and or active drug delivery strategies

Model development and numerical simulation of thermo sensitive hydrogel and microgel based drug delivery

Ngày tải lên : 26/11/2015, 12:31

... since most works are experimental-based Few efforts have been made on the theoretical understanding and model development For example, Varshosaz and Falamarzian (2001) claimed that drug release ... thesis, and his dedication to research and preciseness inspire me in my future work Specially, I want to thank Dr Wang Xiaogui for his contribution and support throughout the course of study and ... Rongmo and Zhang Jian for their encouragement, help and friendship during the course of research and study Finally, I greatly appreciate the constant support, love and concerns of my parents and...

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Transdermal and Topical Drug Delivery Principles and Practice doc

Ngày tải lên : 05/03/2014, 22:21

... 2011019937 Printed in Singapore 10 For my husband Tony for his patience and support, and Tom, Sam, and Victoria for their inspiration Heather For my wife Becky, my mum and dad, and my brother Tom Adam ... Product Development for Transdermal Drug Delivery: Understanding the Market Opportunity 345 Hugh Alsop 18 Transdermal and Topical Drug Delivery Today 357 Adam C Watkinson 19 Current and Future Trends: ... nitroglycerin for cardiovascular disorders, estradiol and testosterone for hormone replacement, fentanyl for pain management, nicotine for smoking cessation, rivastigmine for Alzheimer ’s disease, and methylphenidate...

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drug targeting, strategies, principles, and applications

Ngày tải lên : 10/04/2014, 22:17

... delivery used the plant toxin ricin or its enzymatically active A chain as the bioactive agent for intracellular delivery (2–7), whereas subsequent work used saporin (8) or gelonin (9) Access to the ... Vol 25: Drug Targeting: Strategies, Principles, and Applications Edited by: G E Francis and C Delgado © Humana Press Inc., Totowa, NJ 27 28 Newton and Rybak Centricon and 30 microconcentrators (Amicon ... should be stored in the pyridyl disulfide-modified form until just before use The thiol group is very reactive and unwanted conjugations will result if the thiol form is allowed to remain for any...

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electrochemotherapy, electrogenetherapy and transdermal drug delivery

Ngày tải lên : 11/04/2014, 00:29

... of cell transformation and cell coloring suggest that the mechanism for the electroporative transport of both genes and drugs into 22 Neumann, Kakorin, and Toensing the cell interior has essential ... pore formation and enlargement of existing pores Principles of Electroporation and Transport 2.1.2 Born Energy and Ion Transport Membrane electropermeabilization for small ions and larger ionic ... the pore formation The curvature term ∫∆ r β dH can be as large as a few kT per one pore (30) For small vesicles or small organelles and cells the curvature term is particularly important for the...

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báo cáo hóa học: " Beyond platinum: synthesis, characterization, and in vitro toxicity of Cu(II)-releasing polymer nanoparticles for potential use as a drug delivery vector" ppt

Ngày tải lên : 21/06/2014, 02:20

... loading and stimuli-responsive release of transition metals and any drug molecule in general from a delivery are major factors that ultimately determine the success or failure of that vector when ... UNT Laboratory of Imaging and Mass Spectrometry and the UNT Center for Advanced Research and Technology MC was an NSF-REU scholar (grant CHE-1004878) at the University of North Texas Authors’ contributions ... thank Guido Verbeck and William Hoffmann for their help with ICP MS studies, Nancy Bunce, David Diercks, and David Garrett for aid with EDX, XPS, and SEM analysis Portions of this work were conducted...

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Báo cáo hóa học: " Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Leve" pptx

Ngày tải lên : 22/06/2014, 00:20

... be used for controlled drug delivery: any bioactive factor could be released in a spatially and temporally controlled manner The proposed approach represents an interesting solution for building ... experiments The CNT array owns a forest-like structure that could be exploited for the deposition of a polymeric thin ﬁlm acting as drug delivery device For drug release kinetics investigation, ... should have ideal properties (low detection limits and high temporal resolution) for capturing neural signalling events Nguyen and collaborator also found that PC12 cells cultured on PPy-coated...

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báo cáo khoa học: "Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis" pptx

Ngày tải lên : 11/08/2014, 00:22

... importance in pharmaco-gene therapy of CF airway [6] In this study, proteasome inhibitors- LLnL and doxorubicin enhanced the CFTR gene delivery and hence CFTR-mediated short-circuit currents Moreover, ... vehicles for bronchial epithelial cell delivery targeted delivery into specific sites and across complex biological barriers The development of novel nano-systems for pulmonary gene or drug delivery ... The nanodrug delivery system here provides controlled and sustained PS-341 delivery for selective inhibition of proteostasis Recent studies have identified several novel “correctors” and molecular...

