and anti inflammatory cytokines in sepsis
báo cáo hóa học: " Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures" pot
Ngày tải lên :
19/06/2014, 22:20
... role of cytokines in epileptogenesis remains to be elucidated Cytokines may contribute initially to incite seizures in the developing brain after being induced by seizure or tissue injury, and they ... (20080918/06-2008-74/76) Informed consent was obtained from each child’s parents Cytokine measurement Levels of pro -inflammatory cytokines including HMGB1, IL-1b, IL-6, interferon (IFN)-b, TNF-a, and anti- inflammatory ... epileptogenesis in the developing brain In order to determine whether active inflammation, including HMGB1 and pro -inflammatory cytokines, occurs in children with febrile seizures and pediatric epilepsy,...
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Báo cáo y học: " Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD" doc
Ngày tải lên :
12/08/2014, 13:22
... divided into subpopulations Proinflammatory, or classically activated macrophages (M1) display pro -inflammatory and cytotoxic properties and can eradicate intracellular pathogens In contrast, antiinflammatory ... hypothesize that in moderate to severe COPD patients i) ex-smokers have more M2 and anti- inflammatory mediators in BAL and induced sputum compared to current smokers; ii) M2 and anti- inflammatory ... 80% After drying for hour, the cytospins were wrapped in aluminum foil and stored at -80°C pending immunocytochemical staining Immunocytochemical staining Frozen cytospins of BAL and sputum were...
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Báo cáo hóa học: "Clinically important improvement in the WOMAC and predictor factors for response to non-specific non-steroidal anti-inflammatory drugs in osteoarthritic patients: a prospective study" docx
Ngày tải lên :
21/06/2014, 19:20
... corticosteroid or intra-articular hyaluronic acid joint injection within weeks before randomization, a known allergy of indomethacin or diclofenac and history of abuse use of alcohol or drug use within year ... of an instrument to detect such a small difference is essential in order to quantify the minimal difference that patients and their physicians consider clinically important The minimal clinically ... pharmacological interventions, including the use of non-steroidal anti- inflammatory drugs (NSAIDs) A major goal of OA treatment is, therefore, pain management to optimize algo-functional features, and to...
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Báo cáo khoa học: " The Antinociceptive and Anti-inflammatory Effect of Ethylacetate Extracts from Bang-Poong (Radix ledebouriellae) on the Freund’s Adjuvant-Induced Arthritis in Rats" pot
Ngày tải lên :
07/08/2014, 15:20
... characterized by degenerative joint destruction, deformity and inflammatory pain in most cases Currently non-steroidal anti- inflammatory drugs (NSAIDs) such as indomethacin are commonly used to cure ... effects in human To find effective component of BP on inflammation, ethylacetate fraction of BP (BPE) and hexane fraction of BP (BPH) were extracted from whole BP and antinociceptive and anti- inflammatory ... (B) and spinal Fos expression in SDH and NP (E) In contrast to this, BPH did not inhibit these arthritis-related changes (C and F ) The Antinociceptive and Anti- inflammatory Effect of Ethylacetate...
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Báo cáo y học: "Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27" pptx
Ngày tải lên :
09/08/2014, 01:24
... T gondii and T cruzi are disseminating infections that induce strong innate immune responses and high serum levels of inflammatory cytokines [43] In these infectious diseases, innate involvement ... response to infection Nonetheless, these findings indicate that IL-27 is generated in response to various inflammatory stimuli and imply a role for this cytokine in the regulation of infectioninduced ... IL-6/IL-12 family cytokines play key roles in the generation and regulation of inflammatory responses [24,25,32] For instance, IL-12 promotes resistance to intracellular infection by inducing the production...
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Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps
Ngày tải lên :
09/08/2014, 08:23
... producing a variety of both pro- and anti- inflammatory cytokines, including TNF-α, IL-1, and IL-10, as well as the major MMPs and tissue inhibitors of MMPs (TIMPs) [28] In this study, we used anti- CD14-conjugated ... important player in promoting the production of inflammatory and degradative mediators in the OA synovium In particular, our results indicate a role for both TNF-α and IL-1β in driving inflammatory ... in RA and in OA, with stronger NF-κB dependence observed in RA [[38,43,44] versus [28]] The third major finding in this study Figure and methods and reaction data from link protein, chain in Figures...
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Báo cáo y học: "Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study" pps
Ngày tải lên :
12/08/2014, 15:21
... the initial cytokine in the cascade, TNFα This supports a role for a delicate cytokine balance between pro -inflammatory TNFα and anti- inflammatory IL-10 in both resolution of inflammation and ... associated with increased airway inflammation[17,18] Cytokines such as IL-6 and CXCL8 are rarely produced individually instead they are more usually released in combination with other cytokines and mediators ... modifications and their role in disease progression As therapeutic approaches aimed at preventing the inflammatory cascade in COPD are currently focused on pro -inflammatory mediators, antiinflammatory interventions...
