Transcranial direct current stimulation in neuropsychiatric disorders

421 226 0
Transcranial direct current stimulation in neuropsychiatric disorders

Đang tải... (xem toàn văn)

Tài liệu hạn chế xem trước, để xem đầy đủ mời bạn chọn Tải xuống

Thông tin tài liệu

Transcranial Direct Current Stimulation in Neuropsychiatric Disorders Clinical Principles and Management André Brunoni Michael Nitsche Colleen Loo Editors 123 Transcranial Direct Current Stimulation in Neuropsychiatric Disorders André Brunoni • Michael Nitsche Colleen Loo Editors Transcranial Direct Current Stimulation in Neuropsychiatric Disorders Clinical Principles and Management Editors André Brunoni Interdisciplinary Center for Applied Neuromodulation University Hospital and Service of Interdisciplinary Neuromodulation Department and Institute of Psychiatry Laboratory of Neurosciences (LIM-27) University of São Paulo São Paulo, Brazil Michael Nitsche Department of Psychology and Neurosciences Leibniz Research Center for Working Environments and Human Factors Dortmund, Germany Colleen Loo School of Psychiatry Black Dog Institute & St George Hospital University of New South Wales Sydney, NSW, Australia ISBN 978-3-319-33965-8 ISBN 978-3-319-33967-2 DOI 10.1007/978-3-319-33967-2 (eBook) Library of Congress Control Number: 2016951923 © Springer International Publishing Switzerland 2016 This work is subject to copyright All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed The use of general descriptive names, registered names, trademarks, service marks, etc in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland Foreword Why write a book on transcranial direct current stimulation (tDCS)? This question is especially relevant in the face of the rapidly increasing numbers of journals, open access publications, wikis and blogs In parallel to the exponential spread of information sources, information and beliefs also tend to be found in shared virtual spaces, where they are amplified and reinforced Critical reflection on concurrent and opposing opinions, or a synopsis of such opinions, is underrepresented in such “echo chambers” This is the case for the general public discourse and may also be true for the reception of scientific findings tDCS is a technically extremely simple method and easy to apply Thus, people can be tempted to build the equipment themselves or try do-it-yourself (DIY) application without any expert guidance—numerous video clips for DIY tDCS on the web are just one form of public sharing of knowledge and convictions about this method that are echoed by other followers People are also tempted to follow intuitive attitudes or convictions about tDCS, e.g nonverified dose/parameter response assumptions, hypotheses on the functional anatomy of tDCS effects or a general idea of reinforcing brain functions with no side effects (cognitive enhancement) The 2016 paper “tDCS modulates neuronal activity and learning in pilot training” [1] is just one example where the title immediately and strongly suggests an application in real-world settings Karl R Popper’s general rule, however, “that we are not to abandon the search for universal laws and for coherent theoretical system, nor ever give up our attempts to explain causally any kind of event we can describe” [2], which he proposed to be closely associated with the “principle of causality”, should remind us to be careful about making assumptions Admittedly, though, we often follow associative or correlative relations, particularly when applying insights from neuroscience to clinical situations Of course, a single book cannot counterbalance or overrule current trends in a scientific discussion Moreover dispersed, “open access” pieces of data and information are also extremely valuable in a thorough discussion of scientific findings Nevertheless, because this book combines a critical amount of data and hypotheses it allows the reader to appraise findings and theories on tDCS and its variants Andre Brunoni, Michael Nitsche, Colleen Loo and the other authors, all pioneers and leading experts in the field, have taken a brilliant approach to this endeavour and guide us through the state of the art in tDCS The different chapters cover tDCS