cancer notably in families with multiple breast cancer cases
Báo cáo toán học: "MAINTENANCE HORMONAL TREATMENT IMPROVES PROGRESSION FREE SURVIVAL AFTER A FIRST LINE CHEMOTHERAPY IN PATIENTS WITH METASTATIC BREAST CANCER" docx
Ngày tải lên :
08/08/2014, 17:20
... sites (single versus multiple) ; type of first-line chemotherapy (anthracycline- and/or taxane-containing regimen versus other); previous line of hormonotherapy administered in metastatic setting ... breast cancer during first-line paclitaxel chemotherapy Anticancer Res 2003; 23(2C): 1939-42 Nomura Y Different survival determinants of metastatic breast cancer patients treated with endocrine ... maintenance therapy for patients with metastatic breast cancer in complete remission following induction treatment J Clin Oncol 1998; 16 (5): 1669-1676 French Epirubicinn Study Group Epirubicin-based...
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Báo cáo y học: " Autonomic Dysfunction Presenting as Postural Orthostatic Tachycardia Syndrome in Patients with Multiple Sclerosis"
Ngày tải lên :
26/10/2012, 09:39
... experience with the management of patients with POTS Initial therapy consisted of an increase in salt and fluid intake as well as aerobic reconditioning with resistance training to increase lower ... the medulla In addition there can be interference with the descending autonomic nervous system pathways during their course in the brainstem or spinal cord (6) Although orthostatic dizziness has ... autonomic nervous system, including the brain stem, spinal cord, hypothalamus and cerebral cortex Demyelinating plaques may disrupt reflex pathways in the insular, cingulated and ventromedial...
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Báo cáo hóa học: " Vaccination with a plasmid DNA encoding HER-2/ neu together with low doses of GM-CSF and IL-2 in patients with metastatic breast carcinoma: a pilot clinical trial" pptx
Ngày tải lên :
18/06/2014, 16:20
... and/ or improved time to relapse when administered in the adjuvant setting in women with Her2-expressing breast cancer as a single agent or in combination with chemotherapy [3-7] However, trastuzumab ... the first amino acid in the Her2 protein) were in computer modelling predicted to bind multiple human leukocyte antigen (HLA)-DR molecules and indeed found to exhibit high-affinity binding to a ... pDNA vaccination is often considered an ineffective approach for immunization in humans Notably, vaccine efficacy in animal models has been improved by including cytokines or plasmids coding for...
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báo cáo hóa học: "The impact of regular physical activity on fatigue, depression and quality of life in persons with multiple sclerosis" pot
Ngày tải lên :
18/06/2014, 19:20
... fatigue in MS include hypo-functioning within the central nervous system [34], reduced glucose metabolism in the cortical regions of the brain [35], reduced inhibition of the primary motor cortex in ... standardized physical stress in multiple sclerosis Brain Behav Immun 2003, 17(6):473-481 White LJ, Castellano V, Mc Coy SC: Cytokine responses to resistance training in people with multiple sclerosis J ... Impact Scale Competing interests The authors declare that they have no competing interests Authors' contributions NS was involved in all aspects of this study She was involved in the concept and...
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báo cáo hóa học:" The impact of regular physical activity on fatigue, depression and quality of life in persons with multiple sclerosis" pdf
Ngày tải lên :
20/06/2014, 16:20
... fatigue in MS include hypo-functioning within the central nervous system [34], reduced glucose metabolism in the cortical regions of the brain [35], reduced inhibition of the primary motor cortex in ... standardized physical stress in multiple sclerosis Brain Behav Immun 2003, 17(6):473-481 White LJ, Castellano V, Mc Coy SC: Cytokine responses to resistance training in people with multiple sclerosis J ... Impact Scale Competing interests The authors declare that they have no competing interests Authors' contributions NS was involved in all aspects of this study She was involved in the concept and...
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Báo cáo hóa học: " Changes in the criticality of Hopf bifurcations due to certain model reduction techniques in systems with multiple timescales" pdf
Ngày tải lên :
20/06/2014, 23:20
... bifurcations in typical physiological models with multiple time scales We show that in some cases in which a Hopf bifurcation involves the fast variables, all the information needed to determine the ... coupled cells where such intrinsic transient dynamics might play a role in forming new attractors In many physiological models, we are interested in the onset of oscillations, i.e in the existence and ... splitting the system into the k-dimensional fast subsystem obtained in the singular limit ε → of (1) and known as the layer problem, and the one-dimensional slow subsystem obtained in the singular...
