... depend on the trigger type and on the level of interference with the Wnt pathway We conclude that the type ofthe trigger andthe regulation level within the Wnt pathway decide about the gene ... cells We conclude from these findings that the activating trigger andthe level of activation within thepathway are crucial for the selection of a target gene andthe trend ofthe promoter regulation ... the right sides ofthe gels these ofthe two other isoforms (Fig 6) These results correlate to the protein bands of 38 kDa (Plf1) and 27 kDa (Mrp4) [27], which were detected in the western blot...
... dual inhibitor ofthe mTOR pathwayand telomerase in breast cancer cells, and yield enhanced anticancer therapeutic efficacy, the objectives ofthe study are to: Validate breast cancer cells as ... HYPOTHESIS AND SIGNIFICANCE OF STUDY The literature explored thus far highlights the relevance and importance ofthe mTOR pathwayand telomerase in initiating, regulating and driving cancer phenotypes, ... IMR-90 cells Altogether these results suggest that while breast cancer cells may be a useful model to study the dual inhibition ofthe mTOR pathwayand telomerase, the activation of these two players...
... distribution, prevalence of lifestyle factors, histologic type of lung cancer, stage of lung cancerand so on The random effects model incorporates an estimate ofthe between-study variance and tends to ... are: 1) low frequency ofthe "at-risk" genotype, which would reduce the statistical power ofthe studies and 2) small size ofthe studies Ethnic differences in the roles ofthe polymorphism may ... alteration ofthe ERCC5/XPG activity and modulation of lung cancer susceptibility The Asp/Asp genotype ofthe Asp1104His polymorphism was associated with a significantly decreased risk of lung cancer...
... 36% ofthe interaction ofthe full peptide with the binding cavity of SM3 The sizes ofthe surfaces were determined using distances between ligand ˚ atoms and protein atoms of less than A These ... a distance of A or less to the ligand The C-terminal part ofthe peptide (RPAP) has close contacts to the next protein in the crystal cell and is therefore stabilized on the surface of SM3 It ... reference pairs The build-up ofthe trNOE between Asp2-b and b¢ is much faster than that ofthe other two reference points indicating differences ofthe rotational correlation times of these proton...
... quartile (1/4 ofthe population) who ate the least amount of fruits and vegetables had about twice the risk ofcancer compared to those who in the upper quartile who ate the most fruits and vegetables ... high fruit and vegetable diet would reduce cancers ofthe mouth and pharynx, esophagus, lung, stomach, and colon and rectum; evidence of probable risk reduction was found for cancers ofthe larynx, ... urinary secretion of isothiocyanates, was inversely related to the risk of breast cancer; the quartile with the highest intake only had 50% ofthe risk ofthe lowest intake group [89] In the Nurses'...
... quantitative analysis ofthe most critical parameters ofthepathway regarding this goal requires the knowledge ofthe intracellular concentrations of all metabolites involved and a kinetic model ... minimization ofthe difference between experimental time course data andthe corresponding values predicted by the solution ofthe differential equations derived from a mathematical model ofthe kinetic ... extreme modulations of enzyme activities In particular, in the combinations involving the decrease of glyoxalase II activity the effect is equivalent to the modulation ofthe other parameters alone,...
... promoter in lung cancer factors that control the use ofthe p73 P1 promoter and, subsequently, the relative expression of p73 isoforms in lung cancer by using lung cancer cell lines and tumour samples ... processes Therefore, all of these issues should be addressed in the future Taken together, our findings make it clear that there is a link between the expression of Sp1 and p73 isoforms in lung cancer ... for the identification ofthe exact TAp73 isoform expressed in these samples (D) The mean levels of TAp73c and Sp1 in 26 NSCLCs samples were compared with the corresponding mean levels in the...
... Biological Therapy ofCancer Acknowledgements From the iSBTc Executive Office, Chloé Surinak monitors and supports the subsection interactions with the iSBTc leadership, its membership and BioMed ... Director ofthe iSBTc provides executive management and development ofthe Society Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most ... development for disseminating the results of biomedical researc h in our lifetime." Sir Paul Nurse, Cancer Research UK Your research papers will be: available free of charge to the entire biomedical...
... with radiotherapy The aim of this study was to investigate the effect ofthe combined treatment of perifosine and radiotherapy on human prostatecancer Methods Cell culture The human prostate ... collected the data, interpreted the results ofthe study, performed the statistical analysis and drafted the manuscript BX and BT oversaw the project completion, analyzed the data and completed the ... prostatecancer PC-3 cells Cells were irradiated in the absence (control) or in the presence of perifosine andthe colony formation assay was conducted Shown are the means and standard deviation of...
... Background Patients and methods Prostatecancer is the leading form ofcancer diagnosed among Canadian men and accounts for approximately 27% of new cancer cases and 11.4% ofcancer deaths [1,2] ... localized prostatecancer during the period January 2000 to December 2002, in the department of Radiation Oncology at the Allan Blair Cancer Center (ABCC), in Regina, Canada One ofthe standard ... margin of 0.7–1 cm and received a dose of 26–30 Gy in 13–15 fractions (2-Gy per fraction) over two and half to three weeks at the discretion ofthe treating Radiation Oncologist None ofthe patients...
