biological factors in bipolar disorder in childhood and adolescence

Báo cáo y học: "Background: Mood disorders including depression and bipolar disorders are a major cause of morbidity in childhood and adolescence, and hospitalizations for mood disorders are the leading diagnosis for all hospitalizations in general hospit

Ngày tải lên : 13/08/2014, 18:22

... in 2000, increasing to 45% in 2006, and, correspondingly, the proportion paid by private insurance decreased from 57% to 45% Over the same period, teaching hospitals accounted for an increasingly ... between19941995 and 2002-2003, but did not report on depressive disorders [2] In contrast to our findings, researchers studying hospitalizations in Germany between 2000 and 2007 found increase in population-based ... S: Bipolar disorder in children and adolescents in Germany: national trends in the rates of inpatients, 2000-2007 Bipolar Disord 2010, 12:155-163 Zuvekas SH: Prescription drugs and the changing...

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Báo cáo y học: "Validation of a specific measure to assess healthrelated quality of life in patients with schizophrenia and bipolar disorder: the ‘Tolerability and quality of life’ (TOOL) questionnaire" doc

Ngày tải lên : 09/08/2014, 01:21

... afford greater insight in describing and grading the impact of side effects associated to antipsychotic drugs [15,16] A brief instrument is preferred for use in clinical practice and in investigations ... schizophrenia or bipolar disorder as established by the Structured Clinical Interview for DSM-IV, being clinically stable (defined as having had no changes in severity or new treatments initiated in the ... complex needs and improve alliances between patients and clinicians [8] The importance of involving patients in their own healthcare, and of patient-reported assessments, is increasingly recognised...

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Báo cáo y học: "Long-term outcome and prognosis of dissociative disorder with onset in childhood or adolescence" pot

Ngày tải lên : 13/08/2014, 18:21

... balanced [2-5] From childhood to adolescence the proportion of affected females as well as prevalence and incidence rates increase [6] In Australia the incidence of conversion disorder in specialist ... department The finding that conversion disorders affecting motor control and sensation as well as pseudoseizures were in the foreground is well in line with other studies on child psychiatric and paediatric ... conversion and would have been classified as having somatoform disorder according to DSM-IV's terminology (in DSM-IV the term "dissociative" only refers to mental and cognitive symptoms and does not include...

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Báo cáo y học: " Carotid Intima-media thickness in childhood and adolescent obesity relations to abdominal obesity, high triglyceride level and insulin resistance"

Ngày tải lên : 25/10/2012, 11:40

... to lg (HOMA-IR) and TG in both bivariate correlation and multiple stepwise linear regression analysis, suggesting a link between IMT, insulin resistance and dyslipidemia Insulin resistance is ... probably be influenced by other risk factors which have not been tested in our study In conclusion, atherosclerosis begins in obese children and adolescents, and this tendency is intensified in the ... factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study JAMA 2003; 290: 2277-83 Li S, Chen W, Srinivasan SR, Bond MG, et al Childhood...

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Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx

Ngày tải lên : 18/02/2014, 04:20

... coronal section and scheme of the coronal section at E14.5 in (F) (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline Surprisingly, the ... before and after birth in mouse brains [122,124] No HSF4 DNA-binding activity was reported in the developing mouse brain so far However, Hsf4b is expressed in the adult mouse brain, including cerebellum, ... seems to be intimately correlated with neurogenesis and neuronal migration in different parts of the mouse brain HSF1 and HSF2 might interact in the developing mouse brain in a stage- and tissue-speciﬁc...

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Báo cáo khoa học: "Study protocol of the German "Registry for the Detection of Late Sequelae after Radiotherapy in Childhood and " ppsx

Ngày tải lên : 09/08/2014, 09:22

... ionizing radiation is used in childhood and adolescence due to potential higher vulnerability of growing tissue and longer expected life span [1-3] For radiotherapy, late effects after treatment in ... levels and older radiation techniques in some cases Recently, the characterization of late effects after cancer therapy in childhood including chemotherapy, surgery and radiation has been of rising ... insufficient data regarding radiation organ dose levels So this approach turned out to be not sufficient in view of answering open questions regarding the risks of radiotherapy in childhood and...

