15δpgj2 production is induced by mgdg treatment in il 1α treated cells
Báo cáo y học: "Anti-inflammatory activity of monogalactosyldiacylglycerol in human articular cartilage in vitro: activation of an antiinflammatory cyclooxygenase-2 (COX-2) pathway" doc
... production is induced by MGDG treatment in IL1 a treated cells There is increasing evidence of COX-2 involvement in the resolution of inflammation via its product 15ΔPGJ2 [18,19] Since in the same cells ... Figure 5B mPGES expression and PGE2 production is induced by IL1 a and inhibited by MGDG treatment Since mPGES is induced in cartilage in pathological and inflammatory conditions [13,17] we probed ... Activated Protein Kinase), involved in IL- 6 (Interleukin-6) and IL- 8 (Interleukin-8) production A) Inhibition of IL- 6 and IL- 8 synthesis by the p38 inhibitor SB 203580 Human chondrocytes were treated...
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báo cáo khoa học: " Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-a" doc
... doubled in vitro and increased even more in vivo following treatment with recombinant human IL- 6 Our results show that UTI inhibits the expression of IL- 6 Interleukin-8 (IL- 8) is produced by monocytes, ... suggested that IL- 8 promotes leukin chemotaxis into tumors, leading to tumor neovascularization and the acceleration of tumor growth and metastasis IL- 8 enters cells by combining with the chemokine receptor ... being most effective As one of the core cytokines, interleukin-6 (IL- 6), is produced by lymphocytes, mononuclear cells, fibroblasts, vascular endothelial cells, and some cancer cells, primarily...
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Báo cáo y học: "Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor" ppt
... induced by LPS stimulation, and no inhibition by p38 MAPK inhibitor was observed This latter finding is in accordance with the study by Lai and co-workers showing that LPS induction of MMP9 in ... activated in endothelial cells and in the lining layer [10] Inhibition of p38 MAPK therefore could provide an interesting target for intervention in inflammation, as it occurs in the synovia in RA In ... protein production, so inhibition is already apparent at the level of transcription R389 p38 MAPK activity in RA is found predominantly in the synovial lining layer and in endothelial cells in...
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Báo cáo y học: "Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile Christine Lyn Le Maitre, Judith Alison Hoyland and Anthony J Freemont" ppsx
... synthesis of IL- 1α, IL- 1β, IL- 1 receptor type I (RI), IL- 1β converting enzyme and IL- 1Ra by the resident chondrocyte-like cells in human IVDs with significant increases in IL- 1α, IL- 1β, IL- 1RI and IL- 1β ... Photomicrographs illustrating immunohistochemistry staining for IL- 1β, tumour necrosis factor (TNF)α and their receptors in human intervertebral discs discs Results for non-degenerate discs (grade ... Joint Bone Spine 2006, 73:151-158 Available online http://arthritis-research.com/content/9/4/R77 28 Tobinick E, Britschgi-Davoodifar S: Perispinal TNF-alpha inhibition for discogenic pain Swiss...
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Báo cáo y học: "Primary effusion lymphoma associated with Human Herpes Virus-8 and Epstein Barr virus in an HIV-infected woman from Kampala, Uganda: a case repor" pptx
... (Figure 1A) They included multinucleated and Reed-Sternberg-like cells From these findings a preliminary diagnosis of PEL was made Since immunohistochemistry is not routinely available in Uganda, it ... patients [14,16] HHV-8, by definition, has to be present in the tumor cells in order to make a diagnosis of PEL [15] The co-infection of HHV-8 and EBV in this patient is interesting Both HHV-8 and ... This was the first AIDS defining illness in this patient even though she had very low CD4 counts The strong positivity for HHV-8 in this patient is similar to what other authors have found in...
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báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc
... higher in hES cells than in EB, and this result was consistent with both our microarray results and a previous report [26], indicating that the let-7 family plays important role in the maintaining ... was increased by 4,324-fold, LEFTY1 by 769-fold, and TDGF1 by 2,443-fold We did not find that Nanog was upregulated in hES cells by microarray analysis, and by qRT-PCR its expression was increased ... development The miR-200 family is also required for the proper differentiation of olfactory progenitor cells in zebrafish model [51], indicating that the miR-200 family is involved in development It has...
