another management at each institution is responsible for
Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... determined at two different substrate concentrations of carnitine: mm (for standard comparison with other published data), and a concentration equal to the Km for carnitine of each enzyme (for comparison ... analyzed at carnitine concentrations equal to the Km for each enzyme Each construct was assayed at least three times with at least two independent mitochondrial preparations Values statistically ... glutamate by aspartate at position 17, and isoleucine by valine at position 31 However, the sole amino acid change between pig, human and rat CPT1B is the substitution of glutamate by aspartate at...
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Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... of an isoleucine, a b-branched amino acid that is not exible In the active conformation, Val371 forms contacts with neighboring residues that are important for stabilizing the active state (e.g ... zymogen (red) and activated (green) FXI The Ile371 residue, in both structures, is displayed by space-lled atoms The catalytic triad (blue space-lled atoms) is also shown The conformational movements ... represented by mutations within the FXI gene (F11), which is located on chromosome 4q35.2 and consists of 15 exons spread over a genomic region of $ 23 kb To date, > 100 mutations responsible for FXI deciency...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... and r32 are cytosolic substrates for HflB In addition, HflB also acts on several membrane-associated substrates, for which the mechanism of proteolysis is probably somewhat different [21] Whether ... only for CII? We examined the mode of the inhibitory action of CIII on proteolysis of the heat shock sigma factor r32, another substrate of HflB Like proteolysis of CII, r32 proteolysis requires ATP ... this proteolysis is much slower in vitro, because of a lack of chaperone machinery The in vitro proteolysis requires ATP [14] We examined the proteolysis of purified r32-C-his (1.2 lm) by glutathione...
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Báo cáo khoa học: Human salivary a-amylase Trp58 situated at subsite )2 is critical for enzyme activity potx
... mediate the information flow during substrate binding and catalysis [13] The conformation adopted by the loop structure in W58L is another snapshot for different possible conformations that can ... exception is the region 304–310, the mobile surface loop, which adopts a completely different conformation (Fig 4B) This adaptation of a loop conformation is in accordance with the absence of substrate ... sample chromatogram is given in Fig 2B and the distribution of the products were calculated for a given substrate and summarized in Table The product distribution for the W58L mutant is different...
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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
... showed that the increase in the amount of saturated fatty acids observed under conditions of impaired unsaturated fatty acid synthesis (i.e heme depletion) is specifically associated with phosphatidylinositol ... cytoskeletal regulation [1–5] The fatty acid composition of this phospholipid is quite distinctive in living organisms because, in comparison with other phospholipids, PI is by far the most saturated In ... synthesis, it might be involved in the stearic acid incorporation after the de novo synthesis of this lipid (i.e the second hypothesis) According to this hypothesis, previously raised for mammals...
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Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc
... 4-t-Butyl catechol, 4-methyl catechol, and catechol have been shown to have synergistic effect on the oxidation of Dopa by tyrosinase It has been demonstrated that this effect is mediated by oxidation ... precise (150 mV for Dopa and 195 mV for compound 1), but indicate that the formation of the phosphonic o-quinone is not favored Thus, two other factors drive the reaction: much slower enzymatic ... characteristics of the diphenolic substrate modulate the rate of oxidation [23,25], it appears that the size of the side substituent is not the primary factor It has been demonstrated recently that...
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Báo cáo y học: " JNK activation is responsible for mucus overproduction in smoke inhalation injury" potx
... contributions WIC was responsible for carrying out the experiments, for data analysis, and for drafted this manuscript; KYK was responsible for the analysis and design for the histologic study; OS ... 0.01 M phosphate buffered saline (PBS) for min, the sections were digested with Proteinase K (20 μg/ml) at room temperature for 20 min, and were washed twice with distilled water for each The endogenous ... of luminal obstruction for each cross-sectioned airway present A mean obstruction score was determined for each animal and then for each group [6] Pathology scoring The pathological changes were...
