background and utility of the drug discrimination paradigm
Báo cáo khoa học: Structure of the substrate complex of thymidine kinase from Ureaplasma urealyticum and investigations of possible drug targets for the enzyme pdf
Ngày tải lên :
30/03/2014, 11:20
... of the phosphate donor in the dNK family, there is a domain in hTK1 and Uu-TK that contains a structural zinc atom and lasso-like loop In the feedback inhibitor complexes of Uu-TK and hTK1, the ... dotted lines The tight binding site for the 2¢ position between the main chain of Lys180-Ile181 and Met21 Any substitution at the 2¢ position hinders proper closure of the lasso, and thereby weakens ... substrates and have the highest activities The iodo atom has the same van der Waals radius as the methyl group of thymine, and the corresponding analogue has an activity comparable to that of dT The...
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present and future of the cosmic microwave background proceedings of the workshop held in santander spain 28 june-1 july 1993
Ngày tải lên :
03/07/2014, 21:10
... beyond the null in the thermal Sunyaev-Zel'dovich effect at 220 GHz, and achieve the spectral separation of the thermal and kinematic effects The measurement of the radial peculiar velocity of a ... shown in Fig 3, but there is a hint of structure between the scales of the 1.8-arcmin b e a m of the OVRO telescope and the 0.5-arcmin resolution limit of the Ryle data Even with the small (13-m ... seen at the point closest to the X-ray center for each cluster (offset from the scan center in the case of Abell 665), and the apparent angular sizes of the effects are consistent with the predictions...
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Báo cáo y học: " Presence and utility of IgA-class antibodies to cyclic citrullinated peptides in early rheumatoid arthritis: the Swedish TIRA project" docx
Ngày tải lên :
09/08/2014, 10:23
... [32] In the present study on early RA we found anti-CCP antibodies of the IgA isotype in 29% of the patients in total, and in 47% of the patients testing positive for anti-CCP antibodies of the IgG ... that they have no competing interests Authors' contributions AS, AK and TS participated in the conception and design, acquisition of data, analysis and interpretation of the data, and writing the ... patients at the time of diagnosis, and from 72 of these patients at the 3-year follow-up The patients were prescribed disease-modifying anti-rheumatic drugs (DMARDs) as judged appropriate by the treating...
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Báo cáo y học: "The utility of the new generation of humanized mice to study HIV-1 infection: transmission, prevention, pathogenesis, and treatment" docx
Ngày tải lên :
13/08/2014, 01:21
... component of the IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptors and is the gene involved in X-linked SCID [13] The addition of the gc mutation to the Rag1, Rag2, and NOD/SCID backgrounds further ... xenoengraftment observed to date, in terms of the spectrum of human cells produced, the penetration of human cells into various organs, the duration of engraftment, and the ability to generate primary human ... summary of all viral pathogens and other immunogens studied thus far in the new generation of humanized mice is provided in Table One of the most exciting developments for the new generation of humanized...
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Advantages and challenges of the spray drying technology for the production of pure drug particles and drug loaded polymeric carriers
Ngày tải lên :
02/09/2015, 13:31
... adjust the solubility of the polymer and the drug and the boiling point that results in particles with the desired properties In the latter case, the advantage of water is associated with the non-toxicity ... evaluate the effect of the formulation components and the spray-drying process on the PT immunogenicity of the HAC1 vaccine Based on the in vitro evaluation of the antigen RI content (process loss and ... advantages and challenges of the spray-drying method for the production of pure drug particles and drug- loaded polymeric particles and discusses the potential of this technique and the more advanced...
