atm but not atr with viral dna
Báo cáo y học: "Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels" ppt
... also did not correlate with the local CpG or GC content, which was not significantly different between both groups of genes (P > 0.1, Mann Whitney U-test) Active DNA demethylation coincides with ... DNA glycosylase or MBD4 to demethylated sites using ChIP assays (data not shown) This may suggest that repair processes related to DNA demethylation are different from those associated with DNA ... may contribute to DNA methylation dynamics in both settings Although the observed DNA demethylation events clearly point to active enzymatic processes, the underlying mechanisms are not completely...
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Báo cáo y học: "Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi" pot
... chromosome, we analyzed restriction digested genomic DNA With DNA from non-treated parasites, NotI digestion generated two bands detectable with probe Tb2, indicative of differences in the lengths ... transfected with linearized vector DNA and transformants selected with G418 [22] (see Materials and methods) Chromosomal DNA from wild-type (WT) and transfected (T) parasites was separated by CHEFE with ... indicated above or below the corresponding track Genomic DNA was ScaI digested, Southern blotted, probed with plasmid DNA, then re-hybridized with β-tubulin as a loading control deposited research...
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Báo cáo y học: "Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk – A Meta-Analysis"
... with p53 Arg75Pro for the Pro/Arg+Pro/Pro genotypes, compared with the Arg/Arg genotype Figure ORs (log scale) of esophageal cancer associated with GSTP1 Ile106Val for the Ile/Val+Val/Val genotypes, ... esophageal cancer, but this conclusion was consistent with Hiyama T et al’ s review.[40] These findings suggest that the GSTP1 Ile105Val genotype alone does not show any association with the susceptibility ... by odds ratio (OR) with 95% confidence intervals (95%CI) For all studies, we evaluated the risk of the variant genotypes (Pro/Pro, Val/ Val), compared with the wild-type genotype (Arg/Arg, Ile/...
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Tài liệu Báo cáo khoa học:Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau ppt
... the association of tau with Fyn-SH2, but not with Fyn-SH3 This demonstrates that different molecular mechanisms exist for these two distinct interactions of Fyn and tau, with probably disparate ... cells with pervanadate did not affect the interaction of wild-type or mutant tau with Fyn-SH3 (Fig 3) These findings indicate that, unlike the case for Fyn-SH2, tyrosine phosphorylation does not ... agreement with the findings of our previous study with synthetic tau peptides [21] Fig Pro216 in tau is important for its interaction with Fyn-SH3 CHO cells were transiently cotransfected with Fyn...
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Báo cáo sinh học: " EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in north African nasopharyngeal carcinomas" pptx
... to contribute to the malignant phenotype of NPC cells [3,9] Another aspect of EBV association with NPC is the presence of aberrant levels of circulating antibodies directed against viral proteins, ... such as EA (early antigen) and VCA (Viral Capsid Antigen) but with low antibody levels against LMP1 [10-13] Although viral lytic cycle proteins are usually not detected in malignant cells there ... patient to another and within a given tumor We found no NPC specimens with complete absence of S12 staining Even when staining was minimal, a fraction of cells were nevertheless LMP1-positive with moderate...
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Báo cáo sinh học: " Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA" pdf
... viral DNA synthesis and suggests that this gene product functions as part of the viral DNA replication machinery Discussion Figure in Defects DNA synthesis associated with pUL114 Defects in DNA ... association with ppUL44, which is known to interact with the DNA polymerase [9] imply that this molecule is part of the viral DNA replication complex This interpretation of the data is consistent with ... did not colocalize to the nucleus when co-expressed with the observed decrease in viral DNA described previously [31] and also with the data showing a defect in the transition to late phase DNA...
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báo cáo hóa học: " Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice" ppt
... death [14] however, this does not rule out that inflammation had been present but resolved by the time of autopsy Therefore, Aβ based immunotherapy has potential but more research is required ... produced by priming with Aβ1–40/ 42, followed Anti-Aβ1 by boosting with Aβ40/42 or dAβ1–15 Anti-Aβ antibodies are produced by priming with Aβ1–40/42, followed by boosting with Aβ40/42 or dAβ1–15 ... alone (n = 6) or boosted with Aβ1–15 peptide (n = 8) did not produce any detectable antibodies Wildtype littermates immunized with a priming dose of Aβ1– 40/42 and boosted with dAβ1–15 (n = 4) generated...