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Báo cáo y học: "Increased plasma homocysteine levels in patients with multiple sclerosis and depression" ppsx
Ngày tải lên :
08/08/2014, 23:21
... results With a single exception [10], these studies concluded that Hcy levels are increased in MS patients [8,9] In most cases, however, Hcy increases were observed in MS patients with vitamin B12 ... results, in agreement with Vrethem et al [8] and Ramsaransing et al [9], indicate that Hcy increases may occur in MS in the absence of vitamin B12 and folate deficiency Of particular interest ... interaction and inhibiting tumour necrosis factor (TNF)α and interleukin (IL)1β production [29,30] The clinical implications of our finding are not entirely clear Since Hcy is associated with an atherogenic...
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Báo cáo khoa học: "Rapid detection of pneumothorax by ultrasonography in patients with multiple trauma" pptx
Ngày tải lên :
13/08/2014, 02:24
... time for US examination was 2.3 ± 2.9 minutes (range 1.5 to minutes) The time interval between requesting a CXR and obtaining access to it was 12.4 ± 6.7 minutes (range to 23 minutes), and another ... size of pneumothorax was inferred by ascertaining such points at different intercostal spaces When these points are lined up, the contour of the pneumothorax is also outlined Statistical analysis ... radiography were interpreted by independent radiologists who were unaware of patients' conditions and the findings of US In patients with clinical suspicion of large or tension pneumothorax requiring immediate...
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Báo cáo y học: "The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes" ppt
Ngày tải lên :
13/08/2014, 18:22
... general anesthesia was induced by intravenous injection of mg/kg etomidate (Braun) Anesthesia was maintained by continuous intravenous injection administration of ketamin hydrochloride (5 to ... output The results of blood serum examination were monitored The main observed indexes included alanine aminotransferase, aspartate aminotransferase, creatinine, blood urea nitrogen, white blood ... Direct fluorescent staining was used to detect dual binding of FITC-labeled Ulex europaeus agglutinin (UEA-1) (Sigma) and 1,1-dioctadecyl-3,3,3,3-tetramethylindocarbocyanine-labeled acetylated...
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Báo cáo y học: "IL-6 predicts organ dysfunction and mortality in patients with multiple injuries" pps
Ngày tải lên :
13/08/2014, 23:20
... A Barney Resident Research Award winner The inflammatory profile of interleukin-6, interleukin-8, and soluble intercellular adhesion molecule-1 in postinjury multiple organ failure Am J Surg 1996, ... competing interests Acknowledgements Patients with MODS did not have higher levels of IL-1β as compared to patients without MODS This is in accordance with findings from other studies in which ... in the early clinical course The evaluation of clinical state and prognosis still remains one of the greatest challenges during treatment of patients suffering from multiple injuries Many clinical...
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Risk of second primary cancer in men with breast cancer docx
Ngày tải lên :
22/03/2014, 17:20
... discoveries Cancer Lett 2002, 181:125-164 The Breast Cancer Linkage Consortium: Cancer risks in BRCA2 mutation carriers J Natl Cancer Inst 1999, 91:1310-1316 Thompson D, Easton DF, Breast Cancer Linkage ... was also observed for second breast cancer with higher excess risks starting in the
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Báo cáo khoa học: "Intraoperative frozen section assessment of sentinel lymph nodes in the operative management of women with symptomatic breast cancer" ppt
Ngày tải lên :
09/08/2014, 07:21
... Any remaining sentinel nodal tissue after frozen sectioning were fixed in formalin and embedded in paraffin with subsequent examination by H&E staining (again an average of levels per node with ... formal paraffin section remain widespread In this study, we describe our experience of routine intraoperative frozen section of sentinel nodes in women with invasive breast cancer but without overt ... surgical technique Consecutive, consenting, clinically node negative women with unifocal, invasive breast cancer undergoing surgical treatment for invasive breast cancer between December 2004 and December...
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Báo cáo khoa học: "Radio-induced malignancies after breast cancer postoperative radiotherapy in patients with Li-Fraumeni syndrome" docx
Ngày tải lên :
09/08/2014, 09:20
... we attempted to assess the incidence of radio-induced malignancies in a prospective cohort of families with germ-line p53 mutations, focusing on breast cancer occurring as the first malignancy ... both occurring since the date of the diagnosis Contralateral breast cancer was either ductal carcinoma in situ (DCIS) or invasive carcinoma Distant disease was defined as breast carcinoma recurrences ... already been described as a germ-line mutation in LFS families and the mutation in patient 8, which induces buried DNA-binding function, has already been described in LFS families Discussion To our...
