biochemical group that play key role in fetal programming of adult disease
Báo cáo khoa học: "SemiPro-inflammatory cytokines play a key role in the development of radiotherapy-induced gastrointestinal mucositis" pptx
... Pro-inflammatory cytokines were upregulated at later time points of radiotherapy suggesting that these cytokines can ultimately induce more tissue injury and inflammation in the intestine with increasing total ... the intestinal epithelium of rats receiving radiotherapy Previous research into expression at the protein level has shown conflicting findings In one study, proinflammatory cytokine protein levels ... Expression of pro-inflammatory cytokines in the jejunum and colon IL-1b In general, there was weak-moderate IL-1b staining in the jejunal crypts There was predominantly weak staining of the villi The intensity...
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Báo cáo khoa học: Acylation of lysophosphatidylcholine plays a key role in the response of monocytes to lipopolysaccharide ppt
... suggesting a role for LPCAT in the LPS-induced signaling pathways in monocytes In addition, LPCAT was found to be crucial for IL-6 production in a similar manner, indicating that it may generally in uence ... quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 Pradines-Figueres, A & Raetz, C.R (1992) Processing and secretion of tumor ... monocyte in ammatory cytokine responses to LPS Our results suggest that acyltransferases play a key role in the production of in ammatory cytokines from LPSstimulated monocytes our findings support...
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báo cáo khoa học: " The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis" potx
... regulator of Pi starvation responses and is involved in the up-regulation of the IPS1 gene in Pi-deficient plants [25] In the promoter of IPS1, PHR1 binds the P1BS cis-acting element, defined as ... remain largely unknown Using bioinformatics analysis, we found that the P1BS cis-acting element was present in the promoters of the genes SULTR1;3 and SULTR2;1, raising the possibility of the involvement ... specifically with early events involved in Pi sensing and signaling, including responses typically associated with local Pi sensing or long-distance signaling [47-50] The influence of phosphite on SULTR1;3...
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Peptidylarginine deiminase (PAD) is a mouse cortical granule protein that plays a role in preimplantation embryonic development docx
... were incubated at room temperature in M16 culture medium containing anti-ePAD (1:100) for 45 minutes, washed in M16, and incubated 45 minutes at room temperature in M16 containing antiguinea ... PADs are a family of calcium dependent enzymes that catalyze the conversion of arginine into citrulline in proteins In the mammalian PAD family, approximately 50% of the amino acids are identical ... with all isoforms of PAD and stained the nuclei, cortex, and interior cytoplasm of germinal vesicle intact oocytes [26], indicating that the antibody reacts with more than one isoform of PAD, as...
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Báo cáo Y học: Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? ppt
... surface of the protein Binding of 4E-BP1 or eIF4G to this region induces conformational changes that greatly increase the affinity of eIF4E for capped nucleotide It is therefore puzzling that the binding ... that there is a second form of human Mnk2, generated by alternative use of coding exons during splicing, resulting in proteins with quite different C-termini (Fig 2) The final 80 amino acids of ... replacement of this residue by lysine greatly decreases the binding of eIF4E to RNA [51] It thus appears that phosphorylation of eIF4E does not result in closure of the RNA-binding cleft (clamping)...
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Báo cáo Y học: The a1b1 contact of human hemoglobin plays a key role in stabilizing the bound dioxygen Further evidence from the iron valency hybrids potx
... with increasing hydrogen ion concentration, involving a proton-catalysis by the distal (a58) histidine with pKa 6.2, as with the separated chains The value of ks also increased with increasing ... autoxidation rate of MbO2 or HbO2 Insofar as we have examined for more than a dozen of myoglobins, such a proton-catalyzed process could never be observed in the autoxidation of myoglobins lacking the ... DISCUSSION In hemoglobin research, the central problem is understanding the cooperative binding of molecular oxygen to the a2b2 tetramer For human HbA, the a and b chains contain 141 and 146 amino-acid...
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báo cáo khoa học: " Do mitochondria play a role in remodelling lace plant leaves during programmed cell death?" pps
... treatment groups The mean ratio of number of perforations per cm of leaf length decreased with increasing concentrations of CsA, indicating that the inhibition of the PTP via CsA reduced the amount of ... on their location in a window stage leaf areole Our findings also indicate that within a single areole of a stage (window stage) leaf a gradient of TUNEL-positive nuclei staining exists TUNEL-positive ... [13,19], increases in ATP, ROS, and phosphate, as well changes in pH [20,21] In addition, evidence suggests that cyclosporine A (CsA) can act in disrupting the PTP by displacing the binding of CyD...
