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Part 1 book “Robbins basic pathology” has contents: Cell injury, cell death, and adaptations, inflammation and repair, hemodynamic disorders, thromboembolism, and shock, diseases of the immune system, neoplasia, genetic and pediatric diseases, environmental and nutritional diseases, general pathology of infectious diseases,… and other contents.
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Go to studentconsult.com; Sign in Click the “Activate Another Book” button Gently scratch off the surface of the sticker with the edge of a coin to reveal your Pin code Enter it into the “Pin code” box; select the title you’ve activated from the drop-down menu Click the “Activate Book” button REGISTER s 'OTOSTUDENTCONSULTCOMCLICKh2EGISTER.OWv s &ILLINYOURUSERINFORMATIONANDCLICKh!CTIVATEYOUR account” ACTIVATE YOUR BOOK s #LICKTHEh!CTIVATE!NOTHER"OOKvBUTTON s 'ENTLYSCRATCHOFFTHESURFACEOFTHESTICKERWITHTHE edge of a coin to reveal your Pin code s %NTERITINTOTHEh0INCODEvBOXSELECTTHETITLE you’ve activated from the drop-down menu s #LICKTHEh!CTIVATE"OOKvBUTTON Access to, and online use of, content through the Student Consult website is for individual use only; library and institutional access and use are strictly prohibited For information on products and services available for institutional access, please contact our Account Support Center at (+1) 877-857-1047 Important note: Purchase of this product includes access to the online version of this edition for use exclusively by the individual purchaser from the launch of the site This license and access to the online version operates strictly on the basis of a single user per PIN number The sharing of passwords is strictly prohibited, and any attempt to so will invalidate the password Access may not be shared, resold, or otherwise circulated, and will terminate 12 months after publication of the next edition of this product Full details and terms of use are available upon registration, and access will be subject to your acceptance of these terms of use For technical assistance: email online.help@elsevier.com call 800-401-9962 (inside the US) / call +1-314-995-3200 (outside the US) Robbins Basic Pathology This page intentionally left blank Basic Pathology ROBBINS NINTH EDITION Vinay Kumar, MBBS, MD, FRCPath Donald N Pritzker Professor Chair, Department of Pathology Biologic Sciences Division and Pritzker School of Medicine University of Chicago Chicago, Illinois Abul K Abbas, MBBS Distinguished Professor and Chair Department of Pathology University of California San Francisco San Francisco, California Jon C Aster, MD, PhD Professor of Pathology Harvard Medical School Brigham and Women’s Hospital Boston, Massachusetts ARTIST James A Perkins, MS, MFA 1600 John F Kennedy Blvd Ste 1800 Philadelphia, PA 19103-2899 ROBBINS BASIC PATHOLOGY 978-1-4377-1781-5 International Edition: 978-0-8089-2432-6 Copyright © 2013, 2007, 2003, 1997, 1992, 1987, 1981, 1976, 1971 by Saunders, an imprint of Elsevier Inc No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein) Notices Knowledge and best practice in this field are constantly changing As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein Library of Congress Cataloging-in-Publication Data Robbins basic pathology / [edited by] Vinay Kumar, Abul K Abbas, Jon C Aster – 9th ed p ; cm Basic pathology Includes bibliographical references and index ISBN 978-1-4377-1781-5 (hardcover : alk paper) – ISBN 978-0-8089-2432-6 (International ed : hardcover : alk paper) I. Kumar, Vinay, 1944– II. Abbas, Abul K. III. Aster, Jon C. IV. Robbins, Stanley L (Stanley Leonard), 1915–2003. V. Title: Basic pathology [DNLM: 1. Pathology QZ 4] 616.07–dc23 2011048699 Executive Content Strategist: William Schmitt Content Development Manager: Rebecca Gruliow Publishing Services Manager: Patricia Tannian Senior Project Manager: Sarah Wunderly Design Direction: Louis Forgione Printed in Canada Last digit is the print number: 9 8 7 6 5 4 3 2 Working together to grow libraries in developing countries www.elsevier.com | www.bookaid.org | www.sabre.org DEDICATION To Our children and a special grandchild Kiera Chapman Kumar This page intentionally left blank Contributors Charles E Alpers, MD Professor and Vice Chair Department of Pathology University of Washington Seattle, Washington Kidney and Its Collecting System Jonathan Epstein, MD Professor of Pathology, Urology, and