biochemical and biological evaluation of cc 1065 analogs and conjugates with polyamides
Synthesis and biological evaluation of natural products and their analogs as new cancer chemotherapeutic agents
... SYNTHESIS AND BIOLOGICAL EVALUATION OF NATURAL PRODUCTS AND THEIR ANALOGS AS NEW CANCER CHEMOTHERAPEUTIC AGENTS FANG ZHANXIONG (B.Sc.(Hons.) NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ... Analogs of 2-9 and 2-10 synthesized 36 Table 2.3 Analogs of 2-2 synthesized 37 Table 2.4 Analogs of 2-4 synthesized 45 Table 2.5 Analogs of 2-30 synthesized 47 Table 2.6 Cytotoxicity of conjugated ... gatekeepers, caretakers and landscapers Gatekeepers consist of oncogenes and tumorsupressor genes and they control the growth and differentiation pathways of the cell The function of the caretakers...
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design, synthesis, and biological evaluation of new anti-cancer nitrogen-containing combretastatins and novel cysteine protease inhibitors for the treatment of chagas
... Derivatives of Combretastatins A-1 and A-4 66 Synthesis of Cold Precursors of Radio-labeled Combretastatins CA-1 and CA-4 70 Synthesis of OXi8007 and a Nitrogen-Based Indole 75 Biological and Biochemical ... of Cold Precursors of Radio-labeled Combretastatins CA-1 and CA-4 117 Synthesis of OXi8007 and a Nitrogen-Based Indole 122 Biological and Biochemical Results 131 iv Inhibition of tubulin polymerization, ... Blockage of these vessels will stop tumor growth, produce necrosis, and prevent proliferation of cancer cells through the body Herein, the synthesis of novel VDAs and evaluation of their biological...
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Synthesis and biological evaluation of 2 substituted benzimidazole derivatives
... activity of the test compounds was evaluated by carrageenan induced rat paw edema model of Winter et al (1962) Rats of either sex were treated with benzimidazole derivatives (100 mg/kg p.o.) and standard ... appearance of a sharp singlet at 5.54–7.14 ppm confirmed the presence of NH of benzimidazole in all the compounds The appearance of multiplet at 6.30–8.0 ppm indicated the presence of aromatic and hetero-aromatic ... compared with the control 3.4 Screening of anti-inflammatory activity From the Table 2, it was found that most of the tested compounds showed significant results in comparison with standard diclofenac...
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Part i synthesis and biological evaluation of phosphoglycolipid PGL1 analogues part II synthesis and biological evaluation of andrographolide analogues
... PART I SYNTHESIS AND BIOLOGICAL EVALUATION OF PHOSPHOGLYCOLIPID PGL1 ANALOGUES PART II SYNTHESIS AND BIOLOGICAL EVALUATION OF ANDROGRAPHOLIDE ANALOGUES HADHI WIJAYA (BSc ... SYNTHESIS AND BIOLOGICAL EVALUATION 90 OF ANDROGRAPHOLIDE ANALOGUES AS POTENTIAL INHIBITORS OF NF-B 4.1 Introduction 90 4.2 Results and Discussion 93 4.2.1 Synthesis of Analogues 93 4.2.2 Biological ... BASED PROTEIN PROFILING OF POTENTIAL CELLULAR TARGETS OF ANDROGRAPHOLIDE 3.1 Introduction 58 3.2 Results and Discussions 63 3.2.1 Design of probes 63 3.2.2 Synthesis of probes 67 3.3 Biological Results...
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Synthesis and biological evaluation of isoindigo derivatives as anti proliferative agents
... interactions with the active site and this involved only one of the two dihydroindolone rings The interactions were N1H with C=O of Glu81, and C2=O with HN of Leu83 (Figure 2-4) Both isoindigo (1-1) and ... spite of extensive investigations on the mode of action of meisoindigo in CML and other malignancies, there are still gaps in our understanding of its mode of action Unlike indirubins where CDK and ... CDK2 and is held in position by hydrogen (H) bonds As depicted in Figure 2-2, these are H bonding between N1 H of 5BI to C=O of Glu 81, C2 =O of 5BI to NH of Leu 83 and N1’ -H of 5BI to C=O of...
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Solid phase synthesis and biological evaluation of 1, 3, 5 triazine derivatives
... values of 3-17 165 Table 4.3 Structures and inhibition values of 2-2 165 Table 4.4 Structures and inhibition values of 3-38 and 3-45 166 Table 4.5 Structures and inhibition values of 3-28 and 3-29 ... This multifaceted profile bodes well for the interaction of such heterocycles with a variety of biological targets, which has consequently led to the development of a number of synthetic strategies ... research scholarship to pursue my doctorate degree i TABLE OF CONTENTS TABLE OF CONTENTS SUMMARY LIST OF TABLES LIST OF FIGURES LIST OF SCHEME LIST OF ABBREVIATIONS ii vi vii viii xi xiv Chapter 1: Introduction...