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Báo cáo y học: "The role of high-mobility group box-1 (HMGB-1) in the management of suspected acute appendicitis: useful diagnostic biomarker or just another blind alley?" docx
... chromosomal protein Its role as a pro-inflammatory cytokine in sepsis and rheumatoid arthritis has been described, and more recently its role in community-acquired infections and sepsis investigated ... HMGB1 as a cytokine in inflammation The mechanism of inflammation and damage is binding to toll-like receptor (TLR4), which mediates HMGB1-dependent activation of macrophage cytokine release This ... positions HMGB1 at the intersection of sterile and infectious inflammatory responses Thus, the increased level of HMGB1 likely reflects a systemic inflammatory response syndrome (SIRS) in patients with...
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Báo cáo y học: "Migration events play significant role in genetic differentiation: A microsatellite-based study on Sikkim settlers" ppt
... populations of adjoining areas This substantiates that migratory events have played a significant role in the differentiation of mongoloids of India Background The origin, dispersal and antiquity of ... one-fourth of the world population and exhibit a high level of diversity In India, mongoloids contribute approximately 3% of the total population, mainly inhabiting the hills and adjoining plains of ... Mongoloids in India are originally the migrant groups and their settlements in different regions of the country were not as a single influx; rather, a process of larger or smaller waves of migration...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... satisfactory in the evaluation of nodal status in this patient group Since the highly cellular tissue in reactive lymph nodes may also show increased intensity, the role of DWI and ADC in distinguishing ... administration of intravenous contrast media for assessment of the lesion boundaries and tumor perfusion For ADC to be used in a clinical setting in gynecological diseases, further study into ... node Conclusions In combination with conventional MRI, DWI and ADC findings provide additional information in patients with gynecological diseases We found that the combination of DWI and conventional...
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Tài liệu Báo cáo khoa học: Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen pdf
... Roghi et al Role of GRASP55 in MT1-MMP activation l l l l l l l l l l l l l MINT-7897617, MINT-7897659, MINT-7897681, MINT-7897702, MINT-7897725, MINT7898032, MINT-7898011, MINT-7897907, MINT-7897884: ... implicating a leading role for MT1-MMP in such processes [12,14] There is mounting evidence that the short intracellular domain (ICD) of MT1-MMP (21 amino acids) plays an important role in multiple ... UK) were maintained in DMEM containing 10% (v/v) fetal bovine serum (Hyclone Laboratories Inc., UT, USA), mm l-glutamine, 100 UÆmL)1 penicillin and 100 lgÆmL)1 streptomycin at 37 °C in 5% CO2...
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Tài liệu Báo cáo khoa học: High affinity copper binding by stefin B (cystatin B) and its role in the inhibition of amyloid fibrillation docx
... loss of copper binding could still allow domain swapping to occur It is of interest that a N-terminally truncated prion protein, lacking the copper binding domain is capable of domain swapping ... high affinity copper binding protein, and (b) that amyloid fibril formation of this protein is diminished in presence of Cu2+ ions Another interesting finding is that copper binding gets less strong ... obtained from injections of the metal into a solution of the protein Typically an initial injection of lL copper chelate solution was followed by a further 29 injections of lL of Cu(II) into...
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Tài liệu Báo cáo Y học: The b-1,4-endogalactanase A gene from Aspergillus niger is specifically induced on arabinose and galacturonic acid and plays an important role in the degradation of pectic hairy regions pdf
... important role of GALA in the degradation of both linear and L-arabinose-substituted galactan side chains of pectin This is in agreement with a previous study in which the synergy of enzymes degrading ... control of the xylanolytic activator protein [32,41] The increase in expression levels of galA in the CREA mutant, indicates that at least one of the detected putative CREA binding sites in the ... [1] The absence of expression of galA in the presence of pectic galactan indicates that galactose is not an inducer of galA expression This is in agreement with a role for L-arabinose and D-galacturonic...
