akt pkb and bcl 2 pathway cd133

Báo cáo y học: " Upregulation of Bax and Bcl-2 following prenatal cocaine exposure induces apoptosis in fetal rat brain" doc

Ngày tải lên : 08/08/2014, 17:20

... 20 05, 3 12: 1 12- 119 24 25 26 27 28 29 Xiao Y, He J, Gilbert RD, Zhang L Cocaine induces apoptosis in fetal myocardial cells through a mitochondria-dependent pathway J Pharmacol Exp Ther 20 00, 29 2:8-14 ... ischemic and excitotoxic neuronal damage Proc Natl Acad Sci U S A 1997, 94 :20 07 -20 12 46 Adams JM, Cory S The Bcl- 2 protein family: arbiters of cell survival Science 1998, 28 1:1 322 -1 326 3 02 ... the representative immunoblots obtained for Bcl- 2 and Bax at the expected size of 26 kDa and 21 kDa, respectively, and shows an increase in Bcl- 2 and Bax in the brains treated with cocaine The...

8
403
0

báo cáo khoa học:" Expression of caspase-3, p53 and Bcl-2 in generalized aggressive periodontitis" ppsx

Ngày tải lên : 11/08/2014, 23:22

... acidsdecrease humangingival keratinocyte proliferation and increase apoptosis and necrosis J Clin Periodontol 1999, 25 :311-315 23 24 25 26 27 28 29 30 31 32 33 34 35 Kurita-Ochiai , Fukushima K, Ochiai ... grade p53 grade p53 grade 62. 5 37.5 4 40 20 40 Bcl- 2 grade Bcl- 2 grade Bcl- 2 grade 25 75 * - 60 40 - * Significant difference (P < 0.05) active caspase-3, Fas, FasL and p53 in the inflammatory ... Gingival index Plaque index Control Group (N = 10) 34. 12 ± 4.54 * 4.44 ± 0.75 * 1.01 ± 0 .21 1. 52 ± 0.54 24 .7 ± 7.13 2. 22 ± 0.36 1.10 ± 0. 32 1.10 ± 0 .29 * Significant difference (P < 0.05) Page of (page...

7
275
0

Báo cáo khoa học: " AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis" pdf

Ngày tải lên : 09/08/2014, 10:20

... threshold Bcl- 2 and Bcl- XL are important inhibitors of apoptosis and frequently overexpressed in a variety of human tumors [2- 7] Increased levels of Bcl- 2 and Bcl- XL have been associated with radioand ... human prostate cancer Mol Cancer Ther 20 05, 4:197 -20 5 Page of 10 (page number not for citation purposes) Radiation Oncology 20 09, 4:47 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 Li ZM, ... cancer Anticancer Res 20 02, 22 :33-38 Oliver CL, Miranda MB, Shangary S, Land S, Wang S, Johnson DE: (-)Gossypol acts directly on the mitochondria to overcome Bcl2 - and Bcl- X(L)-mediated apoptosis...

10
284
0

Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot

Ngày tải lên : 07/03/2014, 04:20

... activity of Bud32p is relevant for its in vivo functionality The wild-type [W303 and BUD 32- HA (WT)], the bud 32 mutants K52A-HA (K52A), D161A-HA (D161A) and the BUD 32 deleted strain (bud32D) were grown ... Journal 27 5 (20 08) 5919–5933 ª 20 08 The Authors Journal compilation ª 20 08 FEBS 5 921 Role of Bud32p in a new signaling pathway in yeast C Peggion et al A C B D Fig Bud32p coimmunoprecipitates with and ... (D161A, K52A) and deletion mutants (bud32D), and observed that cells were almost FEBS Journal 27 5 (20 08) 5919–5933 ª 20 08 The Authors Journal compilation ª 20 08 FEBS C Peggion et al Role of Bud32p in...

15
414
0

Báo cáo khoa học: The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco⁄endoplasmic reticulum calcium stores ppt

Ngày tải lên : 07/03/2014, 09:20

... ª 20 07 FEBS N R Brady et al Bcl- 2 and calcium control of autophagy A 100 Steady-state ** * 80 80.3 78 .2 60 40 15.7 42. 9 10.4 5.6 20 Vector Beclin1 Beclin1 Bcl2 BD FM Vector Beclin1 Beclin1 Bcl2 BD ... GFP -Bcl- 2 WT Endo -Bcl- 2 100 Steady-state S/ER Cumulative 75 B % TG-induced Change in Fluo-4 Fluorescence % Cells with Numerous GFP-LC3 Punctae B * 50 25 Vector Bcl- 2- wt Bcl- 2- ER Fig Bcl- 2 control ... Bcl- 2- ER versus vector (cumulative) Furthermore, in cells expressing Bcl- 2- ER, TG reduced autophagic activity to an even greater extent 40 * 30 20 10 -10 -20 Vector Bcl- 2- wt Bcl- 2- ER ** Fig Bcl- 2...

