amp gamble feeling the heat
Tài liệu Turn Down the Heat - Why a 4C warmer world must be avoided doc
Ngày tải lên :
16/02/2014, 11:20
... reflect the views of The World Bank, its Board of Executive Directors, or the governments they represent The World Bank does not guarantee the accuracy of the data included in this work The boundaries, ... Examples of such events include the European heat wave of 2003 (Stott et al 2004), the Greek heat wave of 2007 (Founda and Giannaopoulos 2009), the Australian heat wave of 2009 (Karoly 2009), the ... increase in the surface area of the planet experiencing extreme heat since the 1950s The area of the Earth’s land surface affected by drought has also likely increased substantially over the last...
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Tài liệu Báo cáo khoa học: The heat shock factor family and adaptation to proteotoxic stress pdf
Ngày tải lên :
18/02/2014, 04:20
... cells from thermal stress by regulating the expression of heatinducible genes other than classical heat shock genes Expression of nonclassical heat shock genes induced by HSFs Although the heat shock ... through the activation of the heat shock genes [10,11] HSPs prevent the denaturation and aggregation of cellular proteins, and support their renaturation when the cells are recovering [1] At the ... swapped with the corresponding domains of chicken HSF3, and the chimeras possessing the chicken HSF3 activation domain induced the expression of the classical heat shock genes in response to heat shock...
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Báo cáo khoa học: Differential recognition of heat shock elements by members of the heat shock transcription factor family ppt
Ngày tải lên :
07/03/2014, 00:20
... activation by hHSF4–VP16, without changing the magnitude of the heat shock response (cp3) The mutational analysis of the CRYGA and CRYGC HSEs suggests that the nucleotide sequences and configuration ... with the human c-crystallin promoters These results show that the configuration of nGAAn units in the promoter is important in determining which hHSF members are involved in the regulation of the ... show that the members of the hHSF family differentially recognize HSEs, and suggest that the regulated expression of different hHSF target genes is dependent upon the architecture of the HSE HSE-type...
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Báo cáo khoa học: The hyperfluidization of mammalian cell membranes acts as a signal to initiate the heat shock protein response pptx
Ngày tải lên :
07/03/2014, 12:20
... nm) To compare the effects of heat with these alcohols on the free cytosolic Ca2+ levels, the cells were heated at 42 °C for The averaged [Ca2+]i value obtained is displayed by the bar in Fig ... monitoring of the synthesis of the major HSP, HSP-70 The critical concentrations of each of the two fluidizers were selected so that their addition to the cells caused identical increases in the plasma ... 2) The decrease in the lipid order was followed in the membrane interior of the K562 cells by monitoring the DPH anisotropy change The fluidizing effects of the alcohols in the glycerol and upper...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
Ngày tải lên :
08/03/2014, 08:20
... activation, even thought they were able to bind the ST peptide (Fig 2) Therefore, there appeared to be a correlation between the presence of the 145 kDa form of GC-C, which represents the mature glycosylated ... level over the time period of the experiments as conducted here As shown below, alterations in the levels of the differentially glycosylated forms of GC-C regulate the cellular response to the ST-peptide, ... indicating that only the ligandresponsive form of the receptor is perhaps routed to the lysosomal compartment for degradation The continued presence on the surface of cells of the 130 kDa form,...
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in the heat of the night
Ngày tải lên :
21/03/2014, 22:04
... driving in the night because he didn't want to drive in the extreme heat of the day so he decided to go in the cooler part of the day, night time In the end, the fact of the matter was that the police ... In The Heat Of The Night Vocabulary Word: Outskirt (noun) - The outer part of a town, far from the center of the town.Vocabulary Sentence: The house was located in the lonley outskirts of the ... in the pits for the whole day Then the daughter of Mr Mantoli came in and talked to Sam about the murder Sam said that he was innocent of the murder charges She then told him to look her in the...
