care for families facing alzheimer s disease primary care practice implications from research
Báo cáo y học: "Current pharmacologic options for patients with Alzheimer''''s disease" pps
Ngày tải lên :
08/08/2014, 20:23
... measures The standard psychometric tool used to assess cognition in the majority of these studies is the Alzheimer' s Disease Assessment Scale (ADAS) [15] The section of the scale from which scores ... needs of the caregiver, who may be especially burdened by disease progression The disease process AD progresses through several clinical stages (Figure 1) Loss of recent memory, or forgetfulness, ... Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grundman M and Ferris S An inventory to assess activities of daily living for clinical trials in Alzheimer' s disease The Alzheimer' s Disease...
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Tài liệu Báo cáo khoa học: A facile method for expression and purification of the Alzheimer’s disease-associated amyloid b-peptide pdf
Ngày tải lên :
18/02/2014, 13:20
... of synthetic peptides, a bacterial expression system allows isotope labeling, which is essential for high-resolution structural analysis of Ab using NMR spectroscopy and allows use of high specific ... analysis and sequencing Amino acid analysis was performed at the Amino Acid Analysis Center, University of Uppsala, Sweden Sequence analysis was performed using an Applied Biosystems Procise 492 ... is required for the production of synthetic genes bearing Alzheimer s disease- associated point mutants Bacterial expression Sequence-verified plasmids from wild-type and each mutant were transformed...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
Ngày tải lên :
07/03/2014, 10:20
... is increased in cerebrospinal fluid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper ... a risk factor for Alzheimer s disease? J Alzheimers Dis 3, 471–477 17 Lovell MA, Robertson JD, Teesdale WJ, Campbell JL & Markesbery WR (1998) Copper, iron and zinc in Alzheimer s disease senile ... availability for treating AD P J Crouch et al established, but the role for metal dyshomeostasis in all aspects is clear In the AD affected brain, metal dyshomeostasis is evident in the form of a substantial...
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Báo cáo khoa học: Amyloid–cholinesterase interactions Implications for Alzheimer’s disease pot
Ngày tải lên :
23/03/2014, 07:20
... Butyrylcholinesterase is also present in neurofibrillary tangles In Alzheimer s disease the expression of butyrylcholinesterase increases substantially in Alzheimer s disease patient s brain [47] ... of Alzheimer s disease Ann NY Acad Sci 695, 65–68 Nakamura S, Kawashima S, Nakano S, Tsuji T & Araki W (1990) Subcellular distribution of acetylcholinesterase in Alzheimer s disease: abnormal ... acetylcholinesterase associated with senile plaques differs from the enzyme found in normal fibers and neurons with respect to optimal pH, inhibition by excess substrate and protease inhibitor sensitivity...
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Guideline for Alzheimer’s Disease Management pdf
Ngày tải lên :
23/03/2014, 23:21
... University Scale for Psychopathology in Alzheimer s Disease, is brief and effective in assessing psychotic symptoms, but is not appropriate for assessing changes in severity of symptoms (Devanand, ... Americans now have Alzheimer s Disease (Alzheimer s Association, 2008), an increase of 25% since the previous version of this Guideline was published Alzheimer s Disease destroys brain cells, causing ... presentation or history of depression is atypical or complex (Lyketsos & Lee) Since administering assessment tests for depression to Alzheimer s Disease patients is often challenging (Warshaw,...
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báo cáo hóa học: " Vascular consequences of passive Aβ immunization for Alzheimer''''s disease. Is avoidance of "malactivation" of microglia enough?" docx
Ngày tải lên :
19/06/2014, 22:20
... by Aβ was at least partially responsible for AD-associated degeneration, others had pointed to microglial phagocytosis as a desirable consequence of activation For the purposes of discussion, the ... expression of neurotrophic factors under many of the same conditions in which they show inflammationrelated responses such as phagocytosis, retraction of processes, release of excitotoxins, and ... Humphrey J, Quadros A, Patel N, Crescentini R, Crawford F, Mullan M: Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer' s disease: role of inflammation...