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Báo cáo Y học: Functional expression of human liver cytosolic b-glucosidase in Pichia pastoris Insights into its role in the metabolism of dietary glucosides ppt
... ¯ow rate of mLámin)1 The following gradients were used: incubations containing arbutin or salicin as substrate; 100% C initial, increasing D to 20% (10 min), 50% (15 min), 100% (5 min), held ... remained following 30 and 50 incubation with and lM inhibitor, respectively b-Glucosidase activity was not recovered following extensive dialysis of the inhibited enzyme, indicating that inhibition ... Naringenin-7-GlcRha (naringin) Hesperetin-7-GlcRha (hesperidin) Phloretin-7-Glc (phlorizin) Oleuropein Cyanidin-3-Glc (kuromanin) Cyanidin-3,5-diGlc Flavanones Dihydrochalcones Secoiridoids Anthocyanidins Ó FEBS...
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Báo cáo khoa học: Lipins from plants are phosphatidate phosphatases that restore lipid synthesis in apah1Dmutant strain of Saccharomyces cerevisiae ppt
... cultivated in minimal medium containing 0.67% (w ⁄ v) yeast nitrogen base, 2% (w ⁄ v) raffinose, 20 mgÆL)1 adenine, arginine, tryptophan, methionine, histidine and tyrosine, 30 mgÆL)1 lysine and ... method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 Jamal Z, Martin A, Gomez-Munoz A & Brindley DN ˜ (1991) Plasma ... and mL of the chloroform, which contained the [3H]DAG product, was dried and quantified by scintillation counting The times of incubation (normally 30 min) were adjusted so that < 15% of the PA...
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Báo cáo khoa học: No evidence for a role in signal-transduction of Na+/K+-ATPase interaction with putative endogenous ouabain potx
... Experiments pointing to a pivotal role of ouabain in signal-transduction In the following, more details are discussed concerning the experiments with ouabain that led to the explicit formulation of a cascade ... cascade of events Based mainly on observations with rat myocytes, additional roles in signal-transducing function of ouabain’s interaction with Na+/K+-ATPase were attributed to tyrosine protein kinase, ... independent of a small increase in [Na+]i and also occasionally independent of the subsequent increase in [Ca2+]i [10], whereas in other publications, activation of the Ras/MAPK cascade was interpreted...
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Báo cáo khoa học: Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins pptx
... N-terminal domain of the polypeptide of each of these organisms is followed by a stretch of hydrophobic amino acids that is presumably involved in the protein’s anchoring to the membrane Also in ... several copies in the N-terminal domain of all PEX5s [22,32,38] In this paper, in vitro experiments showed that also in T brucei the N-terminal part of TbPEX14 (amino acids 1–146) interacts specifically ... showed by an in vitro analysis that the LdPEX14 binds to the previously characterized LdPEX5 [39] with a binding constant Kd of 2.75 lM, and that the amino-terminal domains of the two peroxins were...
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Báo cáo y học: "Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration" ppt
... A block of tissue (incorporating AF and NP in continuity) was fixed in 10% neutral buffered formalin and processed to paraffin wax Sections were taken for haematoxylin and eosin staining to score ... time that in non-degenerate discs the incidence of senescent cells increases with age In particular, we have found that telomeric erosion increases with age together with increased levels of p16INK4a ... decrease in MTL of 0.85 kbp per decade of life in non-degenerate discs (Figure 1a) Interestingly, the MTL differed according to the degree of degeneration in two discs from the same individual...
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Báo cáo y học: " Neuroprotective peptide ADNF-9 in fetal brain of C57BL/6 mice exposed prenatally to alcohol" pptx
... ALC/SAL(ADNF-9) groups in order to determine the effects of ADNF-9 administration in the changes of the level of expression of proteins Table shows all the proteins that are regulated as a result of ADNF-9 ... Upregulation of the level of histone-binding protein RBBP4 was found in the ALC/ADNF-9 treated group This protein is considered as a core histone-binding subunit that interacts with chromatin assembly ... focused our study to investigate the role of trophic peptide, ADNF-9, in prevention of alcoholinduced alteration of key proteins that are involved in fetal brain development Thus, quantitative proteomic...
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Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot
... involves its interaction with receptors consisting of a heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation ... phosphorylation of signal transduction molecules including motifs similar to those involved in insulin signaling, the insulin receptor substrate (IRS)-1, IRS2 and signal transducer and activator of transcription ... induction of VCAM-1 are activities shared with the related cytokine IL-13 reports Animal studies demonstrating the role of IL-4 in asthma Neutralizing IL-4 with anti-IL-4 antibodies in mice inhibits...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25