absorption of folic acid
Structure basis for molecular recognition of folic acid by folate receptor
... form of folate in circulation is 5-methyl tetrahydrofolate (5-methyl THF) [7] a) b) Figure Chemical structure of folic acid and folate derivatives a) Constitution of folic acid b) Tetrahydrofolate ... acid binding mechanism of FRα First, the overall shape and charge distribution of FRα ligand binding pocket is complementary to folic acid The basic pteroate head of folic acid is buried within ... and refinement statistics .66 ix LIST OF FIGURES LIST OF FIGURES Figure Chemical structure of folic acid and folate derivatives Figure Metabolism of folates .6 Figure Folate transport...
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Báo cáo y học: "The primary prevention of birth defects: Multivitamins or folic acid"
... multivitamins containing low dose of folic acid b) The HCCSCA Int J Med Sci 2004 1(1): 50-61 54 The case group consisted of 22,843 malformed offspring The prevalence of folic acid treatment during pregnancy ... while 1,152 (75.0%) continued folic acid supplementation until the end of pregnancy Of 2,617 cases with mothers who started the use of folic acid in the second month of gestation, 636 (24.3%) discontinued ... the dose of folic acid Among candidate CAs, a reduction was found in the prevalence at birth of cardiovascular CAs both after the use of the multivitamin and the high dose of folic acid However,...
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báo cáo khoa học: "Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate and vitamin B12: a case report" pps
... interference of dihydrofolate reductase (DFR) and polymorphisms of methyltetrahydrofolate reductase L-methyl-THF (MTHFR), that is, MTHFR 667TT, inhibits generation of 5-methyltetrahydrofolate reductase ... ingesting mg total of a 1:1 mix of (folic acid and methyl THF) and 5mg of cyanocobalamin daily 19 FA+ B12 18 Discontinued 12 10 FA 8mg PO/d 11/5/09 Docetaxel + B12 5mg PO/d * CV of Ultrasensitive ... children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin) N Engl J Med 1948, 238:787-793 Skipper HE, Chapman JB, Bell M: Studies on the role of folic acid in the leukemic...
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Báo cáo y học: "Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acidaminopterin conjugate" doc
... the enzymatic conversion of dihydrofolic acid to tetrahydrofolic acid by DHFR and the disappearance of the cofactor nicotinamide adenine dinucleotide phosphate at Page of 18 340 nm The results ... conditions [20] While clinical success of antifolates for the treatment of inflammatory diseases validates the pharmacology of this class of agents, the issues of toxicity and temporal response highlight ... type of joint; = swelling in two types of joint; = swelling in three types of joint; = swelling of the entire paw [37] A total score for each rat is calculated by summing the scores for each of...
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Targeted delivery of doxorubicin conjugated to folic acid and vitamin e d a tocopheryl polyethylene glycol succinate (TPGS
... structure of Vitamin E TPGS…………………………………………… 65 Scheme 2-5 Structure of Doxorubicin……………………………………………………………71 Scheme 2-6 Structure of Folic Acid ……………………………………………………………75 Scheme 3-1 Scheme of TPGS-DOX ... means of carrying the drug in a stable form to specific sites while avoiding non specific interactions that clears any foreign particles from the body 2.3.1.2 Folic Acid Folic Acid is one of the ... increased risk of several types of cancer For example, studies suggest that people whose diet is high in fat have an increased risk of cancers of the colon, uterus, and prostate Lack of physical...
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Báo cáo y học: "A folate-rich diet is as effective as folic acid from supplements in decreasing plasma homocysteine concentrations"
... bioavailable synthetic folic acid, 100 µg of natural folate from unfortified foods has been equated to 60 µg of synthetic folic acid from fortified food and to 50 µg of synthetic folic acid from supplements ... used: one consisted of a variety of foods which are good sources of folate and the other of capsules containing 500 µg of synthetic folic acid The first treatment consisted of take-away food-packages ... attained with a folate-rich diet The toxicity of folic acid is extremely low even after prolonged use of high doses (21) It has been shown that folic acid in doses between 0.2 and 15 mg/day can...
