... Maddison et al including a good safety profile, small displacement volume, and minimal indicator loss [9-12] However, in a recent laboratory investigation in porcine models of acute lung injury, both ... volume of paired using the single-thermal indicator diluBland-Altman analysis made bythe indocyanine green-thermal indicator water (EVLW) volume made by using the single-thermal indicator dilution ... Edwards JD, Little RA, Dark PM: Estimation of errors in determining intrathoracic blood volume using thermal dilution in pigs with acute lung injury and haemorrhage Br J Anaesth 2004, 93:546-551 Nirmalan...
... aggravation of brain injury, while brain imaging, physical examination, and electrophysiology all focus on the consequences of brain injury NSE is a protein located in nerve cells and detectable in body ... course interval listed in Table 4, the following four studies investigated the clinical usefulness in predicting neurological outcome after CPR not in accordance with time course interval Reisinger ... prospective study involving blood sampling between and 12 hours after resuscitation at a time point specified by interval from onset of CA would be most helpful in investigating the clinical usefulness...
... randomised, double-blind, placebo-controlled study Pain Clinic 2003, 15:193-202 Farar JT, Halpern SD: Understanding clinical trials inpain research In Cancer Pain, Assessment and Management Edited by: ... Pain 2000, 88:287-294 Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole RM: Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale Pain ... as in all centers they are standard care for patients requiring analgesic treatments for pain control, according to each center and investigator policy In the case a RCT will be activated in...
... seen in 12 patients Hepatotoxicity grade ≥ was observed in two patients; vomiting grade ≥ 2, in two patients; and rash grade ≥ 2, in one patient Hematological toxicity grade 3/4 was observed in ... participated in its design and coordination and helped to draft the manuscript HC and HY participated in the collection of samples and follow-up All authors read and approved the final manuscript Competing ... PFS in NSCLC patients treated with gemcitabine-based chemotherapy No significant correlation was found between PBMC RRM1 mRNA expression and the efficacy of gemcitabine Patientsand Methods Patients...
... comorbid back painin this patient population SF-36 bodily pain domain was designed for general bodily pain (e.g back pain) as opposed to knee pain Veerapen et al., found that back pain was more ... patient was interviewed in English by a trained interviewer one week before, six months after, and two years after surgery using a standardized questionnaire including a generic HRQoL instrument ... was more common than knee joint painin Asian populations [27] and back pain was reported as a significant factor influencing post-TKR SF36 bodily pain, vitality, and mental health scores [9]...
... agents, including gemcitabine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α [25] Lastly, the association between TMA and BMT ... therapy and develops in 20% to 40% of BMT recipients [47] Amphotericin during conditioning Acyclovir during conditioning Vancomycin during conditioning The main site of liver damage in this setting ... chains bind to a specific peptide domain on the Tamm-Horsfall protein [17]; variations in CDR3 in both the κ and λ light chains influence binding [20] Additionally, hypovolaemia, sepsis, urinary...
... placed on a cooling mattress (Blanket roll 2; Cincinnati Sub-Zero Products, Inc., Cincinnati, OH, USA), and at the same time, ice-cold lactated Ringer solutions (4°C) were administered with a ... mL/minute and a maximum of 30 mL/kg body weight of the patient Infusions were stopped if the target temperature (32°C to 34°C) was reached The induced cooling was maintained by using this cooling ... Amsterdam, The Netherlands, were included The study protocol was approved by the local institutional review board, and a signed informed consent form was obtained from the next of kin for patients eligible...
... such as echinocandins and triazoles show advantages compared to classic imidazol-based azoles and polyenes concerning efficacy, specifity, toxicity profile and patient comfort Promising results ... therapy and early wound closure gain a key function in limiting the risk of fungal infection in burn patients [2,3,5] Fungal infections should not be underestimated in modern burn care Abbreviations ... Promising results are to be expected by candida-secretoric aspartic proteases (SAPs) inhibitors and calcineurin signaling pathway blockers [6] However, despite the introduction of new antimycotic substances,...
... MF: Infection controlin burn patients: are fungal infections underestimated? Scand J Trauma Resusc Emerg Med 2009 in press Ballard J, Edelman L, Saffle J, et al.: Positive fungal cultures in ... analysis Ann Intern Med 2005, 143:857-869 Wood GC, Mueller EW, Croce MA, et al.: Candida sp isolated from bronchoalveolar lavage: Clinical significance in critically ill trauma patients Intensive ... with azoles in high-risk, surgical intensive care unit patients: A meta-analysis of randomized, placebo-controlled trials Crit Care Med 2006, 34:1216-1224 Publish with Bio Med Central and every...
... Figure sFlt-1 and VEGF-A levels inpatients with FN Combined analysis sFlt-1 and VEGF-A levels inpatients with FN Actual sFlt-1 and VEGF-A serum levels obtained at fever onset andafter 48 hours ... disease in children and young adults, and its limited validation in the outpatient setting andinpatients with acute leukemia still preclude its widespread adoption for the management of FN patients ... 3) Figure Serum sFlt-1 and VEGF-A levels in FN Serum sFlt-1 and VEGF-A levels inpatients with FN Box plots representing serial concentrations of sFlt-1 and VEGF-A inpatients with FN with non-complicated...
