andrea damascelli probing the electronic structure of complex systems by arpes
Báo cáo khoa học: Probing the unfolding region of ribonuclease A by site-directed mutagenesis potx
... studied the effect of the mutations on the thermodynamic and kinetic stability. The similarity of the impact on both the thermodynamic and kinetic stabilitiessuggests a predominant effect on the ... stability is caused by destabilization of the native state relative to th e unfoldedstate. The decrease in the thermodynamic s tability of the other less s table v ariants, all of which were exclusivelyobtained ... Fstartis the signal of the substrate before the addition of enzyme, Fendis the signalafter cleavage of all substrate, and [E] is the concentration of RNase A .CD spectroscopyCD spectra of RNase...
- 10
- 491
- 0
Tài liệu Báo cáo khoa học: The crystal structure of human a-amino-b-carboxymuconatee-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis ppt
... present for the last four residues at the C-terminus. The stereochemistry of the model hasbeen assessed using the program procheck [23]. Ninetyper cent of the residues fall in the most favouredregions ... metal-bound hydroxyl group onto the substrate, as observedin other members of the amidohydrolase superfamily[24,25]. However, as no structure of complexes witheither the substrate, product or inhibitors ... content of 50%. Data were pro-cessed using the program mosflm [38], and the ccp4 suite of programs [39] was used for scaling. Structure deter-mination for hACMSD was performed by means of the...
- 9
- 796
- 0
Tài liệu Báo cáo khoa học: The crystal structure of coenzyme B12-dependent glycerol dehydratase in complex with cobalamin and propane-1,2-diol pptx
... A˚resolution by the molecular replacement method. The schematic view of the overall structure is shown in Fig. 3A.Theenzymeexistsasadimeroftheabc heterotrimer. Thereis a noncrystallographic twofold ... cob(II)alamin by X-rayirradiation [59]. Therefore, we believe that the structure reported in this paper is also that of the glyceroldehydrataseÆcob(II)alamin complex. The dihedral angle of the northern ... from a bulk of water by the corrin ring of cobalamin. Figure 4B shows the structure around the enzyme-bound cobalamin. The cobalaminmolecule is bound between the a and b subunits in the so-called...
- 11
- 602
- 0
Tài liệu Đề tài " The causal structure of microlocalized rough Einstein metrics " pptx
... the form curl/π(2)+ E(2).5. Strategy of the proof of the Asymptotics TheoremIn this section we describe the main ideas in the proof of the AsymptoticsTheorem.(1) Section 6. We start by ... given a detailed proof of the theorem by relying heav-ily on a result, which we have called the Asymptotics Theorem, concerning the geometric properties of the causal structure of appropriately ... I+0is the future domain of the originon Σ0.Remark 9.3. The proof of Corollary 9.2 requires an extension argument. The estimates of the Asymptotics Theorem, which are uniform with respectto the...
- 50
- 407
- 0
Tài liệu Báo cáo khoa học: Probing the molecular determinants of aniline dioxygenase substrate specificity by saturation mutagenesis docx
... to the enzyme. This may indicate that the steric limitation of the enzyme’s binding pocket takes place in the areabetween the ortho and para positions of the aromaticsubstrate.On the basis of ... removes the steric hindrance and allows the approach of 2IPA towards the catalytic iron.Residue I248 lies at the entrance of the substrate-binding pocket of the enzyme, leading to the substratechannel. ... [14]. The lack of characterization of the structural determinant of the substrate specificity of the AtdA enzyme has thus limited its development as abiocatalyst for the bioremediation of a wide...
- 12
- 634
- 0
Tài liệu Báo cáo khoa học: "Understanding the Semantic Structure of Noun Phrase Queries" pptx
... bestIM:Type full timeIM:Title the godfatherOther the, in, that Other the, in, that Other the, in, thatTable 3: Label sets and their respective query segment examples for the intent class Movie, Job ... goal of this work is to identify the semantic labels of IMs,i.e., the attribute names they implicitly refer to. Weuse Acto denote the set of IM semantic labels for the intent class c.OtherAdditionally, ... name of an intent class.For example, the IH of the query “alice in won-derland 2010 cast” is “cast”, which is an attributename of Movie. By issuing the query, the user in-tends to find out the...
- 9
- 674
- 0
Tài liệu Báo cáo khoa học: The solution structure of reduced dimeric copper zinc superoxide dismutase doc
... A˚,respectively, for the backbone of the two subunits. The difference between rmsd of monomeric and dimeric speciesis due to the indetermination of the reciprocal orientation of the two subunits. The average ... was used to back calculate the NOESYcross-peaks from the calculated structure to assess the quality of the structure. The final family was made up of 30 structures with the lowest target function. ... is c onsidered. The c omparison of the present structure with the X -ray structures of the humanoxidized protein ( 1SOS) [11] and its G 37R mutant [50]show that the protein has the same folding...
