... without the benefit of hindsight, by ensuring that the examiner assesses the invention through the eyes ofthe person skilled inthe art, with the benefit of his common general knowledge The inventive ... ofthe claim in question is then construed, and the differences between the state ofthe art and the inventive concept ofthe claim are identified This then enables the examiner to approach the ... relating to Biotechnological Inventions inthe Intellectual Property Office Assessing inventive step: Fulfilling a need 41 The fact that other workers were attempting to find recombinant methods of...
... losses in other domains [22] The role of leisure in maintaining or restoring psychological wellbeing inthe presence of arthritis pain warrants further study Psychosocial approaches to managing ... psychosocial functioning and coping of mothers with chronic pain (including mothers with arthritis) to mothers without pain, with regard to their ratings of parenting efficacy There was a significant ... comparison of conventional pain coping skills training and pain coping skills training with a maintenance training component: A daily diary analysis of short- and long-term treatment effects J Pain 2006,...
... using the direct binding assay as described in Experimental procedures Inset: Linearized plot ofthe binding data for apoE(263–286) (symbols) shown in panel A The solid line represents the linear ... fraction inthe presence of both apoE isoforms However, a greater increase inthe ordinate maximum and area under the curve is obvious inthe presence ofthe apoE4 isoform (Fig 7C, open symbols), indicating ... particular, the binding footprint for the apoE4 isoform, corresponding to 3.0 amino acids per phospholipid, is almost twofold greater than the apoE3 isoform (Table 2), suggesting these isoforms differ in...
... another The grandmother held the floor most ofthe time from the beginning ofthe story in her decision where to go, in her introduction ofthe scenery along the journey While the father, the mother ... setting Technique has to with the structuring ofthe story into the plot so that the writer can convey the theme and the manipulating ofthe language in order to express the ideas ofthe writer in ... aftermath, led the American to the golden age of booming national prosperity with the highest standard of living inthe history ofthe world economy, as indicated inthe increase ofthe Gross National...
... decided the control strategy for theselectionof well-settling sludge Then, we applied the strategy to the formation of aerobic granular sludge in a continuous experiment In addition, the effect of ... granulation in a continuous-flow reactor We focused our attention on the controllable factors influencing theselectionof well-settling sludge because the sludge selection is one ofthe most important ... and is influent feeding mode In Run 1, ammonia-rich wastewater was continuously fed from the bottom ofthe reactor, while the wastewater was intermittently fed (sequencing batch mode) in Run...
... cytokines, including IL-1b, TNF-a and IFN-c (B) Chemokines expressed inthe joint recruit leukocytes into the joints In addition to functioning in cell trafficking, several chemokines have other biological ... concentrations of several chemokines Chemokines inthe joints of patients Table Chemokines and chemokine receptors expressed inthe joint of RA patients Systemic name CC chemokines CCL2 CCL3 ... et al Chemokines inthe joints of patients CXC chemokines C and CX3C chemokines Interleukin-8 ⁄ CXCL8 (a ligand of CXCR1 and CXCR2) was the first chemokine identified to be involved in leukocyte...
... development ofthe game situation Inthe Figure 5, we have illustrated this inthe same way we did for the case of interruption The left hand side ofthe solid line is lower than that ofthe dotted ... completely uttered The right part ofthe dotted line is lower than that ofthe solid, because the importance ofthe second utterance decreases over time when waiting interruption : with interruption ... Thus, the sum ofthe importance ofthe uttered propositions can no longer be used to access the system's performance Instead, the area between the lines and the horizontal axis indicates the total...
... presence of Cu(II), the protein shows the presence ofthe ion coordinated in a small cavity ofthe surface at the polar opposites of each monomer, close to another dimer present inthe crystal packing ... ofthe interactions that were assumed to involve Cag proteins [16,17] These findings, combined with previous analysis on single components, have allowed the proposal of preliminary models ofthe ... thus supporting the idea that it might be involved inthe translocation as a putative effector protein rather than being a component ofthe T4SS apparatus Finally, interaction studies indicated...
... The substrate also maintained its relative position inthe active site during the simulation These data not preclude the existence of other possible conformations further away from the starting ... 604, 611) inthe loop, particularly Gly603, in maintaining the plasticity ofthe active site and the full range of function of TOP Most recently [30], potential new substrates adhering to the size ... [0.31] the end ofthe simulation, despite having a close prox˚ imity between Tyr hydroxyl groups (e.g 2–3 A) and the substrate inthe initial model In addition to reducing the flexibility of the...