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báo cáo hóa học: " Secretory PLA2-IIA: a new inflammatory factor for Alzheimer''''s disease" pot
Ngày tải lên :
19/06/2014, 22:20
... postmortem interval (hours) for AD cases was 2.59 ± 0.45 and for ND cases was 2.63 ± 0.62 (mean ± SD) Stimulation of sPLA2-IIA mRNA expression in astrocytes from human post-mortem brains Astrocytes ... was used for determination of levels of sPLA2-IIA mRNA in brain tissues Taqman primers and probes specific for human sPLA2-IIA and ribosomal 1 8S RNA were obtained from Applied Biosystems (Foster ... Tukey posthoc multiple comparison test was used to analyze data using the GraphPad Prism software Significant differences between groups were assumed for P values < 0.05 Results Expression of sPLA2-IIA...
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báo cáo hóa học: " Replication of the association of HLA-B7 with Alzheimer''''s disease: a role for homozygosity?" pptx
Ngày tải lên :
19/06/2014, 22:20
... 0.36) Similar patterns were seen both in controls and in cases Possible associations of AD with HLA-B & C alleles Tables and show the overall results for the 26 studied alleles Apart from the associations ... blind to diagnosis Unadjusted p values were by Fisher 's exact test; odds ratios were also adjusted for age, gender and APOE4 status by logistic regression analysis Potential interactions were examined ... Registry for Alzheimer' s Disease; CI, confidence interval; HLA, human leukocyte antigen; NINCDS-ADRDA, National Institute of Neurological, Communicative Diseases and Stroke -Alzheimer' s Disease...
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báo cáo hóa học: " The contribution of activated astrocytes to Ab production: Implications for Alzheimer’s disease pathogenesis" pot
Ngày tải lên :
19/06/2014, 22:20
... RNA from each sample was used for first-strand cDNA synthesis using the Invitrogen SuperScript III reverse transcription system cDNA was amplified using quantitative real-time PCR with Assays-onDemand ... Alzheimer s disease: the challenge of the second century Sci Transl Med 2011, 3:77sr1 De Strooper B: Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process Physiol ... Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer s disease Brain Res 2001,...
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Báo cáo y học: " Sigma-1 receptor agonist fluvoxamine for delirium in patients with Alzheimer’s disease pot
Ngày tải lên :
08/08/2014, 23:21
... mechanisms of different effects of these SSRIs [4-6] although a further detailed study is necessary Delirium is regarded as syndrome that consists of several domains of symptoms, such as disturbance ... is currently stable Discussion To our knowledge, this is the first report demonstrating that fluvoxamine monotherapy is effective for treating the delirium of patients with Alzheimer s disease ... patients with Alzheimer s disease because of the risk of extrapyramidal side effects by antipsychotic drugs More detailed double-blind studies should be performed to clarify the role of sigma-1...
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Báo cáo y học: "Fish-on-a-chip: a sensitive detection microfluidic system for alzheimer’s disease" pdf
Ngày tải lên :
10/08/2014, 05:21
... Haines JA: Genetic susceptibility to Alzheimer disease Trends Genet 1995, 11:504-508 23 Sisodia SS: Series Introduction: Alzheimer s disease: perspectives for the new millennium J Clin Invest 1999, ... polymorphisms; SPR: Surface plasmon resonance Authors Contributions JPD performed the FISH- based detection for chromosomal abnormalities and microfluidic chip- based detection for Alzheimer s Disease ... chips are one of the most useful devices for detecting neurodegenerative diseases such as AD For AD, early identification is important as this type of neurodegenerative disease has dangerous effects...