development, related technologies (e.g transcranial v Foreword vi alternating current stimulation, tACS, or transcranial random noise stimulation, tRNS), physiology and translational research from animal experiments to preclinical studies in humans involving neurocognitive and neuropsychological approaches, electroencephalography and magnetic resonance imaging (MRI) Several chapters cover specific applications ranging from cerebellar and spinal tDCS to different applications in neuropsychiatric disorders The final part of the book outlines and discusses safety-related, ethical and regulatory issues tDCS is part of the armamentarium of non-invasive brain stimulation (NIBS), which constitutes a growing array of techniques such as transcranial magnetic stimulation (TMS), paired associative stimulation (PAS) and transcutaneous vagal nerve stimulation Each NIBS technique, but also each variant of tDCS, is a neurophysiologically distinct method The authors of this book are aware that tDCS is used as a non-focal approach on the most complex organ/system of the human body and that the differential action of tDCS on single neurons or neuronal circuits or glial cells is difficult to predict or target Dose-response curves often show non-linear functions, which are currently not fully understood Furthermore, dynamic effects of repeated tDCS administration, which are particularly important for therapeutic applications, still need to be elucidated The combination of tDCS with psychotherapy and other interventions is currently being tested in pilot studies and is proving to be extremely challenging [3] Such open methodological fields would provide a large experimental terrain for preclinical studies in cellular and animal models, but studies in this preclinical field are still underrepresented Thus, the book may stimulate the transfer of research based on clinical or experimental data in humans to the preclinical field of cellular or animal research strategies (reverse translation) This book is comprehensive and as such valuable The task of preparing it motivated the editors and authors to move systematically through the field of research and to also cover topics which are not on the main track, e.g the history of tDCS and ethical and regulatory issues Consequently the content of chapters may overlap, as a reflection of different perspectives This book allows the reader to jump between chapters to compare information, hypotheses and views It is an excellent resource for senior and junior scientists, doctorate students and others to introduce them to this fascinating field of research Frank Padberg References Choe J, Coffman BA, Bergstedt DT, Ziegler MD, Phillips ME Transcranial direct current stimulation modulates neuronal activity and learning in pilot training Front Hum Neurosci 2016;10:34 doi:10.3389/fnhum.2016.00034 Popper KR The logic of scientific discovery 11th impression rev London: Hutchinson & Co Publishers Ltd.; 1959 p 61 Bajbouj M, Padberg F A perfect match: noninvasive brain stimulation and psychotherapy Eur Arch Psychiatry Clin Neurosci 2014;264 Suppl 1:S27–33 Preface The clinical interest in non-invasive brain stimulation has grown exponentially over the past 25 years, with the development of non-pharmacological, neuromodulatory techniques such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) TDCS, the youngest sibling of the brain stimulation family, is in fact a “new old technique” With anecdotal reports of the use of the torpedo fish to treat pain and headache via its electrical discharges during the ancient history, electricity was indeed used in the nineteenth and twentieth centuries to treat several neurologic and psychiatric ailments, usually with sparse scientific foundations Although more recently, in the 1960s and 1970s, the treatment of some psychiatric disorders was investigated using brain polarization (a technique similar to modern tDCS), the research did not endure—perhaps due to the stigma of electroconvulsive therapy or the concomitant development of pharmacotherapy in that period TDCS reappraisal only took place in 1998–2000, when two independent European groups showed that the electric currents applied over the motor cortex induced changes in