cancer etiology and signal transduction
Báo cáo y học: "Cancer, oncogenes and signal transduction" pps
Ngày tải lên :
09/08/2014, 20:20
... genotype of cancer cells and which signaling pathways are activated in them if we are to be able to treat these malignancies efficiently Invasion and metastasis Recent work by Richard Treisman (Cancer ... by Akt and mTOR, is highly oncogenic, and cancers overexpressing this factor failed to respond to rapamycin These results provide a clear example of how critical it will be to understand the ... for the treatment of cancers that have mutations in LKB1 A major hope is that knowledge gained from understanding the role of signaling pathways in regulating cell growth and proliferation can...
- 3
- 178
- 0
Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer ppt
Ngày tải lên :
29/03/2014, 08:20
... (DAPK) and signal transduction: blebbing in programmed cell death FEBS J 276, doi:10.1111/j.1742-4658.2009.07412.x Kang C & Avery L (2009) Death-associated protein kinase (DAPK) and signal transduction: ... Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci clustering Cancer Res 60, 4894– 4906 ... kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells Clin Cancer Res 11, 6924–6932 50 Buettner...
- 7
- 427
- 0
Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
Ngày tải lên :
07/03/2014, 16:20
... Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction J Biol Chem 273, 2617–2623 17 Blaukat A, ... differential signaling is less likely to explain differences in internalization than in two receptors signaling through different G proteins Internalization patterns of truncations I347* and N338*, and ... motifs in the region between the palmitoylated C324 and N338 Candidates would include G328-C329 and ⁄ or the negatively charged residues E332 and E337, as they are highly conserved in B2wt among...
- 12
- 595
- 0
Plant physiology - Chapter 14 Gene Expression and Signal Transduction potx
Ngày tải lên :
07/03/2014, 21:20
... is called a signal transduction pathway Typically, the end result of signal transduction pathways is to regulate transcription factors, which in turn regulate gene expression Signal transduction ... porin genes, ompC expression is repressed and ompF expression is stimulated (From Parkinson 1993.) Gene Expression and Signal Transduction cyanobacteria, and it appears to be related to bacterial ... the 26S proteasome 13 Gene Expression and Signal Transduction Sensor protein Response regulator + P – Input signal Input Transmitter Receiver Figure 14.10 Signaling via bacterial two-component...
- 30
- 567
- 1
Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death ppt
Ngày tải lên :
29/03/2014, 08:20
... et al DAPK and signal transduction to use this information to understand developmental or disease processes Classically, genetic screens in tractable organisms, such as yeast, worms and flies, ... have been used for defining the landscape of a protein ⁄ pathway However, many cancer- and immunity-related genes are confined to vertebrates and a full understanding of how these proteins operate ... Autophagy Fig Signalling to DAPK DAPK plays an important role in a diverse range of signal transduction pathways The biological outcome of DAPK activity depends on the input signal and includes...
- 10
- 270
- 0
Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death docx
Ngày tải lên :
29/03/2014, 08:20
... adhesion and survival signalling [53], and can inhibit the association of talin head domain with integrin to suppress the integrin–Cdc42 polarity pathway [60] These studies are intriguing and suggest ... complex and the formin Dia1, are not present in blebs of filamin-deficient blebbing cells [4] However, the presence of regulators of actin nucleation, RhoA and RhoGEFs, at the bleb membrane and the ... by phosphorylation of MLC at Thr18 and Ser19 by DAPK family proteins, such as DAPK and zipper (ZIP) kinase In the case of DAPK, phosphorylation of MLC at Thr18 and Ser19 can occur either directly...
- 8
- 285
- 0
Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis doc
Ngày tải lên :
29/03/2014, 08:20
... Autophagy and signaling: their role in cell survival and cell death Cell Death Differ 12(Suppl 2), 1509–1518 Meijer AJ & Codogno P (2006) Signalling and autophagy regulation in health, aging and disease ... calcineurin and DAPK signaling pathways and the systemic regulation of autophagy (Fig 3) FoxO3 FoxOs are evolutionally conserved and well-known downstream targets of the insulin signaling pathway ... phosphorylates and activates Ga interacting proteins and stimulates autophagy and (f) the eukaryotic initiation factor 2a, which regulates starvation- and virus-induced autophagy As these autophagy signaling...
