a natural drug for the treatment of alzheimer s disease

Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx

Ngày tải lên : 07/03/2014, 10:20

... AD affected brain, metal dyshomeostasis is evident in the form of a substantial increase in the levels of extracellular metals and a decrease in the levels of intracellular metals Here, we have ... is of particular relevance These authors demonstrated that an increase in oxidative stress alters APP processing and generates an increase in Ab production If an oxidative stressinduced increase ... Ceruloplasmin is increased in cerebrospinal ﬂuid in Alzheimer s disease but not Parkinson s disease Alzheimer Dis Assoc Disord 8, 190–197 Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers...

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báo cáo khoa học: " Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer’s disease" doc

Ngày tải lên : 11/08/2014, 12:21

... data) and studies of disease- associated molecules and their assemblies beyond the pathway-centric view To address data integration, sophisticated approaches are needed to segment the image data ... validate, such as in diseases of the central nervous system One recent example is a metabolomic study of Huntington s disease [55], for which early disease markers were sought in patients and a transgenic ... modeling of the data in the context of disease pathophysiology In AD, the adoption of a systems approach is particularly challenging since even at the molecular level the disease pathogenesis is highly...

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Báo cáo khoa học: "A multidisciplinary approach for the treatment of GIST liver metastasis" docx

Ngày tải lên : 09/08/2014, 07:21

... hospitalization The postoperative course was complicated by the formation of a subhepatic abscess that was successfully treated with drainage catheters and systemic antibiotics Imatinib was discontinued ... performed for abdominal symptoms The gold standard for diagnosing GISTs is pathological tissue examination, which normally demonstrates atypical splindle cells A positive stain for CD117 carries a specificity ... GI tract, suggesting the liver mass was a late and isolated metastatic manifestation of the prior GIST tumor A multidisciplinary and staged treatment course was recommended Side effects and benefits...

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Báo cáo sinh học: "Therapeutic dendritic cell vaccine preparation using tumor RNA transfection: A promising approach for the treatment of prostate cancer" pps

Ngày tải lên : 14/08/2014, 19:22

... transfecting RNA into DCs The amount of RNA and the DC maturation stage for transfection were also analyzed The prostate tumor cell line (LNCaP) was chosen for this study because it overexpresses PSA and ... very small prostate tumors This, in association with radical prostatectomy and radiation therapies, has contributed to increasing the curative indexes [2] After several years of primary therapy, ... of DC loading with RNA is an important issue for DC vaccine RNA has the advantages of an efficient cytoplasmic expression allowing the use of total tumor antigens repertoire, and safe, because...

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Hydroxyurea for the Treatment of Sickle Cell Disease docx

Ngày tải lên : 05/03/2014, 10:20

... disease, to assess the potential short and long-term harms of its use in patients with sickle cell disease and other diseases, and to discuss barriers to the use of hydroxyurea and other medications ... person-year for Hb S 0 thalassemia, and 0.4 episodes per person-year for Hb SC disease In a study of 1,056 patients with Hb SS disease in California, 70 percent of patients were admitted for a crisis; ... underlying diseases, and between hydroxyurea and therapies for these diseases Further research on the place of hydroxyurea in therapy and its comparative effectiveness is also indicated, since the existing...

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Cultivated conjunctival epithelial transplantation for the treatment of ocular surface disease

Ngày tải lên : 14/09/2015, 18:24

... successfully restores the corneal surface in these eyes, but fails to address the conjunctival damage that is present Damage to the conjunctiva may also arise from various diseases, such as pterygia and ... contralateral donor eye This is then cultivated on various substrates, such as human amniotic membranes or fibrin-based substrates which results in a composite graft tissue that is then transplanted ... conjunctival damage that is present Various disorders involve the conjunctiva, such as pterygia and conjunctival tumors Treatment of these disorders involves surgical excision of the diseased area resulting...

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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx

Ngày tải lên : 05/03/2014, 23:20

... important to accurately diagnose dementia as early as possible This chapter outlines the basic elements of a clinical diagnostic evaluation for Alzheimer s disease (AD) and other dementias; and also ... mental status examination, the physician formulates diagnostic hypotheses The physician then considers all of the data gathered about the patient s history, functional status, laboratory test results, ... visual analysis of scans, describes how quantification with clinically available and friendly software tools can be employed to assist with analysis, and then illustrates a straightforward approach...

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The Handbook of Alzheimer’s Disease and Other Dementias doc

Ngày tải lên : 14/03/2014, 21:20

... inhibitors, the first class of drugs approved by the FDA for treating Alzheimer s disease In 1984, the first clinical criteria for the diagnosis of Alzheimer s disease was published, and the first five Alzheimer s ... clinical and scientific research into the causes, mechanisms, and treatment of Alzheimer s disease and related dementias The first of these was establishing the National Institute on Aging at the National ... Hypothesis Carmela R Abraham 262 viii Contents Other Mechanisms of Neurodegeneration Marina Boziki, Vassilis Papaliagkas, and Magda Tsolaki 277 10 Rational Therapeutics for Alzheimer s Disease and...

