abdominal compartment syndrome in the pediatric patient
báo cáo khoa học: " Comparison of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a murin model of peritoneal carcinomatosis" potx
... been obtained in HIPEC with oxaliplatin [11] Adrenaline also increased the drug content in the muscle of the abdominal wall We observed a ratio of to 17 in drug uptake between an abdominal muscle ... resulting in an increase in the wash out of the cisplatin [33] In contrast with heat, adrenaline at a concentration of mg/l for hour achieved a to 3-fold increase in platinum content in the peritoneal ... adrenaline at 37°C Cellular platinum concentration was increased by hyperthermia in all cells (Figure 1) Extending the incubation to hours also increased the platinum content in all cell lines,...
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Báo cáo y học: "New onset diabetes complicated by haemolysis and rhabdomyolysis: a case report and review of the literature" pot
... that they have no competing interests Authors' contributions Both of the authors were involved in the writing of the manuscript and patient clinical care Both authors read and approved the final ... aspiration pneumonia Clinically the patient improved and began speaking and eating MRI scanning showed no evidence of pontine changes After days the patient was returned to the ward and the regimen was ... medication was stopped apart from the intravenous insulin and intravenous fluids His haemoglobin increased, reticulocytes count rose and serum creatine kinase and bilirubin returned to normal (Figure...
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báo cáo hóa học:" Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)" pptx
... [10] Since Pt-containing chemotherapy drugs remain the major weapon against EOC, improving their efficacy could have a great impact on mortality The combination of hyperthermia with cisplatin has ... scanning in the Brown Cancer Center Small Animal Imaging Facility Intraperitoneal chemotherapy Tumor-bearing mice were anesthetized with 3% isoflurane in an inhalation chamber and maintained ... isoflurane during surgery Incisions (~0.5 cm) were made on both sides of the lower abdominal wall allowing entry into the peritoneal cavity (Figure 2) Inflow and outflow tubes were inserted into the peritoneal...
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Báo cáo hóa học: " Synthesis of Bio-Compatible SPION–based Aqueous Ferrofluids and Evaluation of RadioFrequency Power Loss for Magnetic Hyperthermia" docx
... the thermal fluctuation [25] The interacting nature and hence the enhanced magnetic volume will spoil the performance in biomedical applications So, to study the actual behaviour of the fluid in ... as the field is removed This emphasizes the noninteracting nature of the particles while in the fluid Citric acid, being ionic in nature, may also contribute to this rapid relaxation since the ... that the compound contains no traces of nonmagnetic haematite (a-Fe2O3) There is significant broadening of peaks due to the size reduction in particles The particle size is calculated from the line...
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Chapter 017. Fever and Hyperthermia (Part 1) docx
... commences The individual first notices vasoconstriction in the hands and feet Shunting of blood away from the periphery to the internal organs essentially decreases heat loss from the skin, and the ... the blood bathing the hypothalamic neurons matches the new thermostat setting Once that point is reached, the hypothalamus maintains the temperature at the febrile level by the same mechanisms ... function in the afebrile state When the hypothalamic set point is again reset downward (in response to either a reduction in the concentration of pyrogens or the use of antipyretics), the processes...
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Chapter 017. Fever and Hyperthermia (Part 2) docx
... with drugs that interfere with thermoregulation In patients with heat stroke syndromes and in those taking drugs that block sweating, the skin is hot but dry, whereas in fever the skin can be cold ... occurs in either very young or elderly individuals, particularly during heat waves According to the Centers for Disease Control and Prevention, there were 7000 deaths attributed to heat injury in the ... appears to be caused by the inhibition of central dopamine receptors in the hypothalamus, which results in increased heat generation and decreased heat dissipation The serotonin syndrome, seen with...
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Chapter 017. Fever and Hyperthermia (Part 3) pot
... circulating cytokines lead to fever by inducing the synthesis of PGE2, they also induce PGE2 in peripheral tissues The increase in PGE2 in the periphery accounts for the nonspecific myalgias and arthralgias ... destruction by the lung and gains access to the hypothalamus via the internal carotid However, it is the elevation of PGE in the brain that starts the process of raising the hypothalamic set point for ... that this interaction is the first step in initiating fever—i.e., in raising the set point to febrile levels The key events in the production of fever are illustrated in Fig 17-1 As has been...