brain excitability From then onwards, tDCS has been increasingly investigated and has attracted considerable attention in both basic and clinical research settings In the present book we aimed to present the main advancements regarding the use of tDCS in neuropsychiatric disorders The book is divided into three parts The first part discusses the mechanisms of action of tDCS under different perspectives, which encompass neurophysiological, neuroimaging and neuropsychological studies as well as animal studies and computer-based models In the second part, state-or-the-art evidence of tDCS use in several neurological and psychiatric disorders is presented The third and last part of the book discusses different possibilities of the clinical and research use of tDCS, including safety, ethical and regulatory aspects This book would not have been produced without the invaluable contribution of leading researchers and scientists of the field We are grateful and thank these authors for their time and effort in writing informative, insightful and up-to-date chapters We are also grateful to Springer for supporting our project, particularly Gabriel Natan Pires, the Springer associate editor who encouraged us to edit this book, and Susan Westendorf, the Springer project coordinator responsible for this book production We believe that this book will be useful to neurologists, psychiatrists and physicians interested in the potential clinical applications of tDCS This book will also be of interest for neophytes, who are looking for a primer in vii Preface viii non-invasive brain stimulation More experienced researchers will also enjoy reading this book as it contains top-quality work written by several tDCS experts We, the editors, are convinced that Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: Clinical Principles and Management will be a captivating bedside book for many researchers in the field—us included São Paulo, Brazil Dortmund, Germany Sydney, NSW, Australia Andre Brunoni Michael Nitsche Colleen Loo Contents Part I Introduction and Mechanisms of Action Historical Aspects of Transcranial Electric Stimulation Stefano Zago, Alberto Priori, Roberta Ferrucci, and Lorenzo Lorusso The New Modalities of Transcranial Electric Stimulation: tACS, tRNS, and Other Approaches Andrea Antal, Ivan Alekseichuk, and Walter Paulus 21 Physiology of Transcranial Direct and Alternating Current Stimulation Min-Fang Kuo, Rafael Polanía, and Michael Nitsche 29 Computer-Based Models of tDCS and tACS Dennis Q Truong, Devin Adair, and Marom Bikson Animal Studies in the Field of Transcranial Electric Stimulation Doris Ling, Asif Rahman, Mark Jackson, and Marom Bikson Cortical Inhibition and Excitation in Neuropsychiatric Disorders Using Transcranial Magnetic Stimulation Natasha Radhu, Daniel M Blumberger, and Zafiris J Daskalakis Neurocognitive Effects of tDCS in the Healthy Brain Siobhán Harty, Anna-Katharine Brem, and Roi Cohen Kadosh Transcranial Direct Current Stimulation in Social and Emotion Research Paulo Sérgio Boggio, Gabriel Gaudencio Rêgo, Lucas Murrins Marques, and Thiago Leiros Costa 10 Multimodal Association of tDCS with Electroencephalography Nadia Bolognini and Carlo Miniussi tDCS and Magnetic Resonance Imaging Ainslie Johnstone, Emily Hinson, and Charlotte J Stagg 47 67 85 103 143 153 169 ix 400 regime [56] This report thus further highlights the importance for careful patient screening and monitoring, as well as titration with the use of both novel tDCS protocols and established protocols used in different clinical populations Another potentially relevant aspect to safety is the application of tDCS using an extracephalic reference electrode based on adverse side effects reported in an early study [57] Computer modeling of the use of an extracephalic electrode placed upon the shoulder suggests that cardiac or brainstem activities should not be affected [58, 59] Data in healthy subjects suggests that using an extracephalic electrode reference does not modulate brainstem autonomic activity [60] Notwithstanding, this assumption does not necessarily apply for any tDCS protocol, independent from current intensity, and stimulation duration, and without regard for inclusion/exclusion