... out by one ofthe two authors of this study during the period 2002-2005 Notably, due to the sensitive nature ofthe question, we did not ask respondents about the role they thought they played, ... case studies: the dominant logic, the activity of management accountants, the positioning ofthe management accounting function, and the positive and negative effects of structuring the management ... contexts The Independence-Involvement Dilemma Our analysis raises the issue ofthe independence ofthe management accounting function in relation to operational managers, notably in the context of the...
... drive ubiquitination of p53: a coordinated interaction ofthe N-terminus of MDM2 with the N-terminus of p53, and an interaction ofthe acid domain of MDM2 with the central domain of p53 [24] Accordingly, ... wild-type MDM2 at inhibiting the DNA-binding functionof E2F1 These data are similar to the previously reported inhibition of p53 function by the MDM2–HSP90 complex in the absence of ATP [21] However, ... analyse the role ofthe ATPbinding domain as a modifier of transcription factors in vivo, with the prospect of developing drugs that either stabilize the ATP-bound conformation of MDM2 or inhibit the...
... one, the general 2.2 The analysis if the recurrent potential functionofthe type zυ The HC, besides the gamma function, also has the potential component rk+n-3 The generalized equation ofthe ... http://www.advancesindifferenceequations.com/content/2011/1/60 Page of 14 Namely, here we know that the exponent with the basis ofthe half-edge r ofthe HC function is υ = k+n-3 Now, the mth derivation ofthe HC on the radius is defined by the following ... to zero The greatest values ofthe considered functions are infinite, when k0 = ∞ 2.7 The first derivatives ofthe ch1 functionof HC in relation to the degree of freedom n Since the function...
... zeros ofthe Riemann zeta function They are called the trivial zeros It is noted that the simple zero ofthe sine function on the RHS of (1.11) at s = is canceled by the simple pole ofthe zeta function ... For the detailed properties ofthe family of zeta functions we refer to [3-5,7-12] There have been several generalizations ofthe Riemann zeta function Truesdell [13] studied the properties ofthe ... The representation (3.6) ofthe generalized Riemann zeta function shows that thefunction is meromorphic For ν Î (0, 1) thefunction has a removable singularity at s = as the residue ofthe function...
... the stability ofthe linear functional equation,” Proceedings ofthe National Academy of Sciences ofthe United States of America, vol 27, pp 222–224, 1941 18 S M Ulam, Problems in Modern Mathematics, ... inequality holds for h The rest ofthe proof is similar to the proof of Theorem 3.1 Theorem 3.5 Let X be a linear space and let Z, N be a fuzzy normed space Let ϕ : X × X → Z be a function such that ... − |α| t This completes the proof ofthe theorem Acknowledgment The authors are very grateful to the referees for their helpful comments and suggestions 10 Fixed Point Theory and Applications...
... An } be the set of vertices Let P be an arbitrary point in the interior of A If Bi is the intersection point ofthe extension line of Ai P and the n − -dimensional hyperplane opposite to the point ... , n, 4.1 Proof The proof follows from Theorem 3.1 and Lemma 2.9 together with 1.2 If taking r corollaries and r n in Theorem 4.1, respectively, then we have the following Journal of Inequalities ... means, and their applications,” Bulletin ofthe Australian Mathematical Society, vol 56, no 3, pp 409–420, 1997 P S Bullen, Handbook of Means and Their Inequalities, vol 560 of Mathematics and...
... generically, the left side of (7) equals Ns (T ) In other words, the zeros ofthe derivatives of a generic function are all simple, except for those which are “tied up” in high-order zeros ofthe original ... note that the added information that αj detects zeros on the critical line is of no use in improving our result Everything below is phrased in terms ofthe Riemann ξ -function, but the manipulations ... our lower bounds for the βj were actually equalities, then the lower bound given by (6) is sharp We will accomplish this by showing that the Mn (T ), the number of zeros of ξ(s) with multiplicity...
... that the girth of a graph is the length of its smallest cycle Then, for an orientation O of G to be k-balanced, it is necessary that the girth of G be at least 2k This is not sufficient — the smallest ... of C4 are of two types: in Figure There are orientations ofthe O2 We then calculate the linear extensions {1234, 1243, 2134, 2143} Thus, Figure 5: O2 in practice, consider the 4-cycle C4 The ... Specifically, if {i1 < i2 < · · · < ik } is the image of f , then we obtain π by listing the elements of f −1 (i1 ) in increasing order, then the elements of f −1 (i2 ) in increasing order, and so...
... ANSON the number of rows of X increases relative to the number of columns the advantage ofthe QR over normal equations decreases For example, if there are times as many rows as columns in X, then ... then the QR requires as much as 90 p 100 ofthe storage locations needed by the normal equations If the ratio of number of rows to number of columns exceeds 50, then storage requirements of each ... for various parts ofthe process, amount of storage needed and accuracy of final solutions If X is square, then the QR algorithm requires two-thirds the storage locations ofthe normal equations...
... were calculated: the standard deviation of all R–R intervals; the standard deviation ofthe averages ofthe R–R intervals calculated in segments; the percentage number of pairs of adjacent R– Available ... parasympathetic function Conversely, analysis ofthe power spectrum in the frequency domain has been used to provide insights into the relative contributions ofthe two branches ofthe autonomic ... infarction within the CABG and CAD groups The minimum necessary sample size was determined by setting the statistical power to 0.8 and the alpha error to 0.5 On the basis ofthe results ofthe R–R interval...