14
444
0

Báo cáo khoa học: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis pdf

Ngày tải lên : 28/03/2014, 23:20

... lymphoma -2 BCL- 2- like protein BCL- 2- like -2 Myeloid cell leukemia sequence-1 BCL- 2- like-10 BCL- 2- related protein A1 BCL- 2- associated X protein BCL- 2- antagonist ⁄ killer-1 BCL2 -related ovarian killer BCL- 2 ... the BH3 receptor domain of Bcl- 2 or Bcl- xl, to disrupt the interaction between Bcl- 2 or Bcl- xl and Beclin In addition, Bcl- 2 ⁄ Bcl- xL phosphorylation results in Bcl- 2 ⁄ Bcl- xL dissociation from ... Journal compilation ª 20 10 FEBS F Zhou et al 24 25 26 27 28 29 30 31 32 33 34 35 36 BAX and BAK: a requisite gateway to mitochondrial dysfunction and death Science 29 2, 727 –730 Antonsson B, Montessuit...

11
742
0

Báo cáo hóa học: "A randomized phase II trial of mitoxantrone, estramustine and vinorelbine or bcl-2 modulation with 13-cis retinoic acid, interferon and paclitaxel in patients with metastatic castrate-resistant prostate cancer: ECOG 3899" pot

Ngày tải lên : 18/06/2014, 16:20

... 3% 2% Pleura 3% 0% 2% Other Prior Treatment 11 34% 29 % 20 32% Orchiectomy 10 31% 23 % 17 27 % Prostatectomy 17 53% 15 48% 32 51% Other Surgery 19 59% 20 65% 39 62% Radiation Therapy 18 56% 20 65% ... and 16 patients had Bcl- 2 levels available on Arm A and Arm B, respectively For Arm A, the average Bcl- 2/ actin ratio was 0.88 and 1. 32 on day and day of cycle 1, respectively, and the difference ... Race White 30 94% 28 90% 58 Black 3% 10% 92% 6% Hispanic ECOG PS 3% 0% 2% 15 47% 17 55% 32 51% 16 50% 12 39% 28 44% 3% 6% 5% Measurable, Non-Osseous Disease Present 14 44% 13 42% 27 43% Evaluable,...

9
462
0

Báo cáo sinh học: "Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells" pptx

Ngày tải lên : 18/06/2014, 19:20

... – Si -Bcl- 2 – + Daunorubicin(0 .2 g/ml) 0.09 1.11 0.11 0.61 6.76 10.58 4. 12 22. 63 97.55 1 .25 97.90 1.38 76.31 6.35 60. 82 12. 43 11.86 5.73 9.19 9.74 42. 06 12. 62 86.35 81 .28 1.13 1.60 45.76 2. 44 ... Curcumin( M) 40 60 0. 02 1.81 80 2. 66 0.56 3.83 38 .27 76 .2 19.80 70.89 25 .78 57.34 0.03 7.93 0.03 17 .22 0.00 23 .89 70.95 21 .09 51.47 31 .28 41.55 34.56 5.30 0.90 19.96 0.43 12. 83 54.06 25 .08 9.95 76.79 ... 38 .27 KG1a Red 76.13 Kasumi-1 27 .68 50.05 84.76 20 .25 7 .25 0.36 15 .22 79.73 92. 74 99.63 7.08 U937 2. 58 Red/green ratio (% of control) Green Curcumin( M) Figure Curcumin decreased Bcl- 2 mRNA and...

15
415
0

Báo cáo sinh học: "Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft" pot

Ngày tải lên : 18/06/2014, 22:20

... 1998, 4 :23 2 -23 4 Jansen B, Wacheck V, Heere-Ress E, Schlagbauer-Wadl H, Hoeller C, Lucas T, Hoermann M, Hollenstein U, Wolff K, Pehamberger H: Chemosensitisation 22 23 24 25 26 27 28 29 of malignant ... 10 11 12 13 14 15 16 17 18 19 20 Received: April 20 11 Accepted: 28 July 20 11 Published: 28 July 20 11 21 References Eckstein F: Phosphorothioate oligodeoxynucleotides: what is their origin and what ... Cancer Res 20 05, 24 :24 5 -25 4 39 Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2( -Delta Delta CT) Method Methods 20 01, 25 :4 02- 408 40...