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Design, synthesis and biological evaluation of inhibitors of flavivirus NS2B NS3 protease
... B1 2.2 Results and Discussion 2.2.1 Construction of expression vectors (A) GGC TTA CCA GTA TGT GGT GAA ACC TGT GTA GGT GGT ACC TGT AAT ACC CCA GGG TGT ACC TGT AGC TGG CCA GTA TGT ACC CGT AAT (TAA) ... which is the main focus of the thesis involves the design, synthesis and biological evaluation of inhibitors of Dengue and West Nile virus NS2B-NS3 protease For the design of dengue NS2B-NS3 protease ... 1999 to 2008, with largest ever WNV outbreaks occurring in 2002 and 2003, a total of 29,000 around cases of WNV infection, more than 1100 of whom died, had confirmed infections with the virus...
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Part 1 total synthesis and biological evaluation of antillatoxin and fragments part II synthetic studies towards the total synthesis of cytochalasans and tuberostemonine
... PART I TOTAL SYNTHESIS AND BIOLOGICAL EVALUATION OF ANTILLATOXIN AND FRAGMENTS PART II SYNTHETIC STUDIES TOWARDS THE TOTAL SYNTHESIS OF CYTOCHALASANS AND TUBEROSTEMONINE APPENDIX SILICON-ASSISTED ... Synthesis and Biological Evaluation of Antillatoxin and Fragments Chapter : Total Synthesis of Antillatoxin 1.1 Historical Background Marine cyanobacteriums are well known to be the rich source of structurally ... production of enough quantities for detailed biological evaluations The isolation of antillatoxin (4b) was reported by Gerwick and co-workers in 1995 Based on spectroscopic studies (1D and 2D NMR) and...
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Báo cáo y học: " Fluorodeoxyglucose-positron emission tomography/computed tomography in the staging and evaluation of treatment response in a patient with Castleman''''s disease: a case report" pps
... patient was treated with four cycles of chemotherapy A further CT scan of the abdomen was performed at the end of the treatment and then again in June 2007; a second PET/CT study with FDG was performed ... combination of both anatomical and biological co-registered images acquired in the same session, with a dual gain in diagnostic accuracy Staging is crucial in the identification of the appropriate ... together with clinical signs, a complete disease response Conclusion This case report shows that FDG-PET/CT could have an important role in the staging of Castleman's disease and in its evaluation of...
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báo cáo hóa học:" Evaluation of early atherosclerotic findings in women with polycystic ovary syndrome" docx
... in terms of FBS, TG, TC, LDL and HDL between PCOS and control subjects Table summarises the SBP, DBP and biochemical data of PCOS patients and control subjects Assessment of sex hormone and insulin ... lean individuals and without morbid obesity with PCOS [8,13], but this still remains controversial [6,14,15] We accept the lack of BMI matching as a limitation of our study, and recommend its ... differences between cases and controls in term of LH and 17 OH progesterone levels Table summarises the serum insulin and sex hormone levels in PCOS patients and controls Patients with PCOS demonstrated...
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báo cáo hóa học:" Research Article Performance Evaluation of UML2-Modeled Embedded Streaming Applications with System-Level Simulation" pdf
... performance evaluation process consists of the following steps Some of the concepts of this and the next subsection have been reused and modified from the work in [13]: (1) selection of the evaluation ... S Balsamo and M Marzolla, “Performance evaluation of UML software architectures with multiclass queueing network models,” in Proceedings of the 5th International Workshop on Software and Performance, ... is a set of tasks, Δ is a set of channels, E is a set of external events (or timers), and TC is a set of timing constraints Tasks are further categorized to sets of execution tasks Te and storage...
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Báo cáo khoa học: "Biological characteristics of Chinese hamster ovary cells transfected with bovine Prnp" pptx
... RCP nim 51 rof Co27 ta noisnetxe lanif a neht dna ,ces 03 nim rof Co27 ta noisnetxe ,ces 03 rof Co06 ta gnilaenna ,ces 03 rof Co49 ta noitarutaned fo selcyc 03 yb dewollof ,nim rof Co49 ta noitarutaned ... CATCCTATCCTTAAG-'5 ,remirp esrever a dna ,'3-GGTT GACGGATACACCGAAAAGTGGTACTTAAG-'5 ,remirp drawrof a htiw refsnart eneg eht neercs ot demrofrep saw RCP dna ,)ASU ,agemorP( tik noitacifirup AND ... enivob fo noitpircsnart eneg rof neercs ot evoba debircsed sa demrofrep neht saw RCP dna ,ANR evomer ot nim 02 rof Co73 ta H esaNR fo stinu htiw detaert erew ANDc dednarts-elgnis dezisehtnys...
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Báo cáo khoa học: " Evaluation of partial cranial cruciate ligament rupture with positive contrast computed tomographic arthrography in dogs" ppt
... algorithm, 85 mA, 130 kVp, and field of view of 50 mm CTA protocol A 21-gauge needle was directed midway between the cranial point of the patella and the tibial tuberosity and just medial to the ... before and after partial cranial cruciate ligament rupture Cadaver No Fig Comparison of the pre-operative conventional view (A) and tracing view (C) with the post-operative conventional view (B) and ... rupture, usually within one year of the onset of lameness [13] Furthermore, the definite diagnosis of partial cranial cruciate ligament tears is more complicated than the diagnosis of complete tears...