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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... indicates that the binding of ATP per se is the ‘power stroke’ for drug translocation, and that energy obtained from the hydrolysis process is used to reset the transporter That ATP binding is responsible ... phosphate Thus, ATP and vanadate generate an ADP-vanadate structure mimicking the transition state for the hydrolysis of the c-phosphate of ATP [30] Figure demonstrates the effect of pre-incubation ... conformation to prevent dissociation, and that reorientation occurs following harnessing of the energy from ATP hydrolysis If one of the initial events in the nucleotide catalytic cycle is responsible...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... AGC ATC TTC CAT GGC TTG ATC 3¢ 5¢ ATA CAC ACA AAC TCA CAA GG 3¢ 5¢ CAA CAT ATT TTA AAT AAA ATT GAC AAT 3¢ 5¢ ATA AAA ATG GTA TAC CTC ACT TGT*C 3¢ 5¢ TAA CAA TGA TTC TCT TTC TTT TAG 3¢ 5¢ AAT CTT ... phosphatase hydrolysis), corresponding to that expected for the F variant This result is the first evidence for the heterozygous status (M/F) of the individual goat milk analysed In addition to this, ... CAG ATA TTG AAA AGG AG 3¢ 5¢ CCA GTG AAT ATT CAG GAC TGA T 3¢ 5¢ AGG CTC TAG CAT GAT TTG ATG T 3¢ 5¢ GCA TTT TTA TTT TGA ATG TAA A 3¢ 5¢ TAG TTC AAA TGC ACA TCT TAT 3¢ 5¢ GGC AGA GAA TAC GTT TAT...
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Báo cáo khoa học: ATPase activity of RecD is essential for growth of the Antarctic Pseudomonas syringae Lz4W at low temperature potx
... In each case, Vmax (maximal rate of ATP hydrolysis), Km(ATP) (ATP concentration at the half-maximal rate of reaction) and Km(DNA) (DNA concentration at the halfmaximal rate of ATP hydrolysis) for ... this study for stimulation of ATPase and preparation of various helicase substrates for RecD Table S2 Primers used in this study for cloning and mutagenesis of P syringae recD This material is ... for the reactions were calculated Km(ATP) was determined at a saturating concentration (1 lm) of ssDNA, and Km(DNA) was calculated at a saturating concentration of ATP (2 mm) The values obtained...
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Báo cáo Y học: Barley a-amylase Met53 situated at the high-affinity subsite )2 belongs to a substrate binding motif in the bfia loop 2 of the catalytic (b/a)8-barrel and is critical for activity and substrate specificity pot
... activity for insoluble Blue Starch may reect that substrate binds at (an) as yet unidentied site(s) which is (are) situated far from the site of catalysis and can compensate for hampered substrate ... the typical distortion of the substrate ring at subsite )1 in GH-H catalyzed reactions [66], resulting in very low rate of catalysis, this mutation also promoted transglycosylation This, together ... Terminator Cycle Sequencing kit, PerkinElmer) and the plasmid was used for P pastoris transformation by electroporation [50] upon linearization at the BstXI site Screening was performed for Zeocin...
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Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot
... minutes at 50°C and 10 minutes at 95°C for AmpliTaq Gold activation, followed by 40 cycles of 15 seconds at 95°C for denaturation and minute at 60°C for annealing and extension The specificity of each ... When B-Raf is mutated, oxaliplatin induces TAp73 downregulation, while when B-Raf is wild type, the treatment induces TAp73 upregulation This induction is maintained when the treatment is combined ... were added at the concentrations indicated and incubated for 48 hours at 37°C The concentrations were 10 nM Cetuximab (recommended concentration by Merck and the most used concentration used...
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Báo cáo sinh học: " Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection" ppt
... infection and pathogenesis is not well understood MHV strain 3, which causes fulminant hepatitis, was shown to induce the synthesis of PGE2 in macrophages [25] However, the exogenous administration of ... mock-treated (control) cell cultures Data are presented as mean ± standard error of mean (n = 6) For statistical analysis a one-way ANOVA with the TukeyKramer test was performed using GraphPad Prism ... Analysis of the defects responsible for the impaired regulation of EBVinduced B cell proliferation by rheumatoid arthritis lymphocytes II Role of monocytes and the increased sensitivity of rheumatoid...
