bleeding and thrombosis in acute promyelocytic leukemia

Báo cáo sinh học: "Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt

... Aur-A and induces monopolar spindle in NB4-R2 cells. (A) VX-680 inhibited phosphorylation of Aur-A at Thr288 in NB4-R2 cell line. Cells were incubated with increasing doses of VX-680 for 24 hr and ... bothAnnexin V/PI staining and immunofluorescent stainingwith Hoechst 33342. Annexin V/PI staining showed thatpercentage of apoptosis were 3.66%, 5.52%, 15.83%,24.43% respectively for 24 hr, and ... withprognosis and advanced clinical stage in h ead and necksquamous cell carcinoma [14,15]. Recently study showedthat Aur-A kinase was highly expressed in acute myeloid leukemia (AML) patients and suppression...

báo cáo hóa học:" Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt

Danh mục: Hóa học - Dầu khí

... VX-680 inhibits activation of Aur-A and induces monopolar spindle in NB4-R2 cells. (A) VX-680 inhibited phosphorylation of Aur-A at Thr288 in NB4-R2 cell line. Cells were incubated with increasing ... abnormalmonopolar spindles, suggesting that the inhibitio n ofAurora kinase activity induced defects of mitotic spindle in VX-680 treated cells.VX-680 suppresses cell growth and induces cell apoptosis in NB4-R2 ... Li2,4, Dong-Jun Lin3,4 and Quentin Liu1,3,4*AbstractBackground: Aurora kinase ensures accurate chromosome segregation during cell cycle, maintaining geneticintegrity in cell division. VX-680,...

báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx

Danh mục: Báo cáo khoa học

báo cáo hóa học:" Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells" potx

Danh mục: Hóa học - Dầu khí

... considered independently of its ED action and mighthelp in the understanding of the adverse effects caused in humans.AbbreviationsAKT: RAC-alpha serine/threonine-protein kinase; AML: Acute Myeloid Leukemia; ... FLIP: FLICE Inhibitor Protein; TRAIL: TNFRelated Apoptosis Inducing Ligand; RA: Retinoic Acid; RB:Retinoblastoma.Competing interestsThe authors declare that they have no competing interests.Authors' ... plastic and epoxy resins, which can be used in impact-resistant safetyequipment and baby bottles, as protective coatings inside metal food containers, and as composites and sealants in dentistry....

Chapter 059. Bleeding and Thrombosis (Part 1) pdf

Danh mục: Sức khỏe giới tính

... Chapter 059. Bleeding and Thrombosis (Part 1) Harrison's Internal Medicine > Chapter 59. Bleeding and Thrombosis Bleeding and Thrombosis: Introduction The human hemostatic ... normally inactive GpIIb/IIIa receptor into an active receptor, enabling binding to fibrinogen and vWF. Because the surface of each platelet has about 50,000 GpIIb/IIIa fibrinogen binding sites, ... Fibrin Clot Formation Plasma coagulation proteins (clotting factors) normally circulate in plasma in their inactive forms. The sequence of coagulation protein reactions that culminate in the...

Chapter 059. Bleeding and Thrombosis (Part 2) potx

Danh mục: Sức khỏe giới tính

... Fibrin formation and dissolution. A. Fibrinogen is a trinodular structure consisting of 2 D domains and 1 E domain. Thrombin activation results in an ordered lateral assembly ... associations. FXIIIa cross-links the D domains on adjacent molecules (C). Fibrin and fibrinogen (not shown) lysis by plasmin occurs at discrete sites and results in intermediary fibrin(ogen) degradation ... Thrombin also activates factor XIII (fibrin-stabilizing factor) to factor XIIIa, which covalently cross-links and thereby stabilizes the fibrin clot. Figure 59-2 Chapter 059. Bleeding and Thrombosis...