criteria Hence, careful patient monitoring to demonstrate safety is recommended particularly for novel protocols The most immediate safety risk for tDCS is the potential for skin lesions or burns following repeated treatments [23, 61] Risk to subjects, however, can be substantially ameliorated through the implementation of several previously outlined recommendations [37] (1) Subjects should be screened for skin disease, irritation or lesions underneath where the electrodes will be placed to minimize focalisation of current density Skin should also be checked prior to every tDCS administration (2) A single-use sponge should be placed between the electrode and the scalp, as repeated use of sponges may lead to the build-up of substances, which could cause electrochemical reactions [61] (3) Sponges should be evenly saturated with contact medium (e.g., saline) so that no dry portion of the sponge is in contact with the skin If using electrolyte cream directly on an electrode, the thickness of the cream application should be consistent (~3 mm) and should cover the electrode completely, preventing direct contact of the electrode with the skin (4) Care should be taken to ensure adequate and even contact of the electrode skin interface is achieved (5) Finally, standardized monitoring of A.J Woods and D.M Martin patient comfort (e.g., discomfort/pain during stimulation) and side effects following stimulation should be implemented [37, 62], to regularly assess subjects’ skin condition and risk for burns Monitoring Functional Effects of tDCS There are several possible approaches to monitoring the functional effects of tDCS Effects on motor cortex plasticity and motor cortex excitability, for example, are typically examined through experimental designs which involve firstly determining the motor cortex hotspot for a targeted muscle (e.g., first dorsal interosseous) using single pulse TMS, obtaining a measure of baseline excitability, and then measuring physiological changes following tDCS stimulation [55, 63] Another commonly used approach is to examine cognitive effects either during or following tDCS administration (for review see [64]) Increasingly, investigators are additionally employing neuroimaging tools (e.g., EEG and fMRI) to further explore functional effects EEG, whilst lacking the spatial resolution of other techniques, has the advantage of allowing for enhanced temporal resolution for assessing tDCS related functional effects EEG measures voltage fluctuations resulting from ionic current flow via scalp recorded activity and thus is useful for elucidating changes in processing over time within specific regions or across circuits [18] Similarly to the assessment of functional cognitive changes, functional effects can be measured “online” or “offline” following stimulation Both methods, however, are associated with methodological challenges Firstly, the tDCS electrodes will need to be integrated together with the EEG electrodes, so as to avoid both types of electrodes being in direct contact and potential bridging between tDCS and nearby EEG electrodes via spreading of the conductive medium The latter can be potentially avoided through the use of small sized electrodes, similarly to those used with HD-tDCS [25] Secondly, for “online” protocols, as tDCS involves the application of an electrical current 26 Clinical Research and Methodological Aspects for tDCS Research and EEG directly measures very small electrical changes within the brain, there is the potential for direct interference from tDCS This can thus result in saturation of an EEG recording amplifier that does not have sufficient range Artifacts related to the tDCS device can also introduce external noise Such effects may potentially be accounted for by the use of a phantom head so as to identify potential artifacts introduced by the tDCS device [65] Functional effects may further be investigated using magnetic resonance imaging (MRI), which incorporates several methods including Blood Oxygen Level Dependent (BOLD) fMRI [15, 66], Arterial Spin Labeling [12], as well as proton and non-proton MR Spectroscopy [67] tDCS can be applied within the bore of the magnet, with the option of assessing effects either