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Báo cáo y học: "Variations in the transcriptome of Alzheimer''''s disease reveal molecular networks involved in cardiovascular diseases" potx

Ngày tải lên : 14/08/2014, 21:20

... elements in disease associated genes Figure Steps taken to analyze Alzheimer' s disease using laser capture microdissected microarray data Steps taken to analyze Alzheimer' s disease using laser capture ... Functional annotation of these genes based on their association to human diseases resulted in the identification of 18 disease- related cardiovascular diseases (CVDs), AD/neurodegenerative diseases, stroke ... Online Mendelian Inheritance in Man and the Genetic Association Database These sources assign diseases to gene identifiers and then DAVID maps the diseases to the DAVID database through the gene identifiers...

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Báo cáo y học: "Endoscopic Facet Debridement for the treatment of facet arthritic pain – a novel new technique

Ngày tải lên : 26/10/2012, 09:32

... commonly used RFA, with results durable for at least years Larger scale trials with a control group are warranted to further evaluate the relative efficacy of this surgical treatment in patients with ... in facet-related pain as measured by Visual Analog Scale (VAS) score at final follow-up visit Secondary outcome was change in OSWESTRY disability index from preoperative evaluation to final follow-up ... dorsal nerve medial branch, Staender et al 17 reported a mean VAS pain score reduction of 3.3 at six months follow-up; 40% of patients had relief for at least 12 months, and mean duration of pain...

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Báo cáo khoa học: A guide to taming a toxin – recombinant immunotoxins constructed from Pseudomonas exotoxin A for the treatment of cancer ppt

Ngày tải lên : 22/03/2014, 15:21

... the hypothesis that PE exploits the ERAD system is the amino acid bias against lysine residues in its catalytic fragment [93] Sequence analyses of the catalytic (A) fragments of PE and other protein ... antigens [134] Another PE-based RIT that has reached clinical trials is the anti-mesothelin SS1P Two phase I trials treating patients with mesothelioma, pancreatic cancer or ovarian cancer have ... cells lacking the diphthamide modiﬁcation on EF2 are viable and resistant to NAD+ diphthamide ADP-ribosyltransferases, although they may show effects such as temperature sensitivity and a decreased...

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Pelvic floor muscle training and adjunctive therapies for the treatment of stress urinary incontinence in women: a systematic review doc

Ngày tải lên : 28/03/2014, 14:20

... be guaranteed All relevant studies with an English language abstract were located for assessment against the inclusion criteria Date of the last search was 20 May 2005 Individual strategies were ... appraisal scores and resolved disagreements in scoring by discussion Details of the quality assessment are provided [see additional files &5] with studies ranked according to their quality assessment ... 1 0s/ 2 0s, 40 reps, sets/ week Weekly individual sessions NR NA 5s/ 5s, 10 reps (max), seated/standing, sets/ day 3s/ 3s, 15 reps, (submax) set/day sustained (submax) rep, set/day clinic visits Arvonon...

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$báo cáo hóa học:" Is tension band wiring technique the "gold standard" for the treatment of olecranon fractures? A long term functional outcome study" docx$

báo cáo hóa học:" Is tension band wiring technique the "gold standard" for the treatment of olecranon fractures? A long term functional outcome study" docx

Ngày tải lên : 20/06/2014, 01:20

... Journal of Orthopaedic Surgery and Research 2008, 3:9 Statistics The microsoft excel program was used for the creation of the graphs and the SPSS program 12.0 (SPSS Inc, Chicago, IL, USA) for the ... Mayo Scale (VAS) patient satisfaction score (b) Visual AnaFigure logue Elbow Performance score (MEPS) (a) and Mayo Elbow Performance score (MEPS) (a) and Visual Analogue Scale (VAS) patient satisfaction ... creation of statistics Data analysis was conducted with Chi-square test and Student 's t-test P values less than 0.05 were considered to be statistically significant Results From the total of...

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$báo cáo hóa học:" The use of tibial Less Invasive Stabilization System (LISS) plate [AO-ASIF] for the treatment of paediatric supracondylar fracture of femur: a case report" doc$

báo cáo hóa học:" The use of tibial Less Invasive Stabilization System (LISS) plate [AO-ASIF] for the treatment of paediatric supracondylar fracture of femur: a case report" doc

Ngày tải lên : 20/06/2014, 04:20

... Lam et al.: The use of tibial Less Invasive Stabilization System (LISS) plate [AO-ASIF] for the treatment of paediatric supracondylar fracture of femur: a case report Journal of Orthopaedic Surgery ... bone, articular fractures and extremely short distal fragments [5] In our case, the physis of the distal femur was not closed yet and the supracondylar fracture was distal At the same time, there ... post-operative cast immobilization and there is a chance of intra-articular pin placement, causing septic arthritis and a risk of damaging the growth plate An external fixator is also used for the treatment...

