... and C-C chemokine receptors Chemokines [27,28] and angiotensin II [29] have both shown growth-inhibiting properties with different cancers Interestingly, an orphan receptor (GPR41 in the rat), ... progestin administration was thus associated with the beginning of growth inhibition by progestins GPR30 mRNA is regulated according to the dose of progestin, which also correlated with progestin-induced ... steroid hormones Progestin administration causes an initial increase in cell proliferation lasting about 12–24 h and subsequent GPR30 and progestin (Eur J Biochem 269) 2489 inhibition of proliferation...
... ferently, using the anti-ErbB-2 antiserum cross reacting with the murine receptor resulted in a faint stain of the cytoplasm and rarely in staining of the membrane of the tumor cells (Figure 3B) In the ... E-Cadherin mediated signalling or the Inhibitor of IKB in the NFκB signalling [11], crucial for driving the expression of regulators of cell cycle control, or ii) binding to receptors mediating the ... signalling in both breast and non -breast tumors over expressing the kinase Furthermore, since the inverse correlation of the expression levels of the two genes is highly significant in human breast...
... estrogen receptor 1.2 RET gene 1.2.1 RET and its isoforms 1.2.2 RET gene and its role in human physiology 1.3 Long range chromatin interactions 1.3.1 Estrogen receptor binding sites inbreastcancer ... sequencing), we generated a global map of ERα binding sites in the genome of MCF7 breastcancer cell line From this dataset, we identified two ERα binding sites near the RET (rearrangement during ... human genome revealing the exact positions of estrogen receptor binding site (ERBS) In addition, ChIP-Seq also contains information on the density or strength of receptor binding Based on such...
... Clinical breast examination in primary care Each primary care team should include at least one practitioner who has had specific training in carrying out clinical breast examination (CBE) in ... to breast clinics for investigation of possible or suspected breastcancer are referred by GPs; the remaining 20% are identified by routine screening For historical reasons, breast screening in ... Co-ordinating Group Cancer Services Co-ordinating Group 2000 22 Dewar JA, Twelves CJ, Thomson CS for the Scottish BreastCancer Focus Group and the Scottish Cancer Therapy Network BreastCancer in...
... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring...
... consumption and breastcancer risks for ER-positive and ER-negative breast cancers In this study, we examine the association between coffee consumption and postmenopausal breastcancer risk in a large ... effect of caffeine intake on breastcancer risk for Li et al BreastCancer Research 2011, 13:R49 http:/ /breast- cancer- research.com/content/13/3/R49 Page of 10 Table Validation results in the German ... follow-up Int J Cancer 2008, 122:2071-2076 30 Ishitani K, Lin J, Manson JE, Buring JE, Zhang SM: Caffeine consumption and the risk of breastcancerin a large prospective cohort of women Arch Intern...
... pathway was demonstrated in tamoxifen-stimulated breastcancer tumors by inducing the death receptor Estrogen-Induced Apoptosis inBreastCancer Cells: Translation to Clinical Relevance Fas with ... efficient in apoptosis induction DNA-damaging agents like doxorubicin, etoposide, cisplatin or bleomycin may induce apoptosis via both extrinsic and intrinsic apoptotic pathways (Fulda & Debatin, 2006) ... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breastcancer cell lines (Zhao et al, 2011) Upon administration of...
... delay in operable breastcancer patients Eur J Cancer Prev 2001, 10:53-59 Ebrahimi M, Vahdaninia M and Montazeri A: Risk factors for breastcancerin Iran: a case-control study BreastCancer ... Medicine 2000, 30:174-177 Montella M, Crispo A, Botti G, De Marco M, De Bellis G and Fabbrocini G et al.: Assessment of delay in obtaining definitive breastcancer treatment in southern Italy Breast ... regarding breastcancer concluded that since older age is a risk factor for both developing breastcancer and subsequent delayed presentation, any intervention program should target older women in...
... proteins involved in various cellular processes, including inhibition of apoptosis Hypoxia has been reported to inhibit apoptosis induced by tumor necrosis factor-related apoptosisinducing ligand ... Collectively, the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis inbreastcancer cells ... hypoxia in MDA-MB-468 cells (Fig 2B), resulting in a 35% decrease in nuclear BRCA1 relative to the level in normoxic cells in the presence of 2E5 The decrease in C Fig Hypoxia-induced changes in BRCA1...
... serum protein features of a number of cancers in the near future [47] Translational research inbreastcancerBreastcancerBreastcancer is the most common malignancy among women in the Western ... bladder by oral administration of the epidermal growth factor receptor protein tyrosine kinase inhibitor 4,5-dianilinophthalimide Clin Cancer Res 3, 161–168 68 Bellmunt J, Hussain M & Dinney CP (2003) ... (2003) Circulating interleukin-6 predicts survival in patients with metastatic breastcancer Int J Cancer 103, 642–646 62 Bray GA (2004) Medical consequences of obesity J Clin Endocrinol Metab 89,...