10
483
0

báo cáo hóa học:" Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft" ppt

Ngày tải lên : 20/06/2014, 04:20

... 1998, 4 :23 2 -23 4 Jansen B, Wacheck V, Heere-Ress E, Schlagbauer-Wadl H, Hoeller C, Lucas T, Hoermann M, Hollenstein U, Wolff K, Pehamberger H: Chemosensitisation 22 23 24 25 26 27 28 29 of malignant ... 10 11 12 13 14 15 16 17 18 19 20 Received: April 20 11 Accepted: 28 July 20 11 Published: 28 July 20 11 21 References Eckstein F: Phosphorothioate oligodeoxynucleotides: what is their origin and what ... Cancer Res 20 05, 24 :24 5 -25 4 39 Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2( -Delta Delta CT) Method Methods 20 01, 25 :4 02- 408 40...

10
474
0

Báo cáo y học: "Coaggregation of Fc RI with Fc RIIB Inhibits Degranulation but Not Induction of Bcl-2 Family Members A1 and Bim in Mast Cells" ppsx

Ngày tải lên : 08/08/2014, 21:20

... phosphorylation and expression of forkhead and Bcl- 2 family members Scand J Immunol 20 06;63:1–6 28 Shinjyo T, Kuribara R, Inukai T, et al Downregulation of Bim, a proapoptotic relative of Bcl2 , is a ... expression .22 Antibodies and Reagents AffiniPure rabbit anti-mouse IgG (RAM IgG), AffiniPure RAM IgG F(ab´ )2 fragment (RAM F(ab´ )2) , and AffiniPure mouse anti-rat IgG (H+L) F(ab´ )2 fragment (MAR F(ab´ )2) ... 1997;158:1803–9 24 Hemmings BA Akt signaling: linking membrane events to life and death decisions Science 1997 ;27 5: 628 –30 25 Coffer PJ, Jin J, Woodgett JR Protein kinase B (c -Akt) : a multifunctional...

11
375
0

Báo cáo y học: "α α Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis" pps

Ngày tải lên : 09/08/2014, 01:21

... arthritis Osteoarthritis 22 34 28 – 72 ( 62) 69–78 ( 72) Sex Male 12 14 Female 14 10 20 Location Hip 22 25 Knee 10 Wrist dase reagent (039A Shandon-Upshaw) was applied for 15 and sections were again ... expressing HIF-1α and HIF -2 proteins in normal, rheumatoid, and osteoarthritic synovium Normal (n = 22 ) OA (n = 34) RA (n = 22 ) HIF-1α HIF -2 HIF-1α HIF -2 HIF-1α HIF -2 Minimum 0.00 0.00 20 .00 0.00 ... 43–66%) in OA (Table 2) Normal synovia were, in most cases, unreactive, and only in a small percentage of cases (6 /22 and 4 /22 for HIF-1α and HIF -2 , respectively) exhibited a weak and focal cytoplasmic...

9
391
0

Báo cáo khoa học: "The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells" doc

Ngày tải lên : 09/08/2014, 03:21

... μmol/L, 20 μmol/L, 25 μmol/L and 30 μmol/L) for 24 hours The early and late apoptosis/necrosis rates were 11.49 ± 0.63%, 2. 28 ± 1.46%, 3.97 ± 1 .28 %, 16.94 ± 3. 42% , 21 .50 ± 4.51%, 19.16 ± 4 .21 %, 21 .53 ... Hospital of Wenzhou Medical College, Wenzhou 325 000, China 18 20 21 22 Received: December 20 09 Accepted: 20 April 20 10 Published: 20 April 20 10 23 © 20 10 ZhengofAccess articleBioMed Central Ltd ... antibodies included ant -Bcl- 2 antibody (sc-4 92) (Santa Cruz, 1 :20 0), anti -Bcl- 2 BH3 antibody (Abgent, 1 :20 0) and anti-Bax(6A7) antibody (sc -23 959) (Santa Cruz, 1 :20 0) Protein extraction and western blot...

9
301
0

Báo cáo khoa học: " Differential protection by wildtype vs. organelle-specific Bcl-2 suggests a combined requirement of both the ER and mitochondria in ceramide-mediated caspase-independent programmed cell death" docx

Ngày tải lên : 09/08/2014, 10:20

... stress and phospholipase A2 Nat Immunol 20 03, 4:387-393 Page of (page number not for citation purposes) Radiation Oncology 20 09, 4:41 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 He ... wildtype Bcl- 2 (Bcl- 2 WT) localizing to both mitochondria and the ER, Bcl- 2 ActA targeted to mitochondria, Bcl- 2 cb5 expressed at the ER, and Bcl- 2 ΔTM localized in the cytosol The Bcl- 2 homology ... Bcl- 2 (Bcl- 2 WT), cytosolic Bcl- 2 lacking the transmembrane domain (Bcl- 2 ΔTM) and Bcl- 2 mutants restricted to the outer mitochondrial membrane (Bcl- 2 ActA) or to the endoplasmic reticulum (Bcl- 2...

