antipurines in childhood acute lymphoblastic leukemia
Relapse prediction in childhood acute lymphoblastic leukemia by time series gene expression profiling
... typically involving grouping genes with correlated expressions into bins and then selecting representatives from each bin, have also been used One of the more interesting recent developments in gene ... effects of the training data, and result in prediction failures In contrast, unsupervised learning targets on classifying cases in a dataset into several subgroups by evaluating the major variance ... similarity is calculated between two clusters Candidates include single linkage, complete linkage, average linkage, and centroid linkage Single linkage takes the similarity of the nearest samples between...
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báo cáo hóa học: " Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" potx
... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the...
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báo cáo hóa học:" Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" docx
... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... determinants: monthly income level of parents and assigned hospital class during the diagnostic process Both determinants are obtained routinely during admission to the clinic and recorded in the...
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báo cáo khoa học: " Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia" docx
... insulin and leptin receptors are located in key brain areas, such as the hypothalamic arcuate nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling ... may be the reason of leptin resistance The closed-loop leptin/insulin feedback makes the GH/insulin/leptin relations understandable [30,31] According to Link et al leptin might serve as a good ... and leptin receptor genes on the metabolism of adipose tissue in survivors of childhood ALL In our cohort we found highly significant increase in leptin levels in overweight patients in the entire...
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Báo cáo y học: " Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia" ppt
... antimetabolite-based therapy of childhood ALL to illustrate the challenges we face in individualized medicine, and how they can be addressed Childhood acute lymphoblastic leukemia In the industrialized countries ... medicine and childhood acute lymphoblastic leukemia for implementing individualized medicine the following issues need to be addressed: The patients exhibit variable treatment responses in terms ... of childhood acute lymphoblastic leukemia Leukemia 2010, 24:345-354 Schmiegelow K, Bjork O, Glomstein A, et al: Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase...
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báo cáo khoa học: "The frequency of NPM1 mutations in childhood acute myeloid leukemia" doc
... TCTG-tandem duplication in NPM1exon 12 Leukemia 2007, 21:366-367 Rau R, Brown P: Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukemia: towards definition of a new leukemia entity ... mutations in 1485 adult patients with acute myeloid leukemia Blood 2006, 107:4011-4020 Ahmad F, Mandava S, Das BR: Mutations of NPM1 gene in de novo acute myeloid leukemia: determination of incidence, ... FLT3 mutations in childhood acute lymphoblastic leukemia Med Oncol 2009, 26:460-462 Thiede C, Creutzig E, Reinhardt D, Ehninger G, Creutzig U: Different types of NPM1 mutations in children and...
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báo cáo hóa học: " Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study" pdf
... Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339 ... frequently been used in pediatric oncology studies [22,32-34] and includes subscales with age-specific questions for determining problems in relevant areas during cancer treatment such as pain, nausea, ... confirm these findings and provide more detailed information on the relationship between sleep and QoL, and on factors affecting sleep in pediatric ALL and in children with cancer in general Abbreviations...
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Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt
... cell lines (such as human skin fibroblasts, glioblastoma and colon carcinoma lines) and primary lymphocytes [13-15] Furthermore, CD was induced by IR in human hepatoblastoma cell line performing ... irradiation; IR, ionizing radiation; HVR2, hypervariable region 2; nDNA, nuclear DNA; ALL, acute lymphoblastic leukemia; MGB, minor groove binder; ROS, reactive oxygen species; Competing interest: The ... (ALL) patients undergoging total body irradiation (TBI) precondionting as human beings in vivo irradiation model The advantage of using this model lies in full view of in vivo microenvironment,...
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báo cáo khoa học: "Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study" doc
... clinical significance of TEL-AML1 as MRD in CD 10 positive ALL is needed to determine how to best integrate TEL-AML1 testing into routine patient care Abbreviations ALL: Acute lymphoblastic leukemia; ... Masera G, Bartram CR: Minimal residual disease in childhood acute lymphoblastic leukemia: analysis of patients in continuous complete remission or with consecutive relapse Leukemia 1992, 6:282-288 ... Endo C, Oda M, Nishiuchi R, Seino Y: Persistence of TEL-AML1 transcript in acute lymphoblastic leukemia in long-term remission Pediatr Int 2003, 45:275-280 McLean TW, Ringold S, Neuberg D, Stegmaier...
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báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx
... expressed in myeloid leukemias [7,8] Conclusion We demonstrated the presence of the SET-NUP214 gene in the T-ALL cell line LOUCY and in the AML cell line MEGAL by genomic sequencing In both cell lines, ... SET-NUP214 screening in cell lines SET-NUP214 screening in cell lines SET-NUP214 expression screening performed with a SET exon forward primer and a NUP214 exon 18 reverse primer Cell lines LOUCY and ... recurrent deletion, del(9)(q34.11q34.13) in patients with T-cell acute lymphoblastic leukemia (T-ALL) [4] It has also been reported in a single case of acute myeloid leukemia (AML) [5] SETNUP214 positive...