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Chapter 017. Fever and Hyperthermia (Part 4) potx
... injection into the brain than with IV injection Therefore, CNS production of these cytokines apparently can raise the hypothalamic set point, bypassing the circumventricular organs involved in fever ... particularly helpful in identifying disease in patients with small elevations in body temperature Fever in Recipients of Anticytokine Therapy As of this writing, more than 750,000 patients in the United ... lowering the level of host defenses against both routine bacterial and opportunistic infections The opportunistic infections reported in patients given neutralizing antibodies to TNF-α (infliximab...
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Chapter 017. Fever and Hyperthermia (Part 5) pdf
... with the inhibition of brain cyclooxygenase Acetaminophen is a poor cyclooxygenase inhibitor in peripheral tissue and lacks noteworthy anti-inflammatory activity; in the brain, however, acetaminophen ... oxidized by the p450 cytochrome system, and the oxidized form inhibits cyclooxygenase activity Moreover, in the brain, the inhibition of another enzyme, COX-3, by acetaminophen may account for the antipyretic ... hypothalamic set point is a direct function of reducing the level of PGE2 in the thermoregulatory center The synthesis of PGE2 depends on the constitutively expressed enzyme cyclooxygenase The substrate...
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Chapter 017. Fever and Hyperthermia (Part 6) doc
... indicated in the neuroleptic malignant syndrome and in drug-induced hyperthermia and may even be useful in the hyperthermia of the serotonin syndrome and thyrotoxicosis The neuroleptic malignant syndrome ... Procainamide should also be administered to patients with malignant hyperthermia because of the likelihood of ventricular fibrillation in this syndrome Dantrolene at similar doses is indicated in ... antidepressants, succinylcholine, or halothane) along with appropriate clinical findings (dry skin, hallucinations, delirium, pupil dilation, muscle rigidity, and/or elevated levels of creatine phosphokinase)...
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Chapter 020. Hypothermia and Frostbite (Part 1) potx
... hypothermic Anesthetics can block the shivering responses; their effects are compounded when patients are not covered adequately in the operating or recovery rooms Several types of endocrine ... Parkinson's disease Phenothiazines Spinal cord injury Barbiturates Multisystem Carcinomatosis Trauma Anesthetics Sepsis Neuromuscular blockers Shock Antidepressants Hepatic or renal failure Insufficient ... great risk of exposure, whether it involves injury, changes in weather, or lack of preparedness Ethanol causes vasodilatation (which increases heat loss), reduces thermogenesis and gluconeogenesis,...
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Chapter 020. Hypothermia and Frostbite (Part 2) pot
... stimulation by hypothermia, there is progressive depression of all organ systems The timing of the appearance of these clinical manifestations varies widely (Table 20-2) Without knowing the core temperature, ... minute cycle g catechol tone, amines, adrenal amnesia prolongatio declining steroids, ; n; oxygen triiodot apathy; vasoconstri consumptio hyronin n; e and ia; increase in bronchorrhe thyroxin ... output and bronchospa increase judgme blood in a; ased increase preshiverin volume; dysarthr ction; Incre e; muscle then fatiguing nt; pressure sm metabol malada ptive shiverin r oderate with behavio...
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Chapter 020. Hypothermia and Frostbite (Part 3) doc
... saline is preferable to lactated Ringer's solution, as the liver in hypothermic patients inefficiently metabolizes lactate The placement of a pulmonary artery catheter risks perforation of the ... placed 24 cm below the larynx; it may read falsely high during heated inhalation therapy Relying solely on infrared tympanic thermography is not advisable After a diagnosis of hypothermia is established, ... monitoring should be instituted, along with attempts to limit further heat loss If the patient is in ventricular fibrillation, one defibrillation attempt (2 J/kg) should be administered If the rhythm...
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Chapter 020. Hypothermia and Frostbite (Part 4) pot
... of the gastrointestinal tract or bladder transfers minimal heat because of the limited available surface area These methods should be reserved for patients in cardiac arrest and then used in ... hypothermia Active external rewarming is best accomplished with forced-air heating blankets Other options include radiant heat sources and hot packs Monitoring a patient with hypothermia in a ... that are inserted into the hemithoraces Thoracostomy tubes should not be placed in the left chest of a spontaneously perfusing patient for purposes of rewarming Peritoneal lavage with the dialysate...
