and its catalytic mechanism is very different
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... MAP2 cDNA and its derivativesgenerated by PCR were cloned into pGEX-4T-2. The KINDdomains of Spir-2 and PTPN13 were generated by RT-PCR and inserted into pEGFP-C1 and pGEX-4T-2. The N- and C-terminal ... hereafter as MAP2) is known to modulate polymerization, stability and rear-rangement of microtubules in neuronal dendrites[13–15] and is associated with some neurological and psychiatric disorders [16,17]. ... substrates and regulatorysubunits, implying that the KIND domain, an atypicalnoncatalytic C-lobe, is involved in the interaction withsignaling proteins [3,5,10]. However, the structural and functional...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... [18].Scheme 5. The catalytic cycle of LPO and MPO. In this scheme, the role of H2O2as anoxidant is shown in steps 1 and 2; catalaseactivity is displayed in step 1;CpdIisomeri-zation is taken into ... LPO and generates Cpd III (with bands at 424,550 and 588 nm) (Table 2). In contrast to MPO, LPOCpd III spectral pattern is clearly distinct from that ofCpd II and can be easily distinguished ... describes an integrated vision of the catalytic mechanism of MPO and LPO.A brief survey of the absorption featuresof MPO, LPO and their intermediatesThe absorption spectrum of MPO is characterized...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... in iron metabolism. This includes hepci-din, a 25 amino acid antimicrobial peptide that is expressed in liver cells and is now recognized as a keyregulator of iron homeostasis in the body. ... ActonRT (1999) Two novel missense mutations of the HFEgene (I105T and G93R) and identification of the S65Cmutation in Alabama hemochromatosis probands.Blood Cells Mol Dis 25, 147–155.50 Fleming ... differences inintracellular distribution and co-localization of wt- and mutated forms. Blood Cells Mol Dis 39, 75–81.30 Zhang AS, Davies PS, Carlson HL & Enns CA (2003)Mechanisms of HFE-induced...
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Báo cáo "On the asymptotic behavior of delay differential equations and its relationship with C0 - semigoup " potx
... (see [9], H.Inaba), A : D(A) ⊂ E → E and operatorf : R+× E → E is continuous in t and satisfies all conditions (5), (6), (7). And now, we introducethe delay differential equation:ddtp(t) = ... L(E), f : R+× E −→ E is satisfied (5), (6), (7).Definition 2.2. Eq.(9) and Eq.(10) are said to be asymptotic equivalence if for every solution x(t)of Eq.(9), there exists a solution y(t) of ... space E and (A,D(A)) is generator of T(t) (see [10]). Throughout this paper, we always assume that (T (t))t≥0 is strongly continuous semigroup (C0- semigroup ). We show that if Eq.(4) satisfies...
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Báo cáo khoa học: Identification and characterization of important residues in the catalytic mechanism of CMP-Neu5Ac synthetase from Neisseria meningitidis potx
... thereaction, and by comparing the kinetic parametersdetermined for the alanine mutants we were able toidentify key catalytic residues and put forward arevised catalytic mechanism for CNS.Results and ... molecule and residues Asp225 and Asp98. We propose that theseresidues correspond to Asp209 and Asp211 in theN. meningitidis CNS, and Fig. 3 shows these active-siteresidues in comparison with ... hydrogen-bondingdistance of O7 and O9 of the glyceryl moiety ofNeu5Ac, and a network of noncovalent bonds betweenenzyme and substrate is proposed in the active siteupon substrate binding [12]. This network...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... corresponding to CARP before and after cleavage by calpain 3 (pYFP-CARP-CFP-HIS, pYFP-DNter2-CFP-HIS and pYFP-Nter-CFP-HIS) were injected and transferred by electroporationin tibialis anterior (TA) muscles ... pattern is clearly distinguished at very high magnification, sug-gesting that CARP is localized into a very peculiar, yetunidentified, nuclear subcompartment (Fig. 2A, lowerright panel). This pattern ... pattern is reminiscent of the PMLbodies, a compartment in which Ankrd2 has previouslybeen observed [17]. The localization of pYFP-DNter2-CFP-HIS is undistinguishable from the pYFP-CARP-CFP-HIS...
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CANON VIETNAM CO. LTD AND ITS MARKETING.DOC
... researching market, advertising, and social welfare activities. Benefits and costs analysis show that all costs that Canon has to pay is to satisfy customer demands by its products and services. However, ... benefits, the company’s image will be raised and its income will increase. And the benefits that it gains come from customers, such as customer loyalty. Page 9CANON VIETNAM CO. LTD AND ITS ... process to understand customer demand and their objective is providing customer satisfactions. Moreover, there is not only customers are satisfied but also organizations’ goal is emphasized. To...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... using GLP-1 to lower blood glucose is limited by its very short plasma half-life [5, 6]. This is due to its rapid inactivation by dipeptidyl peptidase IV and by renal clearance. Developing ... a promising thera-peutic agent for type 2 diabetes [3, 12]. However, the clinical application of native GLP-1 is hampered by its very short plasma half-life [5, 6, 13]. This is due to its rapid ... used to express this fusion protein. This vector can produce an N-terminal His-tagged protein. His-tag is often used for protein purification [11]. The affinity of the His-tag for metal ions...
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Báo cáo y học: "ntravenous transplantation of allogeneic bone marrow mesenchymal stem cells and its directional migration to the necrotic femoral head"
... and immunophenotype of MSCs and their potentials of osteogenesis and adipogenesis were determined. Femoral head necrosis animal model The rabbit model of femoral head necrosis was established ... examination and liver and renal func-tions, no manifestations of acute and chronic toxic reactions and graft versus host disease, no local swelling at injection sites, and no lower limb move-ment disorder ... high purity is feasible and safe. Another concern of intravenous transplantation of MSCs is whether the MSCs can migrate into and proliferate in the target tissues, which is the basis of therapeutic...
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Báo cáo y học: " Preparation of RGD-modified Long Circulating Liposome Loading Matrine, and its in vitro Anti-cancer Effects"
... cells and deliver anti-tumor drugs, but also had direct effects on cell viability and apoptosis (29,30). This will need to be confirmed in further studies, and the me-chanism underlying this ... drugs, matrine is able to freely traverse in and out of blood vessels to distribute to non-tumor tissues, resulting in accumulation in the liver, spleen or kidneys, diminishing its effects on ... and prevent hepatic fibrosis (1,2). In recent years, studies have indicated that matrine also inhibits tu-mor cell proliferation (3), and induces cellular diffe-rentiation (4) and apoptosis...
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