... nonpropc~itional) slots in input frames; The history of processing, structured Mong the lines ofthe episodic memory oWaa~zat~on suggested by Kolodner (1984) and including the feedback ofthe results of actual ... contributing factors for selecting one verb over the other;, (I) the intended perspective ofthe situation, (2) the emphasis of one activity rather than another, (3) the focus being on a particular individual, ... outside the context of an utterance Theselectionof closed-class items, therefore, comes as a result ofthe use ofthe various control heuristics that guide the process of generation In other words,...
... same as the size ofthe training IC feature sets This was done by randomly selecting epochs from the NC training set Results In this section, we present our offline analysis ofthe data ofthe four ... from Table 2) The blue line shows the fitness ofthe classifier as a function ofthe number of top features We began by training and testing the classifier using only the feature with the highest ... learning, all ofthe beneficial properties of linear classification methods, such as simplicity, are maintained, however, the overall classification is nonlinear inthe input space, since the...
... argue that the building ofthe LUT using the considered steps requires a lot of time and an accurate resolution ofthe integral in (5) However, the LUT is computed once for all off-line and would ... eigenvalues, but by the product ofthe characteristic matrix and the eigenvectors En The estimated AoAs are then the arguments ofthe complex roots ofthe obtained pseudospectrum One drawback ofthe extended ... test the envelope ofthe fading signal for Rician statistics and then to estimate the K-factor In [22], the K-factor estimator is based on statistics ofthe instantaneous frequency (IF) of the...
... faces in 1996, to avoid compression wood being normally maximum inthe Northeast part ofthe trunk (the dominant winds blow from the Southwest in Belgium) These 14-year-old trees were felled inthe ... selection using indirect method (9% instead of 11.5% – Tab IX) Meanwhile, the lower estimate of gain slightly affects the final selectionofthe clone: in this sample (Tab X) to ofthe first clones ... between the opposite radial faces ofthe same ring, inthe same orientation (North and South): measurements were carried out inthe heartwood, and inthe sapwood The next step was the sawing of each...
... with the breaking of cambial dormancy (Little and Wareing, 1981Moreover, ABA content increases again in reactivating cambium, for example, inthe trunk of Pinus contorta (Savidge and Wareing, ... inactivation of auxin receptor and carrier proteins Later on, the breaking of rest may occur when the conditions of active membrane trans- port are regained Is abscisic acid (ABA) involved inthe regulation ... applied to the lower and upper sides of an inclined stem, respectively Reports concerning the intervention of other phytohormones in this process are somewhat conflicting Several observations indicate...
... procedure of data splitting was implemented, first cumulating increasingly larger numbers of generations from the beginning ofthe experiment (analysis I), and then having separate groups of consecutive ... that of h Inferences are influenced by the amount of data available and the assumed type of a priori distribution ofthe variance components, as shown inthe example in Sorensen et al [15] In this ... out for a limited number of generations, and the main interest is to evaluate the effect ofselection on the means ofthe selected populations On the other hand, long-term selection experiments...
... occurrence and the total number of lambs born per ewe over the first three lambings All these results suggest that indirect selection for high fertility inthe L- line may have been opposing theselection ... litters below the control line That result was attributed to an effect of overloading inthe uterus caused by shorter litter intervals combined with large litter size inthe selected line Results ... (1981) observed an increased regularity ofthe cycle in a line of mice in which litter size was improved, whereas the line selected for small litter size showed a high percentage of irregular cycles...
... EFV monotherapy at the time of therapy interruption selected the K103N mutation, which persisted as the prevalent quasispecies for over years of continual viral replication, inthe absence of selective ... al reported on the persistence of K103N mutation after EFV interruption in patients failing to EFV-containing regimens, documenting variable decay kinetics for the K103N containing quasispecies ... transcriptase inhibitor; NVP, nevirapine; PI, protease inhibitor Competing interests The authors declare that they have no competing interests Consent Written informed consent was obtained from the patient...
... geometric mean ofthe expression values ofthe set ofthe control genes tested The lower the M value, the more stably expressed the gene is Also, the program enables the exclusion ofthe most unstable ... region ofthe gene The M value for both sets of primers was the same, showing that the amplification region had no influence on the expression stability Although the difference inthe M value ofthe ... present in more than 300 angiosperm species [10] and is being investigated by many groups due to thebiotechnological interest of controlling the process of cloning through seeds The occurrence of...
... M: Loss of all ndh genes as determined by sequencing the entire chloroplast genome ofthe Black Pine Pinus thunbergii Proceedings ofthe National Academy of Sciences ofthe United States of America ... contains a portion ofthe 5' end of ycf1 Two segmental inversion events are observed in C exaltata One inversion occurs from trnV-UAC to psbE inthe LSC region, the other inthe SSC encompassing ... free-living seedlings may explain the need for an intact photosynthetic apparatus in this parasitic lineage Use of RuBisCo for lipid biosynthesis may also explain retention of rbcL in other holoparasite...