... those of acute lesions but still markedly higher than those of controls The observed patterns of regulation of [NF(M+H)]P correspond to those of IL-16 (Fig 1) in MS lesions Abnormalities in appearance ... increased levels of phosphorylated medium and heavy chains of neurofilament [NF (M+H)P] in MS lesions Relative levels of NF (M+H)P are markedly increased in MS lesions in (A) brain and spinal (B) ... subacute and chronic MS lesions, and in normal-appearing white matter, from brain and spinal cord of 39 patients with MS and 19 normal controls As anticipated, the highest levels of pro- and secreted...
... surface epithelial cells of ewes: prospective regulatory mechanisms of repair/survival and apoptosis Biol Reprod 2001, 65:1417-1424 Dubeau L: The cell of origin of ovarian epithelial tumors and the ... 2Department of Obstetrics and Gynecology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI, 53792, USA Authors’ contributions JAAG, JPC, and MSP did the majority of the writing of this ... treatment of ovarian cancer has come from intraperitoneal administration of platinum and taxane agents instead of the more conventional intravenous delivery of these drugs [71-73] Of the 654 randomized...
... in one and squamous in one patient Discussion Lymphadenectomy is a routine part of surgical staging in epithelial ovarian carcinomas [8] Despite the vast amount of data detailing the role and extent ... of Surgical Oncology 2010, 8:106 http://www.wjso.com/content/8/1/106 Page of Table Pelvic and paraaortic involvement in early staged patients with epithelial ovarian carcinoma Author Number of ... substages, grades, tumor histology and extend of lymphadenectomies so that it was almost impossible to collect all of these studies under a single Table (Table and 3) Majority of previous studies also...
... localization of metastatic disease in patients with various kinds of malignancies The uptake of the FDG in the normal thyroid gland is homogenous andof low intensity; the normal thyroid gland is usually ... http://www.wjso.com/content/7/1/63 Benign Malignant Figure of benign and malignant thyroid lesions on PET/CT SUVmax SUVmax of benign and malignant thyroid lesions on PET/CT Side by side box plots of SUVmax by groups Statistically ... benign lesionsand malignant lesions (P < 0.001) Page of (page number not for citation purposes) SUVmax World Journal of Surgical Oncology 2009, 7:63 Size of cancer (mm) Figure between SUVmax and...
... Heart Study Offspring cohort included surviving descendants (and spouses of descendants) of the original Framingham Heart Study cohort [25] As part of a study of the inheritance of OA, selected ... Hochberg M: Development of criteria for the classification and reporting of osteoarthritis Classification of osteoarthritis of the knee Diagnostic and Therapeutic Criteria Committee of the American Rheumatism ... quantitative measure of BSAP activity in serum as a measure of osteoblastic activity The sensitivity is 0.7 U/l, and the intra-assay and interassay coefficients of variation at 28 U/l were 3.3% and 7.9%,...
... imaging software cell® (Olympus, Hamburg, Germany) and quantified by counting Page of 12 Cells from F344 (P1 and P2) and Lewis (only P2) were counted in three different wells and portion of SA-bgal-positive ... F344 and Lewis rats Preparation of the dissected mammary gland complexes produced comparable amounts ofepithelial cells in F344 and Lewis rats Marked differences between cells from F344 and Lewis ... the excised mammary gland complexes per single animal were cultured together Identification ofepithelialand mesenchymal cells by immunocytochemistry The proportion ofepithelial cells in culture...
... the aims of this study were to evaluate the distribution of plantar hyperkeratotic lesions in a large sample of older people and to explore associations between the presence oflesionsand physical ... dominant foot Patterns of plantar lesionsOf the 604 feet, 308 (51%) had plantar hyperkeratotic lesions over at least one of the MPJs, or "roll-off" callus on the medial aspect of the 1st MPJ or 1st ... prevention and treatment of these lesions Competing interests HBM is Editor-in-Chief of the Journal of Foot and Ankle Research It is journal policy that editors are removed from the peer review and...
... for PLD and topotecan were 12.3% and 6.5%, respectively, which correlated with a median progression-free survival (PFS) of 9.1 weeks and 13.6 weeks and a median survival of 35.6 weeks and 41.3 ... response rate of 12.3% (95% CI, 7.2-19%) and a DSR of 40% in the platinum resistant population in a phase randomized study [7,20] In our phase study, the response rate of 25.6% and DSR of 76.9% supports ... reductions were 14 events of PPE syndrome and 28 events of neutropenia and/ or thrombocytopenia Safety Treatment-related AEs related to the combination of canfosfamide and PLD are shown in Table...
... small tandem duplications, inversions and deletions were entirely within genes In many cases this affected the exon structure at the transcript level and novel isoforms were observed Some of these ... mutations, that is, random mutational noise, but some must be selected, ‘driver’ events and, as the number and variety of known mutations increases, estimates for the number of ‘driving’ mutations ... Research Centre and Department of Pathology, University of Cambridge, UK Published: 17 March 2010 References Mitelman F, Johansson B, Mertens F: The impact of translocations and gene fusions...
... ENaC and transepithelial Na + transport in primary human airway epithelial cells, and (ii) that EPIhNE4, a specific and potent inhibitor of hNE [22], could block this stimulation The objectives of ... therefore to test the effects of hNE and EPI-hNE4 on ENaC activity and transepithelial Na+ transport in vitro in primary cultures of human nasal epithelial cells from control and CF patients Experimental ... (PBS) with dithiothreitol (5 nM) and antibiotics (100 U/ml of penicillin, 100 mg/ml of streptomycin, 2.5 μg/mL of amphotericin B and 100 mg/ml of gentamicin) and then placed overnight at 4°C...