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Chapter 020. Hypothermia and Frostbite (Part 5) pdf
... of the sick euthyroid syndrome (Chap 335), historic clues or physical findings suggestive of hypothyroidism should be sought When myxedema is the cause of hypothermia, the relaxation phase of the ... than the contraction phase Hypothermia obscures most of the symptoms and signs of infection, notably fever and leukocytosis Shaking rigors from infection may be mistaken for shivering Except in ... affecting light touch, pain, and temperature perception The acral areas and distal extremities are the most common insensate areas Some patients complain of a clumsy or "chunk of wood" sensation in...
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SỐT (Fever and hyperthermia) potx
... gọi chất sinh nhiệt (CSN) ngoại sinh Các chất sinh nhiệt ngoại sinh tác động thông qua chất trung gian gọi chất sinh nhiệt nội sinh Interleukin-1 coi cytokin đảm nhiệm chức Interleukin-1 tế bào ... hoá trình sinh nhiệt Thực chất trình sinh nhiệt dãy phản ứng thần kinhhoá học phức tạp chưa hoàn toàn sáng tỏ Nhìn chung nguyên nhân làm tăng sản xuất chất sinh nhiệt nội sinh Interleukin-1 tăng ... chế ức chế sản xuất interleukin-1 v.v ) Prostaglandin đặc hiệu CSN ngoại sinh CSN nội sinh (IL-1) Prostaglandin Acid arachidonic AMP vòng Hypothalamus (Dưới đồi) TB bắp tăng sinh nhiệt Corticoid...
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báo cáo khoa học: "Inflammatory myopathy and severe rhabdomyolysis induced by leuprolide acetate therapy for prostate cancer: a case report" pot
... and supervised the writing of the case report All authors were involved with the treatment of the patient, and all authors read and approved the final manuscript Competing interests The authors ... without a subsequent increase in his creatine kinase level At his 12-month follow-up examination, the patient was in good clinical condition and had normal laboratory values, including PSA Discussion ... Immunohistochemical staining for CD3 to display T lymphocytes deterioration His prednisone dosage was increased to 70 mg/day, and his serum creatine kinase declined to normal (246 U/L) within six weeks The patient...
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báo cáo khoa học: " Hypothyroidism in a five-year-old boy with rhabdomyolysis and recent history of cardiac tamponade: a case report" pptx
... revised the case report ER revised the case report CL and SS were consulting physicians and revised the case report All authors read and approved the final manuscript Competing interests The authors ... of the Pathology Department of Esperanza Hospital, Universidad Francisco Marroquin for providing the photograph of the biopsy as well as the Cardiovascular Surgery Unit (UNICAR) for providing the ... exacerbated the cardiac tamponade in a previous hypothyroidism-related pericardial effusion in our patient Hypothyroidism is a cause of rhabdomyolysis in adults, but has been described in the pediatric...
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Báo cáo y học: " Near fatal posterior reversible encephalopathy syndrome complicating chronic liver failure and treated by induced hypothermia and dialysis: a case report" pps
... 310mmol/L Induced hypothermia was maintained for 48 hours during which time he regained normal pupillary reflexes with marked improvement in TCD velocities During the passive rewarming phase, the patient ... repeat induced hypothermia (32 to 34°C) Due to the anticipated increase in the serum ammonia level following the massive gastrointestinal hemorrhage, we initiated high-flow continuous venovenous ... imaging, Kale and colleagues demonstrated an increase in interstitial brain water in patients with cirrhosis and hepatic encephalopathy [11] In this study, brain water content increased with increasing...
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Báo cáo y học: "Hypothermia and neurologic outcome in patients following cardiac arrest: should we be hot to cool off our patients" pot
... Hypothermia: favorable outcome in 75 patients (55%) Normothermia: favorable outcome in 54 patients (39%) Hypothermia: favorable outcome in 21 patients (49%) Normothermia: favorable outcome in patients ... reperfusion following ischemia include the production of stress-related proteins, such as heat shock proteins These proteins, in turn, are believed to influence other gene products Elevations in heat shock ... histologically In addition to initiation timing, duration has been investigated Increasing the duration of hypothermia appears to decrease infarct size [12] In a rat model, hypothermia with durations...
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