bone marrow failure syndromes ppt
Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 4) pptx
Ngày tải lên :
07/07/2014, 04:20
... cooperate in a repair
complex to maintain telomere length. In Shwachman-Diamond syndrome, marrow
failure is seen with pancreatic insufficiency and malabsorption; most patients have
compound ... thrombotic episodes occur in patients with large
PNH clones (>50%). Functional studies of bone marrow from PNH patients, even
those with mainly hemolytic manifestations, show evidence of ... an initial clinical diagnosis of PNH, especially
younger individuals, may later develop frank marrow aplasia and pancytopenia;
patients with an initial diagnosis of aplastic anemia may suffer...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 6) ppt
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07/07/2014, 04:20
... history of hematologic
diseases or blood abnormalities may indicate a constitutional etiology of marrow
failure.
Physical Examination
Petechiae and ecchymoses are typical, and retinal hemorrhages ... expression on CD34 cells,
leading to apoptotic cell death; localization of activated T cells to bone marrow
and local production of their soluble factors are probably important in stem cell
destruction. ... presence of immature myeloid forms suggests leukemia or MDS;
nucleated red blood cells suggest marrow fibrosis or tumor invasion; abnormal
platelets suggest either peripheral destruction or...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 1) ppsx
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07/07/2014, 04:20
... Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 1)
Harrison's Internal Medicine > Chapter 102. Aplastic Anemia,
Myelodysplasia, and Related Bone Marrow Failure Syndromes
Aplastic ... leukemia (AML)
Some acute lymphoid leukemia
Some lymphomas of bone marrow
Pancytopenia with Cellular Bone Marrow
Primary bone marrow diseases
Myelodysplasia
Paroxysmal nocturnal
Secondary ... leukopenias).
Hematopoietic failure syndromes are classified by dominant morphologic
features of the bone marrow (Table 102-1). While practical distinction among
these syndromes usually is clear,...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 2) ppsx
Ngày tải lên :
07/07/2014, 04:20
... Aplastic Anemia, Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 2)
Aplastic Anemia
Definition
Aplastic anemia is pancytopenia with bone marrow hypocellularity.
Acquired aplastic ... bone marrow hypocellularity.
Acquired aplastic anemia is distinguished from iatrogenic marrow aplasia, marrow
hypocellularity after intensive cytotoxic chemotherapy for cancer. Aplastic anemia ... typical physical anomalies and the
development of pancytopenia early in life, can also present as marrow failure in
normal-appearing adults. Acquired aplastic anemia is often stereotypical in its...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 3) pdf
Ngày tải lên :
07/07/2014, 04:20
... Chapter 102. Aplastic Anemia, Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 3)
Radiation
Marrow aplasia is a major acute sequela of radiation. Radiation damages ... a notorious cause of bone marrow failure. Vast quantities of
epidemiologic, clinical, and laboratory data link benzene to aplastic anemia, acute
leukemia, and blood and marrow abnormalities. ... environment. The
association between marrow failure and other chemicals is much less well
substantiated.
Drugs
(Table 102-3) Many chemotherapeutic drugs have marrow suppression as a
major toxicity;...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 5) pdf
Ngày tải lên :
07/07/2014, 04:20
...
Related Bone Marrow Failure Syndromes
(Part 5)
Pathophysiology
Bone marrow failure results from severe damage to the hematopoietic cell
compartment. In aplastic anemia, replacement of the bone ...
responsible for benzene-induced tissue injury. Excessive generation of toxic
intermediates or failure to detoxify the intermediates may be genetically
determined and apparent only on specific ... severe damage to the hematopoietic cell
compartment. In aplastic anemia, replacement of the bone marrow by fat is
apparent in the morphology of the biopsy specimen (Fig. 102-1) and MRI of the...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 7) docx
Ngày tải lên :
07/07/2014, 04:20
... anemia. Genetic analysis applicable to the constitutional marrow failure
states is available in some laboratories. Chromosome studies of bone marrow cells
are often revealing in MDS and should be ... patients
with bone marrow hypocellularity have depression of only one or two of three
blood lines, sometimes showing later progression to more recognizable aplastic
anemia. The bone marrow in constitutional ...