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báo cáo hóa học:" Mid-term results of ponseti method for the treatment of congenital idiopathic clubfoot (A study of 67 clubfeet with mean five year follow-up)" pot

Ngày tải lên : 20/06/2014, 04:20

... http://www.josr-online.com/content/6/1/3 Page of Table Details of the Relapse Foot Patient s age at Bilateralism/Unilateralism at the relapse (In months) initiation of the treatment Side of relapsed foot Relapse Treatment offer ... use of anesthesia, as described by Ponseti [4] In all patients, the cavus is corrected first by supinating the forefoot and dorsiflexing the first metatarsal Failure to supinate the forefoot as ... regimen Treatment is started as soon as the skin condition permits and consists of gentle manipulation of the foot and the serial application of long leg plaster casts at weekly interval without the...

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báo cáo hóa học:" Mid-term results of ponseti method for the treatment of congenital idiopathic clubfoot (A study of 67 clubfeet with mean five year follow-up)" docx

Ngày tải lên : 20/06/2014, 07:20

... http://www.josr-online.com/content/6/1/3 Page of Table Details of the Relapse Foot Patient s age at Bilateralism/Unilateralism at the relapse (In months) initiation of the treatment Side of relapsed foot Relapse Treatment offer ... use of anesthesia, as described by Ponseti [4] In all patients, the cavus is corrected first by supinating the forefoot and dorsiflexing the first metatarsal Failure to supinate the forefoot as ... regimen Treatment is started as soon as the skin condition permits and consists of gentle manipulation of the foot and the serial application of long leg plaster casts at weekly interval without the...

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Báo cáo y học: "A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy" pps

Ngày tải lên : 08/08/2014, 17:20

... times before and after treatment. 13 Linear spline fit analysis was used to measure and compare PSA values before, during and after therapy.12 Prostate cancer patients who had failed standard therapy ... by further clinical study Additional studies appear warranted for the use of Apatone as a co–adjuvant, or for emerging salvage chemotherapy in the treatment of late stage prostate cancer Acknowledgements ... Med Sci 2008, 63 Materials and Methods Analysis of PSA changes and Statistics Patient selection PSA velocity (PSAV) and doubling time (PSADT) were calculated using the Prostate Cancer Research...

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Báo cáo y học: " Pregnancy and delivery while receiving vagus nerve stimulation for the treatment of major depression: a case report" pot

Ngày tải lên : 08/08/2014, 21:20

... informed consent The case study patient, a Caucasian woman aged 28 years with a DSM-IV diagnosis of unipolar depression, was enrolled in the acute and long-term phases of the pilot study of VNS ... contributions MMH was the principal investigator of the VNS pilot study DS was the study coordinator KT assisted in data analysis and manuscript preparation 11 12 Acknowledgements The authors gratefully ... CGI-Severity of Illness 31 Score: CGI-Severity of Illness February – May, 1999 Date of Assessment Pregnancy 1999 2000 2001 2002 2003 Date of Assessment The patient 's score on the CGI -S scale also indicated...

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Báo cáo y học: "Deep transcranial magnetic stimulation for the treatment of auditory hallucinations: a preliminary open-label study" pptx

Ngày tải lên : 09/08/2014, 01:21

... Scale (AHRS), Scale for the Assessment of Positive Symptoms (SAPS) and Scale for Assessment of Negative Symptoms (SANS) (with standard error of mean (SEM)) day before treatment (baseline), day ... Assessment of Positive Symptoms (SAPS) and Scale for Assessment of Negative Symptoms (SANS) (with standard error of mean (SEM)) day before treatment (baseline), day after last session (end of treatment) , ... 7.68 AHRS = Auditory Hallucinations Rating Scale; CGI(-I/ -S) = Clinical Global Impression (Improvement/Severity); SANS = Scale for Assessment of Negative Symptoms; SAPS = Scale for the Assessment...

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báo cáo khoa học: "Surgical perspectives from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of breast cancer" pps

Ngày tải lên : 09/08/2014, 01:24

... balloon applicator placement or ultrasound assessment in these patients was 15, 19 and 16 days Assessment of the balloon and measurement of the distance from balloon surface to skin surface was evaluated ... local anesthesia and sedation Patients were also asked to complete a survey about their participation in the study Patient satisfaction was measured on a scale from (not satisfied) to (very satisfied) ... area of less than 2.5 cm of the skin surface As seen in Figure 2, this can readily be accomplished by using modifications of the standard oncoplastics incisions Since the lesion in this case was...

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