during “online” stimulation, and “offline,” where subjects are removed from the scanner, have tDCS applied, and then are returned in the scanner There are several methodological considerations in regard to the use of tDCS within the MR bore Firstly, due to the potential for premature drying out of the electrodes during concurrent scanning (which may last up to or over an hour), biocarbon electrodes should be attached to the participant using thick electrical conductance paste (e.g., Ten-20 paste), rather than saline soaked sponges or low viscosity electrode gel Secondly, electrodes should be marked with oil-capsules so their position can be checked on the resulting images It is also very important that electrodes are not in contact with the head coil, or headphones, to prevent electrode displacement and unexpected interactions between the stimulator and the scanner Specially designed MRI compatible (nonferrous or appropriately shielded) tDCS cables and electrodes passed through the magnet suite waveguide and into the magnet bore are also necessary, with loops avoided and placed away from subjects to avoid the risk of eddy current induction and potential RF burns Lastly, when analyzing data, consideration should also be given to the potential warping of the magnetic field due to the introduction of tDCS resulting in false-positive findings 401 Concluding Remarks In this chapter, we deliver guidance for technically sound application of tDCS Although the technique is seemingly simple and easy to apply, specific aspects must to be taken into careful consideration to perform reproducible application and obtain reliable results In the absence of careful consideration for the topics covered in this chapter, it is difficult, if not impossible, to interpret study findings, and difficult to facilitate attempts to replicate prior findings In addition to other available technical guides to tDCS [68], this chapter will arm researchers and clinicians new to tDCS with insight into methodological considerations necessary for consistent application of tDCS in both clinical and research settings For experienced researchers, this chapter provides a critical review of methodological aspects of tDCS important for consideration in attempts to replicate existing effects in the literature and important for inclusion in reports of tDCS effects In summary, with careful consideration of the topics covered in this chapter, clinicians and researchers should be well equipped to perform consistent and reproducible tDCS in clinical and research settings References Nitsche MA, Nitsche MA, Paulus W, Paulus W Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation J Physiol 2000;527(Pt 3):633–9 Priori A, Berardelli A, Rona S, Accornero N, Manfredi M Polarization of the human motor cortex through the scalp Neuroreport 1998;9(10):2257–60 Horvath JC, Forte JD, Carter O Quantitative review finds no evidence of cognitive effects in healthy populations from single-session transcranial direct current stimulation (tDCS) Brain Stimul 2015;8(3):535–50 Woods AJ, Bryant V, Sacchetti D, Gervits F, Hamilton R Effects of electrode drift in transcranial direct current stimulation Brain Stimul 2015;8(3):515–9 Batsikadze G, Moliadze V, Paulus W, Kuo M-F, Nitsche M Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans J Physiol 2013;591(Pt 7):1987–2000 402 Nitsche MA, Fricke K, Henschke U, Schlitterlau A, Liebetanz D, Lang N, et al Pharmacological modulation of cortical excitability shifts induced by transcranial direct current stimulation in humans J Physiol 2003;553(Pt 1):293–301 López-Alonso V, Cheeran B, Fernández-Del-Olmo M Relationship between non-invasive brain stimulation-induced plasticity and capacity for motor learning Brain Stimul 2015;8(6):1209–19 Fregni F, Fregni F, Boggio PS, Boggio PS, Nitsche M, Nitsche M, et al Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory Exp Brain Res 2005;166(1):23–30 Hoy KE, Arnold SL, Emonson MRL, Daskalakis ZJ, Fitzgerald PB An investigation into the effects of tDCS dose on cognitive performance over time in patients with schizophrenia Schizophr Res 2014;155(1-3):96–100 10 Monte-Silva K, Kuo M-F, Liebetanz D, Paulus W, Nitsche MA Shaping the optimal repetition