- 8
- 376
- 0
Báo cáo khoa học: Molecular and genetic characterization of osmosensing and signal transduction in the nematode Caenorhabditis elegans docx
Ngày tải lên :
30/03/2014, 03:20
... accumulation and WNK and Ste20 kinase signaling C elegans will undoubtedly continue to provide new understanding of how animals detect and protect themselves from osmotic stress Given the fundamental and ... studies of osmosensing and associated signal transduction mechanisms Little is known about the molecular bases of these processes in animals The forward and reverse genetic and molecular tractability ... about the molecular mechanisms of osmotic stress resistance, osmosensing and signal transduction in C elegans Osmosensing and signaling in C elegans Osmoregulatory organs in C elegans C elegans has...
- 8
- 495
- 1
Báo cáo khoa học: M1 – Peptidomimetics and Signal Transduction Inhibition potx
Ngày tải lên :
30/03/2014, 20:20
... Abstracts signaling pathways, selectively in cancer cells [3] One of the key elements is to induce in the targeted cancer cells signaling pathways that induce strong by-stander effects, ... target and their conversion into novel drug candidates for Mycobacterium tuberculosis infected patients M R M Fontes1, A A S Takeda1, T Teh2, R F Standaert3 and B Kobe2 Department Physics and Biophysics, ... affects SP signal transmission due to their co-existence relation To understand the time course and spatial distribution of SP with its receptor and the mutual actions in lung between SP and CGRP,...
- 20
- 359
- 0
Báo cáo y học: "Gene regulation and signal transduction in the immune system" pptx
Ngày tải lên :
14/08/2014, 20:22
... addressing how signal transduction and gene regulation control diverse and fundamental biological processes This was underscored at the 2008 meeting We look forward to the next meeting in 2010, and anticipate ... promoters of many primary response genes are marked by CpG islands, which have low histone density and not assemble into stable nucleosomes, and these promoters are induced independently of chromatin ... restraining the expression of pro-myeloid factors (such as Gfi1), and acting directly to induce the recombinase (Rag) genes and thereby recombination at the immunoglobulin heavy-chain locus Interestingly,...
- 4
- 268
- 0
Structure and mechanism of hormone perception and signal transduction by abscisic acid receptors
Ngày tải lên :
10/09/2015, 09:26
... gate-latch-lock mechanism of ligand perception and signal transduction by the PYL ABA receptors 99 Figure 39 Mutations in the PYR1 latch and gate affect ABA signalling in vitro and in vivo ... responses (Pandey and Assmann, 2004; Ullah et al., 2002) and these findings has contributed to speculations that GPCRs may be involved in ABA signal transduction The third ABA receptor candidate, ... previous mentors and colleagues Also, a special mention here to Kah Ying and Terence Last but not least, I would like to thank my family and friends for being understanding and encouraging when...
- 171
- 350
- 0
Tài liệu Báo cáo khoa học: 1. Signal Transduction 1.1 Integration of Metabolism and Survival pdf
Ngày tải lên :
19/02/2014, 07:20
... main role is to control 1.5 Signaling and Cancer: Nuclear Receptor Connection S1.5-1 Androgen action and prostate carcinogenesis F Saatcioglu ¸ ˘ Division of Cellular and Molecular Biology, Department ... instance Helicobacter pylori) and viral (for instance HBV and HCV) pathogens are major risk factors for certain types of cancer, most notably gastric and liver cancers We have postulated that ... that contributes to the development and progression of CAC and other inflammation-linked cancers and is estimated to be involved in up to 20% of all human cancers, we asked whether inflammation...
- 6
- 524
- 0
Báo cáo khoa học: Bistability from double phosphorylation in signal transduction Kinetic and structural requirements potx
Ngày tải lên :
16/03/2014, 13:20
... linked to multifunction and crosstalk between signal transduction networks, which explains how the same signal transduction pathway can be responsible for the transduction of signals resulting in ... cycle (steps and 2) and cycle (steps and 4) (Eqn 7) and the values of a, c and b only depend on the KS value (Eqn 8) The concentrations of interconvertible forms are: c¼a¼ þ KS and b¼ À KS ð8Þ ... requirements in signaling are constrained: a and c only vary between ⁄ and ⁄ 2, whereas b varies between and ⁄ is studied for different sets of parameters, resulting in (a) a single steady state and (b)...
