1b tnf a and il 10
Báo cáo y học: "Abnormal spatial diffusion of Ca2+ in F508del-CFTR airway epithelial cells" pptx
... 5'-AAGTATTAATGTA GGCCCAAGACCTATT-3' 5'-GGAGGGCTTGC GGAGAA-3' 117 hlITPR 5'-AACCGCTACTC TGCCCAAAA-3' 5'-GCGATCTGCA CATCTATGCTG-3' 5'-GGGCTCTCG GTGCCTGA-3' 150 Page of 17 (page number not for citation ... concentration, initiates a rapid, large and almost total release of Ca2+ from intracellular stores [4] These properties place IP3Rs at the heart of calcium signalling pathways Cells Human nasal epithelial ... local Ca2+ wave propagation compared to non CF MM39 cells A Typical traces of Ca2+ mobilization in miglustat-treated and untreated CF-KM4 and MM39 during stimulation by 100 μM histamine in absence...
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Tài liệu Báo cáo khóa học: The effect of mutations surrounding and within the active site on the catalytic activity of ricin A chain pptx
... depurination was calculated by relating the amounts of the small aniline-fragment and 5.8S rRNA and expressing values as a percentage Reassociation and quantification of ricin A- chain variants Purified ... rRNA was isolated and lg was aniline-treated and electrophoresed on an agarose/formamide gel rRNAs were quantified from digital images using IMAGEQUANT software The depurination was calculated ... were quantified from digital images using IMAGEQUANT software The depurination was calculated by relating the amounts of small aniline-fragment and 5.8S rRNA and expressing values as a percentage...
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Tài liệu Báo cáo khoa học: Coordination chemistry of iron(III)±porphyrin±antibody complexes In¯uence on the peroxidase activity of the axial coordination of an imidazole on the iron atom ppt
... N3± According to Brault & Rougee [48], it could then be analyzed by means of the standard equation 1aDA 1aDAI Kd aDAI Â 1a Ln
2 where DA A ) A0 , DAI A ) AI and A0 , AI, and A are the absorbances ... Lauzon et al (Eur J Biochem 269) 28 Takagi, M., Khoda, K., Hamuro, T., Harada, A. , Yamaguchi, H., Harada, A. , Kamachi, M & Imanaka, T (1995) Thermostable peroxidase activity with a recombinant ... heme cofactor and the axial histidine ligand of the iron in peroxidases, whereas a COOH side chain of the antibody acts as a general acid±base catalyst in the same manner as the distal histidine...
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báo cáo hóa học: " The effect of hip abduction on the EMG activity of vastus medialis obliquus, vastus lateralis longus and vastus lateralis obliquus in healthy subjects" pot
... Anat 1989, 11:17-22 Testut L, Latarget A: Tratado de anatomia topográfica com aplicações médico-cirúrgicas 5th edition Salvat: Barcelona; 1932 Testut L, Latarget A: Tratado de anatomia humana ... 1987, 69:545-49 Hamilton WJ: Tratado de anatomia humana 2nd edition Interamericana: Rio de Janeiro; 1982 Scharf W, Weinstabl R, Firbas W: Anatomische untrsuchungen am streckapparat des kniegelenks ... Bevilaqua-Grossi D, Monteiro-Pedro V, Bérzin F: Análise funcional dos estabilizadores da patela Acta Ortop Bras 2004, 12:99 -104 Powers CM: Rehabilitation of patellofemoral joint disorders: a critical...
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Investigations on the antiplasmodial activity of ferrocenyl chalcones
... Pharmaceutical Scientists (AAPS) Nov 10- 14, 2002, Toronto, Canada • Wu X, Go ML, Wilairat P, Kayser O, Kiderlen A Antimalarial and Antileishmanial Activity of Ferrocenyl Chalcones Asian Association ... resources were available to combat malaria It also highlighted the need to address malaria as a global problem that goes beyond the boundaries of individual nations In 1998, the Roll Back Malaria (RBM) ... correlation to antiplasmodial activity assessed by multivariate analytical methods, principal component analysis (PCA) and partial least squares project to latent structures (PLS) To investigate...
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Investigations on the antimalarial activity of alkoxylated and hydroxylated chalcones 3
... hypothesis is that oxygenated chalcones exhibits antimalarial activity and that an optimal substitution pattern exists which will favor activity 102 chalcones have been synthesized and evaluated for ... ring A contribute to antimalarial activity In contrast, ring A appears to 113 have a higher profile than ring B in antileishmanial activity In addition, the size rather than electrostatic nature ... of Parasites 1995 Marr, J.J and Müller M Ed., Academic Press, 89-118 112 Landau, I and Gautret, P Malaria: Parasite Biology, Pathogenesis, and Protection 1998 Sherman I.W Ed., ASM Press, Chapter...