interval for cathodal transcranial direct current stimulation (tDCS) J Neurophysiol 2010;103(4):173540 11 Carvalho S, Boggio PS, Gonỗalves ểF, Vigỏrio AR, Faria M, Silva S, et al Transcranial direct current stimulation based metaplasticity protocols in working memory Brain Stimul 2014;8(2):289–94 12 Stagg CJ, Lin RL, Mezue M, Segerdahl A, Kong Y, Xie J, et al Widespread modulation of cerebral perfusion induced during and after transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex J Neurosci 2013;33(28):11425–31 13 Stagg CJ, Jayaram G, Pastor D, Kincses ZT, Matthews PM, Johansen-Berg H Polarity and timingdependent effects of transcranial direct current stimulation in explicit motor learning Neuropsychologia 2011;49(5):800–4 14 Martin DM, Liu R, Alonzo A, Green M, Loo CK Use of transcranial direct current stimulation (tDCS) to enhance cognitive training: effect of timing of stimulation Exp Brain Res 2014;232(10):3345–51 15 Woods AJ, Hamilton RH, Kranjec A, Minhaus P, Bikson M, Yu J, et al Space, time, and causality in the human brain Neuroimage 2014;92:285–97 16 Gill J, Shah-Basak PP, Hamilton R It’s the thought that counts: examining the task-dependent effects of transcranial direct current stimulation on executive function Brain Stimul 2014;8(2):253–9 17 Antal A, Terney D, Poreisz C, Paulus W Towards unravelling task-related modulations of neuroplastic changes induced in the human motor cortex Eur J Neurosci 2007;26(9):2687–91 18 Bortoletto M, Veniero D, Thut G, Miniussi C The contribution of TMS–EEG coregistration in the exploration of the human cortical connectome Neurosci Biobehav Rev 2014;49C:114–24 19 Fritsch B, Reis J, Martinowich K, Schambra HM, Ji Y, Cohen LG, et al Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning Neuron 2010;66(2):198–204 A.J Woods and D.M Martin 20 Ambrus GG, Al-Moyed H, Chaieb L, Sarp L, Antal A, Paulus W The fade-in – short stimulation – fade out approach to sham tDCS – reliable at mA for naïve and experienced subjects, but not investigators Brain Stimul 2012;5(4):499–504 21 O’Connell NE, Cossar J, Marston L, Wand BM, Bunce D, Moseley GL, et al Rethinking clinical trials of transcranial direct current stimulation: participant and assessor blinding is inadequate at intensities of 2mA PLoS One 2012;7(10):47514 22 Guleyupoglu B, Febles N, Minhas P, Hahn C, Bikson M Reduced discomfort during high-definition transcutaneous stimulation using 6% benzocaine Front Neuroeng 2014;7:28 23 Palm U, Keeser D, Schiller C, Fintescu Z, Reisinger E, Padberg F, et al Skin lesions after treatment with transcranial direct current stimulation (tDCS) Brain Stimul 2008;1(4):386–7 24 Guarienti F, Caumo W, Shiozawa P, Cordeiro Q, Boggio PS, Benseñor IM, et al Reducing transcranial direct current stimulation-induced erythema with skin pretreatment: considerations for sham-controlled clinical trials Neuromodulation 2015;18(4):261–5 25 Datta A, Bansal V, Diaz J, Patel J, Reato D, Bikson M Gyri-precise head model of transcranial direct current stimulation: improved spatial focality using a ring electrode versus conventional rectangular pad Brain Stimul 2009;2(4):201–7.e1 26 Nikolin S, Loo CK, Bai S, Dokos S, Martin DM Focalised stimulation using high definition transcranial direct current stimulation (HD-tDCS) to investigate declarative verbal learning and memory functioning Neuroimage 2015;117:11–9 27 Minhas P, Bikson M, Woods AJ, Rosen AR, Kessler SK Transcranial direct current stimulation in pediatric brain: a computational modeling study Conf Proc IEEE Eng Med Biol Soc 2012;2012:859–62 28 Kessler SK, Minhas P, Woods AJ, Rosen A, Gorman C, Bikson M Dosage considerations for transcranial direct current stimulation in children: a computational modeling study PLoS One 2013;8(9):e76112 29 Gálvez V, Alonzo A, Martin D, Mitchell PB, Sachdev P, Loo CK Hypomania induction in a patient with bipolar II disorder by transcranial direct current stimulation (tDCS) J ECT 2011;27(3):256–8 30 First MB, Williams JBW, Spitzer RL, Gibbon M Structured clinical interview for DSM-IV-TR axis I disorders, clinical trials version (SCID-CT) New York, NY: New York State Psychiatric Institute; 2007 31 Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 J Clin Psychiatry 1998;59 