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Báo cáo khoa học: Deletion of Phe508 in the first nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator increases its affinity for the heat shock cognate 70 chaperone docx
Ngày tải lên :
23/03/2014, 05:22
... previously proposed model of the ERQC, the folding states of CFTR are assessed within the ER at multiple checkpoints [9,10], the first of these involving the Hsc70 ⁄ Hsp70 machinery, the most critical one ... (Fig 2A) reveals that there was only a small decrease in the overall intensity of the fluorescence emitted from F508del-mNBD1 and no shift in the peak wavelength Furthermore, the intensity of fluorescence ... F508del-mNBD1 Assessment of the impact of F508del on the NBD1–Hsc70 interaction To determine the strength of the NBD1–Hsc70 interaction, we thus immobilized the chaperone and quantified the binding of increasing...
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HOW TO BEAT THE HEAT FOR A SAFE SUMMER doc
Ngày tải lên :
28/03/2014, 20:20
... of the house Control temperatures in the home HOW TO BEAT THE HEAT FOR A SAFE SUMMER Is it advisable to go out of the house during the summer period? It is always wise to keep mobile Also, in the ... among the elderly and with a focus on the big cities, Experts have forecast that heatwaves will become even more frequent in Europe in the near future, and we therefore need to be aware of the ... covered by the first question) may not feel thirsty or want to drink even when they perspire a lot, or they may not be able to drink In these circumstances the body temperature may rise, or the body...
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Báo cáo khoa học: The heat shock protein 70 molecular chaperone network in the pancreatic endoplasmic reticulum ) a quantitative approach potx
Ngày tải lên :
30/03/2014, 03:20
... Taken together, we estimate that in the rough ER, the concentrations of the most abundant chaperones such as BiP and ERj5 or their J-domains, such as in the case of ERj2 ⁄ Sec63, are in the low ... accumulate in the ER, various signal transduction pathways are activated that increase the biosynthetic capacity and decrease the biosynthetic burden of the ER This phenomenon is termed the unfolded ... cases In the case of the two luminal Hsp40s ERj3 and ERj5, GST hybrids were analyzed that contained either the J-domains or the full-length proteins When compared to each other, the two types of...
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Báo cáo khoa học: Regulation of the muscle-specific AMP-activated protein kinase a2b2c3 complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme docx
Ngày tải lên :
30/03/2014, 08:20
... Effect of the mutations in the AMPK c3 gene on the AMP dependence of the enzyme Fold stimulation reflects the activation of the corresponding AMPK complexes by 200 lM AMP relative to the basal ... to the activity of the wild-type AMPK complexes measured in the absence of AMP (the activity of the wild-type complex without AMP is set to 1) (C) The activity of the wild-type and mutated AMPK ... both the total activity and the AMP dependence (Fig 1C) We measured the activity of the recombinant AMPK a2b2c3 complexes over a range of AMP concentrations, and calculated the concentration of AMP...
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Báo cáo hóa học: "Sweat rate and sodium loss during work in the heat" ppt
Ngày tải lên :
20/06/2014, 00:20
... However in the summer samples the sweat sodium concentration from both the arms and legs on day showed a substantial reduction from day samples as shown in the same table The concentrations for the ... exercise in the heat following acclimation The findings of the current study would reinforce increased sensitivity to aldosterone as the explanation for the seasonal differences Further, the sensitivity ... ensure they were completely dry before re-dressing into the clothes in which they were originally weighed After reweighing, the sweat rate (mL min-1) was calculated from the weight loss of the subject...
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Báo cáo hóa học: " Research Article Existence of Pseudo Almost Automorphic Solutions for the Heat Equation with Sp -Pseudo Almost Automorphic Coefficients" docx
Ngày tải lên :
21/06/2014, 20:20
... use of the approximation 5.4 rather than 5.5 Throughout the rest of the paper, the constant k α denotes the bound of the embedding Xβ → Xα , that is, u α ≤k α u β for each u ∈ Xβ 5.24 Theorem ... Y The collection of such functions will be denoted by P AA R × Y A substantial result is the next theorem, which is due to Liang et al Theorem 2.19 see The space P AA X equipped with the ... each t ∈ R Therefore for every ε > there exists δ > such that for all X, Y ∈ K with X − Y < δ yield F b σ, X − F b σ, X
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Báo cáo y học: "Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line" pptx
Ngày tải lên :
11/08/2014, 03:20
... While the cell type utilized in the two studies was remarkably similar, the duration of heat shock was different In our study, the cells were subjected to 45 of heat shock in comparison to 30 in the ... reaction using the Reverse Transcriptase System Kit (Promega) as directed by the manufacturer The mixture was heated to 70°C for 10 min, maintained at 42°C for 30 min, and then heated to 95°C ... resting and heat shocked cells Furthermore, these immunoprecipitation studies confirm that exposure to heat shock increases the nuclear HSF-1 binding to PARP-1 Discussion PARP-1 catalyses the covalent...