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Investigations on the antimalarial activity of alkoxylated and hydroxylated chalcones 2
... structure activity relationships for the antimalarial chalcones This was prompted by the fact that the available data set has a “long and thin” rather than “short and fat” appearance, as there are ... Introduction Antimalarial and antileishmanial activities have been found in licochalcone A 64, 68 and 2, 4-dimethoxy-4’-butoxychalcone (41) 70 Of the large number of antimalarial and antileishmanial chalcones ... Structural requirements for antileishmanial and antimalarial activities As anticipated, many of the chalcones demonstrated activity against L donovani amastigotes Table 5.2 summarizes the IC50 and...
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Investigations on the antimalarial activity of alkoxylated and hydroxylated chalcones 1
... debated 100 Practically, a dual acting chalcone against malaria and leishmania may be advantageous as there is an overlapping geographical distribution of these two diseases Dual acting chalcones ... the good antimalarial and antileishmanial activities of licochalcone A and 2,4-dimethoxy-4’-butoxychalcone This will be established by determining both antimalarial and antileishmanial activities ... 1.3.2 Antileishmanial activity Licochalcone A is also an antileishmanial compound It is more active in vitro against intracellular amastigotes than promastigotes of Leishmania donovani 69 Oral administration...
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Tài liệu The Influence of Human Activity on the Environment ppt
... while other plants are killed Sulphur dioxide will dissolve in rain producing Acid Rain • Acid rain damages trees and pollutes rivers and lakes Acid rain causes erosion of buildings and statues ... Improvements in agriculture health and medicine have produced a dramatic rise in the human population This increase in population size leads to an increase in pollution and higher demand for the ... way into rivers and lakes • This causes the water plants to grow and as there is competition for light, some will die • Bacteria decay the dead plants and in so doing use up oxygen from the water...
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Báo cáo khoa học: Effect of annealing time of an ice crystal on the activity of type III antifreeze protein pdf
... crystal image was captured using a Colorvideo 3CCD camera (Sony, Tokyo, Japan) (Fig 1A) , and the temperature status was simultaneously viewed on a display and saved as a video file on a personal ... time, and annealing temperature The data obtained revealed that the TH value is significantly increased when the ice crystal is annealed for a long time at a lower annealing temperature Based on ... structural characteristics of these fish AFPs and their target ice crystal surface are different from those of insect AFPs A faster cooling rate decreases the apparent TH value of fish AFPs, and larger...
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Báo cáo khoa học: Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases pot
... compilation ê 2011 FEBS F Esposito et al Alizarines as new dual HIV-1 RT inhibitors A E VAL10 6A PHE22 7A VAL10 8A Asp 110 O K49 Asp 110 O LEU23 4A Asp186 K49 VAL10 8A Asp186 O O O Asp185 O NNRTIbp Asp185 ... TYR18 8A VAL10 8A O Asp 110 O O O VAL10 6A Asp186 TYR18 8A Trp229 Asp186 PHE22 7A NNRTIbp Asp185 K126 O LEU22 8A O NNRTIbp Asp185 Tyr188 TYR31 8A TRP22 9A Trp229 LEU23 4A LEU10 0A Tyr181 LEU10 0A Cys181 I VAL10 8A ... TYR18 3A Trp229 O O O Asp186 Asp185 NNRTIbp Tyr188 O O O O TRP22 9A LEU23 4A O Tyr188 PHE22 7A Trp229 O O O Asn103 Tyr181 VAL10 8A VAL10 6A LEU23 4A ASN10 3A TYR18 8A Tyr181 D H O O O K126 Asp 110 VAL108A...
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Báo cáo khoa học: Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase pdf
... has in vitro helicase activity Mol Cell 31, 287–293 20 Chino M, Nishikawa K, Tsuchida T, Sawa R, Nakamura H, Nakamura KT, Muraoka Y, Ikeda D, Naganawa H, Sawa T et al (1997) Heliquinomycin, a ... containing m urea The oligonucleotides, A1 0, 17-mer and oligo-dT50, were labelled at their 5¢ ends and used as markers The gel was dried and the radioactivity was detected using a Bio-Image Analyser ... nickel-nitrilotriacetic acid-agarose was added, and the mixture was incubated for h at °C on a rocking platform Agarose beads were then collected by centrifugation and thoroughly washed with buffer A...
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Báo cáo khoa học: Effect of magnesium ions on the activity of the cytosolic NADH/cytochrome c electron transport system pptx
... (Mg-m); (B) at zero time, mitochondria, at addition of lM exogenous cyto-c, and reaction stopped at either 10 or 15 (a) ; alternatively, lM cyto-c added at 10 and reaction stopped at 15 (a) ; at addition ... with 10 lm safranine O at wavelengths of 520 nm (excitation) and 580 nm (emission) [34] Materials All reagents were of analytical grade and mainly obtained from Sigma-Aldrich Chemical Co (St Louis, ... cyto-c activates the NADH/cyto-c electron transport pathway, and more energy is made available for apoptotic processing before the membrane potential dissipation step is activated Indications have...