Oncology The Reinhard Professor of Urological Pathology Director of Surgical Pathology The Johns Hopkins Medical Institutions Baltimore, Maryland Male Genital System and Lower Urinary Tract Mark W Lingen, DDS, PhD Associate Professor Department of Pathology The University of Chicago, Chicago, Illinois Oral Cavity and Gastrointestinal Tract Anirban Maitra, MBBS Professor of Pathology and Oncology The Johns Hopkins University School of Medicine Pathologist The Johns Hopkins Hospital Baltimore, Maryland Genetic and Pediatric Diseases; Pancreas; Endocrine System Agnes B Fogo, MD Alexander J McAdam, MD, PhD Matthew P Frosch, MD, PhD Richard N Mitchell, MD, PhD John L Shapiro Chair of Pathology Professor of Pathology, Microbiology, Immunology, Medicine, and Pediatrics Director, Renal/EM Division of Pathology Vanderbilt University School of Medicine Nashville, Tennessee Kidney and Its Collecting System Lawrence J Henderson Associate Professor of Pathology and Health Sciences & Technology Harvard Medical School Director, C.S Kubik Laboratory for Neuropathology Massachusetts General Hospital Boston, Massachusetts Central Nervous System Aliya Noor Husain, MBBS Professor Department of Pathology The University of Chicago Chicago, Illinois Lung Alexander J.F Lazar, MD, PhD Associate Professor Departments of Pathology and Dermatology The University of Texas M.D Anderson Cancer Center Houston, Texas Skin Associate Professor of Pathology Harvard Medical School Medical Director, Infectious Diseases Diagnostic Laboratory Children’s Hospital Boston, Massachusetts General Pathology of Infectious Diseases Lawrence J Henderson Professor of Pathology and Health Sciences & Technology Department of Pathology Harvard Medical School Staff Pathologist Brigham and Women’s Hospital Boston, Massachusetts Hemodynamic Disorders, Thromboembolism, and Shock; Blood Vessels; Heart Peter Pytel, MD Assistant Professor Department of Pathology The University of Chicago Chicago, Illinois Peripheral Nerves and Muscles Andrew E Rosenberg, MD Clinical Professor of Pathology Director, Bone and Soft Tissue Pathology Department of Pathology Miller School of Medicine University of Miami Miami, Florida Bones, Joints, and Soft Tissue Tumors viii Contributors Husain A Sattar, MD Assistant Professor of Pathology The University of Chicago Chicago, Illinois Female Genital System and Breast Arlene H Sharpe, MD, PhD Professor of Microbiology and Immunobiology, and Pathology Harvard Medical School and Brigham and Women’s Hospital Boston, Massachusetts General Pathology of Infectious Diseases Thomas Stricker, MD, PhD Instructor Department of Pathology The University of Chicago Chicago, Illinois Neoplasia Jerrold R Turner, MD, PhD Sara and Harold Lincoln Thompson Professor Associate Chair Department of Pathology The University of Chicago Chicago, Illinois Oral Cavity and Gastrointestinal Tract Wei-Lien Wang, MD Assistant Professor of Pathology Section of Soft Tissue and Dermatopathology The University of Texas M.D Anderson Cancer Center Houston, Texas Skin Neil D Theise, MD Professor Departments of Pathology and Medicine (Digestive Diseases) Beth Israel Medical Center of Albert Einstein College of Medicine New York, New York Liver, Gallbladder, and Biliary Tract Edward C Klatt, MD Professor and Academic Administrator Department of Pathology Florida State University College of Medicine Tallahassee, Florida Photographic Editor Raminder Kumar, MBBS, MD Chicago, Illinois Clinical Editor for Diseases of the Heart, Lung, Pancreas, Oral Cavity and Gastrointestinal Tract, and Liver Richard N Mitchell, MD, PhD Lawrence J Henderson Professor of Pathology and Health Sciences & Technology Department of Pathology Harvard Medical School Staff Pathologist Brigham and Women’s Hospital Boston, Massachusetts Targeted Therapy (Online) Editor ... ROBBINS BASIC PATHOLOGY 978 -1- 4377 -17 81- 5 International Edition: 978-0-8089-2432-6 Copyright © 2 013 , 2007, 2003, 19 97, 19 92, 19 87, 19 81, 19 76, 19 71 by Saunders, an imprint of Elsevier Inc No part of... Vinay, 19 44– II. Abbas, Abul K. III. Aster, Jon C. IV. Robbins, Stanley L (Stanley Leonard), 19 15–2003. V. Title: Basic pathology [DNLM: 1. Pathology QZ 4] 616 .07–dc23 2 011 048699... online.help@elsevier.com call 800-4 01- 9962 (inside the US) / call +1- 314 -995-3200 (outside the US) Robbins Basic Pathology This page intentionally left blank Basic Pathology ROBBINS NINTH EDITION Vinay