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Báo cáo y học: " Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line." pptx
Ngày tải lên :
11/08/2014, 06:22
... While the cell type utilized in the two studies was remarkably similar, the duration of heat shock was different In our study, the cells were subjected to 45 of heat shock in comparison to 30 in the ... reaction using the Reverse Transcriptase System Kit (Promega) as directed by the manufacturer The mixture was heated to 70°C for 10 min, maintained at 42°C for 30 min, and then heated to 95°C ... resting and heat shocked cells Furthermore, these immunoprecipitation studies confirm that exposure to heat shock increases the nuclear HSF-1 binding to PARP-1 Discussion PARP-1 catalyses the covalent...
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TURN DOWN THE HEAT CLIMATE EXTREMES, REGIONAL IMPACTS, AND THE CASE FOR RESILIENCE.
Ngày tải lên :
08/08/2015, 19:23
... that The World Bank does not necessarily own each component of the content included in the commissioned work The World Bank therefore does not warrant that the use of the content contained in the ... chapters is the nature of the impacts and the associated risks posed to the populations of the regions The possibility of adaptation and its capacity to minimize the vulnerability to the risks ... defined by the local climate variability are considered to be the most relevant index This report analyzes the timing of the increase in monthly heat extremes and their patterns by the end of the 21st...
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Numerical study of the heat transfer in a miniature joule thomson cooler
Ngày tải lên :
27/11/2015, 11:20
... In the pulse-tube refrigerator, the compressed, hot cryogen flows from the pulse tube through the warm heat exchanger and the orifice The expanded cold cryogen in the pulse tube flows past the ... numerical simulation of the heat exchanger in order to produce an optimum heat exchanger vi Thermal Losses Thermal conduction along the walls of the heat exchanger reduces the net cooling power ... thesis, the sophisticated geometry of the Hampson-type J-T cooler is analyzed and incorporated into the simulation, so that the model can be used as a design tool The governing equations of the...
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Feeling the pressure the challenge of enhancing return on equity
Ngày tải lên :
06/12/2015, 23:05
... otherwise, without the prior permission of The Economist Intelligence Unit Limited All information in this report is verified to the best of the author’s and the publisher’s ability However, the ... and the remainder are chief executives or other C-level executives Our editorial team conducted the survey and wrote the paper The author was Christopher Watts and the editor was Rob Mitchell The ... reflect the views of our sponsors Our thanks go to the survey respondents and interviewees for their time and insight © The Economist Intelligence Unit 2008 Feeling the pressure? The challenge...
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Turning up the heat ma in the renewable energy sector
Ngày tải lên :
06/12/2015, 23:10
... targets" Nevertheless, these highervalue companies would still need subsidies to make the profits to justify the valuations Another reason for the rapid increase in valuations is the mismatch ... percentage Source: The Economist Intelligence Unit 2008 © 2008 The Economist Intelligence Unit Ltd All rights reserved Turning up the heat / The competing technologies In the past three years, ... appeal “Not only are there few opportunities left, I doubt whether they would get community approval for them," he says "Mini-hydro has a role, but the big schemes have had their day, certainly...
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When the Discussion Gets Stalled or Heated
Ngày tải lên :
22/08/2012, 22:07
... Exclusionary – leaving someone out of the meeting, discussion or social gathering • Undermining – going behind the back of others or using insults to discredit arguments • Retaliatory – used when other party feels ... ignored important constituencies and then the agreement faces extreme difficulties in the implementation phase SlowFast Approach • Negotiations are conducted slowly to ensure that the final agreement is responsive to major constituents providing ... Keep power in your pocket (e.g. attorney, credible reference) Keep the door open Conflict as a Choice Point Explore whether conflict is a signal for a change View the disagreement as a choice point and explore options for moving ...
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