... method in determining protein linkage Its greatest advantage is the direct visualization of protein–protein interactions under controlled conditions In contrast, other established protein biochemical ... membrane complexes such as chemical crosslinking analysis might introduce artifacts by random protein linkage Although gel filtration chromatography, domain binding studies with recombinant or ... fiber transitions, including CSQ [28] We therefore studied the complex formation of this terminal cisternae Ca2+-binding protein in chronic lowfrequency stimulated muscle fibers During the fast-to-slow...
... research in the review, but without revising its policies in accordance with the findings (SAPRIN2002: 23-24) For its part, the Bank maintains that the findings of the SAPRI review did influence ... labor-intensive participatory planning processes • Technical expertise is highly valued in justifying project and policy lending decisions, for recruitment, and for maintaining one’s status in the ... democratic principles will inform international as well as national decision-making, the pressure on international institutions to democratize and pluralize their decision-making will only rise Indeed,...
... in the left half complexplane But in this paper by considering zeros of pretzel links we shall show that, on the contrary, zeros of Jones polynomial of knots are dense in the whole complexplane ... plane We point out that Sokal proved that chromatic roots are dense in the whole complexplane [10], and Zhang and Chen proved eigenvalues of digraphs are dense in the whole complexplane [11] ... polynomial in q = − w of G − Y , the graph obtained from G by deleting the edges in Y , and a∈Y a denotes the product of labels in Y The following lemma was given implicitly in [12] and explicitly in...
... the C line may be interpreted as interaction between MHC and other immune response genes Moreover, linkage disequilibrium created in the selected lines between MHC genes and linked immune response ... the estimated effects in the selected lines than in the C line (fig 3), giving credibility to the analysis performed in the selected lines The average genetic value of the C line, as measured by ... differed, indicating maternal or sex-linked effects When crossing lines of mice at their selection limit for Ab response to SRBC, positive heterosis was shown and was interpreted as partial dominance...
... spinal injury “Since the arrival of rescue workers was delayed, some untrained response workers and laypeople began evacuating the casualties to nearby cities in private vehicles, without taking ... regarding disaster response The preparedness of the Ministry of Health in Pakistan was far from sufficient regarding the earthquake in 2005 [18] Since there was no disaster management plan during ... 5year experience in disaster medicine and had participated in previous disasters The selection of participants was determined using a purposeful sampling method The participants were included until...
... periodic interval T which performs the symbol period, as has been shown in Weinstein and Ebert (1971) Infrequency domain, the produced Sin function side lobes resulting overlapping spectra The individual ... Since in continuous time, a convolution in time domain is back to the multiplication infrequency domain This concept is true in discrete time but only when the signals are of infinite length ... are its robustness infrequency selective fading channels, and in particular, reducing the complexity of signal processing by frequency domain equalization The basic principle of multicarrier...
... such that B is not invertible in Lp (C) For the proof see [4] Since S L2 →L2 = 1, all operators in (3.8) are invertible in L2 (C) as long as κ < Thus Theorem 3.2 determines the interval around the ... Orisp¨¨ for helping in a aa aa the preparation of the final form of the manuscript University of Helsinki, Helsinki, Finland E-mail addresses: Kari.Astala@helsinki.fi Lassi.Paivarinta@helsinki.fi References ... quasiconformal mappings in the plane, Monograph in preparation [6] ¨ ¨ K Astala, M Lassas, and L Paivarinta, Calder´n’s inverse conductivity problem for o anisotropic conductivities in the plane, Comm...
... hACMSD:DHAP complex represents the first structure of an ACMSD in a ligand-bound form and can be used to provide insights into catalysis In particular, the residues involved in inhibitor binding can ... The (a ⁄ b)8 barrel domain is colored in light blue and the ACMSDspecific small insertion domain in blue The DHAP molecule and the protein residues involved in metal coordination are shown as sticks; ... contributes to Zn2+ coordination but also because of its direct involvement in substrate binding (Fig 3A,B) Indeed, as detailed above, Asp291 stabilizes DHAP through interaction with the inhibitor carbonyl...
... residues while the remaining structures in the study show 1–16 binding (CaMKK) and 1–10 binding (CaMKIIa) [17] The MARCKS peptide structure shows an unusual pattern of binding in that its anchor ... orientation to incorporate the Trp into the larger C-terminal domain binding site In summary, PhKc is known to bind to CaM via its C-terminal extension The data presented here demonstrate that PhK5 interacts ... multidimensional NMR study of calmodulin complexed with the binding domain of skeletal muscle myosin light-chain kinase: indication of a conformational change in the central helix Biochemistry 30,...
... moiety coordinating to the cobalt atom Again, this binding mode is quite similar to that of diol dehydratase [9] Crystallographic indication of the base-on mode of cobalamin binding in class II ... site and the cobalamin-binding site (A) Stereo drawing of the active-site cavity viewed from the direction parallel to the plane of the corrin ring Activesite residues interacting with the substrate ... of cobalamin binding To identify the Co-coordinating base, EPR spectra of the suicidally inactivated complexes of the enzyme with unlabeled and [imidazole-15N2]-labeled adenosylcobinamide 3-imidazolylpropyl...
