KL, Johnson TK & Denell RE (19 91) Lethal (1) aberrant immune response mutations leading to melanotic tumor formation in Drosophila melanogaster Dev Genet 12 , 17 3 18 7 ´ Milan M,...
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Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt
Ngày tải lên :
16/03/2014, 11:20
... 80 10 0 B 12 0 20 40 60 Time (min) 10 0 C 60 40 D 60 40 0 20 40 60 22 10 12 14 16 12 14 16 [ GST - IB ] ( àM) 20 E 20 [ATP] (àM) F 18 16 14 12 10 16 14 nM min -1 Initial velocity (v) 18 nM min -1 120 ... (IjBa) (lM) 7.3 0 .13 0.05 1. 3 2.2 2.6 1. 4 1. 7 0.5 2.2 0.94 0.7 3.83 6 .1 3.7 15 .5 0 .13 0.56 18 0.65 0.6 9.6 2.5 2.3 16 82 kcat (s )1) ã 10 )3 4.5 21. 0 37.0 0.92 3.5 4.56 11 .2 11 .3 2 .15 1. 51 Type of IKK2 ... Ratio Translocation Ratio (Arbitary units) 500 400 300 200 EC50 =0.34ngãmL1 10 0 0.0 01 0. 01 0 .1 10 IL-1alpha conc (ngãmL1) EC50 = 0 .14 8ngãmL1 0.0 01 100 0. 01 C D 5.9 10 0 E 3 .1 glas s / form aldehyde...
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Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot
Ngày tải lên :
16/03/2014, 22:20
... analysis of DNAzyme concentration for cell transfection ranged from 1. 6 to 10 lgÆ(mL cell medium) )1 and showed optimum doses in the range 1. 6–3.2 lgÆmL )1 for minimum cell toxicity and maximum decrease ... receptor gene and its similarity to CD59 and the Ly-6 family Eur J Biochem 227, 11 6 12 2 11 Dang J, Boyd D, Wang H, Allgayer H, Doe WF & Wang Y (19 99) A region between )14 1 and ) 61 bp containing a ... resulting fragments were separated on denaturing 5% acrylamide gel (A) Dz720 cleavage of the uPAR transcript over 12 0 The reaction time and positions of the unreacted substrate (11 13 nucleotides) and...
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Anatomy, Histology, and Cell Biology PreTestTM Self-Assessment and Review pptx
Ngày tải lên :
22/03/2014, 21:20
... viscerocranium and the neurocranium The neurocranium (cranial vault) is composed of a base formed by endochondral ossification (chondrocranium) and sides and roof bones formed by intramembranous ... respiratory epithelium consists of conducting pathways (nasal cavities, naso- and oropharynx, larynx, trachea, bronchi, and bronchioles) and respiratory portions (respiratory bronchioles and alveoli) ... which respond to parasitic infection and release histaminases to counteract basophils and mast cells; and basophils, which contain histamine and heparin and assist mast cell function Bone marrow...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
Ngày tải lên :
23/03/2014, 17:20
... Cancer Invest 14 (2): 15 8 -16 8 Shao, W., E K Keeton, et al (2004) Coactivator AIB1 links estrogen receptor transcriptional activity and stability Proc Natl Acad Sci U S A 10 1(32): 11 599 -11 604 Shiau, ... endometrial carcinoma (EnCa1 01) in athymic mice Cancer Res 50 (11 ): 318 9- 319 2 Gottardis, M M., S P Robinson, et al (19 88) Contrasting actions of tamoxifen on endometrial and breast tumor growth in ... Allen, E., Doisy, E.A (19 23) An ovarian hormone: Preliminary reports on its localization extraction and partial purification and action in test animals JAMA 81: 810 -8 21 Estrogen-Induced Apoptosis...
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Báo cáo khoa học: ERK and cell death: Mechanisms of ERK-induced cell death – apoptosis, autophagy and senescence doc
Ngày tải lên :
29/03/2014, 08:20
... [11 ] [80] U 012 6 PD98059 [ 81] MEKCA U 012 6 PD98059 DN Ras PD98059 PD98059 DN DUSP6 RAF-CAAX MEKCA [82] U 012 6 Raf CA DRAF1 [86] DRaf1 HrasV12T35S [89] U 012 6 MEK siRNA [90] DRaf1:ER U 012 6 [ 91] U 012 6 ... p16 ⁄ INK4A b-galactosidase activity [13 0] [13 1] [97] [12 7] [13 5] [13 3] [13 2] [12 6] [13 4] [13 6] 11 ERK and cell death S Cagnol and J.-C Chambard phenotypic comparison between RasV12-, RasR 61- ... Ras V12 MEKCAQ56P RasV12 MEKCA Ras V12 PAK4 DRaf1:ER DRaf1:ER Human prostate cancer LNCaP cells DRaf1:ER Mouse embryonic fibroblast Primary human fibroblast IMR90 DRaf1:ER Raf-CAAX DRaf1:ER B-Raf...
