... drains the tip ofthe oral tongue, primarily to level I or level II The lateral pathway drains the lateral 1/3 ofthe dorsum ofthe tongue to levels I, II, III The central pathway drains the ... „„sentinel node‟‟ by Cabanas in 1977, studying penile cancer, who defined the concept ofthe sentinel node being the doorway tothe regional node basin (4) The modern concept of SLN represents the ... stain IHC Time 20 mins mins 15 mins mins 15 mins 12 hours mins 10 mins mins mins 10 mins mins 10 mins ix Table Summary of results x Table Summary ofthe secondary analysis inthe supplementary...
... designations are as in Figure Affinity ofthe TBP-bound DNAto nuclear proteins To test changesinthe tight DNA- protein interactions coupled to plant development we performed DNA- binding protein blot assays ... sequences in other sites ofthe gene intensively binding TBPs indicate that TBP binding is not dependent on the presence of MAR TBP binding and transcription The overall intensity oftheDNA association ... enables the discrimination of several types of DNA- protein interactions inthe nucleus including two kinds ofDNA complexes with nuclear matrix proteins that are not revealed by other approaches In...
... collected at the middle parts ofthe grove from points Sampling points St.1 and St.2 are inthe same stream, and sampling point St.3 is inthe other stream The two streams flow together to be one ... through the cultivation and the ratio ofthe increased amount of SS tothe increased amount of Chl.a was higher than that ofthe algae Increased amount of SS were higher inthe cases of high ... the sampling point St.4 is situated inthe joined stream, which is the only stream that flows into the reservoir The reservoir water was also sampled from point Po inthe reservoir close to the...
... secondary to suppression of respiration during hypoxia Inthe absence of differential regulation of a specific nuclear gene coding for the subunits of CytOX, changesinthe microenvironment ofthe cell ... Although succinylacetone and CoCl2 are known inhibitors of heme biosynthesis, these agents also elicit nonspecific and toxic effects in animals To ascertain that the effects of these agents, on the catalytic ... and alters the expression ofthe two nuclear genome coded isoforms of CytOX V [10,32] The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes...
... rate of fat oxidation in PC12 cells We hypothesized that QDs and CoCl2 induce theaccumulationof lipids in cytoplasmic LDs by the activation of HIF-1a Transcription factors involved in signaling ... directly intheaccumulationof lipids triggered by QDs under the conditions of uncompromised cell survival inthe presence of serum On the basis ofthe results obtained in this study showing that ... signaling via the trk receptor in PC12 cells involves caveolin [51], and that caveolin associates with LDs [52] Therefore, NPs may induce theaccumulationof lipids in PC12 cells by disturbing the...
... high, to early evening hours when the sun is setting The decline inthe energy value is due to a combination of increased part-loading of CCGTs, increased displacement ofthe small amount of incumbent ... requirements, the spinning reserves would need to be equivalent to half ofthe total contingency reserves This would imply that the spinning reserve would be increased to 3% ofthe load and the non-spinning ... generation, the commitment decision from the DA process is binding inthe RT, thus limiting the options for maintaining a balance in RT The combined-cycle vintage (CCGT) modeled in this analysis, for instance,...
... accumulate the covalent adduct inthe assay period, thus becoming the major form detected inthe spectra Summarizing, data shown in Fig reinforce our previous findings on the tautomeric forms ofthe internal ... structure inthe enzyme, suggesting several interaction points for the adduct within the catalytic center in addition to those established by the internal aldimine alone From the shape ofthe a-FMH-treated ... histidine residue, corresponding to H197 in rat HDC, also is strictly conserved in group II of mammalian L-amino acid decarboxylases, in which it seems to be stacked in front ofthe cofactor pyridine...
... whathappened to Sonny.As the story nears completion, a single event brings the narrator out ofthe second phase and intohis third phase It is in this final pahse that the narrator obtains a true ... began to see him asa brother He became sensitive to what offended Sonny and took caution to avoid them He was willing tobe interested in what Sonny interested in Finally, he was willing to sit ... way to freedom.Finally, during the third phase, the narrator finally started caring about Sonny instead of try tocare for Sonny He no longer saw him as just something to be taken care of, he finally...