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Báo cáo khoa học: "Endotoxin neutralization and anti-inflammatory effects of tobramycin and ceftazidime in porcine endotoxin shock" ppt
Ngày tải lên :
12/08/2014, 20:20
... intravenous infusion of 140 mg in 100 ml saline solution for 20 min, starting 10 before initiation of endotoxin infusion Ceftazidime was injected as an intravenous bolus dose of g in 10 ml saline before ... possible antiendotoxin effect if endotoxin–aminoglycoside binding is subject to saturation kinetics and if a lower endotoxin dose is used In order to minimise such a risk, the tobramycin dose ... penicillin binding protein-3 induced endotoxin release [5] The inflammatory damage to endothelial cells and other tissue cells mediated by oxygen radicals induces cytokine production [9,21] In several...
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Báo cáo y học: "Relationship between Anti-CCP Antibodies and Oxidant and Anti-Oxidant Activity in Patients with Rheumatoid Arthrit"
Ngày tải lên :
25/10/2012, 11:15
... pathogenesis Anti- CCP antibodies may also be related increased oxidative activity in RA patients Anti- CCP antibodies are directed against antigens containing the nonstandard amino acid citrulline, for example, ... Nonsignificant Table Serum and whole blood oxidant activity; MDA and MPO levels, and antioxidant activity; CAT and GSH-Px levels in anti- CCP(+) and anti- CCP(-) patients with RA Anti- CCP negative positive ... Synovial fluid oxidant activity; MDA and MPO levels, and antioxidant activity; CAT and GSH-Px levels in anti- CCP(+) and anti- CCP(-) patients with RA Anti- CCP antibody Synovial GSHpx (U/ml) negative...
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Role of Non-Steroidal Anti-Inflammatory Drugs in Gynecology potx
Ngày tải lên :
28/03/2014, 14:20
... increase of prostaglandin synthesis within the fetal membranes at term [23] The increase in prostaglandin during labor causes increased uterine contractility and inhibitors of prostaglandin synthesis ... in pain reduction 30-40% in bleeding reduction Up to 82% pain reduction, up to 57% in bleeding reduction Up to 48% in pain reduction Menorrhagia Pain/heavy bleeding associated with intrauterine ... necrotizing enterocolitis and administration of antenatal indomethacin within 72 hours prior to delivery in premature infants Necrotizing enteroclitis with administration of antenatal indomethacin in...
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báo cáo hóa học: " Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9" docx
Ngày tải lên :
19/06/2014, 22:20
... of Neuroinflammation 2006, 3:25 Background Pro -inflammatory enzymes and cytokines are increasingly attractive as therapeutic targets for a variety of inflammatory diseases and for the inflammatory ... the sPLA2 containing samples Kinetic parameters including the properties of CHEC-9 were determined by measuring the initial velocities (Vo) of enzyme reactions (within minutes of initiation) For ... lesions, a subcutaneous injection of CHEC-9 results in anti- inflammatory and neuron survival effects that last for at least days, an effect due in part to an interruption of the inflammatory cascade...
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báo cáo hóa học: " Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway" doc
Ngày tải lên :
19/06/2014, 22:20
... implicated in neurotoxicity but they also are a major source of anti- inflammatory cytokines, antiviral proteins and growth factors Therefore, an immune therapy aiming at suppressing the proinflammatory ... suppress microglial proinflammatory cytokine expression while increasing anti- inflammatory and antiviral gene expression [21] In this study, we systematically examined the changes in microglial gene ... shown to mediate antiviral and anti- inflammatory functions in myeloid cells [33], and IL-10 receptor Intriguingly, IL-1α and IL-1ra, as well as the IL-12 family cytokines IL-23 and IL-27 [34] were...
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Báo cáo y học: "Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study" pps
Ngày tải lên :
09/08/2014, 01:23
... were taking a variety of medications, including non-steroidal anti- inflammatory drugs, external splints and intra-articular injections of prednisone and/ or hyaluronic acid Intra-articular injection ... moderate or definite osteophytes with moderate joint space narrowing; IV, severe with large osteophytes and definite joint space narrowing bScoring was as follows: +/-, minimum staining in one area ... several inflammatory cytokines in SF between HTLV-I carrier patients and HTLV-I-negative OA patients By investigating OA patients only and excluding those with RA, we were able to demonstrate the involvement...
