biological and molecular understanding of basal breast cancer and epithelial

Báo cáo y học: "Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases" docx

... genes and initiate epithelial- mesenchymal transition Complexes of Smad7 and Smurf1 or Smurf2 promote ubiquination and degradation of activated receptors limiting the intensity and duration of signaling ... environment on neoplasia The role of the ECM and stroma in cancer Drivers and mediators of epithelial- mesenchymal transition (EMT) Early stage tumor cells maintain epithelial properties similar to the ... receptors of tumor cells A comprehensive gene expression profile of breast carcinomas noted significant overexpression of the chemokines CXCL14 and CXCL12 in tumor myoepithelial cells and myofibroblasts...

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Familial breast cancer - The classification and care of women at risk of familial breast cancer in primary, secondary and tertiary care potx

Danh mục: Sức khỏe giới tính

... guideline (‘Familial breast cancer: the classification and care of women at risk of familial breast cancer in primary, secondary and tertiary care’) gives details of the methods and the evidence ... dominant inheritance of early onset breast cancer Cancer 73: 643–51 Collaborative Group of Hormonal Factors in Breast Cancer (2001) Familial breast cancer: collaborative reanalysis of individual data ... context of this guideline: All affected relatives must be on the same side of the family and be blood relatives of the woman and each other In cases of bilateral breast cancer, each breast cancer...

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báo cáo hóa học:" Rat model of metastatic breast cancer monitored by MRI at 3 tesla and bioluminescence imaging with histological correlation" ppt

Danh mục: Hóa học - Dầu khí

... of 10 rats MRI and BLI Euthanized of rats MRI and BLI Euthanized all rats MRI Baseline 106 FEPro labeled 231BRL MRI and BLI MRI and BLI MRI and BLI MRI and BLI MRI and BLI MRI and BLI - Euthanize ... MRI and BLI MRI and BLI MRI and BLI MRI and BLI MRI and BLI MRI and BLI - Euthanize rats - Page of 10 (page number not for citation purposes) Journal of Translational Medicine 2009, 7:88 tion and ... development of metastatic breast cancer was organ dependant Figure contains representative BLI and MRI of the distribution of metastases in the spinal cord and bones Prussian blue Page of 10 (page...

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Báo cáo toán học: "Receipt of Standard Breast Cancer Treatment by African American and White Women" doc

Danh mục: Báo cáo khoa học

... Frequencies and percentages of women who received standard of care and addition to standard of care are presented in Table Only two-thirds of all breast cancer cases received standard of care No ... Americans and Whites in receipt of standard of care or addition to standard of care (Table 3) Stage at diagnosis and area of residence were statistically significant in both the standard of care and ... were more likely to have received standard of care and addition to standard of care compared to Whites Therefore, meeting or exceeding standard of care of breast cancer treatment does not explain...

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Báo cáo khoa học: "Reirradiation of recurrent breast cancer with and without concurrent chemotherapy" ppt

Danh mục: Báo cáo khoa học

... Reirradiation of recurrent breast carcinoma of the recurrence and a subgroup of patients (n = 13) are shown Figure Reirradiation of recurrent breast carcinoma Survival proportions of a subgroup of patients ... treatment of patients, and helped to draft the manuscript CP participated in the design of the study and treatment of patients, and helped to draft the manuscript CW participated in the design of the ... results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer N Engl J Med 1989, 320:822-828 Kurtz JM, Amalric R, Brandone...

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báo cáo khoa học: " Comparison of Radioimmuno and Carbon Nanotube Field-Effect Transistor Assays for Measuring Insulin-Like Growth Factor-1 in a Preclinical Model of Human Breast Cancer" doc

Danh mục: Báo cáo khoa học

... accurately and inexpensively help define the therapeutic potential of candidate biomarkers, such as IGF-1 for the early detection of breast cancer These studies are important since the breast cancers ... IGFBP-3 and breast cancer in young women: a pooled re-analysis of three prospective studies Eur J Cancer Prev 2005, 14:493-6 Renehan AG, Frystyk J, Flyvbjerg A: Obesity and cancer risk: the role of ... protein can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women Oncology 1999, 57:330-40...

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Báo cáo y học: " the Value of Serum Biomarkers (Bc1, Bc2, Bc3) in the Diagnosis of Early Breast Cancer"

Danh mục: Y học thưởng thức

... Early Breast Cancer Trialists' Collaborative Group (EBCTCG) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised ... classification of breast cancer by the WHO (1968) and its prognostic value] Arkh Patol 1980;42(4): 13–19 Singletary SE, Greene FL: Revision of breast cancer staging: the 6th edition of the TNM Classification ... rate and MIB–1 index in patients with pT1–2 breast cancer Anticancer Res 2004; 24(5): 3221–3224 Stein RC, Zvelebil MJ: The application of 2D gel-based proteomics methods to the study of breast cancer...