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Báo cáo y học: "Mirror-Image Arachnoid Cysts in a Pair of Monozygotic Twins: A Case Report and Review of the Literature"
Ngày tải lên :
25/10/2012, 11:00
... case of MZ with mirror-imaging of AC in the literature In this case, we describe the second case of MZ with mirror-imaging of AC and discuss the possible clinical implications First, Helland and ... lack of systematic monitoring and follow-up Therefore, a large percentage of patients with AC are probably undiscovered Mirror images, on the other hand, are present in approximately 25% of MZ Therefore, ... consider that it is mandatory to monitor the counterpart of the symptomatic patient with AC as early as possible, irrespective of the absence of symptoms Conflict of Interest The authors have declared...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
Ngày tải lên :
25/10/2012, 11:04
... craniotomy because of the proximity of the sinus to the orbit and the anterior skull base [5] The frequency of bilateral absence of the frontal sinus has been reported in 3-4% to 10% of several populations ... reliability between observers and was 0.86 Fig Unilateral absence of the frontal sinus; on the right, the absence of the frontal sinus, and on the left, the limited aeration of the frontal sinus; axial ... sinuses, although there is only one frontal sinus ostium The size of the sinus and, therefore, its anatomic relationships also depend upon the extent of pneumatization [11] The extent of pneumatization...
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Báo cáo y học: " Post-traumatic glioma: Report of one case and review of the literature"
Ngày tải lên :
25/10/2012, 11:48
... occurrence of the tumor corresponded exactly one to the other; and (4) there was a more than one year interval between trauma and the appearance of the tumor As regards the pathogenesis of post-traumatic ... time interval between trauma and the appearance of the tumor of at least year, a longer latent period increasing the likelihood of a causal relationship The presence of the tumor must be proved histologically ... at the time of the trauma demonstrating significant injury and the follow-up scans demonstrating tumor at the same site4 With the routine use of CT and magnetic resonance imaging (MRI), some of...
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. Scope and Limitations of the Study
Ngày tải lên :
13/04/2013, 10:31
... circumstances In the resolutions of the VIth and the VIIth congresses of the Communists Party and those of the important meeting of the National Assembly, the Government and the Central Party ... assessment the demand of skilled labor and how to solve the gap between demand and supply of skilled labor for sustainable economic growth in Vietnam Objectives of the Study The objectives of the study ... building up the whole system It is hoped that these schools (10-15% of the sector) will reach the standards of the best institutions in the region and gradually those of the world While these school...
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Scope and Limitations of the Study
Ngày tải lên :
13/04/2013, 10:32
... component of most management definitions of strategy Strategy is the determination of the basic long-term goals and objectives of an enterprises, and the adoption of courses of action and the allocation ... features 60 As a rule, then, the lower the price of substitutes, the higher the quality and the performance, and the lower the user’s switching costs, the more intense are the competitive pressures ... market conditions in the supplier industry and the significance of the item they supply The competitive fore of suppliers is greatly diminished whenever the item they provide is a standard commodity...
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Methodology and framework of the study
Ngày tải lên :
13/04/2013, 10:32
... including the rationale of the study, the identification of the problem, the objectives, the scope and limitations as well as the methodology and framework of the study Chapter shows the literature ... 2000 and 80% by 2005 • To improve the quality of plastic products to meet the demand of high quality consumer products of the country, then to increase the quantity and expand varieties of export ... simplified, the level of knowledge of the management organizations and officers in charge of investment are now improved The consolidation of the former SCCI and SPC into one Ministry, which is now the...
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Preparation and characterization of the PVDF-based composite membrane for direct methanol fuel cells
Ngày tải lên :
05/09/2013, 16:11
... polymerization of styrene and the blending of PS and SPS polymers have affected the surface structure of the PVDF membrane obviously The cross-section morphologies of the PVDF membrane, the PVDF-PS ... Thermal analysis of the PVDF-SPS composite membrane The TG analysis curve is presented in Figure for the investigation of the thermal stability of the PVDF membrane, PVDF-PS membrane, and the PVDF-SPS ... to prepare the PVDF composite membrane The structure and the morphology of the PVDF-SPS composite membrane were characterized The proton conductivity and the methanol permeability of the PVDF-SPS...
