and old strategies for the design of antibacterial screening libraries
Báo cáo khoa học: The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity pot
... lactis The results are presented in Table and Fig 4A For the cluster of lowest energy, both the position and the conformation of the ligand are close to those observed in the 3D structure of the ... group of the ligand and the NH2 of Asn470 (equivalent to Asn710 in DPP-IV) Another potential bond can be proposed between the OH atom of Tyr380 and the carbonyl group of the ligand Finally, the ... comparison of the active and specificity sites of the two X-PDAP enzymes, the bacterial PepX (green) and the human DPP-IV (orange) (B) Superposition of the active and specificity sites of the S9 enzymes...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 1
... routes by which the aforementioned environmental toxicants enter the body are through the skin, the lungs, and the gastrointestinal tract and they biotransformed within the body by the process called ... incidentally is the fourth, most common cancer in Singapore For the better understanding of the role of xenobiotics in the progression of ovarian cancer, it is necessary to monitor the levels of these ... plasma and serum Using these techniques, we explored ovarian tumor cyst fluids, one of the less explored body fluids in terms of composition of xenobiotics and their impact on the severity of the...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 2
... [5-8] Therefore, determining the level of estrogens in these body fluids would be very important for the study of their roles in the carcinogenesis of ovarian and breast cancer The role of estrogen ... prepare the device, the longer edge of a polypropylene sheet was folded over to a width of ~2 cm The edge of the fold-over flap was then heat sealed using an electrical sealer to the main sheet The ... coefficients (r) of between 0.996 and 0.999 were obtained This allowed the quantification of the compounds by the method of external standardization The limits of detection (LODs) for the analytes...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 3
... biplot, the observations are the samples and the variables are the chemicals present in those samples In a biplot, the length of the lines approximates the variances of the variables The longer the ... data The goodness of the biplot approximation depends on the axes and the points As for the points, the `quality' of the PCA approximation is found from the R program In this case, the quality 0.627 ... (ultrasonication for 10 with mL of acetone) and stored in the same solvent The choice of sorbent for these four groups of EDCs was tested using different sorbent materials for better extraction efficiency For...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 4
... min-1 and 5˚C min-1 to 320˚C (hold for 10 min) µL of the sample was injected into the GC-MS in splitless mode and the total GC-MS analysis time was 55.00 SIM mode employed for the set of target ... because of their environmental ubiquity and persistence For instance, in a report of a large and statistically representative sampling of 1,800 individuals 12 years of age and older from the U.S ... probable that the dilution reduced the extent of interferences by the protein (clogging on the membrane) and the low viscosity of the matrix that allowed more efficient extraction Standard safety...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 5
... environmental exposure [1-3] The number of elements of interest has increased in the recent decade, not only the trace metals but the heavy metals as well The study of the role of the trace elements has ... emphasized in the search for the possible causes of cancer The International Agency for Research on Cancer has proposed trace elements for their carcinogenesis [4, 5] Some of them or their compounds ... research for the determination of trace metal status of individuals and groups [9-11] Nonetheless, in the case of ovarian tumor, both benign and malignant ovarian cyst fluids are good source of information...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 6
... into the GC syringe and the needle of the syringe was inserted into hollow fibre to about 0.2 cm of the tip of the syringe needle was covered by it The hollow fibre was then dipped into the organic ... that of human the prediction of rate of accumulation of estrogens in zebrafish can reveal the effects of xenobiotic estrogens on humans [12] There is a direct correlation between the rate of bioaccumulation ... a mL vial The organic solvent in the GC syringe was released into the channel of the hollow fibre after which the stir bar in the aqueous phase was activated and at the same time, the stopwatch...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 7
... after the discovery of the first angiogenesis inhibitor and the purification of the first angiogenesis protein in the mid 1980s that resulted in the widespread acceptance of the concept The discovery ... However, as of today, there is no known crystal structure of the protein available Therefore, in an attempt to further comprehend the molecular factors of the biological activity and the chemistry involved, ... molecular mass of polypeptides The speed of migration is dependent on the size of the ‘pores’ in the gel mesh which is in turn determined by the percentage of acrylamide present in the gel The polyacrylamide...
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Bioanalytical strategies for the quantification of xenobiotics in biological fluids and tissues 8
... relevant to the objective of the study Further, the cyst fluids were studied for their and inorganic trace element levels by applying a combination of high throughput analytical strategies The accumulation ... the benign groups With the aid of PCA, their trend in the two groups of samples is compared and individual and compound group trend analysis was also explored in detail In the case of PCBs, the ... understand their synergic effect on the malignant transformation and etiologic research of cancer Based on the conclusions drawn from the current work, the following implications are made for further...
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Development and implementation of efficient segmentation algorithm for the design of antennas and arrays
... BETWEEN THE SPECIFICATIONS AND THE MEASUREMENTS OF THE BANDPASS FILTER 82 TABLE 3.6: SPECIFICATIONS OF THE SERIES-FED ARRAY 84 TABLE 3.7: COMPARISON OF THE RELATIVE ERROR AND THE ... scheme for the Green’s function for fast evaluation of the MoM matrix elements and the computation of the radiation patterns Finally, a patch antenna is analyzed to demonstrate the accuracy of the ... + εr surface wave pole located on the real axis of the complex k ρ plane, and the symbol Res denotes the residues of the integrand at the pole k ρ = k ρρ For the single-layer Green’s function...