... domains, FAT domain andPI3K domain [17] together with exonic information (The size ofthe exons andthe distance between them are not indicative ofthe sizes/distances in the gene/protein) cases ... VNK and ALBD designed the study - TT, LJ and PV genotyped the samples from the American Breast cancer patients - LJ and PV genotyped the samples from the Norwegian breast cancer patients andthe ... protective effect ofthe A allele The contradictory between our study and that of [28] may be a consequence ofthe different ethnicity ofthe populations or possibly a result ofthe limited study...
... for prostatecancer therapy Materials and methods Cell lines and cell culture A human prostate epithelial cell line (RWPE-1) andprostatecancer cell lines (LNCaP, DU145 and PC3) were used and ... mimic the development ofprostatecancer clinically Understanding the regulating effects of XAF1 during the whole progression may help us find potential therapeutic strategies for prostatecancer ... [15,32,33] Human prostate epithelial cells (RWPE-1) andprostatecancer cells (LNCaP, DU145 and PC3), which exhibit different features ofprostatecancer progression from early stages to androgen independent...
... in thePI3K signaling pathway Recombinant microRNA-126 was shown to downregulate the expression of p85b (a regulatory subunit ofPI3K related to the stabilization and transmission ofthePI3K ... arrest and promoted apoptosis in A549 cells PI3K is composed of a p110asubunit and p85 subunit andthe PI3K/ AKT signaling pathway has been shown to play a role in the development and progression of ... ofthe cell cycle and apoptosis is a major determinant dictating the development and progression of a number of cancers PI3K/ AKT inhibitors such as Tipifarnib, cause cell cycle arrest at the...
... acetone in the presence of approximately mg of NaCO3 [37] The extent of lipid peroxidation in the leaves was estimated by measuring the amount of MDA, a decomposition product ofthe oxidation of polyunsaturated ... stress (BiPD and CNX) and osmotic stress (SMP) marker genes were included in the assay to ensure the efficiency ofthe tunicamycin and PEG treatments The combination of ER stress and osmotic stress ... effect on the accumulation of GmNAC6 transcripts in a fashion similar to the induction ofthe NRP-A and NRP-B genes (Figure 1B) These results indicate that the integration of ER-stress and osmoticstress...
... reported expression of Notch family members in adult and even OA cartilage raised the issue ofthe involvement of this pathway in the physiopathology of OA and especially in the changes that chondrocytes ... 1, and These constitute the DSL (Delta/Serrate/Lag2) family (Figure 1) Activation ofthe Notch pathwayThe first described Notch activation cascade consists of a series of cleavages leading to the ... disease andthe degradation ofthe articular cartilage is a complex process involving several actors, including signaling pathways like the Notch pathway Further work is required to understand the...
... Accordingly, the great and urgent need presently is to investigate the role of each ofthe plenitude of genes and proteins important in the progression ofcancer NUCLEAR RECEPTORS The nuclear ... Conventional drugs andthe pathways they influence have been the subject of immense interest to biologists, and there has been some headway in understanding the signal transduction pathways these drugs ... Pervaiz, Professor, Department of Physiology, Yong Loo Lin School of Medicine, NUS Their encouragement and guidance and their critique has been of paramount importance in directing the course of the...
... superficial sensation in the bilateral upper limbs and trunk above the umbilicus, muscle wasting ofthe bilateral thenar and upper limbs, grade III muscle power ofthe upper and lower limbs, reduced ... fossa and excision ofthe arachnoid cyst were then surgically performed A straight median incision was made on the skull via the posterior temporal route The occipital squama was cut off andthe ... within the cyst The cyst tightly adhered to the cerebrum, pons and cervical spinal cord The compartments were then separated andthe posterior wall ofthe cyst was excised to break down the cystic...
... “Introduction” states the rationale ofthe study, Semantics can be simply defined as the study of meaning It defines the aims, objectives andthe significance, presents the is central to the study of communication ... review ofthe research Chapter 3: “Methodology and Procedures” mentions the method and procedures ofthe research Chapter 4: “Findings and Discussions” is the main frame of need to understand semantics ... element ofthe meaning of a word; a description ofthe characteristic feature of what the word refers to E.g the sense of “grasshopper” is “an insect which can jump high the study, which describes and...
... approx 1.5 m The study site Hoa An is located in an area where an interaction ofthe tidal regimes ofthe South Chinese Sea andofthe Gulf of Thailand eliminate each other Here, the tidal amplitude ... from the irrigation ditches ofthe rice fields At both study sites the values for the pH, BOD, NH4 and phosphate are conform to the requirements ofthe Vietnamese standards for the use of surface ... following the Vietnamese standards for ground water TCVN 5944 –1995 (see table 3) The results ofthe analyses ofthe surface water samples were compared to the Vietnamese standards for the use of surface...