bits and pieces metabolism and toxicity
Báo cáo khoa học: Amyloid oligomers: formation and toxicity of Ab oligomers ppt
Ngày tải lên :
06/03/2014, 09:22
... interactions between a-synuclein and Ab therefore indicate that AD and PD could be related Ab also promotes a-synuclein aggregation and toxicity These results suggest that the AD and PD pathologies could ... different sizes and shapes have been reported, which accounts for their biological and structural diversity and for the complexity of AD pathology (reviewed in [4,5,9–11]) SDS-stable dimers and trimers ... antibodies – A11 and OC – which are specific for oligomers and fibrils, respectively They proposed two distinct types of oligomers: prefibrillar oligomers that are A11-positive and OC-negative, and fibrillar...
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Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt
Ngày tải lên :
06/03/2014, 09:22
... and toxicity of polyQ-expanded Huntingtin indicated that fragile amyloid, which is rich in exposed and flexible regions, is significantly more toxic than rigid amyloid, which comprises buried and ... interacts with the hydrophobic surfaces of denatured and misfolded proteins, prevents aggregation of polyQ-expanded proteins and inhibits their toxicity [37–39] The cytosolic chaperonin CCT is a ... recognizing hydrophobic b-strands [40]; this chaperone prevents aggregate formation and toxicity of polyQ-expanded proteins [41–44] CCT weakly recognizes monomeric and oligomeric forms (2–5 mers)...
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Bioavailability and toxicity of cd to microorganisms and their activities in soil
Ngày tải lên :
15/03/2014, 23:21
... 0.87% C different soils: River sand, Gley, Gray lowland, Andosol and Humic Andosol (pH 5.7–8.5) different soils—River sand, Gley, Gray lowland, Andosol and Humic Andosol (pH 5.7–8.5)q2% sludge ... Cd toxicity to soil microbes and their activities; (ii) compare its toxicity between field and laboratory studies; (iii) determine the relationship between Cd bioavailability and toxicity; and ... decomposition of glutamic acid in both sandy and silty loam soils, but not in clay and sandy peat soils (Haanstra and Doelman, 1984) The mineralization of carbon and nitrogen in different soils were...
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EDTA enhanced heavy metal phytoextraction metal accumulation leaching and toxicity
Ngày tải lên :
16/03/2014, 00:07
... amounts and modes of EDTA application on Pb, Zn and Cd uptake by test plant Brassica rapa We monitored the leaching of HMs and EDTA through the soil profile We also tested phytotoxicity and toxicity ... in soil solution and bioavailability due to complexation with organic and inorganic soil colloides, sorption on oxides and clays and precipitation as carbonates, hydroxides and phosphates (Ruby ... presumption and to evaluate the influence of EDTA treatment on mycorrhizal development The toxicity of EDTA on soil bacteria, actinomycetes and fungi was studied with PLFA and DGFA methods PLFA and DGFA...
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Báo cáo khoa học: Modulation of amyloid-b aggregation and toxicity by inosose stereoisomers pot
Ngày tải lên :
16/03/2014, 06:20
... Control No effect No effect Inhibits Inhibits Increase Inhibits No effect Inhibits Inhibits No effect No effect No effect Inhibits Increase Inhibits Increase Inhibits Inhibits No effect L-chiro-1-Inosose ... Guengerich FP (2001) Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity Chem Res Toxicol 14, 611–650 27 Spector R (1978) The transport and metabolism of scyllo-inositol ... the presence and absence of Ab40 and Ab42 with increasing ratios of compounds for 24 h Toxicity was measured using two well-established assays for Abinduced toxicity, Alamar blue and sulfhydryl...
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Báo cáo khoa học: Superoxide radical-scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds potx
Ngày tải lên :
23/03/2014, 07:20
... antioxidative effects and cytotoxicity of four newly synthesized organic selenium compounds: two selenoureas (selenourea A and selenourea B) and two tertiary selenoamides (selenoamide A and selenoamide ... generation and oxidative stress with ageing and exercise: differential effects in the myocardium and liver Acta Physiol Scand 169, 343–351 Møller P & Loft S (2006) Dietary antioxidants and beneficial ... 1.11.1.9) and catalase (EC 1.11.1.6), and low molecular weight antioxidants, such as vitamins and various biological dyes, can reduce ROS in vivo [16–19] GPX is an important oxidative enzyme and a...
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Dermal Absorption and Toxicity Assessment pot
Ngày tải lên :
28/03/2014, 22:20
... Prediction and Assessment, edited by Jennifer B Dressman ¨ and Hans Lennernas 107 Drug Stability: Principles and Practices, Third Edition, Revised and Expanded, edited by Jens T Carstensen and C T ... Hickey and David Ganderton 113 Pharmacogenomics, edited by Werner Kalow, Urs A Meyer and Rachel F Tyndale 114 Handbook of Drug Screening, edited by Ramakrishna Seethala and Prabhavathi B Fernandes ... Drug Trials and Tribulations: Second Edition, Revised and Expanded, edited by Allen Cato, Lynda Sutton, and Allen Cato III 121 Modern Pharmaceutics: Fourth Edition, Revised and Expanded, edited...
