can we exploit the cancer stem cell paradigm in search for new antitumor agents

báo cáo hóa học:" MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells" ppt

Ngày tải lên : 20/06/2014, 07:20

... role in the pathogenesis of ovarian cancer In this study, we have investigated increased expression of HER2 and the cancer stem cell population in MUC4 overexpressed ovarian cancer cells Further, ... ALDH1 in different cancers [1] Few of these markers were used for the confirmation of an MUC4 enriched cancer stem cell population Stem cells and cancer stem cells are known to possess the phenomenal ... and enrich the cancer stem cell population It also showed that MUC4 is expressed in the ovarian cancer stem cell population Discussion Ovarian cancer is the fourth leading cause of cancer deaths...

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báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" pot

Ngày tải lên : 20/06/2014, 04:20

... assay Cells obtained from spheres formed by CD133+ cells were capable of forming new spheres containing both CD133- and CD133+ cells, indicating that CD133+ cells can differentiate into CD133- cells ... responsible for forming the bulk of the tumor [14-16] They are similar to stem cells and may arise from the transformation of stem cells or the de-differentiation of non -stem cells They are quiescent ... treatments The Cancer Stem Cell Hypothesis The cancer stem cell hypothesis proposes that within a heterogeneous tumor there is a small subpopulation of cells called cancer stem cells (CSCs)” that...

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báo cáo hóa học:" Targeting the osteosarcoma cancer stem cell" ppt

Ngày tải lên : 20/06/2014, 07:20

... assay Cells obtained from spheres formed by CD133+ cells were capable of forming new spheres containing both CD133- and CD133+ cells, indicating that CD133+ cells can differentiate into CD133- cells ... responsible for forming the bulk of the tumor [14-16] They are similar to stem cells and may arise from the transformation of stem cells or the de-differentiation of non -stem cells They are quiescent ... treatments The Cancer Stem Cell Hypothesis The cancer stem cell hypothesis proposes that within a heterogeneous tumor there is a small subpopulation of cells called cancer stem cells (CSCs)” that...

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báo cáo khoa học: " LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett’s Esophagus?" ppsx

Ngày tải lên : 10/08/2014, 10:21

... stem cells, these might be the actively cycling Barrett (cancer) stem cells Our findings are in line with current cancer models [8] suggesting an integration of the CSC hypothesis and the clonal ... to be involved in the pathogenesis of different human cancer entities, including hepatocellular carcinoma [28], basal cell carcinoma [29], endometrial cancer [30], colon cancer and ovarian cancer ... by a cancer stem cell compartment [8] The existence of cancer stem cells would explain why only a small minority of cancer cells is capable of extensive proliferation within the tumor Furthermore,...

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Báo cáo sinh học: "Cancer stem cell subsets and their relationship" pot

Ngày tải lên : 18/06/2014, 19:20

... precancerous stem cells undergo the transformation from normal stem cells to primary cancer stem cells Precancerous lesions progress to cancer when precancerous stem cells transform into primary cancer stem ... Relationships among cancer stem cell subsets Up to now, precancerous stem cells, primary cancer stem cells and migrating cancer stem cells have been proven to exist in the progression of cancer [45,52,61,62], ... tumor stem cells can be transformed into primary cancer stem cells (Figure 1) Primary cancer stem cells may play the most important role in the progression of cancer and recurrence Thus the transformation...

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báo cáo hóa học:" Cancer stem cell subsets and their relationships" pot

Ngày tải lên : 20/06/2014, 03:20

... precancerous stem cells undergo the transformation from normal stem cells to primary cancer stem cells Precancerous lesions progress to cancer when precancerous stem cells transform into primary cancer stem ... Relationships among cancer stem cell subsets Up to now, precancerous stem cells, primary cancer stem cells and migrating cancer stem cells have been proven to exist in the progression of cancer [45,52,61,62], ... tumor stem cells can be transformed into primary cancer stem cells (Figure 1) Primary cancer stem cells may play the most important role in the progression of cancer and recurrence Thus the transformation...