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Báo cáo khoa học: ERK and cell death: ERK1⁄2 in neuronal death Srinivasa Subramaniam1 and Klaus Unsicker2 pptx
Ngày tải lên :
29/03/2014, 08:20
... receptors upon respective ligand binding In addition, stimulation of endogenous EGF receptors promotes transient ERK1 ⁄ and proliferation, and EGF receptor overexpression induces sustained ERK1 ⁄ and ... far, only the temporal pattern of activation of ERK1 ⁄ in permanent MCAO suggests a role for ERK1 ⁄ in neuronal death [63,64] Conclusions and perspectives Initially, ERK1 ⁄ activation was considered ... for extracellular signal-regulated kinase ⁄ 2-dependent oxidative neuronal cell death Mol Pharmacol 74, 11 41 11 51 19 Lu KT, Cheng NC, Wu CY & Yang YL (2008) NKCC1-mediated traumatic brain injury-induced...
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Báo cáo khoa học: ERK and cell death: ERK location and T cell selection pdf
Ngày tải lên :
29/03/2014, 08:20
... membrane and lead to Ras-GRP1 recruitment to that location Recent work has demonstrated that in T cells, PLCc1 activation leads to activation of Ras-GRP1 and its recruitment to the Golgi and ... that leads to Raf1–MEK1 ⁄ 2–ERK1 ⁄ activation The phosphorylation of ERK1 ⁄ is important for positive selection and dispensable for negative selection [12 15 ] Interestingly, positive and negative ... the regulation of Ras-GRP1 localization [42,43] The location of Ras-GRP1 and SOS in turn lead to the recruitment, activation and compartmentalization of Ras to the different membranes within...
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Báo cáo khoa học: ERK and cell death: cadmium toxicity, sustained ERK activation and cell death pot
Ngày tải lên :
29/03/2014, 08:20
... observation has been reported by several groups, in experiments performed using relatively low concentrations of cadmium (generally between and 10 lm) [16 ,18 – 21] This phenomenon is illustrated in ... rat skin keratinocytes J Biol Chem 2 61, 13 013 13 018 52 Alessi DR (19 97) The protein kinase C inhibitors Ro 318 220 and GF 10 9203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and ... Pharmacol 13 8, 9 01 911 32 Kim J & Sharma RP (2006) Cadmium-induced apoptosis in murine macrophages is antagonized by antioxidants and caspase inhibitors J Toxicol Environ Health A 69, 11 81 12 01 33...
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Báo cáo khoa học: Activation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cells potx
Ngày tải lên :
30/03/2014, 13:20
... 8, 15 1 15 7 17 Gilmore, A.P & Romer, L.H (19 96) Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreased cell motility and proliferation Mol Biol Cell 7, 12 09 12 24 18 Schmitz, ... of each of Rac1, Cdc42 and RhoA to assess the involvement of Rho family members in LPA-induced PAK1 activation N17Rac1- or N17Cdc42-transfected cells showed reduced activation of PAK1 by LPA, ... PAK1 phosphorylation Rac1 and Cdc42 are required for LPA-induced PAK1 activation Rho-like GTPases, including Rac1, Cdc42 and RhoA, have been implicated in the control of a wide range of biological...
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Báo cáo khoa học: PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AM pptx
Ngày tải lên :
30/03/2014, 16:20
... 11 960 11 965 Trinh KY, Jin T & Drucker DJ (19 99) Identification of domains mediating transcriptional activation and cytoplasmic export in the caudal homeobox protein Cdx-3 J Biol Chem 274, 6 011 –6 019 ... lines, InR1-G9 and STC -1 (see below, and data not shown) On the other hand, when the same )769 Cdx-2 ⁄ LUC fusion reporter construct was transfected into the three nonendocrine colon cancer cell ... ⁄ I as the positive control, and vehicle (V) as the negative control] Cdx-2 expression and ERK1 ⁄ phosphorylation were then examined Antibodies against b-actin and total ERK1 ⁄ were utilized to...
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schaum's easy outline molecular and cell biology - william stansfield, raul j cano, jaime s. colome
Ngày tải lên :
08/04/2014, 12:52
... expression includes both transcription and translation! The information for synthesizing a particular RNA is located in only one of the two DNA strands The strand that contains the information for ... The operons in a regulon are generally not contiguous Transcription Initiation and Termination Transcription of a structural gene can only occur if there is a promoter for RNA polymerase binding ... promoters A region on the nonsense strand about 10 bp before transcription initiates ( 10 sequence) has a consensus 5Ј-TATAAT-3Ј and another region about 35 bp up (−35 sequence) has a consensus sequence...
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