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Báo cáo hóa học: " Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection" pptx
... infection and pathogenesis is not well understood MHV strain 3, which causes fulminant hepatitis, was shown to induce the synthesis of PGE2 in macrophages [25] However, the exogenous administration of ... mock-treated (control) cell cultures Data are presented as mean ± standard error of mean (n = 6) For statistical analysis a one-way ANOVA with the TukeyKramer test was performed using GraphPad Prism ... Analysis of the defects responsible for the impaired regulation of EBVinduced B cell proliferation by rheumatoid arthritis lymphocytes II Role of monocytes and the increased sensitivity of rheumatoid...
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Báo cáo hóa học: "Amplify-forward relaying for multiple antenna multiple relay networks under individual power constraint at each relay EURASIP Journal on Wireless Communications and " doc
... noted before, the articles that investigate this configuration either suggest the relay gain matrix heuristically or concern another constraint such as a limited power constraint at the destination, ... ni for i = 1,2, ,K and n are assumed to be statistically independent Furthermore, as it is noted earlier, a scalar operation is merely done at each destination In other words, the weight matrices ... SNR (TSNR) is set to 12 dB It can be observed that for each channel realization, there is an optimum value for η that is dependent upon the instantaneous first and second hop channel matrices Thus,...
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summary of doctoral dissertatio market risk management at vietnam joint stock commercial bank for industry and trade
... banks Therefore, when working on issues of market risk management, this thesis only focus on issues: interest rate risk management and foreign currency risk management 2.2.1 Real situation of interest ... Finance Division RiskManagement Division Human Resources Division Marketing Division Information Division Supporting Division Business Division Treasury & Capital Market Division Business Division ... the dissertation Therefore, it can be confirmed that the thesis titled “ Market risk management at Vietnam Joint Stock Commercial Bank for Industry and Trade” is the first doctoral dissertation...
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Báo cáo khoa học: " Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells" pot
... USA) Statistical analysis Results are shown as mean ± SE Statistical analyses were performed following analysis of variance (ANOVA) for multiple comparisons or Students t-test when data consisted ... added to each well, and the plates were incubated for additional hrs at 37oC After removing media, 100 µl of DMSO was added to each well The plates were shaken for 10 at room temperature, and ... concentration-dependent increase of Apaf-1 protein expression at early time point However, such pattern was not found at later time-point, indicating that initial apoptosis is associated with...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" ppsx
... after irradiation This group of patients could not be distinguished from the other patients by any of the patient characteristics listed in Tables and In the patients who developed infiltrates, levels ... co-localisation of inflammatory lesions and local accumulation of SBCs was seen (Figure 3) The latter group of patients could not be distinguished from the other patients by any of the characteristics ... (FcγR)-mediated clearance of apoptotic cells It is conceivable that this leads to inflammation given that ligation of FcγR induces the release of pro-inflammatory cytokines [17,18] In this study,...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" pot
... containing 5% non-fat milk for hour at room temperature followed by incubation overnight with the appropriate antibody at 4°C The membrane was washed three times and incubated with horseradish peroxidase-conjugated ... microplate reader at an excitation wavelength of 530 nm and an emission wavelength of 590 nm The number of cells is expressed as relative fluorescence units Statistical analysis Data are expressed ... PUMA-mediated apoptosis requires functional p53 It is of interest that neither of these relationships is effective in cultured FLS This cell lineage can Page of (page number not for citation purposes)...
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Báo cáo y học: "Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes" pptx
... destruction rather than formation of the cartilage extracellular matrix by chondrocytes Thus, metabolic homeostasis is perturbed at the cellular level in OA because chondrocyte catabolism predominates ... proanabolic activity for matrix formation is exclusively mediated through activation of FGFR3 in human articular cartilage [33] Accumulated cell-associated proteoglycan and cellular proliferation were ... and that activation of FGFR3 by FGF18 is anabolic for human articular cartilage homeostasis [33, 34] FGFR1 is responsible for the upregulation of MMP-13 and ADAMTS5, as well as downregulation...
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