Suppl 2:22–33;quiz 34–57 32 Keel JC, Smith MJ, Wassermann EM A safety screening questionnaire for transcranial magnetic stimulation Clin Neurophysiol 2001;112(4):720 26 Clinical Research and Methodological Aspects for tDCS Research 33 Nitsche MA, Jaussi W, Liebetanz D, Lang N, Tergau F, Paulus W Consolidation of human motor cortical neuroplasticity by D-cycloserine Neuropsychopharmacology 2004;29(8):1573–8 34 Brunoni AR, Valiengo L, Baccaro A, Zanao TA, Oliveira AC, Goulart AC, et al The sertraline versus electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial JAMA Psychiatry 2013;70(4):383–91 35 Nitsche MA, Lampe C, Antal A, Liebetanz D, Lang N, Tergau F, et al Dopaminergic modulation of longlasting direct current-induced cortical excitability changes in the human motor cortex Eur J Neurosci 2006;23(6):1651–7 36 Brunoni AR, Ferrucci R, Bortolomasi M, Scelzo E, Boggio PS, Fregni F, et al Interactions between transcranial direct current stimulation (tDCS) and pharmacological interventions in the major depressive episode: findings from a naturalistic study Eur Psychiatry 2013;28(6):356–61 37 Loo CK, Martin DM, Alonzo A, Gandevia S, Mitchell PB, Sachdev P Avoiding skin burns with transcranial direct current stimulation: preliminary considerations Int J Neuropsychopharmacol 2010;14(03):425–6 38 Brunoni AR, Ferrucci R, Bortolomasi M, Vergari M, Tadini L, Boggio PS, et al Transcranial direct current stimulation (tDCS) in unipolar vs bipolar depressive disorder Prog Neuropsychopharmacol Biol Psychiatry 2011;35(1):96–101 39 Loo CK, Alonzo A, Martin D, Mitchell PB, Galvez V, Sachdev P Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial Br J Psychiatry 2012;200(1):52–9 40 Kalu UG, Sexton CE, Loo CK, Ebmeier KP Transcranial direct current stimulation in the treatment of major depression: a meta-analysis Psychol Med 2012;42:1791–800 41 Fertonani A, Ferrari C, Miniussi C What you feel if I apply transcranial electric stimulation? Safety, sensations and secondary induced effects Clin Neurophysiol 2015;126(11):2181–8 42 Merrill DR, Bikson M, Jefferys JGR Electrical stimulation of excitable tissue: design of efficacious and safe protocols J Neurosci Methods 2005;141(2):171–98 43 Minhas P, Bansal V, Patel J, Ho JS, Diaz J, Datta A, et al Electrodes for high-definition transcutaneous DC stimulation for applications in drug delivery and electrotherapy, including tDCS J Neurosci Methods 2010;190(2):188–97 44 Minhas P, Datta A, Bikson M Cutaneous perception during tDCS: role of electrode shape and sponge salinity Clin Neurophysiol 2011;122(4):637–8 45 Kronberg G, Bikson M Electrode assembly design for transcranial direct current stimulation: a FEM modeling study IEEE Eng Med Biol Soc Annu Conf 2012;2012:891–5 46 Kessler SK, Minhas P, Woods AJ, Rosen A, Gorman C, Bikson M Dosage considerations for transcranial direct current stimulation in children: a computational modeling study PLoS One 2013;8(9), e76112 403 47 Klem GH, Lüders HO, Jasper HH, Elger C The tentwenty electrode system of the international federation The International Federation of Clinical Neurophysiology Electroencephalogr Clin Neurophysiol Suppl 1999;52:3–6 48 Oostenveld R, Praamstra P The five percent electrode system for high-resolution EEG and ERP measurements Clin Neurophysiol 2001;112(4):713–9 49 Seibt O, Brunoni AR, Huang Y, Bikson M The pursuit of DLPFC: non-neuronavigated methods to target the left dorsolateral pre-frontal cortex with symmetric bicephalic transcranial direct current stimulation (tDCS) Brain Stimul 2015;8(3):590–602 50 Agnew WF, McCreery DB Considerations for safety in the use of extracranial stimulation for motor evoked potentials Neurosurgery 1987;20(1):143–7 51 Bronstein JM, Tagliati M, McIntyre C, Chen R, Cheung T, Hargreaves EL, et al The rationale driving the evolution of deep brain stimulation to constant-current devices Neuromodulation (US) 2015;18(2):85–9 52 Brunoni AR, Amadera J, Berbel B, Volz MS, Rizzerio BG, Fregni F A systematic review on reporting and assessment of adverse effects associated with transcranial direct current stimulation Int J Neuropsychopharmacol 2011;14(8):1133–45 53 Durand S, Fromy B, Bouyé P, Saumet JL, Abraham P Vasodilatation in response to repeated