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báo cáo hóa học: " Can we make the basilic vein larger? maneuvers to facilitate ultrasound guided peripheral intravenous access: a prospective cross-sectional study" ppt

Ngày tải lên : 21/06/2014, 00:20

... the same location Basilic vein measurements for each maneuver were obtained using the following procedures: First, the vein was identified at the location of skin markings on the short axis Then, ... branching point off the basilic vein was identified within the 2-4 cm area, it was also used as a landmark The skin marking and branch points were used to ensure that measurements of the vein during ... extremity deformity, or upper extremity surgery If the subjects had any of the above in both arms they were excluded from the study If the items in the questionnaire were present in only one arm, the...

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Báo cáo y học: " MAPK signalling in rheumatoid joint destruction: can we unravel the puzzle? " pps

Ngày tải lên : 09/08/2014, 07:20

... Arthritis Research & Therapy October 2005 Vol No Meyer and Pap at the same time they strengthen the concept of p38 and ERK as important MAPKs in the inflamed synovium In line with previous data, the ... stimuli [8,9] The second interesting observation by Goertz and colleagues is the inability of TNF-α blocking agents to completely reverse the activation of p38 and ERK in hTNFtg mice In the light ... AM, Firestein GS: c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis J Clin Invest 2001, 108:73-81 Mengshol JA, Vincenti MP,...

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Báo cáo y học: "How can we reduce the risk of serious infection for patients with systemic lupus erythematosus" ppt

Ngày tải lên : 09/08/2014, 14:22

... being immunosuppressive in that they downregulate the processing of low affinity antigens (for example, self peptides) while preserving the processing of high affinity antigens (for example, foreign ... guidelines have not been developed for SLE With the exception of the live attenuated vaccines, other vaccinations should be kept up-to-date in patients with SLE Caring for patients with SLE includes ... that non-live vaccines are safe and prevent infectious complications among patients with SLE Guidelines are in place recommending the influenza vaccine and pneumococcus vaccine for patients with...

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Báo cáo khoa học: " Long-term outcome after intensive care: can we protect the kidney" pptx

Ngày tải lên : 13/08/2014, 03:21

... epidemiology in general, and to the field of acute kidney injury in particular Competing interests The authors declare that they have no competing interests We addressed the same issue as the Beginning ... anaesthesiological principles for bulbar polio: manual IPPR in the 1952 polio-epidemic in Copenhagen Acta Anaesthesiol Scand 1994, 38:420-431 Gokal R: Quality of life in patients undergoing renal ... than in those treated with CRRT (hazard ratio = 2.3, 95% confidence interval = 1.3–4.1) In conclusion, the Beginning and Ending Supportive Therapy study shows that CRRT and IRRT are used for quite...

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Báo cáo y học: "Liposarcoma cells with aldefluor and CD133 activity have a cancer stem cell potential" pot

Ngày tải lên : 13/08/2014, 15:21

... when cells were cultured in RPMI, indicating that the combined expression of these two stem cell markers had been induced by factors in the stem cell media Subsequently, we were interested in evaluating ... Furthermore, when cells were initially incubated in RPMI for days and then transferred into SC-medium for the remaining period, the percentage of cells displaying Aldefluor activity increased (data ... double-positive, independent of medium Finally, we tested Aldefluor in combination with CD133 and found that no cells were double-positive when the cells were incubated in RPMI However, interestingly we found...

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Báo cáo y học: "Can we find the genes involved in complex traits" pptx

Ngày tải lên : 14/08/2014, 14:21

... underscored the benefit of incorporating distinct disciplines, in this case engineering, in defining and understanding new phenotypes He also pointed out the importance of understanding the relationships ... Cancer Institute, Bethesda, USA) showed how informative eQTLs can be even without an understanding of the underlying genetics that produced them He confirmed in mice that the expression levels ... and, in the case of the Abca1 gene, expression data She provided some of the best evidence that a critical mass of converging information and understanding has now tipped the scale and will, in the...

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Can we use the universal instance assumption without using NULLS

Ngày tải lên : 11/03/2015, 16:15

... Nội dung •Universal instance •Marked NULL •Subsum •Thể tiêu biểu •Ràng buộc khóa ngoại có sửa đổi •Kết luận Universal Instance? Universal Instance thể quan hệ phổ quát, quan hệ ... phép chiếu ACF có kết {111} • Nếu chiếu tập thuộc tính ABCDF ta có kết {11121} Modified Foreign-key Constraint (Ràng buộc khóa ngoại có sửa đổi) Xét LĐCSDL {ABCDE, CDEF, AFE} Giả sử ta thêm vào ... thông tin Ràng buộc đề nghị ràng buộc khóa ngoại có sửa đổi Ngoài ra, lược đồ quan hệ thỏa mãn điều kiện ta không cần phải thêm ràng buộc Trong trường hợp quan hệ CSDL cập nhật cách độc lập Xin...