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Báo cáo y học: " Interactions between genes and environmental factors in asthma and atopy: new developments" pps

Ngày tải lên : 12/08/2014, 18:20

... polymorphisms in candidate genes for asthma/atopy have been identified Linkage and candidate gene studies in asthma and atopy Linkage studies Results from linkage studies (genome-wide searches and candidate ... candidate gene regions Despite the high degree of inconsistent findings, it is intriguing that chromosomal regions linked to asthma have also shown evidence for linkage to other inflammatory and ... are involved in the allergic inflammation (shown in Supplementary Figure 1) Multiple single nucleotide polymorphisms (SNPs) in candidate genes for asthma and atopy have been identified, and they...

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Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx

Ngày tải lên : 12/08/2014, 18:20

... stages in the proposed pathway are indicated Genistein is an inhibitor of tyrosine protein kinase and competitive inhibitor of ATP in other protein kinase reactions; NaF is a nonspecific kinase inhibitor; ... pull NF-κB off DNA, and export NF-κB back to its resting state in the cytoplasm Thick lines indicate the activating pathway; thin lines indicate the inactivating pathway IκB-independent pathways, ... significance of maintaining reducing conditions in cells and the fight against the damaging effect of ROS intermediates [17,22,35,37–39] Oxidants, for instance, can cause carcinogenesis, sclerosis,...

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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx

Ngày tải lên : 14/08/2014, 07:21

... which included 17 genes with p53 binding sites in cluster A and 26 genes with NF-κB binding sites in cluster B In cluster A genes with p53 binding sites, putative models containing three and four ... transcription factors associated with NF-κB were ETSF (human and murine ETS1 factors; 8/14) and ZBPF (zinc binding protein factors; 8/14) In most cases the locations of NF-κB binding sites were ... NM_003528 h IGFBP2 Insulin-like growth factor binding protein (36 kDa) NM_000597 hmr (hr) LGALS3BP Lectin, galactoside-binding, soluble, binding protein NM_005567 hmr MATN2 Matrilin NM_002380 h (hmr)...

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Báo cáo y học: "The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease" docx

Ngày tải lên : 14/08/2014, 14:21

... be mediated by two distinct domains In VEGF-A, these correspond to the basic heparin-binding domain encoded by exon and the NRP1/heparin-binding domain encoded by exons and [10] The nuclear magnetic ... the heparin-binding domain; N, encodes the NRP1/heparin-binding domain; NP, encodes the amino-terminal propeptide domain; SP, signal peptide; VHD, encodes the VEGF/PDGF homology domain Information ... mammals; VEGF-A121 lacks exons and 7, and VEGF-A165 lacks exon (Table 2) Exon encodes a heparinbinding domain, while exons and encode a NRP1/heparin-binding domain; with the exception of VEGF-A121,...

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Báo cáo y học: "Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities"

Ngày tải lên : 25/10/2012, 10:51

... influencing obesity in bipolar patients include nutrient intake and physical activity In assessing the nutrient intake of persons with bipolar disorder, Elmslie and colleagues found that they had increased ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks ... (Tegretal and others), clozapine (Clozaril), droperidol (Inapsine and others), gabapentin (Neurontin), haloperidol (Haldol and others), lamotrigine (Lamictal), lithium (Eskalith and others), metformin...

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Báo cáo y học: "Risk and resiliency factors in posttraumatic stress disorder" pptx

Ngày tải lên : 08/08/2014, 20:23

... risk factors that make an individual vulnerable towards developing a disorder [8] Risk factors can be divided into two main categories: severity and type of traumatic event, and predisposing personal ... this study, being female, separation from parents in childhood, and family and personal history of psychopathology were significant predictors of PTSD Coping Factors Coping has been defined as the ... GC, Andreski P and Peterson E Traumatic events and posttraumatic stress disorder in an urban population of young adults Arch Gen Psychiatry 1991, 48:216-222 Collins DL, Baum A and Singer JE Coping...

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Báo cáo y học: "Lithium alters brain activation in bipolar disorder in a task- and state-dependent manner: an fMRI study" ppt

Ngày tải lên : 08/08/2014, 21:20

... clinical interview for DSM-IV (SCID) All patients also had a physical examination including weight and blood pressure, biochemical screening including full blood count, urea and electrolytes, and ... personal and family history was obtained and diagnosis was made using Diagnostic and Statistical Manual of Mental Disorders version IV (DSM-IV) criteria for bipolar disorder [11], using a the ... Quetiapine, venlafaxine, lamotrigine Venlafaxine Risperidone Table 2: Working Memory Task change in the BOLD signal for each region of interest pre-post lithium The change in each region of interest...