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báo cáo hóa học:" EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in north African nasopharyngeal carcinomas" pptx
... to contribute to the malignant phenotype of NPC cells [3,9] Another aspect of EBV association with NPC is the presence of aberrant levels of circulating antibodies directed against viral proteins, ... such as EA (early antigen) and VCA (Viral Capsid Antigen) but with low antibody levels against LMP1 [10-13] Although viral lytic cycle proteins are usually not detected in malignant cells there ... patient to another and within a given tumor We found no NPC specimens with complete absence of S12 staining Even when staining was minimal, a fraction of cells were nevertheless LMP1-positive with moderate...
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báo cáo hóa học:" Human cytomegalovirus uracil DNA glycosylase associates with ppUL44 and accelerates the accumulation of viral DNA" potx
... viral DNA synthesis and suggests that this gene product functions as part of the viral DNA replication machinery Discussion Figure in Defects DNA synthesis associated with pUL114 Defects in DNA ... association with ppUL44, which is known to interact with the DNA polymerase [9] imply that this molecule is part of the viral DNA replication complex This interpretation of the data is consistent with ... did not colocalize to the nucleus when co-expressed with the observed decrease in viral DNA described previously [31] and also with the data showing a defect in the transition to late phase DNA...
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báo cáo hóa học:" Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected kenyan adults not initially requiring combination antiretroviral therapy" potx
... was associated with lower CrCl, but not with lower eGFR Lower enrolment weight was associated with lower CrCl, but in contrast, lower weight was associated with higher eGFR Of note, the median ... associated with both a CrCl < 60 mL/min and eGFR < 60 mL/min/ 1.73 m2 Being female was associated with lower eGFR, but not with lower CrCl, at enrolment Having WHO disease stage (compared with stage ... Reduced renal function is associated with progression to AIDS but not with overall mortality in HIV-infected kenyan adults not initially requiring combination antiretroviral therapy Journal of the International...
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Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx
... Aggregation with 2.4G2 rat Ab together with TNP7-MAR F(ab´)2 does not cause degranulation, which indicates that expression of Fc␥RIII (an activating low-affinity receptor for IgG) on C57 cells does not ... multiple comparison with the Wilcoxon matchedpairs test Fc⑀RI and Fc␥RIIB C57 cells were sensitized with murine IgE and challenged with polyclonal RAM F(ab´)2 to aggregate Fc⑀RI or with RAM IgG to ... used another system for Western blot analysis, one by which each receptor can be aggregated separately or coaggregated C57 cells were sensitized with murine anti-DNP IgE and incubated with or without...
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Báo cáo khoa học: "Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy" ppt
... the pMR group, but not in the pCR group, when compared to the pLR (p = 0.03, 0.07 respectively) p-ERK activation is associated with survival, but not pAKT AKT activation status, but not ERK activation ... patients with the wild-type (WT) KRAS gene These drugs are now used in the treatment of mCRC, with response rates ranging from 8% with single agent cetuximab[36] to 23% in combination with irinotecan, ... proteins Another small study of A predominantly stage II and III CRC tumors evaluated the KRAS/BRAF/ERK pathway p-ERK was correlated with KRAS codon 12 mutations (p = 0.016) but not with codon...
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Báo cáo y học: " High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life" pdf
... sensitivity C-reactive protein Page of (page number not for citation purposes) Why the relationship with hsCRP was seen in the tibial compartment but not the patella compartment is unclear However, ... intercurrent illness, women were asked not to attend for their blood test on a day they were not well Another limitation to our study is that the cross-sectional design does not provide information regarding ... number, not by name, and the study was conducted in accordance with the Declaration of Helsinki principles Measurement of hsCRP Measurement of hsCRP was performed using a particle enhanced immunoturbidimetric...
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Báo cáo y học: "Rheumatoid cachexia is associated with dyslipidemia and low levels of atheroprotective natural antibodies against phosphorylcholine but not with dietary fat in patients with rheumatoid arthritis: a cross-sectional study" pdf
... 0.046) Treatment with glucocorticoids and mean dose given did not differ between those who were cachectic and those not (data not shown) Discussion This study shows that ambulatory patients with RA ... associated with high levels of oxLDL and low levels of anti-PC Patients compliant with Mediterranean and vegetarian diets did not differ in body composition from the rest of the patients, but had ... antirheumatic drugs or not Furthermore, patients with RA have increased levels of oxidized lowdensity lipoprotein (oxLDL) in serum compared with healthy subjects, which may contribute to the increased...
