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(BQ) Part 1 book “Managing cardiovascular complications in diabetes” has contents: The vascular endothelium in diabete, new biomarkers of cardiovascular disease in diabetes, kidney disease in diabetes, vascular imaging, hypertension and cardiovascular disease and its management,… and other contents.
Managing Cardiovascular Complications in Diabetes Managing Cardiovascular Complications in Diabetes EDITED BY D John Betteridge BSc, MBBS, PhD, MD, FRCP, FAHA Consultant Physician University College London Hospital; Dean Royal Society of Medicine London, UK Stephen Nicholls MBBS, PhD, FRACP, FACC, FESC, FAHA, FCSANZ SAHMRI Heart Foundation Heart Disease Team Leader South Australian Health & Medical Research Institute; Professor of Cardiology, University of Adelaide; Consultant Cardiologist, Royal Adelaide Hospital Adelaide, SA, Australia This edition first published 2014 © 2014 by John Wiley & Sons Ltd Registered office: John Wiley & Sons, Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial offices: 9600 Garsington Road, Oxford, OX4 2DQ, UK The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK 111 River Street, Hoboken, NJ 07030-5774, USA For details of our global editorial offices, for customer services and for information about how to apply for permission to reuse the copyright material in this book please see our website at www.wiley.com/wiley-blackwell The right of the author to be identified as the author of this work has been asserted in accordance with the UK Copyright, Designs and Patents Act 1988 All rights reserved No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs and Patents Act 1988, without the prior permission of the publisher Designations used by companies to distinguish their products are often claimed as trademarks All brand names and product names used in this book are trade names, service marks, trademarks or registered trademarks of their respective owners The publisher is not associated with any product or vendor mentioned in this book It is sold on the understanding that the publisher is not engaged in rendering professional services If professional advice or other expert assistance is required, the services of a competent professional should be sought The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting a specific method, diagnosis, or treatment by health science practitioners for any particular patient The publisher and the author make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of fitness for a particular purpose In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions Readers should consult with a specialist where appropriate The fact that an organization or Website is referred to in this work as a citation and/or a potential source of further information does not mean that the author or the publisher endorses the information the organization or Website may provide or recommendations it may make Further, readers should be aware that Internet Websites listed in this work may have changed or disappeared between when this work was written and when it is read No warranty may be created or extended by any promotional statements for this work Neither the publisher nor the author shall be liable for any damages arising herefrom Library of Congress Cataloging-in-Publication Data Managing cardiovascular complications in diabetes / edited by D John Betteridge, Stephen Nicholls p ; cm Includes bibliographical references and index ISBN 978-0-470-65949-6 (pbk.) I Betteridge, John, editor of compilation II Nicholls, Stephen J., editor of compilation [DNLM: Cardiovascular Diseases – etiology Diabetes Complications Cardiovascular Diseases – therapy WK 835] RC660.4 616.4′ 62 – dc23 2013049546 A catalogue record for this book is available from the British Library Wiley also publishes its books in a variety of electronic formats Some content that appears in print may not be available in electronic books Cover image: iStock - File #21522822 © janulla Cover design by Steve Thompson Typeset in 9.5/13pt MeridienLTStd by Laserwords Private Limited, Chennai, India 2014 Contents List of Contributors, vii Introduction, ix The Vascular Endothelium in Diabetes, Andrew Lansdown, Elizabeth Ellins, and Julian Halcox New Biomarkers of Cardiovascular Disease in Diabetes, 30 Hitesh Patel, Sujay Chandran, and Kausik K Ray Kidney Disease in Diabetes, 58 Amanda Y Wang, Meg Jardine, and Vlado Perkovic Vascular Imaging, 87 Kiyoko Uno, Jordan Andrews, and Stephen J Nicholls Glycemia and CVD and Its Management, 116 Jeffrey W Stephens, Akhila Mallipedhi, and Stephen C Bain Hypertension and Cardiovascular Disease and Its Management, 140 José A Garc´ıa-Donaire and Luis M Ruilope Dyslipidemia and Its Management in Type Diabetes, 165 D John Betteridge Thrombosis in Diabetes and Its Clinical Management, 185 R.A Ajjan and Peter J Grant Diet and Lifestyle in CVD Prevention and Treatment, 215 Alice H Lichtenstein 10 Management of Acute Coronary Syndrome, 238 