Chapter 059. Bleeding and Thrombosis (Part 3) docx

Danh mục: Sức khỏe giới tính

... PAI1 and PAI2, inhibit the physiologic plasminogen activators; and (2) α2 antiplasmin inhibits plasmin. PAI1 is the primary inhibitor of tPA and uPA in plasma. α2 antiplasmin is the main inhibitor ... of antithrombin. The rate of formation of these inactivating complexes increases by a factor of several thousand in the presence of heparin. Antithrombin inactivation of thrombin and other activated ... fibrin. In response, the endogenous fibrinolytic system is then activated to dispose of intravascular fibrin and thereby maintain or reestablish the patency of the circulation. Just as thrombin...

Chapter 059. Bleeding and Thrombosis (Part 4) potx

Danh mục: Sức khỏe giới tính

... contributed to the bleeding or thrombotic state. In addition, the history can give clues as to the etiology by determining (1) the bleeding (mucosal and/ or joint) or thrombosis (arterial and/ or venous) ... Chapter 059. Bleeding and Thrombosis (Part 4) Approach to the Patient: Bleeding and Thrombosis Clinical Presentation Disorders of hemostasis may be either inherited or acquired. ... Bleeding A history of bleeding is the most important predictor of bleeding risk. In evaluating a patient for a bleeding disorder, a history of at-risk situations, including the response to past...

Chapter 059. Bleeding and Thrombosis (Part 5) ppt

Danh mục: Sức khỏe giới tính

... Chapter 059. Bleeding and Thrombosis (Part 5) Epistaxis is a common symptom, particularly in children and in dry climates, and may not reflect an underlying bleeding disorder. However, ... mild bleeding disorder such as vWD. All NSAIDs, however, can precipitate gastrointestinal bleeding, which may be more severe in patients with underlying bleeding disorders. The aspirin effect ... factor XI deficiency and in symptomatic carriers of hemophilia A. Women with underlying bleeding disorders are more likely to have other bleeding symptoms, including bleeding after dental extractions,...

Chapter 059. Bleeding and Thrombosis (Part 6) doc

Danh mục: Sức khỏe giới tính

... Coexisting coagulopathies, as seen in liver failure or disseminated coagulation; infection; platelet-inhibitory drugs; and underlying medical conditions can all increase the risk of bleeding in ... risk is inherited or acquired. Note: APC, activated protein C; TAFI, thrombin-activatable fibrinolysis inhibitor; TFPI, tissue factor pathway inhibitor. Chapter 059. Bleeding and Thrombosis ... patient with a bleeding tendency must therefore include a thorough assessment for evidence of underlying disease. Bruising or mucosal bleeding may be the presenting complaint in liver disease,...

Chapter 059. Bleeding and Thrombosis (Part 7) pptx

Danh mục: Sức khỏe giới tính

... prospectively to determine its utility in predicting bleeding risk, although such studies are underway. For routine preoperative and preprocedure testing, an abnormal prothrombin time (PT) may detect ... Venous thrombosis: A multicausal disease. Lancet 353:1167, 1999.] Laboratory Evaluation Careful history taking and clinical examination are essential components in the assessment of bleeding and ... coagulation assays, proper sample acquisition and handling is critical to obtaining valid results. In patients with abnormal coagulation assays who have no bleeding history, repeat studies with attention...

Chapter 059. Bleeding and Thrombosis (Part 8) pptx

Danh mục: Sức khỏe giới tính

... Vitamin K deficiency – late Direct thrombin inhibitors Prolonged thrombin time Heparin or heparin-like inhibitors Mild or no bleeding – dysfibrinogenemia Frequent, severe bleeding – ... the bleeding risk of a mildly elevated INR in this setting. The aPTT assesses the intrinsic and common coagulation pathways, factors XI, IX, VIII, X, V, II, fibrinogen, and also prekallikrein, ... formation) and coagulation test abnormalities is shown in Table 59-4. Chapter 059. Bleeding and Thrombosis (Part 8) Screening Assays The most commonly used screening tests are the PT, aPTT, and...