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Báo cáo y học: " HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors" docx
... individuals, several factors contribute to drug failure The highly error-prone nature of HIV-1 RT [5,6] combined with a robust rate of viral replication [7,8] provides the virus with an ideal context for ... In order to address this notion, we previously used a phenotypic screen based on the in situ detection of RNAdependent DNA polymerase activity of HIV-1 RT expressed within bacterial colonies, ... (10-fold) to DNA aptamer RT8, while the N265D mutant displayed wild type levels of sensitivity (Table 1) However, with respect to the DNA aptamer RT10 and the single RNA aptamer tested (Rknot1.1),...
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Báo cáo y học: " Nef-specific CD45RA+ CD8+ T cells secreting MIP-1β but not IFN-γ are associated with nonprogressive HIV-1 infection" ppsx
... individuals with early infection and low viral set point thereafter [15] In these studies, ART naive individuals with detectable viremia were chosen as controls and compared to NP with low or ... infected individuals with different histories of infection Eleven NP were compared to 10 progressors (PR) with unrestricted control of viral replication All NP and PR had not received ART before ... CD8+ T cells were prevalent in individuals in whom the viral load was kept under control either naturally or with the help of antiretroviral treatment Of particular interest, we identified a novel...
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Báo cáo y học: "De novo acute megakaryoblastic leukemia with p210 BCR/ABL and t(1;16) translocation but not t(9;22) Ph chromosome" pdf
... 109/L, with 21% blast cells Relapse was established with bone marrow smear The patient was treated with cytarabine (2 g/m2/day on days - 3) and daunorubicin (45 mg/m2/day on days - 3), with no ... very poor prognosis We here report a 45-year-old woman with de novo AMKL with BCR/ABL rearrangement and der(16)t(1;16)(q21;q23) translocation but negative for t(9;22) Ph chromosome Upon induction ... best of our knowledge, this is the first report of de novo AMKL with p210 BCR/ABL and der(16)t(1;16)(q21;q23) translocation but not t(9;22) Ph chromosome [Key words] Imatinib, Acute megakaryocytic...
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Báo cáo khoa học: "Respiratory compliance but not gas exchange correlates with changes in lung aeration after a recruitment maneuver: an experimental study in pigs with saline lavage lung injury" pptx
... USA) Parameters correlating with nonaerated lung Venous admixture correlated directly with nonaerated lung volume (r = 0.678, p = 0.004) (Fig 1d), but the PaO2 did not (p = 0.098) Similarly, nonaerated ... PaO2 did not (p = 0.098) Similarly, nonaerated lung volume correlated with physiologic dead space (r = 0.534, p = 0.04), but not with the arterial blood partial carbon dioxide pressure (PaCO2; p ... massive pulmonary edema, but did not change after the recruitment maneuver either (see Additional file 1; Table 2) In summary, changes in compliance of the respiratory system but not in gas exchange...
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Báo cáo y học: "Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitors" pps
... was noted between macrophage-tropism and sensitivity to the gp41 mabs or T20 In summary, R5 macrophage-tropism correlated with sensitivity to reagents that interfere with gp120:CD4 binding but not ... increased sensitivity to PRO 542 but decreased sensitivity to Q4120 and BMS378806 HIV-1 R5 macrophage-tropism also correlated with sensitivity to 2G12 but not with b12, TAK779, SCH350581 or T20 ... correlated with R5 macrophage-tropism with very high significance Thus, our data strongly indicates that R5 macrophage tropism predominantly correlates with sensitivity to reagents that interfere with...
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Báo cáo khoa học: "Kerbs von Lungren 6 antigen is a marker of alveolar inflammation but not of infection in patients with acute respiratory distress syndrome" docx
... with ARDS but is not elevated in critically ill patients at risk of the disease BALF KL-6 correlated with plasma KL-6 and was related to the severity of inflammation Alveolar infection does not ... normality test was used to test the distribution of the data The plasma and BALF KL-6 data were not normally distributed, and therefore are presented as the median with 95% confidence interval (CI) for ... (Figure 2) The plasma KL-6 level correlated significantly with the Murray Lung Injury Score (r = 0.68 P = 0.001) (see Figure 3) but not with the systemic injury scores – Simplified Acute Physiology...
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