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Báo cáo khoa học: "Evaluation of volumetric modulated arc therapy (VMAT) with Oncentra" pps
... IMRT and VMAT plans and drafted the manuscript FP and OK helped to draft the manuscript and designed the medical aspects of it BD participated in the design of the study and coordination of it and ... at 150° and stopped at 330° was performed with a collimator angle of 90 degrees and a couch angle of 270°, for dual arc VMAT an additional arc from 250° to 100° with collimator angle 0° and couch ... the feasibility of VMAT with the combination of Oncentra MasterPlan® and an Elekta SynergyS® linear accelerator for head and neck cancer in general, rather than a plan comparison with statistical...
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báo cáo khoa học: " Developing the protocol for the evaluation of the health foundation''''s ''''engaging with quality initiative'''' – an emergent approach" pps
... College and Association of Coloproctologists of Great Britain and Ireland To improve the quality of care for patients with cancer of the large bowel Audit and feedback Time series analysis of repeat ... 4: Aims of the EwQI external evaluation (with related tasks identified by the external evaluation team) Aim one: to work with award holders on the development and implementation of their evaluation ... developmental approach was adopted, and an evaluation was planned The latter was to be evaluation at two levels – an external evaluation of the EwQI as a whole, and a set of self-evaluations at project level...
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Báo cáo khoa học: " Evaluation of furosemide regimens in neonates treated with extracorporeal membrane oxygenation" doc
... of ECMO and at the start of the furosemide treatment were 50 (38–78) mm Hg and 167 (102–237) beats per minute and 51 (37–74) mm Hg and 138 (88–198) beats per minute, respectively Median MAP and ... treated with CAVH One patient was treated with CAVH because of acute renal failure (creatinine 74 μmol/l and urea 4.8 mmol/l) and the other patient was treated from the start of ECMO with CAVH ... Hg and 130 (107–162) beats per minute, and 51 (48–56) mm Hg and 124 (114–180) beats per minute, respectively At the start of ECMO and after 24, 48, and 72 hours on ECMO, eight, five, four, and...
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Tài liệu Báo cáo khoa học: Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain pdf
... synthesis of GIF, albeit at seemingly much lower levels than within astrocytes Neuronal synthesis of GIF is highly localized to specific subsets of cortical and hippocampal neurons, and is found within ... associated with AD Potential role of metal-binding/exchange properties of GIF in AD One of the primary pathological hallmarks of AD is the formation of b-amyloid (Ab) plaques, composed primarily of Ab(1–40) ... proliferation and migration in vitro [14] It is possible, then, that the upregulation and secretion of GIF by astrocytes in the immediate vicinity of a lesion could contribute to the accumulation of reactive...
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Báo cáo Y học: Synthesis, conformational analysis and biological activity of cyclic analogs of the octadecaneuropeptide ODN Design of a potent endozepine antagonist pot
... the response with that of ODN and OP revealed that, at a concentration of 1028 M , cyclo128 OP was more efficient than ODN and OP (Fig 3C) Administration of graded concentrations of OP and cyclo128 ... formation of intramolecular hydrogen bonds (i, i 2) between the C ¼ O of Pro2 and the NH of Leu4 to form a ring associated with a standard g turn, and (c) a hydrogen bond (i, i 3) between the C ¼ O of ... analysis of the calculated structures revealed a short distances between NH of Leu7 and the side chain carboxyl group of the Asp6 residue (< 0.28 nm), and NH of Leu7 residue and C¼O of Leu5 (
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cientific Evaluation of Biological Opinions on Endangered and Threatened Fishes in the Klamath River Basin ppt
... associated with aridity and with the drainage of many rivers directly to the Pacific Human intervention in the water cycle of the West is especially pervasive because of the general scarcity of water and ... welfare of the fish have not coincided with years of low water level, and the highest recorded recruitment of new individuals into the adult populations occurred through reproduction in a year of ... Scientific Evaluation of Biological Opinions on Endangered and Threatened Fishes in the Klamath River Basin: Interim R http://books.nap.edu/catalog/10296.html i SCIENTIFIC EVALUATION OF BIOLOGICAL...
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báo cáo khoa học:" Biological and biomechanical evaluation of interface reaction at conical screw-type implants" doc
... technique and on the microscopic and macroscopic morphology of the implant used The osseointegration mode of implants is influenced by the features of the implant system Important aspects of a fast ... morphology of the implants was designed with the help of finite element analysis (FEA) The geometry of the implant was designed to allow micromovements of a magnitude between 500 and 3,000 µstrain ... health Healing periods of days and 28 days were allowed for half of the implants respectively After days and 28 days animals were sacrificed (4 minipigs each) with an overdose of T61 given intravenously...
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