Christopher M Huff and A Michael Lincoff 11 Management of Peripheral Arterial Disease, 267 Rüdiger Egbert Schernthaner, Gerit Holger Schernthaner, and Guntram Schernthaner Index, 307 Color plate section facing p50 v List of Contributors R.A Ajjan MRCP, MMedSci, PhD José A García-Donaire MD Associate Professor and Consultant in Diabetes and Endocrinology Division of Diabetes and Cardiovascular Research Leeds Institute of Genetics, Health and Therapeutics Multidisciplinary Cardiovascular Research Centre University of Leeds Leeds, UK Nephrologist Hypertension Unit Hospital 12 de Octobre Madrid, Spain Jordan Andrews BS South Australian Health & Medical Research Institute Adelaide, SA, Australia Stephen C Bain MA, MD, FRCP Professor of Medicine (Diabetes) Honorary Consultant Physician Swansea University College of Medicine Swansea, UK D John Betteridge BSc, MBBS, PhD, MD, FRCP, FAHA Consultant Physician University College London Hospital; Dean Royal Society of Medicine London, UK Sujay Chandran MRCP SpR Cardiology Department of Cardiology St Georges Hospital London, UK Elizabeth Ellins BSc(hons), MA Senior Vascular Scientist Swansea University College of Medicine Swansea, UK Peter J Grant MD, FRCP, FMedSci Professor of Medicine Honorary Consultant Physician University of Leeds and Leeds Teaching Hospitals NHS Trust; Division of Cardiovascular and Diabetes Research The LIGHT Laboratories Leeds, UK Julian Halcox MA, MD, FRCP Professor of Cardiology Director, Cardiovascular Research Group Cymru Swansea University College of Medicine Swansea, UK Christopher M Huff MD Cardiology Fellow Heart and Vascular Institute Cleveland Clinic Cleveland, OH, USA Meg Jardine MBBS, PHD, FRACP Senior Research Fellow Renal & Metabolic Division The George Institute for Global Health; Consultant Nephrologist Concord Repatriation General Hospital Sydney, NSW, Australia Andrew Lansdown MBChB, MRCP Clinical Research Fellow Institute of Molecular and Experimental Medicine Cardiff University School of Medicine Cardiff, UK vii viii List of Contributors Alice H Lichtenstein DSc Stanley N Gershoff Professor Friedman School of Nutrition Science and Policy Director and Senior Scientist, Cardiovascular Nutrition Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University Boston, MA, USA A Michael Lincoff MD Kausik K Ray BSc (Hons), MBChB, MD, FRCP, MPhil (Cantab), FACC, FESC, FAHA Professor of Cardiovascular Disease Prevention Cardiac and Vascular Sciences St George’s University of London London, UK Luis M Ruilope MD, PhD Professor Hospital 12 de Octobre Madrid, Spain Professor of Medicine Cleveland Clinic Lerner College of Medicine Case Western Reserve University; Vice Chairman, Heart & Vascular Institute Cleveland Clinic Cleveland, OH, USA Gerit-Holger Schernthaner MD Akhila Mallipedhi MBBS, MRCP Guntram Schernthaner MD Specialist Registrar in Diabetes & Endocrinology Department of Diabetes & Endocrinology Morriston Hospital, ABM University Health Board Swansea, UK Professor and Head Department of Medicine I Rudolfstiftung Hospital Vienna Vienna, Austria Stephen Nicholls MBBS, PhD, FRACP, FACC, FESC, FAHA, FCSANZ SAHMRI Heart Foundation Heart Disease Team Leader South Australian Health & Medical Research Institute; Professor of Cardiology, University of Adelaide; Consultant Cardiologist, Royal Adelaide Hospital Adelaide, SA, Australia Hitesh Patel MBBS, BSc Cardiology Registrar Department of Cardiology St George’s Hospital London, UK Vlado Perkovic MBBS, PhD, FRACP, FASN Executive Director The George Institute for Global Health; Professor of Medicine University of Sydney Sydney, NSW, Australia University Professor of Medicine Department of Medicine II Division of Angiology Medical University of Vienna Vienna, Austria Rüdiger-Egbert Schernthaner MD Department of Radiology Division of Cardiovascular and Interventional Radiology Medical University of Vienna Vienna, Austria Jeffrey W Stephens BSc, MBBS, PhD, FRCP Professor of Medicine (Diabetes & Metabolism) Honorary Consultant Physician Swansea University College of Medicine Swansea, UK Kiyoko Uno MD Departments of Cardiovascular Medicine and Cell Biology Cleveland Clinic Cleveland, OH, USA Amanda Y Wang MBBS, MSc, FRACP Medical Fellow Renal & Metabolic Division The George Institute for Global Health; Consultant Nephrologist Sydney Adventist Hospital Sydney, NSW, Australia ... disease* 26505 2.00 (1. 83–2 .19 ) 64 (54– 71) Coronary death 11 556 2. 31 (2.05–2.60) 41 (24–54) Non-fatal mycardinal infarction 14 7 41 1.82 (1. 64–2.03) 37 (19 – 51) Ischaemic stroke 3799 2.27 (1. 95–2.65) (0–20)... Haemorrhagic stroke 11 83 1. 56 (1. 19–2.05) (0–26) Unclassified stroke 4973 1. 84 (1. 59–2 .13 ) 33 (12 –48) Other vascular deaths 3826 1. 73 (1. 51 1. 98) Stroke subtypes* (0–26) 698,782 people in 10 2 prospective... not have insulin therapy She has an HBA1c of 10 .0% (86 mmol/mol), BP 16 0 /10 0 mmHg, creatinine 18 5 μmol/L (2 .10 mg/dL), eGFR 25 ml/min, ACR 10 Multiple-Choice Questions Which of the following risk