... chain of Ala (Fig 6A) In PR, the two Cc atoms of Val82 ˚ formed van der Waals contacts with indinavir, of 3.8 A In PRV82A, the change inthe position ofthe main chain atoms placed the Cb atom of ... carbonyl oxygen of Gly27, the OD1 of Asp29¢ and the NE atom of Arg8 The N4 atom of indinavir interacted with the carbonyl oxygen of Gly27¢ The indinavir O1 and O3 atoms formed hydrogen bond interactions ... and more distal changes propagating tothe inhibitorbinding site Fig Structural variation in residues 81–82 near indinavir Stereoview showing the benzyl group of indinavir interacting with residues...
... domain and also with the idea that binding ofthe PCP tothe A domain in a productive manner increases the compactness ofthe protein Further control reactions with a noncognate inhibitor ofthe ... position inthe closely related A domains ofthe tyrocidine and bacitracin NRPS Cys331 is part ofthe binding pocket ofthe amino acid inthe active site [11] The mutation Cys331Leu decreased the ... 2C) Interestingly, however, we had to increase the amount of trypsin four-fold to observe a reasonable degree of degradation inthe former case These findings indicated, within the resolution of...
... met: • the power to revoke the trust remains with the grantor (the owner ofthe interest), and • the grantor (the owner ofthe interest) is a trustee ofthe trust If the owner ceases to be a ... either the company or the continuing owners can buy an owner’s interest to stop the transfer of an owner’s interest Inthe case of a corporation, if the corporate entity, rather than the continuing ... through, they must pay the owner for the interest according tothe price and terms inthe agreement Keep in mind that, if the company or the nontransferring owners buy the interest, the transferring...
... mice With the addition of mifepristone treatment tothe Ad5IL-12 vector, cytotoxic activity inthe TSLN is enhanced These results indicate that the inclusion of RU486 in a proinflammatory-based ... TSLN Both of these effects would appear to be advantageous towards inducing better tumor immunity and protecting against the spread of tumor cells into the draining TSLN While most ofthe anti-tumor ... therapy including prostate cancer with promising results including the ability to aide inthe suppression of lung metastases [40,41] The anti-tumor activities of IL-12 are known and include inducing...
... http://www.translational-medicine.com/content/8/1/138 Page of 14 Figure CD14 expression inthe liver tissues of rats CD14 staining inthe liver tissues of rats from the sham and BDL groups Staining of liver sections using ... http://www.translational-medicine.com/content/8/1/138 Page 11 of 14 Figure 10 Endotoxin staining inthe liver tissues of rats Immunohistochemical stain ofthe liver sections using a monoclonal antibody against lipid ... enhance endotoxin clearance [15,34] During cholestasis, theaccumulationof endotoxin may induce hepatocyte injury and impair CD14 synthesis during late-stage BA Although studies of liver injury should...
... evaluating the symmetry of every possible sub-string of a DNA sequence, then nesting them sequentially, beginning at the 5' end The span ofthe first IMR is designated L1; all shorter IMRs within the ... specific goals were to determine whether IMRs span the entire polyprotein, to identify the relationship of IMRs inthe precursor to IMRs inthe mature cleavage products and to assess the relationship ... inthe NC overlap (Fig 3C), and a Zn ion is bound within the region translated by the overlap The Cys-His boxes are zinc finger binding domains which enable NC to bind to nucleic acids, and the...
... At5g59780), the ninth one (At5g59430) corresponds tothe telomeric repeat-binding protein (TRP1), which also contains the typical MYB motifs [26] Eight out of these nine genes were also included inthe ... computing the log2 ofthe ratio between the gene expression level in TEV-infected plants and control plants (mock inoculated) and normalized by the number of genes inthe set To minimize the number ... three tryptophan repeats found in other MYB-like proteins and, second, it has a proline rich domain at the carboxi terminal end ofthe protein [27] The functional categories of response to water...
... April 2007 Taking this opportunity, the researchers examined how the HRQOL of subjectively healthy schoolteachers changed The goal ofthe present study was to investigate the effects ofthe smoke-free ... after the enforcement ofthe smokefree policy were evaluated using paired t-test in both groups The level of significance was set at 5% In addition, the differences ofthe net changesin each ... After the enforcement ofthe smoke-free policy, 16 (14%) ofthe 111 smoking teachers completing the followup survey had quit smoking successfully Table shows the baseline characteristics of the...