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SELF ASSEMBLY AND DRUG DELIVERY IN AMPHIPHILIC PEPTIDES MICROSCOPIC INSIGHTS FROM COARSE GRAINED SIMULATIONS

Ngày tải lên : 09/09/2015, 08:13

... for the formation of a nanodonut structure.38 Chapter Introduction 1.3.3 Drug and Gene Delivery The hydrophobic core and hydrophilic shell formed by amphiphilic peptides can be used for drug delivery ... biodegradable and kinetically stable.11 In this context, amphiphilic peptides have emerged as “smart” materials for drug delivery They were tested for delivering drug or gene or both, and better ... biodegradable and biocompatible, important characteristics for ideal drug carriers They can form nano-sized micelles with hydrophobic cores allowing for encapsulation of hydrophobic drugs, and thus...

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Application of biologically active micelles in drug delivery across the blood brain barrier

Ngày tải lên : 11/09/2015, 09:10

... couple or physical force to encapsulate the drug molecules to a vector or carrier The vector or carrier may help drug molecules cross the BBB through receptor mediated transcytosis or absorptive ... (Begley and Brightman, 2003) 3.1.4 Active transport Active transport system is the most important transport pathway in the drug delivery from the blood to the brain It can be divided into absorptive-, ... vector for CNS delivery and can be linked to a drug or biologically active peptide or protein which normally can not cross the BBB The binding of the OX26 antibody to the transferrin receptor...

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Drug delivery systems for antiangiogenesis and anticancer activities

Ngày tải lên : 11/09/2015, 09:58

... antiangiogenesis inhibitors in different phases of clinical trials 1.3 Drug delivery system for vascular targeted antiangiogenesis or antitumor therapy 1.3.1 Conjugation of drug with ligand for vascular ... cells and normal organs And some tumor cells also express integrins on their cellular membrane surface All of these characteristics make integrin a good targeting ligand for both tumor and antiangiogenesis ... Jain and co-workers have proposed that certain antiangiogenetic agents can transiently normalize the abnormal structure and function of the tumor vasculature, and make it more efficient for oxygen,...

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Multifunctional folate conjugated polymeric micelles for active intracellular drug delivery

Ngày tải lên : 12/09/2015, 08:20

... the structure and physiology of normal and tumor tissues can be used for designing drug delivery systems facilitating tumor-specific delivery of the drug or prodrug and specific drug activation ... different tumor models, drug sensitive model and drug resistant model, were compared Different drug formulations were evaluated to compare their targeting ability and MDR inhibition Tumor and heart ... Chapter 2.1.3 Tumor Targeting In general, three destinations in the tumors are used as targets for delivery of anticancer drugs-tumor vasculature, extracellular space in the tumors and tumor cells Mechanisms...

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Controlled release alginate based microparticulate systems for drug delivery and chemoembolization

Ngày tải lên : 13/09/2015, 20:39

... gratitude and appreciation for their support and encouragement over the years of my study And my special thanks and appreciation to my wife and my daughter for their encouragement and patience ... -D-mannuronate (M for short) and -L-guluronate (G for short), linked randomly by -1,4 and -1,4 glycosidic bonds Sodium alginate, which is available commercially, is used primarily for its ability to form an ... been developed as a drug delivery system (DDS) for many peptide and protein drugs (Chan and Heng, 1998) An ideal DDS is able to control the drug concentration at the target site for a desired period...

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Advanced control strategies for automatic drug delivery to regulate anesthesia during surgery

Ngày tải lên : 14/09/2015, 08:25

... of the drugs This would be useful for optimizing the drug dosages while not compromising on patient’s comfort and safety during and after the surgery • Constraints on drug delivery rate and maximum ... is to develop the MPC control strategies for regulation of hypnosis with various drugs and thoroughly evaluate and compare MPC controller’s performance with the performance of other control structures ... compensation, handling of input and output constraints and drug minimization 1.2 Drugs and their Eﬀect during Anesthesia • A well-designed drug administration policy should suppress the inter- and intra-individual...

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Design and fabrication of microneedles for drug delivery

Ngày tải lên : 14/09/2015, 11:17

... varying delivery of different therapeutics, which is essential for a more effective drug delivery system The direct delivery of DNA/portent based drugs into the metabolic system and the continuous delivery ... there for me and watching over me I also would like to thank my parents and the rest of my family, for their understanding and continual support I would like to thank my mum and dad for their ... are designed for transdermal therapies to deliver drugs such as insulin and heparin On the other hand, microneedles can also be used for local delivery of other drugs, for example, drugs in anti-restenosis...

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