... the CHD is much more restricted The header portions ofthe genetic files offer a higher degree of freedom in terms of active control then the preset headers ofthe CHD The Page 18 of 29 D’Onofrio ... and functional molecules in their role of forming the “language” of genetic information There is a functional equivalence between the orthogonality of magnetic representation of data on the CHD ... CHD to the orthogonal representation of information in the form of Qbits on the DHD The generation of various types of RNA from the DNA code convert the coded information into a poly-functional...
... understand the pattern of spread of cancer in the neck About a third of all the lymph nodes in the body are in the head and neck region Most squamous cell carcinomas ofthe head and neck are at least ... drains the tip ofthe oral tongue, primarily to level I or level II The lateral pathway drains the lateral 1/3 ofthe dorsum ofthe tongue to levels I, II, III The central pathway drains the central ... Squamous cell carcinoma ofthe tongue is one ofthe most prevalent tumors ofthe head and neck region The extent of lymph node metastasis is a major determinant for the staging, the most reliable adverse...
... when the number of samples is increased the SER performance ofthe scheme gets better The narrow margin of difference between the theoretical and simulated values of SER indicates the validity of ... , (36) and the left hand side of (35) would be zero in the absence of noise Using theleastsquares approach with the objective function given by (35), the transmitted symbol can then be detected ... represents the value of x in the absence of noise The remaining terms in (49) gives the contribution of noise terms in determining the value of x Now we will derive an approximate SER expression for the...
... reactivity ofthe pentenoyl group compared with the dienophile 391 groups in the amide based monomer functionalized with the “Reppe Anhydride” allows the synthesis of polyamide oligomers consisting of ... Ligation ofthe (RE-PA)5 with dimethyl-1,2,4,5-tetrazine-3,6-dicarboxylate The first highly active part ofthe construct, allows the ligation of e.g carrier molecules on the desired side ofthe molecule ... chemical reaction by the solid phase peptide synthesis (Figure 4) Ligation ofthe pentamer I with the tetrazine-dicarboxylate 6: One µmol ofthe pentamer I (Figure 3) and 5.5 µmol ofthe tetrazine (intermediate...
... Synthesis ofthe 4-pentenoic acid PNA building block The synthesis ofthe PNA building block functionalized with the 4-pentenoic acid is shown as an example for a myriad of applications The synthesis ... for the synthesis of functional molecules suitable for the design of functionalized building blocks of PNA or other nucleic acid derivatives Here the component 14 is comparable to number in the ... 1/Figure Synthesis ofthe PNA building block backbone In the next step, the synthesis ofthe PNA backbone monomer using the fluorenylmethoxycarbonyl (Fmoc) protection occurred as described by Atherton...
... outside the office The use of ICT for internal communication has been elaborated in the previous section Readers are referenced to the discussion there Here, we will concentrate more on the use of ... teams Yet, there is one critical difference This difference is the way the team members communicate Instead of using the full spectrum and dynamics of in-office face-to-face exchange, they now ... through the internet has also been a choice for TI While the field survey finds no firms that markets through the internet, but it is of no surprise if any of them will start one in the future The...
... functionofthe CXXXC motif of human Sco proteins could therefore be implicated not only in the maturation ofthe CuA site of Cox2 but also in the maintenance of cellular copper homeostasis The ... diffuses across the outer membrane into the IMS through Determinants ofthe elusive functions of Sco proteins either porin or the TOM complex; however, the highly impermeable nature ofthe inner membrane ... been proposed to perform other functional roles in the final step of CuA biogenesis, which are strictly linked to the complete understanding ofthe functional role of their CXXXC motif Structural...
... [9] The KIND domain in these proteins is localized to the N-terminal region, and their specific functional domains are located in the C-terminal region The C-lobe of protein kinases mediates the ... proteins of these subregions (Fig S1C) and 1654 Fig Of all members ofthe KIND family of proteins, only KIND2 binds to MAP2 Pull-down assay (PD) ofthe endogenous MAP2 from cerebellar lysates of P21 ... mean length of dendrites These findings demonstrate the structural and functional importance ofthe Leu474 residue in the v-KIND–MAP2 interaction-mediated regulation of dendrite growth The interaction...
... interacts with both O6 and N7 (Fig 1C) The 2¢OH ofthe ribose is hydrogen bonded to the main chain and the side chain of Asp142 (Fig 1C) Both hydroxyl groups ofthe ribose are involved in coordinating ... product of PRPP from the crystallization solution ing 81 compounds of substrates, products and regulators of other enzymes in the human nucleotide metabolism (Table S1) The library can then be ... conclusion can be made based on the lack of thermal shifts when only the bases were added, whereas the addition of PRPP led to a significant thermal shift Kinetic studies of PRTFDC1 showed that this...
... and A Patel of cell fate Leukemias associated with loss -of- function or gain -of- function variants of MLL1 are prime examples ofthe importance of maintaining the enzymatic activity of MLL1 under ... present This is because the construct used to determine the structure ofthe MLL1 SET domain lacks the evolutionarily conserved Win motif in the region flanking the N-terminus ofthe SET domain [26], ... (green) bound to the central opening of WDR5 (PDB code 3EG6) The position ofthe conserved Arg 3765 is indicated On the left, a stick representation is used to show the position ofthe MLL1 Win motif...