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Human pluripotent stem cell derived cellular vehicles for cancer gene therapy

Ngày tải lên : 09/09/2015, 10:08

... sources of stem cells for gene cancer therapy must be established Therefore, this study aimed to test feasibility of cancer treatment by applying pluripotent stem cells including embryonic stem cells ... 1.2.2 Clinical relevance of stem cell vectors for cancer gene therapy Recent years have witnessed the initiation of a new wave of research that focuses on promoting stem cells as anti -cancer gene ... attractive candidates as vehicles for anti -cancer drug Unfortunately, this approach for cancer treatment can be hindered by common usage of adult stem cells for cell source due to following reasons: The...

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Butch, femme and other labels in the singaporean lesbian community can we escape the heteronormative gender binary

Ngày tải lên : 02/10/2015, 12:56

... that feminine/feminine pairings are becoming increasingly common and accepted within the community, although they are not as prevalent as masculine/feminine pairings; they are also often invisible ... Butch, they look really male, they wear really male clothes, they take the effort to hide away all feminine aspects from themselves The androgynous, there’s still curves, there’s still the boobs, there’s ... because of their femininity, as they can be mistaken for heterosexual friends At the other end of the spectrum exists the masculine/masculine pairing, which may include andro/andro 31 These relationships...

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Clinical significance of cancer stem cell markers and other related proteins in colorectal carcinomas biological and methodological considerations

Ngày tải lên : 03/10/2015, 20:57

... a minority of cancer stem cells These cancer stem cells possess tumour-related features such as uncontrolled growth and the ability to form metastases They also maintain their inherent stem cell ... division in stem cells The mutated cancer stem cells then differentiate into other committed cancer daughter cells This cancer daughter cell harbours a combination of other mutations that can reprogram ... human cancer could be considered as a stem cell disease These studies suggest that many signalling pathways involved in the maintenance of normal stem cells are mutated in human cancers – these include...

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As a student, how can we protect the environment

Ngày tải lên : 17/06/2016, 10:33

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Why We Buy: The Science of Shopping--Updated and Revised for the Internet, the Global Consumer, and Beyond

Ngày tải lên : 15/03/2014, 15:16

... watching and filming and timing and interviewing and so on Until then, however, these were the kinds of problems that had remained hidden in plain view While watching the record store customers, we ... for the past thirty years remains the piece of paper we call the track sheet, in the hands of the individuals we call trackers Trackers are the field researchers of the science of shopping, the ... aspirin would sell well, but just the opposite happened The main customers for cold drinks were teenagers, and our observation showed many of them entering and making a beeline for the coolers In...

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Báo cáo hóa học: " Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection" pdf

Ngày tải lên : 20/06/2014, 01:20

... RSV or influenza virus by the IN route or were mock-infected On day 34, the animals were secondarily infected with RSV by the IN route, VV-M2 by the IN or ID route, or influenza virus, as indicated ... titers in the tissue were determined by plaque titration of lung homogenates In animals infected by the IN route, the following titers (log10 PFU per g of lung tissue) were detected in the two ... or for intracellular IFNγ staining following in vitro stimulation with the M2-1 or NP peptide [15] This experimental design allowed us to analyze the dependency of the CD8+ CTL response in the...

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Chapter 067. Applications of Stem Cell Biology in Clinical Medicine (Part 1) ppt

Ngày tải lên : 07/07/2014, 01:20

... of Stem Cells for Tissue Repair Different types of stem cells include embryonic stem (ES) cells, umbilical cord blood stem cells, organ-specific somatic stem cells (e.g., neural stem cells for ... for treatment of the brain), and somatic stem cells capable of generating cell types specific for the target rather than the donor organ (e.g., bone marrow mesenchymal stem cells for cardiac repair) ... marrow stem cells, and they are less likely to be contaminated with herpesvirus However, it is unclear how many different cell types these cells can generate, and methods for differentiating them into...

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