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Báo cáo khoa học: The ‘pair of sugar tongs’ site on the non-catalytic domain C of barley a-amylase participates in substrate binding and activity potx
... sense strand, and 5Â-TTTGGTACCTCAGTTCTTCTCCCAGA CGGCGTA-3Â as antisense primer Mutant cDNA was amplied using 5Â-TTTGAATTCCATGGGGAAGAACG GCAGC-3Â as sense orientation primer and a puried megaprimer ... of an N-terminal catalytic (b a) 8-barrel (domain A) , a domain B, protruding between b-strand and a- helix 3, and a C-terminal antiparallel b-sheet domain-C [3,4] The isozymes show functional and ... a- amylase sugar tongs mutants S Bozonnet et al Plant a- amylases mobilize starch in plastids, tubers and seeds, and barley isozyme and (AMY1 and AMY2) are de novo synthesized in seed aleuron...
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Báo cáo khoa học: The antibiotic activity of cationic linear amphipathic peptides: lessons from the action of leucine/lysine copolymers on bacteria of the class Mollicutes doc
... effects of alpha-amphi series peptide length on antibacterial and haemolytic activities Antibacterial activities (black curve) are expressed as MIC)1 The data were normalized in such a way that the ... compared with melittin was the same in A laidlawii and S melliferum with respect to the extent of membrane depolarization and the delay necessary to reach a steadystate level of depolarization Actually, ... method after a h peptide treatment Spiroplasma cell deformation by the peptides In contrast with other mollicutes (e.g acholeplasmas and mycoplasmas), spiroplasmas exhibit a helical shape and motility...
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Báo cáo khoa học: On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus pptx
... bananin for four passages and then 100 lm bananin for an additional four passages The bananin-resistant virus variants were identified by a plaque assay in the presence of 100 lm bananin as The predicted ... Mechanisms of bananin activity against SARS-CoV Z Wang et al tool (adt) was used to optimize ligand and protein by adding polar hydrogens and loading Kollman united atoms charges, as well as to perform ... against SARS-CoV [14] Bananins are a class of compounds with a unique structural signature incorporating a trioxa-adamantane moiety covalently bound to a pyridoxal derivative to add potential cytoprotective...
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Báo cáo khoa học: The two IQ-motifs and Ca2+/calmodulin regulate the rat myosin 1d ATPase activity pptx
... Regulation of Myo1d ATPase activity ATPase activity in Myo 1a- c and also the actin-activated ATPase activity of Myo1b The translocation of actin laments by these class I myosins in the gliding assay ... Myo1d-IQ2FLAG, the two overlapping fragments were amplied with the two primer pairs 5Â-GGCAAACTTGATGATGAGCG CTGC-3Â (forward 1) 5Â-CAGAGCTGCCTTGACGAGCATCTG-3Â (reverse 1) and 5Â-CAGATGCTCGTCAA GGCAGCTCTG-3Â ... Pardee and Spudich [32] Puried calmodulin was purchased from Sigma-Aldrich ATPase assays Steady-state ATPase activities were determined at 37 C as described in detail previously [21] All assay...
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Báo cáo khoa học: Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4 doc
... of NATA (a and b) and D16W-D24)37 GGN4 (c and d) in water (a and c) and in 10 mM SDS micelles (b and d) were measured with an excitation wavelength of 280 nm positioned among the acyl chains ... nm and a weak and broad band around 222 nm, indicating a predominantly random-coil conformation with a slight helical propensity [17,22,23] Especially, the D16W GGN4 showed a rather significant ... gray, respectively The direction of view is approximately perpendicular to the helical axis in panels A and B, and is parallel to the helical axis in panels C and D rapid exchange of the Hz amino...
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Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx
... consisting of xCTBP/xALDH1, NAD+ and T3 For human mitochondrial and cytoplasmic ALDHs, T3 and Triac were competitive inhibitors against NAD+ and uncompetitive inhibitors against propionaldehyde [31] ... tadpole tissues J Biol Chem 250, 8337–8343 Hashizume, K., Miyamoto, T., Ichikawa, K., Yamauchi, K., Kobayashi, M., Sakurai, A. , Ohtsuka, H., Nishii, Y & Yamada, T (1989) Purification and characterization ... protein, whereas NADH, NADPH and iodothyronines inhibit the ALDH activity Detailed studies revealed that NAD+ and T3 each act as a noncompetitive inhibitor on the T3-binding and enzyme activities of...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng 9 tr 25