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Báo cáo y học: "Mechanical complications and reconstruction strategies at the site of hip spacer implantation"
... of prosthesis reimplantation, the spacer head can be easily removed and the modular prosthesis parts (neck and head) placed This procedure offers a stable fracture treatment and facilitates the ... removal, and insertion of a cement-coated modular prosthesis with a spacer head The cement mantle of the prosthesis is also antibiotic-loaded according to the sensitivity profile of the causative organism ... lag screws and Charnley prostheses, respectively [5] The authors reported that all constructs based upon the Charnley prostheses and the commercial spacers did not fail at 3000 N; the other two...
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Speaking and Writing Strategies for the TOEFL iBT part 32
... note map Try and identify the main topic The main topic is the most important part of this task If you can identify the main topic, you might be able to remember the premise and the supporting ... raters The response for each task is rated on a scale of to For example, on the next page, three raters have scored your independent Speaking Task #1 The average of the three scores is your score for ... Develop and deliver responses for each of the following tasks using G+3TiC=C If you are practicing alone, record your response, then check it for OPDUL=C using the Integrated Speaking Proficiency...
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Speaking and Writing Strategies for the TOEFL iBT part 33
... summarization of the lecture and/ or the reading is not clear or accurate U The essay demonstrates a serious lack of topical and grammatical unity; the main points in the lecture and the reading ... points in the reading P The essay demonstrates a clear and consistent progression of ideas D The essay demonstrates development-summarization of the introduction, body and conclusion of both the lecture ... lack of organization; the connection between the main points in the lecture and the main points in the reading is not clear or accurate P The essay demonstrates a serious lack of progression D The...
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Speaking and Writing Strategies for the TOEFL iBT part 34
... The response demonstrates a lack of unity-synthesis; the connection of ideas is not clear, accurate or consistent; the response is often off topic because the test-taker does not understand the ... proficiency in all of the following areas O The response demonstrates a clear and consistent method of organization P The response demonstrates a clear and consistent progression of ideas D The ... proficiency in all of the following areas O The response demonstrates a clear and consistent method of organization P The response demonstrates a clear and consistent progression of ideas D The...
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Speaking and Writing Strategies for the TOEFL iBT part 35
... great art movements: Impressionism in France and the Pre-Raphaelite Brother in England The PreRaphaelites, a group of poets and painters, believed that the individual artist “should have genuine ... shark but the bull shark Thriving in both salt and fresh water, the bull shark has the highest testosterone level of any animal 10 People are often divided by the so-called personality theory Basically, ... reading, listening, speaking and writing Many scientists use induction when developing theories First, they observe phenomena, then they formulate conclusions based on their observations Not Einstein...
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Speaking and Writing Strategies for the TOEFL iBT part 36
... “leaving the old in search of the new.” His purpose was profit As for Columbus being the symbol of progress, nothing could be further from the truth By 1492, the year in which Columbus “sailed the ... control the growing and manufacturing of marijuana both in America and in their home countries There is simply too much money for the cartels to suddenly disappear Worse, these same cartels, once they ... with the intention of being a democracy but, believe me, those days are long gone The internet these days is about two things: information and money Big money One of the biggest money makers on the...
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Speaking and Writing Strategies for the TOEFL iBT part 37
... professor The guy showed up for the first class After that, grad students did all the teaching while the professor was off lecturing That’s what star professors They spend more time promoting themselves ... effective, and the demand for orange roughy so great, that they were practically wiped out Another fish directly impacted by the bottom trawling is the armorhead In the 1960’s, huge numbers of armorheads ... When they lick nectar or eat flowers, their bodies become covered in pollen which they, in turn, carry to other trees and plants thereby acting as pollinators In fact, many of the fruits and vegetables...
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Speaking and Writing Strategies for the TOEFL iBT part 38
... stars and European nobility How did Madoff get away with it and for so long? The answer is simple Madoff was one of the most respected men on Wall Street He’d served as chairman of the Board of ... Skywalker leading the rebel force, he frees Princess Leia and together she and Luke are honored as heroes in their homeland In the end, Luke Skywalker and Princess Leia are unerring symbols of good conquering ... western In Hollywood westerns, the kidnapped maiden is always rescued in the end with the Indians all dead and the good guys returning to the safety of their own land This is exactly what happens...
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Speaking and Writing Strategies for the TOEFL iBT part 39
... once before A student accused her professor of plagiarism Woman: And? Man: The professor was fired Woman: Great Maybe I should just forget the whole thing Maybe I should be flattered that a professor ... When they lick nectar or eat flowers, their bodies become covered in pollen which they, in turn, carry to other trees and plants thereby acting as pollinators In fact, many of the fruits and vegetables ... some form of HRT That, then, is a brief history of estrogen use in America But is the news all good? No A lot of research has been done on estrogen, the most striking of which was a report by the...
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Speaking and Writing Strategies for the TOEFL iBT part 40
... logical and aesthetically consistent relation of parts; writing and speaking in a clear and consistent manner context situation; position in time; the background story deduction a form of logic ... Nova Press Master the LSAT (608 pages; includes software and official exams) GMAT Prep Course (624 page; includes software and online course) The MCAT Physics Book (444 pages) The MCAT Chemistry ... rater for TOEFL, a person trained by ETS to rate (measure) test-taker speaking and writing proficiency according to a set of standardized rubrics rhetorical strategies methods speakers and writers...
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