... proteins involved in immune responses Insect Biochem Mol Biol 38, 677–682 Yu XQ & Kanost MR (2000) Immulectin-2, a lipopolysaccharide-specific lectin from an insect, Manduca sexta, is induced inresponse ... proSpatzle-1B, contained a 30 bp insertion in the ¨ ORF, beginning at nucleotide 516 This resulted in insertion of a 10 amino acid segment (TREIDYPETI) and one substitution (Ser fi Gly) at the C-terminal end ... Spatzle-processing enzyme required for toll signaling activation in Drosophila innate immunity Dev Cell 10, 45–55 Jiang H & Kanost MR (2000) The clip-domain family of serine proteinases in arthropods Insect...
... pollution incidents in recent years in China, including the high profile Songhua River toxic chemical spill in November 2005, and drinking water source pollution by algae in the Tai Lake, Wuxi in May ... the Rhine catchment area The convention has the following goals: • Promoting sustainable development of the Rhine ecosystem, by a) maintaining and improving the Rhine water quality by avoiding, ... leading role in accident investigation, often making findings publicly available Lessons learnt are shared through industry associations or through the release of legally binding notices to industry...
... DNA-binding domains involved in binding), or 1DR-short (as a dimer, but presumably with only one domain involved), or indeed when bound as a monomer to 1DR This suggests that binding to both inverted ... in a binding stoichiometry of : 1, i.e dimer binding The reactant concentrations were too high to obtain relevant information on the binding afnity For binding to 1DR, the best t yielded a binding ... sequence present in 1DR-short, it is likely that only one of two WH2 DNA-binding domains in RepA dimers is involved in binding This also makes sense energetically, the RepA dimer binds operator...
... Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in the ... thought of as either invasive or passive (merely gathering information), social science research may be more invasive than researchers think, especially in emergency settings Institutional review ... before beginning research, indicating the range of types of research that are possible and the unique risks and benefits of research in each setting (Waldman) 12 RESEARCH ETHICS INCOMPLEX HUMANITARIAN...
... sequence-independent artefacts, most of which are attributable to their ability to bind a number of heparin-binding proteins [28] In our search for allele-speci®c inhibitors based on singlenucleotide ... ODN-mediated inhibition of gene expression in vivo This would be compatible with the ®nding that antisense ODNs can be very effective in inhibiting gene expression in the brain [44± 46] In both fetal ... cells in our study could therefore simply be explained by postulating a cell-speci®c factor that inactivates the PS-ODNs in these cells, which would imply that this factor is inactive in the in...
... Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers It is autonomous in its administration and in the ... thought of as either invasive or passive (merely gathering information), social science research may be more invasive than researchers think, especially in emergency settings Institutional review ... before beginning research, indicating the range of types of research that are possible and the unique risks and benefits of research in each setting (Waldman) 12 RESEARCH ETHICS INCOMPLEX HUMANITARIAN...
... Redzynia et al Chagasin–papain complex structure B A C D Fig Interactions of chagasin and cystatin B with papain Color coding: chagasin (green)–papain (pink); cystatin B (brown)–papain (gray) (A) Stereoview ... residues in the cathepsin B complex were found to bind a phosphate ion [21] The chagasin–papain interface The papain chain in the present complex starts with residue I1e, which is well defined in the ... angle in the chagasin–papain complex is 5.8°, indicating that the chagasin molecule is slanting towards the R domain The angle of approach of cystatin B is )12.7°, and the inhibitor molecule is inclined...
... membrane-spanning protein with N- and C-termini facing the lumen [14] APH-1 contains seven putative transmembrane domains and has a variety of isoforms with differing C-terminal domains; in humans, ... detected in a 360 kDa complex with nicastrin in embryonic mouse brain and SY5Y cells Preliminary investigation of optimal conditions for PS1 complex analysis from mouse brain by BN/PAGE indicated ... for Tg2576* indicated increased APP immunoreactivity with the PS1 complex region NCT was strongly detected in SY5Y membrane complex and weakly in adult mouse C100 brain complex b-catenin was detected...
... processes are introduced Finally, the theories of organizational learning, including individual and organizational learning, in single and double loop and a systemic model in building learning organizations ... 14 Introduction 1.1 Business transformation in the manufacturing industry 1.1.1 Globalization and changes in the business environment As a result of globalization, the business environment in ... transferred to the emerging markets in line with the trend in other manufacturing branches Despite expectations, not all the business start-ups of multinational companies in China have been very successful...
... resulting collector or drain current while the input frequency ff ,,is increased drain current while the input frequencyin is increased in We note that, as ff increases, the input capacitance of ... that, as in increases, the input capacitance of the in device lowers the input impedance, Zin, and hence the device lowers the input impedance, Zin, and hence the input voltage Vin = IIinZinand ... studied in the time domain (e.g., by applying a step) or in the frequency domain (e.g., by applying a sinusoid) The frequencyresponse of a circuit corresponds to the latter test As the frequency...