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Báo cáo khoa học: "Can prophylactic breast irradiation contribute to cardiac toxicity in patients with prostate cancer receiving androgen suppressing drugs?" ppt
Ngày tải lên :
09/08/2014, 09:22
... adequately In the prostate cancer patients, MeV was appropriate in cases, MeV in cases, 12 MeV in cases and 15 MeV in case The median distance between skin and outer heart contour decreased with age ... cardiac morbidity in prostate cancer patients receiving androgen suppression therapy It was performed both in cancer patients and randomly selected individuals having had CT examinations for other ... Distinct Moderate Distinct Moderate** Moderate** Moderate** Moderate** Distinct** Moderate** Moderate** * prostate cancer patient **when using the standard MeV beam in the absence of CT scan information...
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Báo cáo y học: "Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer" pdf
Ngày tải lên :
13/08/2014, 13:20
... detect minimal changes in protein levels [15] Three large independent sample sets with adequate clinical and outcome information were used for training and testing Bioinformaticians were closely involved ... described in Methods, we computed a continuous prognostic score (PS) based on the grouping defined in the training set A Cox proportional hazards model on the training set (CoxTrain) using PS to ... Supervised clustering of breast cancers with quantification data for 10 proteins derived using reverse phase protein arrays The 712 breast tumor samples (Training set, 1A) were clustered with the 10...
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the reliability, validity and sensitivity to change over time of the figure of eight method measuring hand size in patients with breast cancer related lymphoedema
Ngày tải lên :
22/12/2014, 21:42
... stiffness index UK – United Kingdom YB – Yolande Borthwick Chapter Introduction Breast cancer is the most common cancer affecting women in Scotland, accounting for 28% of all cancers in the Scottish ... population (World Cancer Research Fund 2013) Breast cancer in Scotland has increased by 13.7% since 2001 to a level that 29.4% of all women diagnosed with cancer in 2011 had breast cancer (ISD Scotland ... deaths from lung cancer (188,000 deaths) (http://globocan.iarc.fr/factsheets/cancers /breast. asp) Global incidence of breast cancer continues to increase (WHO 2008) and breast cancer survival rates...
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Báo cáo y học: "Changes of uterine blood flow after vaginal radical trachelectomy (VRT) in patients with early-stage uterine invasive cervical cancer"
Ngày tải lên :
25/10/2012, 11:48
... disinfection with popidone iodine, bed rest, and administration of ritodrine and an ulinastatin vaginal suppository were continued as a new follow-up modality for pregnant patients who received RT Finally, ... Patients and methods In the period from January 2003 through December 2009, a total of 20 women with early-stage invasive uterine cancer underwent vaginal RT with lymphadenectomy in Sapporo Medical ... CT imaging of a patient with normal uterus after the delivery A: Ascending branch of right uterine artery B: Ascending branch of left uterine artery C: Descending branch of right uterine artery...
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Báo cáo khoa học: The in vitro effects of CRE-decoy oligonucleotides in combination with conventional chemotherapy in colorectal cancer cell lines potx
Ngày tải lên :
07/03/2014, 15:20
... chemotherapy Indeed, it has been shown that a palindromic trioctamer of this sequence can interfere with CREB binding, and specifically inhibit PKA subunit expression, interfering with the CRE-PKA ... containing 10 lM BrdU for 30 mins before fixing with ice-cold 70% (v/v) ethanol and permeabilization in M HCl with 0.5% (v/v) Triton X-100 Samples were washed and incubated with fluorescein isothiocyanate-conjugated ... combining CDO with cytotoxic agents in HCT116 and GEO cells Cells were cultured with CDO (C) alone or in combination with 5-FU, SN38 or VP16 There were significant reductions in cell number in...
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A Psychoeducational Intervention for Sexual Dysfunction in Women with Gynecologic Cancer ppt
Ngày tải lên :
22/03/2014, 10:20
... detailed instructions from the investigator before leaving the testing room on how to insert the probe Once inserted, they were encouraged to relax on a reclining chair for 10 minutes before watching ... depressed women at baseline who especially improved on this measure with the PED Increasingly, the importance of combining quantitative with qualitative methods is being encouraged in women’s sexuality ... Targeting Sexual Arousal Complaints in Gynecologic Cancer Patients Segment (60 Discussion of the possible predisposing, precipitating, perpetuating, and minutes) protective factors implicated in...
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Cancer Research UK’s strategy 2009–2014: Cancer Research UK’s aim is to reduce the number of deaths from cancer. Our future plans are ambitious, but they are in line with the challenge and the responsibility we face. docx
Ngày tải lên :
22/03/2014, 16:21
... future, pioneering the development and provision of relevant training in our Institutes and Centres and working in partnership where possible - Maintain our current investment in training schemes ... current deficit in clinician scientists working at the translational interface and in cancer surgery and pathology Our Centres and Institutes will play a key role in this training, balancing the experience ... areas – research, information and influencing public policy Research remains our primary focus, complemented with public-facing information and influencing public policy Within each of these areas...
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