- 12
- 301
- 0
Báo cáo khoa học: Principles behind the multifarious control of signal transduction ERK phosphorylation and kinase/phosphatase control potx
Ngày tải lên :
16/03/2014, 18:20
... both duration and integral signal strength The control for all processes together equaled for peak amplitude and nal signal strength and it equaled )1 for duration and integral signal strength ... amplitude of signaling; the nal intensity of signaling; the duration of signaling and the integral signal intensity (which corresponds to the area-under-the-curve) For MAPK and other signaling pathways, ... concerning protein kinase signaling, such as the possibility of spatially resolved signaling [21] and have also shed light on the control of kinases and phosphatases on signal transduction [22] For...
- 15
- 434
- 0
Báo cáo khoa học: Salicylic acid and the hypersensitive response initiate distinct signal transduction pathways in tobacco that converge on the as-1-like element of the PR-1a promoter pot
Ngày tải lên :
23/03/2014, 15:21
... the tobacco PR-1a promoter is targeted by at least two distinct signal transduction pathways, elicited by SA and by a yet unknown signal produced during the HR, respectively, which mediate PR-1a ... view of the results presented, it seems plausible that two distinct signal transduction pathways could be targeted by SA and by signals released during the HR, respectively, resulting in the independent ... support for our model of distinct signal transduction pathways leading to the independent activation of the tobacco PR-1a gene by SA and by an unknown HR released signal, we have made use of transgenic...
- 11
- 452
- 0
biochemistry of signal transduction and regulation 3d ed - gerhard krauss
Ngày tải lên :
08/04/2014, 12:41
... structural and biochemical properties of signaling molecules and their regulation, the interaction of signaling proteins at VIII Preface the various levels of signal transduction and to work ... Receptor 135 Signal Amplification 139 Regulation of Inter- and Intracellular Signaling 141 Membrane Anchoring and Signal Transduction 142 Myristoylation 144 Palmitoylation 145 Farnesylation and Geranylation ... different signaling proteins and their subspecies, on the supramolecular organization of signaling proteins and on the interplay between different signaling pathways The enormous complexity of signaling...
- 544
- 365
- 0
signal transduction and human disease
Ngày tải lên :
11/04/2014, 10:31
... Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies 307 Michael A Beaven and Thomas R Hundley 11 Rheumatology and Signal Transduction 357 Keith M Hull and Daniel L Kastner 12 Molecular ... for- Signal Transduction and Human Disease, Edited by Toren Finkel and J Silvio Gutkind ISBN 0-471-02011-7 Copyright © 2003 John Wiley & Sons, Inc ATHEROSCLEROSIS: SIGNAL TRANSDUCTION BY OXYGEN AND ... host defense or signal transduction (Fig 1.7) 13 14 ATHEROSCLEROSIS: SIGNAL TRANSDUCTION BY OXYGEN AND NITROGEN RADICALS Figure 1.7 The divergent role of high and low levels of RNS and ROS A potential...
- 477
- 188
- 0
báo cáo hóa học:" Functional significance of the signal transduction pathways Akt and Erk in ovarian follicles: in vitro and in vivo studies in cattle and sheep" ppt
Ngày tải lên :
20/06/2014, 07:20
... of bands after background subtraction and are relative to white (value 0) and black (value 256) The blots each show a single band for Akt and p-Akt at about 60 kDa and each show a double band ... bovine model Increases in Akt and Erk signalling proteins in response to FSH and IGF stimulation suggest a role for Akt and Erk signal transduction pathways in FSH and IGF mediated granulosa cell ... double band for Erk and p-Erk at about 44 and 42 kDa Experiment Effects of LH in combination with PD98059 and/ or LY294002 on cell number and secretion of androstenedione and progesterone from...
- 13
- 438
- 0