... Figure sFlt-1 and VEGF-A levels inpatients with FN Combined analysis sFlt-1 and VEGF-A levels inpatients with FN Actual sFlt-1 and VEGF-A serum levels obtained at fever onset andafter 48 hours ... disease in children and young adults, and its limited validation in the outpatient setting andinpatients with acute leukemia still preclude its widespread adoption for the management of FN patients ... 3) Figure Serum sFlt-1 and VEGF-A levels in FN Serum sFlt-1 and VEGF-A levels inpatients with FN Box plots representing serial concentrations of sFlt-1 and VEGF-A inpatients with FN with non-complicated...
... ICU remains elusive [17] Serum creatinine concentrations and creatinine clearance are unreliable indicators for acuteand abrupt changes in kidney function [27] Serum creatinine only comes into ... an apoptotic-inflammatory AKI, the administration of caspase inhibitors (CI) gains increasing interest Indeed, CI ameliorate ischemia-reperfusion injury in different organs, including the kidneys ... Anticoagulation remains the topic of continuous development and research, in particular since the introduction of citrate and upcoming dedicated machines Unfractionated heparin (UFH) remains the most...
... abstraction After pretesting and refining the forms on two trials of surfactant therapy in adults and clarifying definitions based on feedback from the reviewers, two reviewers then independently abstracted ... (respiratory therapist not involved in patient care) 100% More immunosuppressed incontrol group (30 versus 22) Yes No aPatients randomized but not included in the analysis bPotentially clinically significant ... trials, randomizing 311 patientsand reporting data for 305 patients There were no deaths reported in the three RSV/severe bronchiolitis trials; thus our estimate is based on three trials randomizing...
... knowledge in two ways First, our finding that most patients entering the ICU so on the day of developing their clinical insult is new, and it underscores the potential need for rapid intervention in ... for acute lung injury and the acute respiratory distress syndrome N Engl J Med 2000, 342:1301-1308 Bersten AD, Edibam C, Hunt T, Moran J: Incidence and mortality of acute lung injury and the acute ... Aardal S, Thorsteinsson A, Frostell CG, Bonde J: Incidence and mortality afteracute respiratory failure andacute respiratory distress syndrome in Sweden, Denmark, and Iceland The ARF Study...
... further increased to 10-3 – 10-4 (while retaining specificity) by lowering the annealing temperature to 60°C and increasing the number of PCR cycles but at the expense of a stronger 657 bp sideband ... tested in serial dilutions of cell lines Deltaretrovirus PCR tested in serial dilutions of cell lines Cell line DNA was diluted in genomic DNA from healthy individuals A: cell line Mo T (HTLV-II-infected), ... (HTLV-II-infected), B: cell line MJ (HTLV-I-infected), C: cell line BL3.1 (BLV-infected) First and last lane in every gel: φX174/Hae III size standard (QIAGEN, Hilden/Germany) No cell line harboring STLV-III,...
... There are no other competing financial or nonfinancial interests References Zausig YA, Busse H, Lunz D, Sinner B, Zink W, Graf BM: Cardiac effects of induction agents in the septic rat heart Crit ... whether combinations of drugs will produce less cardiovascular depression, and whether longer-term infusions will produce differences in cardiovascular outcomes and patient recovery Competing interests ... KM, Schmidt MB: Transthoracic echocardiography for cardiopulmonary monitoring in intensive care Eur J Anaesthesiol 2004, 21:700-707 Royse CF, Seah JL, Donelan L, Royse AG: Point of care ultrasound...
... patient pain scores during flexion at Final time point The chart shows the level of pain for each patient in the Control group andin the InterX group at both preNIN therapy and at post-NIN therapy ... painand no patients reporting being pain free Overall, at the Final pre-treatment measure, only three patientsin the InterX group had a higher pain score than at Baseline compared to thirteen control ... moderate pain (VRS = 4-7); subject (4%) reported severe pain (VRS 8-10) The control group had no patients with zero pain scores, 14 subjects(47%) with mild pain; 9(30%), with moderate pain; and (23%)...
... Huber R, Mueller P, Knehr S, Bauchinger M: Combined FISH painting and harlequin staining for cell cycle-controlled chromosome analysis in human lymphocytes Int J Radiat Biol 1995, 68:25-27 23 ... thiocyanate for 10 at 90°C instead of pre-treatment with pepsine [21] For a discrimination between first and second cycle metaphases (harlequin staining), prior to painting, slides were treated ... counterstained chromosomes, and of centromeric signals, using the PAINT nomenclature system [23] to describe the observed painting patterns For the subsequent statistical analysis, painted chromosomes...
... [20] observed an increase in TRECs counts after an initial drop to undetectable levels, starting 2-3 months after HSCT and reaching a plateau months after HSCT, indicating ongoing thymic output ... , and CD45RO + /CD4 + T cells after HSCT are shown in Figure In the early period after HSCT (within 12 weeks), the frequencies of CD45RA + /CD4+, CD45RA+/CD8+, and CD45RO+/CD4+ T cells inpatients ... cells remained at low levels within weeks after HSCT, and higher after week 12 post-HSCT (P = 0.003) Within weeks post-HSCT, the CD45RO+ T cells that expanded were predominant, but after week...
... connecting element between inflammation and thrombosis [36] Not only have increased plasma levels of sP-selectin been found inpatients with venous thromboembolism in a short time after the acute incident ... fragments of insoluble fibrin detectable in plasma after fibrin coagulum has been cleaved by plasmin Increased plasma level of D-dimer results from pathological activation of blood clotting and occurs ... necrosis, tumours or infections Nevertheless, we did not find any clinical or laboratory markers of infection in our sample of patients The increased plasma level of D-dimer inacute psychosis may...