... tissue and gastrointestinal tract, as well as other sites, are known to reach the CNS to effect changes in feeding behavior and energy expenditure Thus, insulin, leptin and ghrelin, as well as other ... closely and rapidly with reciprocal changes inthe levels ofthe orexigenic and anorectic Signaling mediators inthetreatmentof obesity neuropeptide expression inthe hypothalamus [22] Thus an increase ... explored further Other areas ofthe brain have also been shown to regulate feeding via AMPK [35,36] Of interest is the extensive use of fructose as a sweetener inthe human diet [37] Glucose and fructose...
... at each phase ofthe cell cycle by various complexes of cell-cycle-related molecules, including cyclins, cyclin-dependent kinases, their inhibitors andthe retinoblastoma protein (RB), as well ... calorie intake induces expression of RMI1 and E2Fs in adipocytes, and these changes in expression are expected to increase a positive interaction between the molecules The increased expression of ... recruitment of preadipocytes [12], suggesting that these cyclin-dependent kinase inhibitors are important inthe regulation of adipocyte number The S-phase kinase-associated protein (Skp)1–CullinF-box...
... effective inthetreatmentof psychotic major depression, andthe switch to sertraline worsened the psychotic symptoms inthe patient The mechanisms underlying the opposite effects of these two ... fluvoxamine binds to sigma-1 receptors inthe intact human brain at therapeutic doses [25], suggesting that sigma-1 receptors are involved inthe active mechanisms of fluvoxamine [19] Interestingly, ... that activation ofthe dopaminergic system by the inhibition of dopamine transporter may be involved inthe mechanism of unwanted effects (deterioration of psychosis) of sertarline in this case,...
... approved the final manuscript Competing interests The funding source had no influence on study design, inthe collection, analysis, and interpretation ofthe data, inthe writing ofthe manuscript, ... telbivudine are more widely used intreatmentof CHB In this systematic review, we focus on the comparison ofthe efficay of lamivudine and telbivudine inthe Figure Effect of telbivudine vs lamivudine ... ofthe healthcare system is not satisfactory There are limitations inthe reimbursement of anti-HBV therapy, either inthe selection of agent or the duration of dosing Therefore, lamivudine and...
... further investigations in controlled, randomized and probably multicentre trials to evaluate the clinical value andthe appropriate dosage of L-carnitine in each of these conditions Competing interests ... pathophysiology and significance of VPA-induced carnitine deficiency and evaluated the literature pertaining to carnitine supplementation during VPA therapy in children Despite the lack of prospective, randomized ... [38] Administration of exogenous carnitine is thought to decrease ammonia levels by binding to VPA, thereby enhancing the β-oxidation process and production of acetyl-CoA, and relieving the inhibition...
... pressures and short-term survival, in comparison to the single use of epinephrine This study adds some evidence to the existing literature ofthe epinephrine-vasopressin combination benefits and further ... vasoconstrictive Page of (page number not for citation purposes) effect ofthe combination ofthe two drugs in comparison to epinephrine alone inthe first minute of CPR with an increase of CPP This increase ... interpretation ofthe clinical outcome in vasopressin studies The authors recognize several limitations inthe interpretation ofthe present findings The study was conducted on apparently healthy pigs and...
... [16] andthe possibility of costs minimization [8, 14] The disadvantage of lacking inspections ofthe sponges can be compensated by daily controlling ofthe canister fluid and monitoring ofthe inflammation ... of an endoprosthesis involving the local tissue and causing an immune reaction [15] The most common problem hereby is the draining sinus, prolongating and preventing wound healing The pathophysiological ... haemodynamics, the surrounding tissue is decompressed and local microcirculation is re-established The increase ofthe oxygen gradient facilitates the transportation of toxins and inhibitors inducing thereby...
... approximately 15 minutes, the physicist then loaded the corresponding radiation plan onto the controller unit contaminating the field The catheter end was passed through a hole inthe drape and a FlexiShield™ ... Results The radiation oncologist then broke scrub, attached the XB controller to the catheter, and inserted the radiation source into the balloon The radiation therapy was then Figure and no evidence ... cc was found to be the proper size, a × cm XB balloon catheter kit was then opened by the OR staff The CED was then deflated and removed and a XB was then inserted in place ofthe CED If a 40 cc...
... developed the design ofthe randomised clinical trial and participated in writing the article MSLY is the principal investigator and writer of this manuscript DDN, MSLY, JPF, NLMV, JBN, NMV and PM ... placebo in reducing the severity ofthe three symptom clusters of PTSD, as well as alleviating the symptoms of depression, andin improving the quality of life measures The current evidence base of ... Although there are limited clinical studies with topiramate inthetreatmentof PTSD, the findings of prior topiramate studies suggest that this anticonvulsant may be promising inthe management of...
... 2004, of portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution ... syndrome), including carbamazepine, phenytoin, phenobarbital, and lamotrigine The triad of hypersensitivity includes fever, rash and internal organ involvement with onset of symptoms within to weeks of ... pre-dialysis and 2–3 hrs following the post-dialysis dose There is a case report in which lithium levels were maintained inthe therapeutic range by intraperitoneal administration of lithium during continuous...