ameliorated by suppression of the immune system to allow recovery of the
patient's residual bone marrow function. Hematopoietic growth factors have
limited usefulness and glucocorticoids are...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 8) potx
Ngày tải lên :
07/07/2014, 04:20
... Chapter 102. Aplastic Anemia, Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 8)
Hematopoietic Stem Cell Transplantation
This is the best therapy ... suitable marrow donor, and
immunosuppression is the treatment of choice. Overall survival is equivalent with
transplantation and immunosuppression. However, successful transplant cures
marrow failure, ... patients continue to have some degree of blood count
depression, the MCV remains elevated, and the bone marrow cellularity returns
toward normal only very slowly, if at all. Relapse (recurrent pancytopenia)...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 9) docx
Ngày tải lên :
07/07/2014, 04:20
... respond to immunosuppressive
Chapter 102. Aplastic Anemia, Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 9)
Outcomes following both transplant and immunosuppression have
improved ... Cell Aplasia
Other, more restricted forms of marrow failure occur, in which only a
single circulating cell type is affected and the aregenerative marrow shows
corresponding absence or decreased ... regimen of 2 units every 2 weeks will replace normal losses
in a patient without a functioning bone marrow. In chronic anemia, the iron
chelators deferoxamine and deferasirox should be added at...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 10) pot
Ngày tải lên :
07/07/2014, 04:20
...
Related Bone Marrow Failure Syndromes
(Part 10)
Definition and Differential Diagnosis
PRCA is characterized by anemia, reticulocytopenia, and absent or rare
erythroid precursor cells in the bone ... characterized by anemia, reticulocytopenia, and absent or rare
erythroid precursor cells in the bone marrow. The classification of PRCA is shown
in Table 102-4. In adults, PRCA is acquired. An identical ... patients have etiologic mutations in a ribosomal RNA processing gene
called RPS19. Temporary red cell failure occurs in transient aplastic crisis of
hemolytic anemias due to acute parvovirus infection...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 11) docx
Ngày tải lên :
07/07/2014, 04:20
... preparation
made from the marrow biopsy of a patient with metastatic carcinoma.
Chapter 102. Aplastic Anemia, Myelodysplasia, and
Related Bone Marrow Failure Syndromes
(Part 11)
Persistent ... mediated by immune complex
deposition.
Figure 102-2
Pathognomonic cells in marrow failure syndromes. A.
Giant
pron
ormoblast, the cytopathic effect of B19 parvovirus infection ... congenital, acquired, or iatrogenic immunodeficiency, persistent
viral infection may occur. The bone marrow shows red cell aplasia and the
presence of giant pronormoblasts (Fig. 102-2), which is...
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Chapter 102. Aplastic Anemia, Myelodysplasia, and Related Bone Marrow Failure Syndromes (Part 12) pot
Ngày tải lên :
07/07/2014, 04:20
... 102-
5 World Health Organization Classification of
Myelodysplastic Syndromes
Disease Freque
ncy
Blood
Findings
Bone
Marrow
Findings
Prognos
is
Refractory
anemia (RA)
5–10% Anemia
... characterized by cytopenias associated with a dysmorphic (or
abnormal appearing) and usually cellular bone marrow, and by consequent
ineffective blood cell production. A clinically useful nosology of ...
hypolobated
nuclei
<5%
blasts
No
Auer rods
Isolated
del(5q)
Long
survival
Note: BM, bone marrow.
Source: Extracted from Jaffe ES et al (eds):
Pathology and Genetics of
Tumors of Haematopoietic...
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Báo cáo hóa học: "Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion" doc
Ngày tải lên :
18/06/2014, 16:20
... resurrection after bone- marrow- derived
Anastasiadis et al. Journal of Translational Medicine 2011, 9:12
http://www.translational-medicine.com/content/9/1/12
Page 4 of 5
Chronic ischemic heart failure epidemic. ... al.: Hybrid approach of ventricular
assist device and autologous bone marrow stem cells implantation in
end-stage ischemic heart failure enhances myocardial reperfusion.
Journal of Translational ... Cardiol 2002, 39:1189-1198.
8. McMurray JV, Pfeffer MA: Heart failure. Lancet 2005, 365:1877-1889.
9. Gheorghiade M, Bonow RO: Chronic heart failure in the United States: a
manifestation of coronary...
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Báo cáo sinh học: " Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow" ppt
Ngày tải lên :
18/06/2014, 22:20
... experimental
metastasis to bone and bone marrow. Cancer Res 1988, 48:6876-6881.
41. Argüello F, Baggs RB, Graves BT, Harwell SE, Cohen HJ, Frantz CN: Effect of
IL-1 on experimental bone/ bone marrow metastases. ... as
previously described [30].
For human BMSC isolation, bone marrow aspirates
were obtained from patients under going bone marrow
harvest for autologous bone marrow transplantation,
after informed c onsent. ... in the prevention a nd treatment of bone
metastases.
List of abbreviations
The abbreviations used are: COX-2: cyclooxygenase-2; BM: bone marrow;
BMSC: bone marrow stromal cell; CM: conditioned...
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