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Báo cáo y học: "Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading" ppt
... analysis of the response of articular cartilage to increased joint instability and altered mechanical loading, and thus to gain more insight into the very early stages of mechanically induced cartilage ... Knee instability is very likely to increase inappropriate mechanical loading in many parts of the joint and, in keeping with this, col II and YKL40 expression rose in all locations after ACLT in ... two distinct chitinase-like molecules, called YKL39 and YKL40 While YKL40 has been linked with tissue remodeling, with joint injury and with in situ inflammatory macrophages [35-40], clinical...
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Báo cáo y học: " DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines" ppt
... RNA-sequencing in 69 of the 77 samples [24] Methylation profiling was performed in duplicate using the Illumina HumanMethylation27 DNA Analysis BeadChip assay, which is based on genotyping of bisulfiteconverted ... histone modifications, and TF binding sites 1.0 Methylation 0.8 0.6 0.4 0.2 0.0 In Out CGIs In Out H3K27ac In Out H3K4me3 In Out H3K9ac In Out TF binding sites Figure Distribution of methylation ... obtained at SNP rs2187102 with probe cg27519424 in gene HLCS, which is thought to be involved in generegulation by mediating histone biotinylation [44] The proportion of variance explained by...
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Báo cáo y học: " The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis" pps
... was not involved in inflammation, we hypothesized that it would be involved in lung fibrosis This is based on the following: 1) CAT2 is upregulated in bleomycin -induced pulmonary fibrosis [19] ... bleomycin -induced pulmonary fibrosis Third, in contrast to the fibrosis data, we show that CAT2 expression is not required for lung inflammation in either allergen -induced or bleomycin -induced ... unable to further increase lung fibrosis In order to assess the fibrosis by an independent method, we stained lung tissue sections by trichrome staining As seen in Figure 4C, both wild type and CAT2-deficient...
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Báo cáo y học: "Functional significance of nerve growth factor and its receptor (TrkA) in inflammatory arthritis" pps
... cartilage and underlying cortical bone [4] We noticed that proinflammatory cytokines upregulate NGF/TrkA in FLSs, NGF/TrkA is upregulated in FLSs of in ammatory arthritis (Table 1), and NGF is ... rheumatoid arthritis in uence angiogenesis and cell trafficking [3] In patients with RA or PsA, pannus tissue adheres to the surface of articular cartilage; proliferating FLSs produce proteinases that ... RA, rheumatoid arthritis; SF, synovial fluid; SpA, spondyloarthritis; ST, synovial tissue Competing interests The authors declare that they have no competing interests Published: 28 June 2010 References...
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Báo cáo y học: "Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxiainduced mitochondrial mutagenesis in inflammatory arthritis" pot
... synovial fibroblast cells in the lining layer, along with infiltration of T, B and plasma cells The precise mechanisms involved in regulation of persistent synovial infiltration and invasion are unclear, ... temperature for 20 minutes, fixed in acetone for 10 minutes and washed in PBS for minutes Non-specific binding was blocked using 10% casein in PBS for 20 minutes The sections were incubated with primary ... mutagenesis and dysfunction in inflammatory arthritis Arthritis Rheum 2011 Kim J, Xu M, Xo R, Mates A, Wilson GL, Pearsall AWt, Grishko V: Mitochondrial DNA damage is involved in apoptosis caused by...
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Báo cáo sinh học: "Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues" docx
... adenohypophysis FTO is a well studied gene that is abundantly expressed in the hypothalamus and adenohypophysis and related to food intake and obesity [34,35] RHOB is a GTP-binding protein involved in ... roles in maintaining homeostasis of metabolites in blood Here, we report an association analysis between gene expression profiles in five endocrine tissues and plasma metabolites in pigs The ... reflecting biological processes that operate within tissues In contrast, hub nodes in module corresponded to four tissues including hypothalamus, thyroid, adenohypophysis and backfat, suggesting...