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ESTERS OF CARBOXYLIC ACIDS – CONVENTIONAL METHODS
... introduction of ester functions of dicarboxylic acids or mixed derivatives containing aliphatic ester moieties and ester functions of dicarboxylic acids, 4.1 Acylation with Carboxylic Acid Chlorides ... important polysaccharide ester of a carboxylic acid, and is prepared industrially or at the laboratory scale by conversion of cellulose with a mixture of acetic acid and acetic anhydride (10–40% ... the presence of sulphuric acid as catalyst (up to 15%, w/w) It is assumed that intermediately the mixed sulphuric acid acetic acid anhydride is formed (usually called acetyl sulphuric acid) generating...
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Microbial Production of Amino Acids in Japan
... various amounts of sodium pyruvate, g of ammonium acetate, 0.6 g of pyrocatechol, 0.2 g of sodium sulfite, 0.1 g of EDTA, and cells harvested from 100 ml of broth, in a total volume of 100 ml.The ... production of glutamate even in the presence of excess amounts of biotin and suggested that the overproduction of glutamate is caused by the imbalance of the coupling between fatty acid and glutamate ... soybea1ns contain lower amounts of lysine, which is one of Microbial Production of Amino Acids in Japan 77 the essential amino acids for those livestocks The estimated amount of l-lysine produced in...
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Tài liệu Báo cáo khoa học: Multi-targeted activity of maslinic acid as an antimalarial natural compound pdf
... proteolytic hydrolysis of haemoglobin as a source of amino acids constitutes one of the essential processes which take place along the intra-erythrocytic stage of the parasite Degradation of haemoglobin ... structure of the available inhibitors of cathepsin D [19], a lysosomal protease of mammalian cells, and chalcones and phenothiazines have been assayed as inhibitors of falcipain-2 [20,21] Inhibition of ... inhibition of falcipain [38] or by the indirect effect on the functionality of the vacuole as a result of the accumulation of partially hydrolysed peptides, leading to the accumulation of uncleaved...
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Tài liệu THE ROLES OF AMINO ACID CHELATES IN ANIMAL NUTRITION pdf
... Association of Feed Control Officials, a metal amino acid chelate is lithe product resulting from the reaction of a metal ion from a soluble salt with amino acids with a mole ratio of one mole of metal ... presence of chelation The amino acid chelate definition also disbarred the complexing of metals with protein or peptides, both of which require further digestion before absorption The formation of ... 47 76 xx Contents EVALUATION OF THE NUTRITIONAL EFFICIENCY OF AMINO ACID CHELATES 86 Silvano Maletto and Germano Cagliero AN ASSESSMENT OF LONG TERM FEEDING OF AMINO ACID CHELATES 106 Robert B...
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Tài liệu Báo cáo khóa học: Tungsten-containing aldehyde oxidoreductase of Eubacterium acidaminophilum ppt
... acetaldehyde One unit of aldehyde oxidoreductase activity was defined as the amount of enzyme catalyzing the reduction of lmol of benzyl viologen per minute For a fast check for the presence of aldehyde ... colorimetric technique as described [28] Analysis of pterin cofactor The pterin cofactor content was determined as described previously [29] After oxidation of the cofactor with potassium permanganate, protein ... sizes of the products were analyzed using GENESCAN software (Perkin Elmer Applied Biosystems) Results Isolation of aldehyde oxidoreductase The specific activity of aldehyde oxidoreductase from E acidaminophilum...
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Tài liệu Folic acid gia tăng chức vụ của màng trong mạch máu và giảm huyết áp những người hút thuốc lá: một thử nghiệm mới pptx
... thuốc: nhóm folic acid/ bên tay không chích thuốc: 5.7 0.5 , nhóm placebo: 5.4 0,5, nhóm folic acid / bên tay có chích thuốc 5.6 0.7, nhóm placebo: 5.5 0,5 Nh đoán trớc, folic acid làm giảm ... tăng folic acid máu biến đổi ngợc chiều với giảm xuống homocysteine 121 TCNCYH 28 (2) - 2004 Nhóm folic acid giãn nở động mạch tuỳ thuộc vào tác dụng màng nội gia tăng rõ rệt chứng tỏ folic acid ... al.) Folic acid tác dụng độ giao thông sóng mạch (pulse wave velocity) Do tác dụng folic acid động mạch bị cứng cha đợc tìm hiểu hay chứng minh rõ ràng Tác dụng làm giảm huyết áp folic acid có...