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Báo cáo y học: "Association between anti-nucleophosmin and anti-cardiolipin antibodies in (NZW × BXSB)F1 mice and human systemic lupus erythematosus" doc
Ngày tải lên :
09/08/2014, 07:20
... mouse and SLE staining pattern of anti- nucleophosmin-positive Immunofluorescence sera on HEp-2 cells WB mouse and SLE sera on HEp-2 cells An anti- nucleophosmin (antiNPM) mouse mAb and anti- NPM antibody-positive ... anti- NPM and aCL antibodies and define a subset of patients with aCL antibodies The demonstration that NPM binds to CL in vitro and increases the CL-binding activity of a WB-derived aCL mAb indicates ... The nucleolar staining disappeared when sera were preincubated with recombinant NPM (Fig 2f) in lupus mice Correlation between anti- nucleophosmin and anti- cardiolipin antibodies in lupus mice A...
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Báo cáo y học: "The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus" ppt
Ngày tải lên :
09/08/2014, 07:20
... CA, USA) Biotinylated antibodies were detected using an allophycocyanin-conjugated streptavidin antibody (Pharmingen-Becton Dickinson) Staining was performed in the presence of saturating concentration ... containing no dsDNA to allow determination of the non-specific binding to streptavidin Bound antibodies were detected and quantified as above For quantitative immunofluorescence, fluorescein isothiocyanate ... induced in mice by the administration of a single high dose of LPS This induces a pulse of nucleosomes and chromatin in the plasma within the first 12 hours post-injection accompanied by an increase...
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Báo cáo y học: " Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system" pdf
Ngày tải lên :
12/08/2014, 13:22
... aqueous control preparation containing 0.75% peppermint oil as a masking agent was administered in a single-blinded manner as a single 50 μl application in each nostril using a metered spray applicator ... in PBS-Tween (0.1%) with 5% nonfat dry milk and incubated overnight at 4°C Following antibodies were used for immunoblotting: anti- HO1 (Abcam), anti- NQO1 (Novus Biologicals), anti- GCLm, and anti- GAPDH ... proinflammatory signaling was abrogated in the nasal mucosa by the treatment, possibly through mechanisms involving increased intracellular antioxidant activity leading to reduced inflammatory drive In addition,...
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Báo cáo y học: "Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study" doc
Ngày tải lên :
12/08/2014, 15:23
... study from Finland reported 12% of coexistence of anti- topo I and anti- U1RNP [30] Detection of anti- topo I in MCTD patients indicates coexisting anti- topo I and anti- U1RNP [31] Regarding the issue ... be an interesting and possibly clinically useful exception In addition to cases reported mainly from Japan [27-29], frequent association of anti- topo I and anti- U1RNP in a large Japanese and American ... approved by the Institutional Review Board (IRB) This study meets and is in compliance with all ethical standards in medicine, and informed consent was obtained from all patients according to the...
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Báo cáo y học: " Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells" docx
Ngày tải lên :
12/08/2014, 16:20
... placed in Dulbecco's modified Eagle medium (DMEM) containing 20% (v/v) foetal bovine serum (FBS) and 1% (v/v) antibiotic/antimycotic at 37°C, 5% CO2 Cells were maintained in DMEM containing 5–10% ... activity in these cells; and (3) the role of PDE4 in regulating cAMP levels, DNA synthesis, proliferation, apoptosis and gelatinase activity, using selective PDE4 inhibitors alone and in combination ... X-100 After fixation in 25% isopropanol and 10% acetic acid for 10 min, gels were stained in 0.25% Coomassie blue for 1–2 h and destained in fixing/destain solution until bands of activity were...
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Báo cáo y học: "Anti-allergic and anti-inflammatory effects of butanol extract from Arctium Lappa " pdf
Ngày tải lên :
13/08/2014, 13:22
... significantly inhibited antigen-induced b-hexosaminidase release Atopic dermatitis is a chronic, allergic inflammatory skin disorder, and we investigated both the anti- allergic and anti- inflammatory ... IL-4 and IL-5 supports the possibility that ALBE may have antiallergic and anti- inflammatory effects Conclusions ALBE may exert anti- allergic and anti- inflammatory activities by suppressing the ... b-hexosaminidase and histamines also causes the production of proinflammatory cytokines, such as IL-4, IL-6, and TNF-a, which can potentiate inflammatory immune responses through the subsequent induction...
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Báo cáo y học: "Mild hypothermia alone or in combination with anesthetic post-conditioning reduces expression of inflammatory cytokines in the cerebral cortex of pigs after cardiopulmonary resuscitation" ppt
Ngày tải lên :
13/08/2014, 20:21
... damage, and inhibition of excitatory neurotransmitter release [4] There is growing evidence on the damaging nature of the inflammatory response following brain ischemia Various inflammatory cytokines ... Hypothermia was induced by 1,000 mL saline (4°C) and maintained by a cooling device (Icy catheter and CoolGard 3000; Alsius Corp, Irvine, CA, USA) that was introduced into the femoral vein According to ... be due, in part, to suppression of post-injury pro -inflammatory factors by microglia However, the role of hypothermia in modulating anti- inflammatory cytokines, for example, IL-10, remains controversial...
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