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REVIEW AND APPLICATION OF THE TULSA LIQUID JET PUMP MODEL
Ngày tải lên :
23/10/2013, 08:42
... fluid, and therefore the fluid pressure The smaller flow area, the higher velocity of the fluid The static pressure of the fluid drops as the square of the velocity increase and will reach the vapour ... as the return conduit and the tubing as the power fluid string For this type of installation, the production of free gas through the pump causes reduction in the ability to handle liquids The ... data it is referred to the thesis The analysis of the data followed the model of Petrie, Wilson and Smart (PWS) This model is based on conservation of mass and energy, and is widely familiar...
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The fall and rise of the American petty bourgeoisie
Ngày tải lên :
01/11/2013, 07:20
... participation All of these, except for professional services, contributed positively both to the sectoral shift in self-employment and the class shift At the other end of the spectrum, 11 of the 12 sectors ... at the decomposition of these effects on self-employment, the picture becomes somewhat more complex In both the 1970s and the 1980s, the detailed sectors of the economy within which there was the ... at the sector-shifts From the 1950s on, there is a steady reduction of the effect of declines in the extractive sector (primarily agriculture) on selfemployment Agriculture is the sector of the...
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Sub-regional cooperation and protection of the Arctic marine environment - the Barents Sea
Ngày tải lên :
01/11/2013, 09:20
... important are other bureaucratic entities, like the Ministry of Economy, the Ministry of Atomic Energy, the Ministry of Defence and the Navy.62 In general, the domestic clout of the Russian environmental ... composed of municipal representatives from the three North Norwegian fylker of Nordland,Troms and Finnmark, the northernmost Swedish and Finnish län Norrbotten, Västerbotten, Lappland and Oulu – and ... Agreement Between the Government of the United States of America and the Government of the Union of Soviet Socialist Republics Concerning Cooperation in Combatting Pollution in the Bering and Chukchi...
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World Population and Area of the Countries
Ngày tải lên :
08/11/2013, 16:11
... Sweden Switzerland Syria Taiwan (Republic of China) Tajikistan Tanzania Thailand Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine ... Philippines Pitcairn Poland Portugal Puerto Rico Qatar Reunion Romania Russia Rwanda Saint Helena Saint Kitts and Nevis Saint Lucia Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa ... NLD 149 Netherlands Antilles ANT 150 New Caledonia NCL 151 New Zealand NZL 152 Nicaragua NIC 153 Niger NER 154 Nigeria NGA 155 Niue NIU 156 Norfolk Island NFK 157 Northern Mariana Islands MNP...
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Tài liệu Paper and Key of the first term test TQC Senor High School - Hoi An Town
Ngày tải lên :
23/11/2013, 10:11
... until the end of the 14th century Illiteracy was not seen as a problem until the end after the invention of printing in the 15th century The first significant decline in illiteracy came with the ... attack on illiteracy as one of their goals, with the former Soviet Union, China, and Cuba being among the most successful in the 20th century According to the passage, the anti-illiteracy a adults ... instructors for the public Throughout most of history most people have been illiterate In former society, the ability to read and write was of value only to clergy and aristocracy The first known...
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Đo kiểm đánh giá can nhiễu mạng truyền hình cáp The Measurement and Analysis of the effect of interference in Television Cable network
Ngày tải lên :
26/11/2013, 20:44
... SCHWARZ - SOUND and TV BROADCASTING – CCIR and FFC tv standards – Printed in the federal republic of Germany 18 3GPP2 C.S0011-C, version 2.0 – Recommended Minimum Performance Standards for cdma2000 ... channel coding and modulation systems for Broadcasting, Interactive Services, News Gathering and other broadband satellite applications (DVB – S2) 14 Tim Williams – EMC for Product Designers – ... Measurements and Technologies -1996 IEEE Press 16 Walter Ciciora, James Farmer, David Large, Michael Adams – Modern Cable Television Technology: Video, Voice and Data communications – The Morgan...
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