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báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc
Ngày tải lên :
11/08/2014, 12:21
... Lovestone S: Alzheimer s disease- do tauists and baptists finally shake hands? Trends Neurosci 2002, 25:22-26 14 Mattsson N, Zetterberg H, Hansson O, Andreasen N, Parnetti L, Jonsson M, Herukka SK, ... for this disease A similar strategy could also be useful in the studies involving transgenic mouse models of AD [56] Conclusions The pathogenesis of AD is complex and there is a strong case for ... the findings from experimental disease models with clinical phenotypes This is particularly relevant for diseases in which animal models are difficult to validate, such as in diseases of the central...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
Ngày tải lên :
14/02/2014, 18:20
... hereditary diseases like Wilson s disease Huntington s disease is an involuntary movement disorder that is often associated with dementia Parkinson s disease is a progressive brain disorder and ... cardiovascular disease, also called ischemic heart disease, the blood vessels that supply the heart muscle with oxygen and nutrients narrow These diseases can cause strokes and heart disease (heart ... Psychological Disorders Alzheimer s Disease and Other Dementias Psychological Disorders Addiction Alzheimer s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
Ngày tải lên :
16/02/2014, 09:20
... microtubule-associated protein that normally serves to assemble and stabilize microtubules Genetics and risk factors implicated in Alzheimer s disease pathogenesis Familial forms of AD, with an autosomal ... Authors Journal compilation ª 2010 FEBS 1391 Animal models of Alzheimer s disease O Philipson et al Transgenic animal models Models devoid of any disease- causing APP mutations Animal models expressing ... hypothesis comes mainly from studies of families in which AD is inherited as a dominant trait due to mutations in APP, PS1 or PS2 The evidence that the theory applies to sporadic AD is less solid,...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
Ngày tải lên :
05/03/2014, 21:20
... Information from the neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based ... of phrases from the Boston Diagnostic Aphasia Evaluation [19] Abstract reasoning was evaluated using WAIS-R Similarities subtest [66], and the non-verbal Identities and Oddities subtest of the ... skills remained stable Increased age was associated with lower scores in all cognitive domains while increased education was associated with higher scores APOE-4 was not associated with poor performance...
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LifeOut of Focus Alzheimer’s Disease and Related Disorders ppt
Ngày tải lên :
05/03/2014, 23:20
... OF FOCUS: ALZHEIMER S DISEASE AND RELATED DISORDERS THE COST OF ALZHEIMER S DISEASE As you can imagine, Alzheimer s disease is very expensive The cost of medical care for its victims is only ... loss is probably the most common sign associated with Alzheimer s disease In the initial stages of the disease, close associates may observe that the victim seems forgetful and has problems concentrating ... teenagers The second factor to consider is human memory Memory loss—one of the most obvious and distressing symptoms of Alzheimer s disease is much more serious than forgetting the answers on a history...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
Ngày tải lên :
05/03/2014, 23:20
... Psychiatric Press, 2000 66 Morris JC, Mohs RC, Rogers H, et al Consortium to establish a registry for Alzheimer s disease (CERAD) clinical and neuropsychological assessment of Alzheimer s disease ... and social stimulation for patients, as well as respite for caregivers Planning for illness progression and end-of-life issues is important Patients at risk for dementia or in the early stages ... Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive impairment associated...
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Báo cáo khoa học: Therapeutic approaches for prion and Alzheimer’s diseases pot
Ngày tải lên :
07/03/2014, 10:20
... are capable of forming amyloid deposits The presence of amyloid deposits is necessary for making the diagnosis CONFORMATIONAL DISORDERS Alzheimer s Disease Mainly Random Coil Monomers Non-Toxic ... is called ‘the species barrier’ Therefore, scrapie (a prionosis affecting sheep) is not transmissible to humans The species barrier does not provide absolute protection; therefore, transmission ... fibrillizes and deposits as plaques within the brain This process is facilitated by various pathological chaperones as well as several metals The aim of most therapeutic interventions for these conformational...
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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
Ngày tải lên :
08/03/2014, 08:20
... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... characterize c-secretase The advantage of this assay over existing systems is that it allows the isolation of cells with stable differences in c-secretase activity We established that the differences in ... DNA constructs into COS-7 and CHO cells resulted in the expression of GFP positive cells Figure 1B shows phase (panels and 3) and fluorescence microscopy (panels and 4) of COS-7 cells transfected...
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The Handbook of Alzheimer’s Disease and Other Dementias doc
Ngày tải lên :
14/03/2014, 21:20
... differs in many ways from what Alzheimer s Disease 31 neuropathologists are now confirming as Alzheimer s disease (Consensus recommendations for the postmortem diagnosis of Alzheimer s disease ... proposed the name Alzheimer s disease Growing from this single case report, Alzheimer s disease is now widely recognized as one of the most common neurological diseases, but it was not always so ... dementias Vascular dementias Psychiatric disorders Important examples Prion diseases, syphilis, Lyme disease, chronic meningidites, PML, HIV, Whipple s disease, hydrocephalus Primary or metastatic...
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