... network
involving other residues and solvent molecules. An unex-
pected result was the extremely high thermostability of
Mn[G77Q] and the very low thermostability of Fe[A141Q]
(Fig. 5). Each of these mutants ... SODs is not governed by
one or even two residues, but is most likely accomplished by
the concerted effects of a combination of key residues.
Further analysis of these and other mutant SODs is
currently ... whether
in vivo or in vitro [3,4]. Second, specificity ofthe reaction is
determined bythe metal ion: the enzyme is active only with
the ÔcorrectÕ metal. Although, in the complete absence of the
ÔcorrectÕ...
... estimate of the
effectiveness ofthe linker in modulating the ribonucleo-
lytic activity and, in essence, provides a measure of the
therapeutic index of a ribonuclease zymogen. For the
1C zymogen, the ... produce the NS3 protease [48], DNA encoding 12
residues ofthe NS4A protein of HCV and a flexible Gly-
Ser-Gly-Ser tether was inserted upstream ofthe NS3 gene.
The protein encoded bythe resulting ... and the K
d
value for the pRI
complex with unactivated 1C zymogen was therefore
estimated to be > 1 lm [37]. The lack of affinity of
unactivated 1C zymogen for pRI puts it in the range
of the...
... about the faith of zinc
bound in Cd
5
Zn
2
-MT2 after the addition of NO, the
amount of cadmium is reduced at this rather extreme NO
Fig. 1. Wavelength and time scans ofthe CD of MT2 in the presence
and ... by nitric oxide. The decay occurs in the
first 10 min after the addition of NO as observed by
monitoring the CD at the maximum ofthe charge transfer
band at 260 nm (Fig. 1B). The lower molar ellipticity ... was equili-
brated for at least 20 min prior to the start ofthe NMR
acquisition. The same experiment was performed in the
presence of GSH, whereby the GSH concentration was
1m
M
for samples containing...
... of lowering the interest rate according to the policy adopted bythe
Conference of Bankers at the beginning ofthe year, the State Bank preserved the status quo
on the grounds that the inflation ... noted that the interest rates of all state-owned banks are nearly same.
On the other hand, the utility package offered bythe banks to the investors mainly
includes the low cost of capital, ... Part 1, the higher the interest is, the lower GDP and the higher the
inflation rate is. However, in almost all economies, there are always objectives of higher GDP
growth rate and lower the inflation...
... distribution of spots. The lighter a particular area ofthe image is, the higher the density of
random spots, or “events”, the algorithm generates in this area. Fig. 9 shows the output ofthe program
used ... sciences and the rise of modernism in the arts in the early twentieth century represent two
facets ofthe same profound shift in the cultural evolution of humankind. The uneasiness many of us
experience ... with the splines
moving freely along the nails, allows the total bending energy ofthe spline to settle down at its minimum
[30]. I marked the contours of two human profiles facing each other...
... complex that supports the
loading of two RuvB ring helicases on opposing duplexes
and of a dimer of RuvC endonuclease on the other face of
the junction in the space between the RuvB rings [ 7,8]. ... resolvasome complex requires
the binding of RuvA to one face ofthe junction and RuvC
to the other [8,9]. Complexes formed bythe loading of both
RuvA and RuvC on a synthetic junction can be detected
using ... blocking the access of other junction process-
ing enzymes such as RecG [24]. Expression of MpRuvA also
reduced survival ofthe ruv
+
AB1157 strain (Fig. 6B).
However, the effect was rather modest...
... 7). These results may be of physiological
relevance because they indicate that the formation of
the ternary complex is correlated with the level of cal-
pastatin present in the cytosol. By quantification ... areas ofthe peaks were normalized on
the basis ofthe amount of protein loaded on the column. The val-
ues reported are the arithmetical mean ± SD of three different
experiments.
Degradation of ... hindrance and a reduction in the catalytic efficiency ofthe protease.
Thus, the recruitment of calpain in the HSP90–NOS complexes reduces the
extent ofthe proteolysis of these two proteins. We have...
... associated with the passage of time
during the year. This is offset against the other cost items and is generally the expected long-
term rate of return on assets multiplied bythe beginning of year ... percent ofthe greater ofthe plan’s PBO or MRVA.
The total ofthe above pieces ofthe NPPC can produce a negative expense, which appears as income on
a company’s financial statements.
The accrued ... equal to the last date ofthe fiscal
year.
6
As of that date, the company sets assumptions and gathers the participant data used to measure
its obligations and determines the fair value of assets...
... is to tackle the cost ofthe system by supporting many more people
into work. Alongside the introduction ofthe Work Programme, we believe there
is a strong case for reforming the system as ... creates the possibility that the level of conditionality would be
determined, not bythe benefit received, but bythe reason for receiving benefit,
creating a single progression to higher levels of ... permission from the copyright holders concerned.
ISBN: 9 7 8 0 1 0 1 7 9 1 3 2 8.
Printed in the UK for The Stationery Of ce Limited
on behalf ofthe Controller ofHer Majesty’s Stationery Of ce.
ID:...
... Interestingly, when there are three or more children in the household,
men are found to work even fewer hours around the house than before the appearance ofthe third
child. Whereas women's ...
men maintain approximately the same number of hours of unpaid work as in childless households,
but the number of hours women work in the home rises to 52 per week, much of it, on doubt, due
to ... this task.
model answer:
The diagram reveals that the number of hours per week spent in unpaid work is unequally
distributed between men and women. In households where there are no children, women...