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báo cáo khoa học: "A case report of male breast cancer in a very young patient: What is changing" docx

Danh mục: Báo cáo khoa học

... with breast cancer [22,23] Estrogen receptors and progesterone receptors have been suggested to play a role in breast cancers in men, and they are present in about 90% and 81% of breast cancers ... Because of weakness and quick deterioration of health state of the patient, it was not possible to perform a biopsy documentation of recurrence and determination of hormone receptor status and HER-2 ... breast cancer [21] The risk of subsequent contralateral breast cancer was highest for men aged less than 50 years at the time of the first cancer diagnosis, which is consistent with studies of...

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Báo cáo khoa học: "A paraneoplastic manifestation of metastatic breast cancer responding to endocrine therapy: a case report" ppsx

Danh mục: Báo cáo khoa học

... with both the nervous system and the underlying cancer Each of these antibodies is associated with a narrow spectrum of clinical syndromes and a restricted subgroup of cancers [2] Paraneoplastic ... Pattern of serum IgG and CK levels with time from treatment Pattern of serum IgG and CK levels with time from treatment Page of (page number not for citation purposes) World Journal of Surgical ... review of 31 reported cases of paraneoplastic neurological syndromes due to breast cancer reported only 29% of patients responded to chemotherapy with an improvement in neurological deficits [3] Often...

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Báo cáo khoa học: " Multidisciplinary approach of early breast cancer: The biology applied to radiation oncology" pps

Danh mục: Báo cáo khoa học

... diagnosis of ACR grade and lesions and for assessment of tissue and molecular signature First, FNA is a rapid and cost-effective tool for breast cancer diagnosis in a one-stop multidisciplinary breast ... of late radiation-induced toxicity Biological tools: To determine breast cancer patients at high risk of local relapse The current locoregional management of early breast cancer consists of breast ... prognostic role of a gene signature from tumorigenic breast- cancer cells N Engl J Med 2007, 356:217-26 van Beers EH, Nederlof PM: Array-CGH and breast cancer Breast Cancer Res 2006, 8:210 Andre F, Michiels...

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báo cáo khoa học: "Molecular understanding of sterically controlled compound release through an engineered channel protein (FhuA)" pptx

Danh mục: Báo cáo khoa học

... data analysis and drafting of the manuscript MF and BH performed data analysis and drafting the manuscript US carried out design, study and drafting of the manuscript All authors read and approved ... Journal of Nanobiotechnology 2010, 8:14 http://www.jnanobiotechnology.com/content/8/1/14 Page of Figure B-factors of the Lys chains averaged on 10 ns of MD simulation stand channel dynamics and to ... Detailed kinetic results of the TMB assay of FhuA Δ1-160 variants are available in Additional file 1: Figure S1 Additional material Additional file Molecular understanding of sterically controlled...

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Báo cáo y học: " MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype" ppt

Danh mục: Báo cáo khoa học

... as diagnostic tools for breast cancer and also furthers our understanding of the role of miRNAs in tumorigenesis Two previous studies of miRNA expression in human breast cancer have focused on ... comprehensive set of miRNA expression profiles for primary human breast cancer we selected 99 primary human tumors, normal breast samples and 33 breast cancer cell lines for miRNA expression profiling ... CB, CC and EAM conceived and designed the study ARG and IOE provided breast cancer samples and clinical information CB, IS and SC performed the experiments under the supervision of CC and EAM...

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Investigations into the effects of traditional chinese medicinal herbs used in the treatment of human breast cancer

Danh mục: Cao đẳng - Đại học

... treatment of disease states like breast cancer 1.4 Rationale and purpose of this study Breast carcinoma is a common cancer in women and is a leading cause of cancerrelated deaths in Singapore and worldwide ... the baseline scores of breast cancer patients in Singapore receiving herbal TCM therapy………… 63 Figure BR-23 scores of breast cancer patients at baseline and after 11-13 weeks of TCM treatment……………………………………………… ... Results of cytotoxicity assays of Solanum nigrum and Scutellaria barbata in MCF-7 human breast cancer cell lines … 82 3.5.2.2 Results of cytotoxicity assays of Solanum nigrum and in...

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Co encapsulation of anti breast cancer drugs in nanoparticles reduce antagonism

Danh mục: Kỹ thuật - Công nghệ

... treatment of ER positive breast cancer and in the reduction of breast cancer risk [42–44] Side effects of DCL included acute toxicities such as hypersensitivity, hypotension, nausea and pain; ... the fight against breast cancer, the totality of tumour treatment dictated therapy outcome and the probability of cancer remission Differential metabolism of docetaxel (DCL) and tamoxifen (TAM), ... towards combination of DCL and TAM—as an in vitro model of cancer to investigate the reduction of antagonistic effects of DCL and TAM, in DDNPs versus free drugs The viability of the MCF7 cell line,...

