... malonyl-CoA and CPT1c in the treatment of obesity Michael J. Wolfgang and M. Daniel LaneDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USAIntroductionAll ... malonyl-CoA;neurometabolism; nutrient sensing; obesity CorrespondenceM. J. Wolfgang, Department of BiologicalChemistry, Johns Hopkins University School of Medicine, Center for Metabolism and Obesity Research, 475 Rangos ... major user of long-chain fattyacids making a brain-specific isoform intriguing.CPT1c was identified and cloned from in silicosequences as a highly homologous member of theCPT1 class of enzymes...
... emerging targets for treatment of obesity and related metabolic diseasesTsuyoshi Kadomatsu, Mitsuhisa Tabata and Yuichi OikeDepartment of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto ... metabolism;insulin resistance; metabolic syndrome; obesity; obesity- related metabolic diseaseCorrespondenceY. Oike, Department of Molecular Genetics,Graduate School of Medical Sciences,Kumamoto University, ... roles of ANGPTL2 and ANGPTL6 ⁄ AGF in obesity andrelated metabolic diseases, and discuss the possibility that both could func-tion as molecular targets for the prevention and treatment of obesity...
... most prevalent form of MetS isassociated with abdominal (visceral) obesity and thatthis type ofobesity contributes to insulin resistance(IR) and the increased release of cytokines, as well ... risk of T2DM, hypertension and CVD;however, the exact underlying pathophysiologicalmechanisms by which obesity increases the risk of VD remains the subject of intensive investigation [20]. Obesity ... deficiencyand hypogonadism-induced obesity remain the subject of intense investigation.Several hypotheses have discussed the relationship of androgen deficiency and obesity. That obesity iscommonly associated...
... use of drugs to counteract obesity risk factors or simply to the latency of the effect. This analysis does not take account of the impact of childhood obesity. The health consequences of overweight ... prevalence of obesity THE DETERMINANTS • 132. The determinants of obesity Main messages• The simultaneous presence of physical inactivity and poor diet to a large extent explains the obesity ... sense of fatalism about their health. Lower socioeconomic status not only increases the risk ofobesity but may result from obesity. Several stud-ies have noted that obesity increases time off...
... Department of Ichthyology and Aquatic Environment, University of Thessaly, 38446, Nea Ionia, Volos, GreeceReceived 19 February 2007; Accepted 29 May 2009Abstract. The reproductive biologyof the ... basis at the mouth of the river using a bag seine net and overall a total of 4 563 individuals were collected. The total length of males ranged between 2.5 and 6.0 cm and that of females between ... throughout most of the year may be a specific character of the marbled goby (F o u d a et al. 1993), as well as of some other goby species (M i l l e r 1984). The marbled goby, one of the few species...
... BirdsMercury Cadmium LeadRange of MeansMedian of MeansNo. of Data SetsRange of MeansMedian of MeansNo. of Data SetsRange of MeansMedian of MeansNo. of Data SetsLoons and Grebes 9.7–10.9 ... LLC490 Biologyof Marine Birdsfor mercury (20 of 21 studies), lead (4 of 7), cadmium (3 of 5), manganese (5 of 5), and selenium(3 of 3), with chromium showing less of a difference (only 1 of 4 ... concentration ineggs of about 1 ppb. Many of the congeners of PCB, PCDF, and PCDD are capable of inducingthis condition, although their potency varies.Increased incidence rates of craniofacial defects...
... CCAMLR applied to the U.S. Because of thecomplex nature of international treaties and the lack of traditional police and courts, enforcement of international law is often extremely difficult to secure.Early ... publish lists of birds, including seabirds, that areendangered, threatened, or are of special concern. For example, the U.S. Fish and Wildlife Act of 1980 created a list of species of concern that ... component of the majorthreats to seabirds, few of which are listed under CITES (see Table 17.2).The Convention on the Conservation of Antarctic Marine Living Resources (CCAMLR) wasenacted because of...
... possibleeffects of a loss of feeding grounds on wading birds (Charadrii). Journal of Applied Ecology 14:721–739.GOSS-CUSTARD, J. D., AND M. E. MOSER. 1988. Rates of change in the numbers of Dunlin, ... MARINE ENVIRONMENTOne of the most spectacular yet poorly understood aspects of shorebirds is their biology duringpassage over large bodies of water. With the exception of phalaropes, shorebirds ... detection in birds: the use of principles of seabed dynamics? Proceedings of the Royal Society of London B 265: 1377–1383.PRATER, A. J. 1981. Estuary Birds of Britain and Ireland. T. & A. D....
... lumbar ROM appearsto be a feature ofobesity and it appears plausible that itmight play a role in the onset of cLBP in obese patients.A rehabilitative spin-off of our study is that targetedexercises ... here:http://www.biomedcentral.com/info/publishing_adv.aspBioMedcentralVismara et al. Journal of NeuroEngineering and Rehabilitation 2010, 7:3http://www.jneuroengrehab.com/content/7/1/3Page 8 of 8➢ absence of a not-obe se cLBP cohort of patients:including such ... kinematics of the spine: under staticconditions, obesity per se seems c orrelated to anincreased anterior pelvic tilt; under dynamic conditions,to impaired mobility of the thoracic spine. Obesity...
... adversely affects health [1]. The rates ofobesity rates have doubled since 1980 [2] and as of 2007,33% of men and 35% of women in the US are obese [3]. Obesity is positively associated to many ... Open AccessEffects ofobesity on bone metabolismJay J CaoAbstract Obesity is traditionally viewed to be beneficial to bone health because of well-established positive effect of mechanical loading ... positive effec ts of body we ight couldnot completely offset the detrimental effects of obesity on bone, at least in obese animal models.ConclusionsAccumula ting data suggest that obesity is detrimental...