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PESTICIDES IN THE MODERN WORLD – PESTS CONTROL AND PESTICIDES EXPOSURE AND TOXICITY docx
Ngày tải lên :
28/06/2014, 09:20
... (4.6% and 5.3%) and Gemmatimonadetes (1.4% and 1.9%) were Pesticides in the Modern World Pests Control and Pesticides Exposure and Toxicity Assessment present Whereas Acidobacteria (7.9%) and ... Table Molecular and microscopic tools in biocontrol research 6 Pesticides in the Modern World Pests Control and Pesticides Exposure and Toxicity Assessment AOBs as well as metabolism rates ... Research 279 Andrea Amaroli Pesticides Toxicity 295 Chapter 15 Molecular Mechanisms of Pesticide Toxicity 297 Olfa Tebourbi, Mohsen Sakly and Khộmais Ben Rhouma Chapter 16 Structural and Dynamic...
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Báo cáo khoa học: " Accelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity" potx
Ngày tải lên :
09/08/2014, 09:20
... mild and the breast pain, edema, or erythema subsided with conservative management Grade and late skin toxicity occurred in (16.7%) and (6.3%) patients, respectively Grade and late subcutaneous toxicity ... surgery and all patients were alive without evidence of disease at the last follow-up Dosimetry, toxicity, and cosmesis The mean V100 and V150 values were 44.7 ± 17.9 cm3 (range 12-101) and 22.8 ... years and every months thereafter, with a physical examination, chest X-ray, and blood tests Mammography and ultrasound examinations of the breast and abdomen were performed at months after APBI and...
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Báo cáo khoa học: " Inverse planned stereotactic intensity modulated radiotherapy (IMRT) in the treatment of incompletely and completely resected adenoid cystic carcinomas of the head and neck: initial clinical results and toxicity of treatment" potx
Ngày tải lên :
09/08/2014, 10:21
... carcinomas of the head and neck are a unique kind of tumour deriving from cells of the major and minor salivary glands, they account for 25% of all malignant salivary gland tumours in different ... rates and toxicity profiles in patients with tumours of the head and neck [4-6] The aim of this publication is to present the inverse planned IMRT treatment technique, initial clinical results, and ... regularly for clinical examination during and after radiation therapy Acute toxicity was specified according to the Common Toxicity Criteria (CTC) during treatment and months afterwards After months,...
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Báo cáo khoa học: " Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy" pps
Ngày tải lên :
09/08/2014, 10:21
... overall and cancer-specific survival was observed (Figure and 2) The 1-year OS in the matched HIV-seropositive and -seronegative cohort was 90 % and 100 %, and the 5year OS was 70 % and 69 %, ... respect of acute toxicity can not be excluded There was no grade toxicity in the HIV-positive group or the matched HIVnegative group Cutaneous and gastrointestinal toxicity: Acute skin toxicity grade ... side effects Toxicity The common terminology criteria for adverse events v3.0 was used for assessing acute and late treatment toxicity [20] Follow-up records addressing long-term toxicity were...
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báo cáo khoa học: "CyberKnife for hilar lung tumors: report of clinical response and toxicity" potx
Ngày tải lên :
10/08/2014, 22:21
... esophagus and mainstem bronchus were 25 Gy (range, 11 - 39 Gy) and 42 Gy (range, 30 - 49 Gy), respectively Early Clinical and Radiographic Response All patients underwent clinical follow-up, and 14 ... declines in the maximum standardized uptake values (Figure 1) Local Control and Survival Despite excellent early clinical and radiographic responses, local control and survival outcomes beyond ... distribution (B: the planning treatment volume is shown in red and the 30 Gy isodose line in blue), and PET/CT at 6, and 12 months post-treatment (C and D) show an initial decrease in SUVmax to 2.5 followed...
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báo cáo khoa học: " Bioaccumulation and toxicity of selenium compounds in the green alga Scenedesmus quadricauda" pps
Ngày tải lên :
12/08/2014, 03:20
... effect of selenite and selenate on the cells, which is probably caused by distinct mechanisms of uptake and further metabolisms of different Se compounds as found in land plants and Cyanobacteria ... proteins and other sulfur compounds In land plants, Se toxicity is associated with the incorporation of selenocystein (SeCys) and selenomethionine (SeMet) into proteins in place of Cys and Met ... selenate or selenite New Phytologist 2008, 178(1):92-102 Anderson JW, Scarf AR: Selenium and plant metabolism In Metals and micronutrients: uptake and utilization by plants Edited by: Robb DA Piermont...
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Development and application of computational methods and tools for adverse drug reaction and toxicity prediction
Ngày tải lên :
10/09/2015, 09:02
... structures and activities [35, 105] SVM shows consistently outstanding classification ability in toxicity and ADR prediction, such as TDP causing potential [17], hepatotoxicity [40] and many other ... similar software programs and it is completely free to the public The main purpose of this thesis is to develop and apply computational methods and tools for ADR and toxicity prediction The methods ... different models on testing and validation sets using CV and RS method CC_AUC, CC_SE and CC_SP indicate the correlation coefficient of AUC, SE and SP values of testing and validation performance...
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Role of multidrug resistance associated protein 4 (MRP4 ABCC4) in the resistance and toxicity of oxazaphosphorines
Ngày tải lên :
14/09/2015, 14:06
... the efficacy and toxicity of CP and IF Hence, further studies on the relationship between MRP4/ABCC4 and CP and IF and on the development of approaches to reducing toxicity of CP and IF are needed ... used in both adults and children with high-dose therapy regimens [156] In contrast to CP, IF shows increased haematological toxicity, neurotoxicity, urotoxicity and nephrotoxicity Hence, IF is ... tumor cell to CP and IF Other proteins associated with the disposition, attack of targets and toxicity of CP and IF may interplay with GSTs - 30 - CP and IF are highly hydrophilic and not diffuse...
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