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Co encapsulation of anti breast cancer drugs in nanoparticles reduce antagonism

Danh mục: Tổng hợp

... treatment of ER positive breast cancer and in the reduction of breast cancer risk [42–44] Side effects of DCL included acute toxicities such as hypersensitivity, hypotension, nausea and pain; ... the fight against breast cancer, the totality of tumour treatment dictated therapy outcome and the probability of cancer remission Differential metabolism of docetaxel (DCL) and tamoxifen (TAM), ... towards combination of DCL and TAM—as an in vitro model of cancer to investigate the reduction of antagonistic effects of DCL and TAM, in DDNPs versus free drugs The viability of the MCF7 cell line,...

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Epithelial mesenchymal transition in breast cancer progression

Danh mục: Tổng hợp

... Progression of Breast Cancer 1.2 Epithelial- Mesenchymal Transition (EMT) 1.2.1 EMT in Normal Development 11 1.2.2 EMT in Breast Cancer 12 1.2.3 Recent Findings Linking EMT with Basal- like Phenotype in Breast ... the role of genetics in the pathology of breast cancer About 20 to 30% of women diagnosed with breast cancer have a family history of breast cancer It is estimated that to 10% of breast cancer ... TABLE OF CONTENTS i Acknowledgements Summary vii List of Tables ix List of Figures x Abbreviations xii Introduction 1 1.1 Breast Cancer 1.1.1 Incidence of Breast Cancer 1.1.2 Etiology of Breast Cancer...

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Báo cáo y học: " Effects of PPARg ligands on TGF-b1-induced epithelial-mesenchymal transition in alveolar epithelial cells" ppsx

Danh mục: Báo cáo khoa học

... effects of RGZ and CGZ were maintained in the presence of GW9662 (RGZ Figure 4B, CGZ data not shown) Figure Regulation of basal E-cadherin and N-cadherin expression by PPARg ligands (A) Effect of ... Page of 13 Figure Regulation of TGF-b1-induced E-cadherin expression by PPARg ligands (A) Effect of TGF-b1 on expression of epithelial marker E-cad (n = 4) (B) Effect of RGZ on regulation of E-cad ... http://respiratory-research.com/content/11/1/21 Page of 13 Figure Regulation of TGF-b1-induced N-cadherin expression by PPARg ligands (A) Effect of TGF-b1 on expression of mesenchymal marker N-cad (n = 4) (B) Effect of PPARg ligands on...

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Runx3 protects gastric epithelial cells against epithelial mesenchymal transition induced cellular plasticity and tumorigenicity

Danh mục: Y - Dược

... morphology and migration 73 Figure 4.3 Expression levels of epithelial- , EMT- and mesenchymalrelated markers in P1 and P2 cells 75 x Figure 4.4 Changes in the expression of EMT- and mesenchymalrelated ... promotes cancer progression and metastasis via epithelial- mesenchymal transition (EMT) , angiogenesis and immuno-suppression (Wakefield and Roberts, 2002) 11 Interestingly, some of the biological ... Introduction 63 4.1.1 Properties of epithelial cells and mesenchymal cells 63 4.1.2 Epithelial- Mesenchymal Transition 64 4.1.3 Regulatory factors controlling EMT 66 4.1.4 TGF-β and Wnt signaling pathways...

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PRL 3 promotes epithelial mesenchymal transition and confers resistance to apoptosis

Danh mục: Kỹ thuật - Công nghệ

... levels of key epithelial and mesenchymal markers 20 There are several molecules that are important features of EMT and cell adhesions Paxillin is part of a complex of cytoskeletal proteins and ... target for cancer therapy The broad ranging expression of PRL-3 in colorectal, breast, ovarian, gastric and liver cancer, and its emergence as a key player in transformation and metastasis of cancer ... affects a number of important cell processes involved in progression of cancer 14 Transformed cell morphology and altered cell adhesion are reminiscent of Epithelial Mesenchymal Transition, which...

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Tài liệu Voices of Fear and Safety¿ Women¿s ambivalence towards breast cancer and breast health: a qualitative study from Jordan pdf

Danh mục: Sức khỏe phụ nữ

... total cancer cases and 22 % of the cancer deaths The age-standardized incidence rate of breast cancer increased from 29/100 000 in 1996 to 50/100 000 in 2008 Breast cancer comprises 37 % of all ... better understanding of Jordanian women’s views of breast cancer and their breast health-seeking behaviour Breast health awareness interventions need to address women’s fears from breast cancer ... and breast cancer does not mean the end of life” (2, 2) Comfort in acquiring breast health knowledge and skills In all the FGDs, women talked about seeing or hearing about breast cancer and breast...

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biological and molecular understanding of basal breast cancer and epithelial mesenchymal transition emt