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Báo cáo khoa học: A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function potx
... enlargement The loss of UMPS activity, in a number of different species, results in the accumulation of orotic acid [30,47] We investigated whether the accumulation of orotic acid in umps-1()) mutants ... levels of orotic acid in umps-1()) embryos Discussion Role of the V-ATPase and PPK-3 in the control of gut granule size We have shown that, with the exception of ppk-3()), disrupting the function of ... amounts of orotic acid were sufficient for gut granule enlargement by feeding animals high levels of orotic acid These treatments did not promote the formation of intestinal vacuoles at any stage of...
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Báo cáo khoa học: Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio) pptx
... uptake of fatty acids across the plasma membrane and transport to various subcellular organelles, (b) modulation of the activity of enzymes involved in fatty acid metabolism, (c) protection of enzymes ... for a polypeptide of 131 amino acids, with a molecular mass of 14 406 Da and an isoelectric point of 6.59 With the exception of some Fabp10s, which have an isoelectric point of 8.8–9.0, all other ... membranes from the detergent effects of excess fatty acids by sequestering them, and (d) modulation of cell growth and differentiation by transport of fatty acids to the nucleus where they activate...
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Báo cáo khóa học: O-acetylation and de-O-acetylation of sialic acids in human colorectal carcinoma docx
... various stages of colorectal carcinoma Sialic acids were isolated and analysed by fluorometric-HPLC The proportion of individual sialic acids is expressed as a percentage of the total sialic acid in ... development, a systematic survey of OAE and OAT activities along with the relative level of O-acetylated sialic acids, was undertaken Here we show that the total level of sialic acid O-acetylation is significantly ... Sialic acid in colorectal carcinoma % Sialic acids in resection margins Table Fluorometric-HPLC and GC-MS analysis of glycoconjugate-bound and free sialic acids isolated from the mucosa of matched...
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Báo cáo khoa học: Local stability identification and the role of key acidic amino acid residues in staphylococcal nuclease unfolding ppt
... Local stability and key acidic amino acids in staphylococcal nuclease by the interactions of E75 with H121 and K97 It is believed that a small number of key amino acid segments play major roles ... structure In order to discern whether it is due to the absence of an acidic residue (glutamic acid or aspartic acid) , or the presence of glycine which destabilizes SNase secondary structure, both ... the presence of an a-helix [13,14] In contrast, the E129G mutant exhibited less CD than the others Thus, while most of the mutations of negatively charged glutamic acid or aspartic acid residues...
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Báo cáo Y học: Molecular cloning and characterization of isomultiflorenol synthase, a new triterpene synthase from Luffa cylindrica, involved in biosynthesis of bryonolic acid ppt
... Luffa cells (A) Time course of accumulation of bryonolic acid and total sterol in cultured Luffa cells Mean of three replicates Bar indicates SD (B) Time course of levels of isomultiflorenol synthase ... with those of authentic isomultiflorenol As the control pYES2 transformant produced no triterpene mono-alcohol [3], accumulation of Fig Multiple alignment of deduced amino -acid sequences of isomultiflorenol ... product of LcIMS1 isomultiflorenol synthase, could not be identified Cloning of isomultiflorenol synthase (Eur J Biochem 268) 6315 Fig Time course of bryonolic acid accumulation and levels of isomultiflorenol...
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Properties of carboxylic acids
... Mechanism of Acid- Catalyzed Ester Hydrolysis Is the reverse of the mechanism for acidcatalyzed esterification Like the mechanism of esterification, it involves two stages: 1) formation of tetrahedral ... stage is analogous to the acidcatalyzed addition of water to a ketone Second stage: cleavage of tetrahedral intermediate O + R'OH RCOH H+ OH RC OH OR' Mechanism of formation of tetrahedral intermediate ... Key Features of Mechanism Activation of carbonyl group by protonation of carbonyl oxygen Nucleophilic addition of water to carbonyl group forms tetrahedral intermediate Elimination of alcohol from...
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