... increase of GDF-15 transcripts was detected in plexiform lesionsof patients with PAH To study the cellular composition of plexiform lesions, transcripts for the endothelial cell marker CD31 and eNOs ... upregulation of the secreted 30 kDa form of GDF-15 To assess the effects of shear stress on the mRNA expression of GDF-15, HPMEC were exposed to laminar flow (5 and 15 dynes/cm2) for h in a cone -and- plate ... induction of apoptosis was observed after 8-12 hours Apoptotic cell death was assessed by measuring the activities of caspases and (Figure 12, panel A), two of the key executioners of apoptosis, and...
... indicator of laminitis: effects of diet and flooring Acta Vet Scand., 1996b, 37, 375-381 Blowey RW, Phipps R, Jones AK, Barringer AJ: A comparison of the effects of high fibre and high starch on hoof lesions ... composition on lameness and hoof health in dairy cows Vet J., 2004, 167, 111113 Offer JE, McNulty D, Logue DN: Observations of lameness, hoof conformation and development oflesions in dairy cattle ... Bergsten C: Effects of conformation and management system on hoof and leg diseases and lameness in dairy cows In: Veterinary Clinics of North America: Food Animal Practice (ed Anderson D) Saunders,...
... human airway epithelial cells and in a variety of transformed alveolar epithelial cells Respir Res 2006, 7:132 Publish with Bio Med Central and every scientist can read your work free of charge ... evidence of apoptosis in primary human small airway epithelial cells Cigarette Cigarette smoke extract caused necrosis with no or little evidence of apoptosis in primary human small airway epithelial ... ethidium bromide and appeared red Percentage of viable (white bars), apoptotic (grey bars) and necrotic/late apoptotic (black bars) determined by counting as described in Materials and Methods Results...
... expression and subsequent PGE2 production via activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappa B in lung epithelial cells The full understanding of the role of ... role of TLR2 and TLR4 in NTHi-induced COX-2 expression in vivo, wild type, and TLR2 and TLR4 knock-out mice were intratracheally inoculated with × 107 CFU of NTHi strain 12, and mRNA expression of ... p38 MAPK and NF-kappa B-dependent manner through TLR2 in lung epithelial cells in vitro and lung tissues in vivo The full understanding of the role of endogenous anti-inflammatory PGE2 and its...
... design and coordination of the study HT and NM were involved in western blot analyses JF was involved in the design and coordination of the study and drafting the manuscript All authors read and ... cytopathic effect of L pneumophila on A549 alveolar epithelial cells is mediated via activation of caspase 3, 8, 9, and Therefore, the mode of cell death could be apoptosis and/ or pyroptosis, ... coordination of the study and drafting the manuscript FH measured HMGB1 levels, and was involved in the design and coordination of the study and drafting the manuscript KH, MA, SH, SY, MK and MT were involved...
... panel of human and rodent alveolar epithelial cell lines, such as human lung cancer cells (H1299), human lung epithelial cells (H441), murine type II epithelial cells (MLE-15), and rat lung epithelial ... variety of alveolar epithelial cells and in primary human small airFigure way epithelial cells Cigarette smoke extract differentially caused cytotoxicity in a variety of alveolar epithelial cells and ... endogenous levels of glutathione status and the amount of 4-HNE is formed IL-8 and IL-6 are important in the recruitment and activation of inflammatory cells The induction of these proinflammatory...
... gait and posture variables reflected specific joint lesions in sows Presence of 'stiff in front and rear legs' and 'forelegs turned out' were highly indicative of osteochondrotic and arthrotic lesions ... 11 variables of the gait and posture, of which buck-kneed forelegs, fore and hind legs turned out, and stiff in front and rear have been shown to be associated with osteochondrosis and arthrosis ... various lesions on the same articular surfaces and between lesionsof opposing articular surfaces in the elbow and knee joints were observed It was not obvious from the correlations which types of lesions...
... are shown in Figure Reactions with isolate V1 and T 551 gave similar bands but some of the T 551 bands were weaker The patterns of isolates T 603 and T 657 were also very similar Discussion To ... isolate T 551B had unique PFGE and RAPD patterns and most probably originates from the herd of which cow 551 was a member No typical lesionsof DD were reproduced in any of the animals in the challenge ... out most of the laboratory analyses, the interpretation of the results and the manuscript preparation LLF carried out the RAPD analysis and contributed to the evaluation of the results HH and MP...
... including interleukin (IL)-5, IL-6 and IL-13, known mediators of plasma cell and stromal expansion" [8] Premalignant lesions It is thought that most epithelial malignancies (and possibly all malignancies) ... colorectal-carcinomas in preexisting colonic lesions, and the occurrence of human malignant-melanomas in preexisting nevi The preexisting benign -lesions often undergo regression and rarely exhibit a malignant ... Lappé's system, the transformation rate of papilloma cells to malignancy was dependent upon the number and duration of papillomas and not upon a papilloma's degree of antigenicity In other words, the...
... an investigation of biophysiology and pathophysiology of cell growth and differentiation of hNESPCs isolated from xii healthy nasal mucosa and NP biopsies, and the implication of this cell model ... regulation of Treg and Th cells may contribute to the development of NP As the results of microorganism stimulation and inflammatory cells disorder, epithelial damage and remodeling occurred in NPs Epithelial ... Expression of p63 and Ki67 proteins 117 Figure 5.9 Expression of p63 and Ki67 proteins in the nasal mucosa of healthy controls and patients with NP 118 xvii Figure 5.10 TEER of cells...