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Báo cáo y học: "Risk factors predict post-traumatic stress disorder differently in men and women" ppt

Ngày tải lên : 08/08/2014, 23:21

... of conducting more research in this area If different factors are important in predicting PTSD in men and women, it may result in differences in the resulting psychopathology, which in turn Page ... severity in women – not even before controlling for NA – but it did predict PTSD severity in men and remained significant even at the final level of analysis This is in line with the findings by ... Caspi-Yavin Y, Bollini P, Truong T: The Harvard trauma questionnaire: Validating a cross-cultural instrument for measuring torture, trauma, and posttraumatic stress disorder in Indochinese refugees...

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Báo cáo y học: "Efficacy and safety of aripiprazole in the treatment of bipolar disorder: a systematic review" pdf

Ngày tải lên : 08/08/2014, 23:21

... the approval of quetiapine and the olanzapine-fluoxetine combination against acute bipolar depression and the approval of olanzapine, quetiapine and aripiprazole for the maintenance phase This ... Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia Clin Pharmacokinet 2008, 47:475-485 Findling RL, Kauffman ... Grunze H, Martinez MI, Post RM: Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion...

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Báo cáo khoa học: " Chemotherapy followed by low dose radiotherapy in childhood Hodgkin''''s disease: retrospective analysis of results and prognostic factors" ppt

Ngày tải lên : 09/08/2014, 10:21

... physical examination, chest x-ray, and routine laboratory studies In addition, restaging studies including CT scans of neck, chest, abdomen, and pelvis, and gallium were recommended at and years ... institution in the period analyzed (1985–2000), IFRT was defined as treatment volume including the initially involved lymph node region(s) and 82.4% of initial clinical stage(I-II) patients in this ... Hodgkin's lymphoma reducing relapses in initially involved sites and improving survival Conclusion This data demonstrating the importance of RT consolidation with low dose and reduced volume, in...

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Báo cáo y học: "Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium" docx

Ngày tải lên : 10/08/2014, 09:20

... bovine serum (GIBCO) and a mixture of penicillin-streptomycinglutamine (PSG from GIBCO) Puromycin-resistant MEF lines were grown, maintained, serum shocked, and serum starved in medium containing ... period/phase altering effects of lithium, (iv) the direct inhibition of GSK3 by lithium in vivo and in vitro, and (v) the role of Sgg/GSK3 in the modulation of period length in fruit fly and murine clocks, ... states, segregating in time those which are mutually incompatible, thus integrating neurotransmitter, endocrine and behavioural mechanisms whose dysregulation may be involved in the pathophysiology...

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TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 1 ppsx

Ngày tải lên : 11/08/2014, 04:20

... use disorder in youth with bipolar disorder The authors also examine multimodal approaches to treating co-occurring substance use and bipolar disorder in adolescents In Chapter 13, Gagan Joshi and ... medicines, including Saint-John’s-wort and S-adenosyl-L-methionine (SAMe) The next two chapters examine the importance of including psychosocial interventions in the treatment plan for children and ... articles and book chapters on bipolar disorder and schizophrenia, and five books, including The Bipolar Disorder Survival Guide Kimberley L Mullen, MA, is a doctoral candidate in clinical psychology...

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TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 2 pps

Ngày tải lên : 11/08/2014, 04:20

... exercised in translating the in vitro and animal findings to humans Lithium and Neurotransmission Preclinical studies and information from adult human studies have provided information regarding the ... 1949) Clinical trials in adult patients with bipolar disorder have established the efficacy of lithium in acute mania and bipolar depression and as a maintenance therapy (reviewed in Goodwin & Jamison, ... bipolar offspring with and at high-risk for bipolar disorder Bipolar Disorders, 7, 589–597 Gelenberg, A J., & Pies, R (2003) Matching the bipolar patient and the mood stabilizer Annals of Clinical...

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TREATMENT OF BIPOLAR DISORDER IN CHILDREN AND ADOLESCENTS - PART 4 pdf

Ngày tải lên : 11/08/2014, 04:20

... have been positive in the treatment of bipolar disorder, including treatmentresistant and rapid-cycling bipolar disorder An early case series of female inpatients with bipolar disorder showed improvement ... carbamazepine Lithium Multiple Verapamil Carbamazepine add on Lithium Lecithin Tamoxifen Nimodipine Diltiazem Diltiazem Nifedipine Nimodipine Nimodipine Nimodipine Nimodipine Nimodipine Nimodipine ... levothyroxine Lithium was then tapered and discontinued He has remained stable on nimodipine for years Protein Kinase C Lithium and valproate both cause specific reductions in protein kinase C...

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