9
388
0

báo cáo khoa học: " Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome " pptx

Ngày tải lên : 10/08/2014, 10:21

... binding to Bcl- 2, which prevents Bcl- 2 from Figure The effect of oxymatrine on the mRNA expression of Bcl- 2 and IAP family The effect of oxymatrine on the mRNA expression of Bcl- 2 family and IAP ... final manuscript 21 Competing interests The authors declare that they have no competing interests 23 22 Received: February 20 11 Accepted: 29 June 20 11 Published: 29 June 20 11 24 References Hidalgo ... chemistry 20 01, 27 6: 323 8- 324 6 Marusawa H, Matsuzawa S, Welsh K, Zou H, Armstrong R, Tamm I, Reed JC: Hbxip functions as a cofactor of survivin in apoptosis suppression The EMBO journal 20 03, 22 :27 29 -27 40...

6
239
0

báo cáo khoa học: "SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status" pptx

Ngày tải lên : 10/08/2014, 22:20

... C) Con.(nM) 0 750 β -actin 25 0 24 hr 500 750 25 0 48 hr 500 750 25 0 72 hr 500 D) 750 24 hr Con.(nM) 25 0 500 750 Bcl- 2 72 hr 25 0 500 750 25 0 500 750 Bcl- 2 Bcl- XL 48 hr Bcl- XL Mcl-1 Bax Bim β -actin ... significance of BCL- 2 expression and http://www.jhoonline.org/content /2/ 1/8 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 bcl- 2 major breakpoint region rearrangement in diffuse large cell ... 2: 8 A) Con.(nM) 24 hr 25 0 500 750 http://www.jhoonline.org/content /2/ 1/8 48 hr 25 0 500 B) 24 hr Con.(nM) 25 0 500 750 48 hr 72 hr 25 0 500 750 25 0 500 750 Bcl- 2 Bcl- 2 Bcl- XL Bcl- XL Mcl-1 Mcl-1 Bax...

13
236
0

Báo cáo y học: "A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history" pptx

Ngày tải lên : 12/08/2014, 04:20

... K7, B15 and A 52 structures and it can be predicted in other proteins from their sequences In N1 protein residues projecting outwards from alphahelix include Asp 22, Lys25, Lys26 and Glu 32, of which ... Acids Res 20 00, 28 :23 5 -24 2 22 Ginalski K, Elofsson A, Fischer D, Rychlewski L: 3D-Jury: a simple approach to improve protein structure predictions Bioinformatics 20 03, 19:1015-1018 23 Proteinkeys ... BMC Evol Biol 20 08, 8:67 29 Csuros M, Miklos I: Streamlining and large ancestral genomes in Archaea inferred with a phylogenetic birth -and- death model Mol Biol Evol 20 09, 26 :20 87 -20 95 30 Count:...

12
306
0

Role of bcl 2 in metabolic and redox regulation via its effects on cytochrome c oxidase and mitochondrial functions in tumor cells

Ngày tải lên : 14/09/2015, 08:42

... and death homeostasis is the key to the onset and maintenance of the transformed phenotype 1 .2 Bcl- 2 and Bcl- 2 family proteins: Since the discovery of Bcl- 2, many other Bcl- 2- like proteins ... group of Bcl- 2 family proteins is anti-apoptotic and contains BH1-4 domains These include Bcl- 2, Bcl- xL, Bcl- w and Mcl-1 (Strasser 20 05) The second group of members is pro-apoptotic and contains ... to as Bcl- 2 homology (BH) domains These domains were shown to be important for the heterodimerization of the Bcl- 2 family proteins, such as the BH1 and BH2 domains necessary for Bcl- 2 and Bax...

78
267
0

Longman-Grammar and Vocabulary for Cambridge Advanced and Proficiency (2)

Ngày tải lên : 05/10/2012, 09:51

... Expressing knowledge and belief 23 0 23 8 Verb cornplernentation Entry test SECTION I SECTION SECTION 20 6 20 8 Exam practice 12 210 Unit thirteen 21 2 23 9 OVERVIEW Verbs followed by -ing and infinitive ... by as 24 0 24 2 24 4 Vocabulary SECTION SECTION Competition, opposition, disagreement Starting and ending: creating and destroying Exam practice 15 24 6 24 8 25 0 Reported speech Entry test 21 2 Progress ... Vocabulary SECTION SECTION Quoting, reporting and interpreting Communicating Exam practice 13 21 8 22 0 22 2 25 2 • Syllabus map Unit one page 16 Grarnrnar Probiem tmses Present Perfect Present Perfect...

288
1.8K
23