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Báo cáo sinh học: " Genetic effects of static magnetic fields. Body size increase and lethal mutations induced in populations of Drosophila melanogaster after chronic exposure" potx
... exposure This variation is non-random since the change in always in the plus direction in all the treated lines Similar results are found with colchicine treatment, in different lines of Loli!cm ... triggered by biomagnetism were reported by Brewer (1979) A significant increase in body size in comparison with both treated and control lines and in the size of the progeny examined in subsequent ... variations obtained in isogenic lines following treatment As each isogenic line presents each of the major chromosomes duplicated and identical both within an individual and in all individuals,...
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Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways" doc
... PI3-kinase, phosphatidylinositol 3-kinase; RA, rheumatoid arthritis except that IL- 17B and IL- 17E appear to bind IL- 17RB [26,27] In our experiment, adding recombinant IL- 17 induced the level of IL- 17R ... abolished the IL- 17 -induced increase in the production of IL- 6 and IL- 8 from RA FLS White bars, unstimulated control cells; gray bars, IL- 17-stimulated FLS; black bars, cells treated with IL- 17 ... compared the IL- 17-mediated induction of IL- 6 and IL- 8 in RA FLS with the effects of other pro- and antiinflammatory cytokines As shown in Fig 3a, IL- 17 induced 1500 1000 500 IL- 17 induces production...
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Báo cáo khoa học: Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production ppt
... cytokines in vivo and in vitro [22], by converting inactive precursors of cytokines such as pro -IL- 1b and pro -IL- 18 into their active forms [18,23], or by enhancing the expression of cytokine ... expression, we have investigated the molecular mechanism of the FasL -induced IL- 8 production in the untransformed human embryonic kidney cell line, HEK293 Conveniently, using this cell line we can exclude ... FP1 mutant inhibited the FasL -induced AP-1 activation These results indicate that the C-terminal 15 amino acids of Fas are dispensable, but the DD of Fas is indispensable for its ability to activate...
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Báo cáo y học: " Glycine tomentella Hayata inhibits IL-1b and IL-6 production, inhibits MMP-9 activity, and enhances RAW264.7 macrophage clearance of apoptotic cells" docx
... naringin, riodictyol, daidzein, glycitein, narigenin, luteolin, genistein, hesperetin, and isorhamnetin could be determined in GTH The major components of GTH were daidzein (42.5%), epicatechin ... in Taichung, Taiwan For induction of UV -induced apoptosis, HaCat cells were exposed to UV radiation at 1650 J/m by using the Spectroline UV Crosslinker with the Auto crosslink mode (Spectroline, ... Electrophoresis was performed using zymogram gelatin gels Gelatin zymography was performed on a 10% sodium dodecyl sulfateacrylamide gel containing 0.1% gelatin (SIGMA), rinsed in dd-H2O followed by incubation...
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Báo cáo y học: "Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in Cystic Fibrosis cells" ppsx
... pretreatment results in an inhibition of inflammatory signaling in cells with CF defects Production of IL- 8 and other pro-inflammatory cytokines is also governed by mechanisms regulating in their mRNA ... increased p38 and, stabilized IL- 8 mRNA and further increased IL- 8 protein formation induced by NFκB-inducing kinase (NIK) [16] The active form of the MAPK-activated protein kinase (MK-2), a downstream ... J, Tabary O: Enhanced IL- 1beta -induced IL- 8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling Biochem Biophys Res...
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Báo cáo y học: " Augmentation of Pulmonary Epithelial Cell IL-8 Expression and Permeability by Pre-B-cell Colony Enhancing Factor" docx
... TNFα induced IL- 8 protein expression in A549 cells In order to examine the role of PBEF in human pulmonary alveolar epithelial cell inflammation, we began by quantifying TNFα induced IL- 8 protein ... PBEF protein and mRNA production in both baseline and TNFα activated A549 cells PBEF silencing attenuated TNFα -induced increases in IL- 8 secretion and IL- 8 mRNA expression within A549 cells Based ... results indicate that PBEF is involved in IL- 8 expression and secretion under both baseline and TNFα-stimulated conditions within the A549 cells PBEF silencing attenuated TNFα -induced increases in IL- 8...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25