... arthritis or other types of pain) or is unwilling to stop taking other medications for thetreatmentof OA Any other condition that, inthe opinion ofthe investigator, would adversely affect the subject's ... one month prior to study and during the study, other than multivitamin and mineral supplements containing vitamins and minerals as the sole medicinal ingredients Use of concomitant prohibited ... Subjects inthe UC-II group were instructed to take two “sugar pills” inthe morning to protect blinding and two UC-II capsules inthe evening accounting for a daily dose of 40 mg UC-II containing...
... medical treatmentin 1998 This was partly because of confusion inthe field about pupil age, and partly because intheearly stages ofthe program several ofthe Kenya Ministry of Health nurses administered ... charts, andthe training of teachers in each treatment school on worm prevention Health education stressed the importance of hand washing to avoid ingesting roundworm and whipworm larvae, wearing ... base their conclusions suffer from several shortcomings First, existing studies randomize the provision of deworming treatment within schools to treatmentand placebo groups, and then examine the...
... the quantum theory The only uncertainty, according to Einstein, lay in our inability or lack of ingenuity in measuring the objective properties of such systems When Bohr and Einstein met at the ... totally independent ofthe state ofthe observer This is the deeper meaning of Einstein’s great discovery Behind all phenomena are laws of nature, andthe form of these laws, their most elegant mathematical ... live within the heart ofthe material world We are all participators inthe world, andthe entrance fee we pay is living with a measure of uncertainty Uncertainty also exists in another and even...
... existing node The links would show up as a numbered list at the bottom of each page, andthe only way of finding information was by browsing the links, starting from the start page The links between ... existing resources The space ofinnovation exists inthe periphery and on the margin, in under-specified, undetermined and unused spaces Innovation can, however, also exist in interstices of current ... At the level of ecology of communities of practice, the speed of recombination has therefore increased The space of recombination has become an increasingly dominant space for innovation The...
... screening including erythrocyte sedimenta- Page of tion rate and C-reactive protein was normal Plain radiographs revealed areas of periprosthetic osteolysis inthe femur andthe tibia, and a ... image ofthe left knee showing the introducing cannula and simultaneous venting ofthe medial tibial condylar cyst Discussion When dealing with massive periprosthetic osteolysis the aims of surgery ... Orthop Scand 2002, 73(2):157-64 Yetkinler DN, Ladd AL, Poser RD, Constantz BR, Carter D: Biomechanical evaluation of fixation of intra-articular fractures ofthe distal part ofthe radius in cadavera:...
... caspase-3 and cleaved PARP proteins in mice Increase inthe expression of caspase-3 and cleaved PARP proteins noticed inthe mice treated in vivo with GnRH-Ag also showed increase inthe number of atretic ... receptors, and steroidogenic and apoptotic factors inthe ovary was investigated following in vivo andin vitro administration of GnRH agonist inthe intact cyclic mice Methods Animals All the experiments ... planned and executed the experiments, responsible for data interpretation and writing ofthe manuscript, AK helped in planning and supervised the work, participated in data analysis and interpretation...
... Journal ofthe International AIDS Society 2004, 6:56 http://www.jiasociety.org/content/6/3/56 sharing, and education that must attend expanding global HIV/AIDS care initiatives Authors and Disclosures ... grants for clinical research and/ or honoraria for educational and/ or advisory activities from Bristol-Myers Squibb, Boehringer Ingelheim, Gilead Sciences, GlaxoSmithKline, Idenix, Merck, and Roche ... Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime."...
... Annals of General Psychiatry 2009, 8:16 thetreatmentof acute mania, the approval of quetiapine andthe olanzapine-fluoxetine combination against acute bipolar depression andthe approval of olanzapine, ... reliability and validity of psychiatric diagnosis perplexes the problem and makes the gathering of scientific data difficult, because the diagnosis of BD in particular is often made retrospectively and ... dose at the end ofthe study was 15.5 mg daily The results suggest that in weeks to and then again at week there is a significant reduction inthe MADRS scores inthe aripiprazole group in comparison...
... concerning radiotherapy and followed up the patient at his out-patient clinic AK was the radiologist performing the preoperative and postoperative CT and MRI scans and wrote the part ofthe paper ... contributions All ofthe authors have been involved in drafting this paper and have read and approved the final manuscript KG conceived the idea ofthe paper, reported the case, performed the literature ... radiotherapy and conventional fractionation while minimising the risks of RT-inducing brain injury like radiation necrosis and cognitive decline The optimal radiation dose has not yet been defined We...
... HT at the Tomotherapy Unit ofthe Grupo IMO inthe context of multidisciplinary national and international treatment protocols All the patients were treated with curative intent, including those ... to the Tomotherapy treatment planning system (Tomotherapy Inc., Madison, WI) to perform inverse treatment planning The planning goal was to deliver the prescription dose to at least 95% ofthe ... Radiation therapy is an integral part inthetreatmentof 40-60% of childhood cancer patients [1] Although many childhood malignancies are cured, the acute toxicity of therapy and significant late treatment...