- 11
- 575
- 0
Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... to the active site. To dissect the structure function relationships of the LPL carboxyl-terminal domain, several residues predicted by the model structure to be essential for the functions of ... modeling of the dimeric structure of LPL. Two dimeric model structures of LPL were constructed usingINSIGHT IIversion 2000 ona Silicon Graphics workstation. The model structure of the closed ... on the crystal structures of the human, porcine, and horse PLs(Fig. 1). A frontal view illustrates the overall saddle shape of the dimeric structure and the key heparin-binding residuesin the...
- 10
- 679
- 0
Publicly Funded Agricultural Research and the Changing Structure of U.S. Agriculture doc
... secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the ... 20418NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawnfrom the councils of the National Academy of Sciences, ... recognizes the superiorachievements of engineers. Dr. Wm. A. Wulf is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciencesto...
- 158
- 403
- 0
Báo cáo khoa học: The crystal structure of NlpI A prokaryotic tetratricopeptide repeat protein with a globular fold potx
... ª 2004 FEBS the full-length HOP, they act to facilitate the assembly of multichaperone regulatory complexes. The struc-tural independence of these TPR domains, and the presence of independent ... First, the only structures of natural TPRs in the PDB (13 TPR-containing coordi-nate sets) consist of nonglobular, extended arrays of helices [9,10,13–21]. Second, the majority of these(11 structures) ... TPR1 and TPR2A of ABDCFig. 2. Solubility of NlpI constructs and the structure of mature NlpI. (A) 10–20% gradient SDS ⁄ PAGE of NlpI expression products, showing the insolubility of the 3-TPR construct...
- 14
- 433
- 0
Báo cáo khoa học: "Understanding the thematic structure of the Qur’an: an exploratory multivariate approach" pdf
... another than to any other profile in the data set. The profiles of G can be summarized by a vector s whose dimensionality is that of the data, and each of whose elements contains the mean of ... disparity in the frequency of its occurrence in A and B is the first significant finding of the proposed methodology. The scaling of the ‘Allah’ variable dominates all the other variables. ... understanding their thematic interrelationships the object of this exercise—but it is not sufficient because it provides no information about the thematic characteristics of the clusters and the thematic...
- 6
- 309
- 0
Báo cáo khoa học: Probing the catalytic potential of the hamster arylamine N-acetyltransferase 2 catalytic triad by site-directed mutagenesis of the proximal conserved residue, Tyr190 pot
... [27]. On the basis of the Ping Pong mechanism, the acetylation rate (k2 )of NAT2 by the acetyl donor is independent of the trans-acetylation rate (k4) of the arylamine substrate.Because the values ... the active site. The more dras-tic mutations, Y190I and Y190A, however, revealed the importance of the phenyl ring of the Tyr sidechain on the pH dependence of enzyme acetylation.Both of the ... trunca-tions, the availability of the Tyr190 mutants makes itfeasible to conduct cell-based studies of the effects of the stability of the acetylated enzyme intermediate on the N-acetylation of aromatic...
- 14
- 350
- 0
Báo cáo khoa học: Molecular mass of macromolecules and subunits and the quaternary structure of hemoglobin from the microcrustacean Daphnia magna ppt
... orientation.Accordingly, the present data on the molecular mass of the native Hb complex as well as the Hb subunitsare inconsistent. In addition, there are only two hypo-thetical models concerning the structure of ... identification of the carbohydrates bound toD. magna Hb subunits, saccharides were released by methanolysis and separated by GC followed by MS.Chromatograms of the carbohydrates of D. magna Hb, of the ... of this interesting molecule. The present study has contributed to this approach:(a) the determination of the molecular mass of the native Hb complex and its subunits as well as the number of...
- 18
- 499
- 0
The Economic Structure of Intellectual Property Law pot
... reduceoutput by restricting the use of the property, and if so this is as much a cost of the property right as the cost of the fence is. Suppose the owner of a shop-ping center does charge for the use of ... for the original. In the case of books and other printed matter, the copier may not beable to match the quality of paper or binding of the original or the crispness of the printing, and there ... numerous, the trans-action costs of their buying the right to use the river from the factory may ex-ceed the value of the right to them. In such a case a liability rule would bebetter, whereby the...
- 449
- 460
- 1
Báo cáo khoa học: Methods to monitor the quaternary structure of G protein-coupled receptors doc
... both by the orientation of the energy transferpartners and by the distance between them [28]. The fact that the efficiency of transfer varies with the 6th-power of the distance between the fluorophorespresents ... is not promoted by the bivalent nature of the antibodies. In studies assessing the effect of ligand-binding on the quaternary structure of the receptors, the possibility that the antibodiescould ... in 50% of the maximalefficacy (R0). As indicated by the Fo¨rster equation, the efficiency of transfer varies inversely with the 6th-power of the distance. The extreme steepness of the relationship...
- 12
- 337
- 0
Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25