... p-value less than 0.05 Injection of free DiD resulted in no increase in fluorescent intensity within the tumor at any time point post-infusion Figure labeling (a) Optical imaging of DiD-labeled cells ... adaptive and innate immune cells during breastcancer progression BreastCancer Res 2007, 9:212 Balkwill F, Charles KA, Mantovani A: Smoldering and polarized inflammation in the initiation and ... human breastcancer Clin Cancer Res 2000, 6:3282-3289 Jin H, Su J, Garmy-Susini B, Kleeman J, Varner J: Integrin alpha4beta1 promotes monocyte trafficking and angiogenesis in tumors Cancer Res...
... measurement in randomized clinical trials inbreastcancer – taking stock Journal of the National Cancer Institute 2003, 95(4):263-281 Montazeri A: Health-related quality of life inbreastcancer ... oncology clinical research [29-31] It has also been validated [32] and found to be responsive [33] specifically inbreastcancer patients and is widely used inbreastcancer research investigating HRQoL ... Patients were included in the trial after finalizing treatment and after giving written informed consent Treatment included surgery and/or radiotherapy and/or chemotherapy Followup appointments took...
... pathway was demonstrated in tamoxifen-stimulated breastcancer tumors by inducing the death receptor Estrogen-Induced Apoptosis inBreastCancer Cells: Translation to Clinical Relevance Fas with ... efficient in apoptosis induction DNA-damaging agents like doxorubicin, etoposide, cisplatin or bleomycin may induce apoptosis via both extrinsic and intrinsic apoptotic pathways (Fulda & Debatin, 2006) ... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breastcancer cell lines (Zhao et al, 2011) Upon administration of...
... [22] There is a growing interest in the possible role of exercise in enhancing QOL, reducing recurrence and other diseases, and extending survival incancer survivors Preliminary research suggests ... research using rigorous methodology is needed to definitively answer questions concerning the role of exercise in enhancing QOL incancer survivors both during and after treatment [12] Breastcancer ... exercise training and natural killer cell cytotoxic activity inbreastcancer patients Int J Sports Med 1995;16:334-7 Stoll BA Diet and exercise regimens to improve breast carcinoma prognosis Cancer...
... invasion begins with inflammation around cancer cells Thus, it has been reported that serum CRP levels are higher in cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal ... TNM staging system of breastcancer thus indirectly correlating with the prognosis of the patient CRP estimation does not seem to be very useful in evaluating the patient with breast cancer, ... significance of interleukin serum levels in patients with ovarian cancer Br J Cancer 1995, 71:354-356 De Vita F, Orditura M, Auriemma A, Infusino S, Roscigno A, Catalano G: Serum levels of interleukin as...
... tumors originating from the interstitial cells of Cajal, which are pacemaker cells regulating autonomic motor activity in the gastrointestinal tract The majority of the GISTs arise in the stomach ... present with abdominal pain, satiety, obstruction, or GI bleeding However, Figure Pre-operative CT scan showed gastric mass with curvilinear calcification penetrating into surrounding soft tissue ... penetrating into the gastric lumen and pericolic soft tissue Other gastrointestinal tumors may also contain calcification At least three types of calcification have been reported in gastric cancer: ...
... survival in invasive breast cancers [24] In conclusion, we found that the incidence of sentinel lymph node metastasis in cases of pure DCIS was 0.39% This incidence was lower than that in IDC-predominant ... Rome BreastCancer Study Group: Sentinel lymph node biopsy in women with pT1a or “microinvasive” breastcancerBreast 2008, 17:395-400 Zavagno G, Belardinelli V, Marconato R, Carcoforo P, Franchini ... IDC-predominant invasive breastcancer had positive sentinel lymph nodes Therefore, the risk of lymph node metastasis was significantly lower in the pure DCIS group than in the IDC-predominant invasive-lesion...
... new era inbreastcancer Invasion, size, and nodal involvement dramatically decreasing as a result of mammographic screening Arch Surg 1996, 131(3):301-308 Fisher B, Slack NH, Bross ID: Cancer ... of the National Cancer Institute early breastcancer trial J Natl Cancer Inst Monogr 1992, 11:27-32 27 Saphner T, Tormey DC, Gray R: Annual hazard rates of recurrence for breastcancer after primary ... 1-98 Collaborative Group; International BreastCancer Study Group: Predictors of early relapse in postmenopausal women with hormone receptor- positive breastcancerin the BIG 1-98 trial Ann Oncol...
... Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breastcancerin Guilin city of China The specimens were fixed in 10% neutral-buffered formalin (pH7.4) ... herceptin 10 11 12 Parkin DM, Bray F, Ferlay J: Global cancer statistics, 2002 CA Cancer J Clin 2005, 55(2):74-108 Zheng Y, Li DL, Xiang YM, Li XJ: The status and trend of breastcancer incidence in ... Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breastcancer treated with trastuzumab Clin BreastCancer 2005, 6(3):240-6...
... detailed investigation Our results showed that there was a single route leading to a single SN in 68% of the patients, multiple routes leading to a single SN in 4%, a single route leading to multiple ... H, Inaji H: Sentinel node biopsy for breast cancer: technical aspects and controversies BreastCancer 2007, 14:25-30 Giuliano AE, Jones RC, Brennan M, Statman R: Sentinel lymphadenectomy inbreast ... blue dye Breast Dis 1998, 8:297-300 De Cicco C, Chinol M, Paganelli G: Intraoperative localization of the sentinel node inbreast cancer: technical aspects of lymphoscintigraphic methods Semin Surg...