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báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc
... showed that the inhibition of BCL11B expression by siRNA selectively inhibited proliferation and effectively induced apoptosis in human T-cell acute lymphoblastic leukemia (T-ALL) cell lines (Jurkat, ... other four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B mRNA expression in most T-ALL cases ... of caspases BCL2L1 may inactivate caspase-8 by decreasing death-inducing signaling complex (DISC) formation in the plasma membrane, nucleus, and Golgi complex while diverting DISC formation to...
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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report." doc
... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in longterm safety monitoring of the drug [11] Hartmut Geiger et al ... Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S: Treatment-related myelodysplasia and acute leukemia in non-Hodgkin’s lymphoma patients J Clin Oncol 2003, 21:897-906 Macdonald...
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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report" potx
... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T-ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... its mutagenic Page of potential Some clinical trials have started to include carcinogenic potential as a point of assessment in longterm safety monitoring of the drug [11] Hartmut Geiger et al ... Armitage JO, Carbone PP, Connors JM, Levine A, Bennett JM, Kroll S: Treatment-related myelodysplasia and acute leukemia in non-Hodgkin’s lymphoma patients J Clin Oncol 2003, 21:897-906 Macdonald...
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CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx
... hypotheses concerning an infectious origin of childhood leukemia ‘Population mixing’ hypothesis by Kinlen In early 1980, an unusual increase in the incidence of childhood leukemia was observed in young ... Identifying the Etiology of Acute Lymphoblastic Leukemia in Children http://dx.doi.org/10.5772/52716 [37] Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D Childhood acute lymphoblastic leukemia ... of the population mixing studies had failed to find an increase in a symptomatic infection in adults or children, paralleling the increase in leuke‐ mia incidence Considering that there are viruses...
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Báo cáo y học: "The impact of therapy for childhood acute lymphoblastic leukaemia on intelligence quotients; results of the risk-stratified randomized central nervous system treatment trial MRC UKALL XI" ppsx
... discussed below The finding of similar outcomes in males and females is reassuring Initial reports of inferior outcomes in girls came from relatively small studies using combinations of methotrexate ... neuropsychological outcome in ALL are poorly understood and in fact in other areas of acute brain injury, such as head injury, girls usually have better outcomes than boys Again, changes in therapy protocols ... intrathecal chemotherapy compared with 18 Gy cranial radiation as CNS treatment in acute lymphoblastic leukemia: findings from Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 J Clin...
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Báo cáo y học: " Precursor B-cell acute lymphoblastic leukemia presenting as obstructive jaundice: a case report" pdf
... rare presentation of acute lymphoblastic leukaemia in an adult JOP 2010, 11:72-74 Takamatsu T: Preferential infiltration of liver sinusoids in acute lymphoblastic leukemia Rinsho Ketsueki 2001, ... report any recent change in his medications and was tolerating his aspirin, sitagliptin, fosinopril, metformin and repaglinide without reported side effects His physical examination was significant ... biopsy of the liver showing small to medium-sized lymphoblasts infiltrating the hepatic parenchyma Page of Figure Bone marrow biopsy showing lymphoblastic infiltration instructions to follow up...
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In vitro and in vivo study of ABT 869 in treatment acute myeloid leukemia (AML) alone or in combination with chemotherapy or HDAC inhibitors insight into molecular mechanism and biologic characterization
... Phosphoinositide 3-kinase Promyelocytic Leukemia Zinc Finger protein Phosphatase of Regenerating Liver Retinoblastoma Protein Red Fluorescence Protein RNA interference Receptor Tyrosine Kinase ... Shock Protein 90 Indirubin Derivative Interferon gamma-inducible gene 16 Immunohistochemistry Intraperitoneally Internal Tandem Duplication c-Jun N-terminal Kinase Kinase Insert Domain Receptor ... CCAAT/enhancer-binding protein α Chromatin Immunoprecipitation Combination Index Chronic Myelogenous Leukemia Colorectal Carcinomas C-terminal Src Kinase 4'-6-Diamidino-2-phenylindole Disease...
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báo cáo hóa học:" High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia" pot
... protein for phosphoserin motifs Regulated the interactions and subcellular localization of signalling molecules γ-Catenin Forms a complex with α- and β-Catenin to Cadherins, that are involved in ... formation and maintenance of the histo-architecture Plasmonogen activator inhibitor-2 (PAI-2) Involved in the regulation and inhibition of binding between urokinase-type plasminogen activator ... distinguishes between acute lymphoblastic leukemia in infants and in older children Blood 1989, 73(2):527-532 Strahler JR, Kuick R, Hanash SM: Diminished phosphorylation of a heat shock protein...
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báo cáo hóa học:" Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells" potx
... able to induce apoptosis in leukemia cells via caspase activation and involvement of both intrinsic and extrinsic pathways of apoptosis Background The Endocrine Disrupting Compounds are defined ... FLIP: FLICE Inhibitor Protein; TRAIL: TNF Related Apoptosis Inducing Ligand; RA: Retinoic Acid; RB: Retinoblastoma Competing interests The authors declare that they have no competing interests ... sub-G1 peack in all the cell lines tested, HL60 being the most resistant one In NB4 cells, a model from promyelocytic leukemia containing the fusion protein PMLRARα and sensitive to retinoids, the...
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