anodal current application in the human skin relies on aspirin-sensitive mechanisms J Physiol 2002;540(Pt 1):261–9 54 Nitsche MA, Liebetanz D, Lang N, Antal A, Tergau F, Paulus W Safety criteria for transcranial direct current stimulation (tDCS) in humans Clin Neurophysiol 2003;114(11):2220–2 author reply 2222–3 55 Nitsche MA, Paulus W Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans Neurology 2001;57(10):1899–901 56 Ekici B Transcranial direct current stimulationinduced seizure: analysis of a case Clin EEG Neurosci 2015;46(2):169 57 Lippold OC, Redfearn JW Mental changes resulting from the passage of small direct currents through the human brain Br J Psychiatry 1964;110:768–72 58 Parazzini M, Rossi E, Rossi L, Priori A, Ravazzani P Evaluation of the current density in the brainstem during transcranial direct current stimulation with extra-cephalic reference electrode Clin Neurophysiol 2013;124(5):1039–40 59 Parazzini M, Rossi E, Rossi L, Priori A, Ravazzani P Numerical estimation of the current density in the heart during transcranial direct current stimulation Brain Stimul 2013;6(3):457–9 60 Vandermeeren Y, Jamart J, Ossemann M Effect of tDCS with an extracephalic reference electrode on cardio-respiratory and autonomic functions BMC Neurosci 2010;11:38 61 Frank E, Wilfurth S, Landgrebe M, Eichhammer P, Hajak G, Langguth B Anodal skin lesions after treatment with transcranial direct current stimulation Brain Stimul 2010;3(1):58–9 404 62 Martin DM, Alonzo A, Ho K-A, Player M, Mitchell PB, Sachdev P, et al Continuation transcranial direct current stimulation for the prevention of relapse in major depression J Affect Disord 2013;144(3):274–8 63 Ho K-A, Taylor JL, Chew T, Gálvez V, Alonzo A, Bai S, et al The effect of transcranial direct current stimulation (tDCS) electrode size and current intensity on motor cortical excitability: evidence from single and repeated sessions Brain Stimul 2016;9(1):1–7 64 Coffman BA, Clark VP, Parasuraman R Battery powered thought: enhancement of attention, learning, and memory in healthy adults using transcranial direct current stimulation Neuroimage 2014;85(Pt 3):895–908 A.J Woods and D.M Martin 65 Veniero D, Bortoletto M, Miniussi C On the challenge of measuring direct cortical reactivity by TMSEEG Brain Stimul 2014;7(5):759–60 66 Baudewig J, Siebner HR, Bestmann S, Tergau F, Tings T, Paulus W, et al Functional MRI of cortical activations induced by transcranial magnetic stimulation (TMS) Neuroreport 2001;12(16):3543–8 67 Stagg CJ, Nitsche MA Physiological basis of transcranial direct current stimulation Neuroscientist 2011;17(1):37–53 68 Woods AJ, Antal A, Bikson M, Boggio PS, Brunoni AR, Celnik P, et al A technical guide to tDCS, and related non-invasive brain stimulation tools Clin Neurophysiol 2016;127(2):1031–48 Index A AB See Attentional blink (AB) ACC See Anterior cortex cingulate (ACC) AEPs See Auditory-evoked potentials (AEPs) AG See Angular gyrus (AG) Alcohol-use disorders (AUD), 285–286 Alternating current stimulation (ACS), 68 Alzheimer’s dementia (AD), 78, 87, 367 anodal tDCS, 274, 275 Apathy Scale, 275 cathodal tDCS, 274 memory training, 274 sham tDCS, 275 Amygdala, 269 Angular gyrus (AG), 117 Anodal tDCS, 274, 275, 279 Anterior cortex cingulate (ACC), 286 Anterior temporal lobe (ATL), 126 Antiepilepotgenic treatment, 296 ANVISA See National Health Surveillance Agency (ANVISA) Anxiety ABM, 268 attentional control, 268 cognitive neuropsychological model, 267–268 tDCS case study, 268 treatment, 268 Apathy Scale, 275 Aphasia, 321–323 Application, tDCS design and methodology (see Design and methodology, tDCS) variability, 394 Arterial spin labelling (ASL), 171, 179–186 Artificial electric energy, ATL See Anterior temporal lobe (ATL) Attention, 109–112 AB, 133 ABM, 268 Attention bias modification (ABM), 268 Attentional blink (AB), 133 AUD See Alcohol-use disorders (AUD) Auditory-evoked potentials (AEPs), 205 Auditory hallucination rating scale (AHRS), 247 Auditory verbal hallucinations AHRS, 247 brain correlation, 254 electrodes, 247 PANSS, 248 predictive markers, 253–254 PSYRATS, 248 schizophrenia, 247, 249–252 B Balloon Analog Risk Task (BART), 286 BD See Bipolar disorder (BD) BDNF See Brain-derived neurotrophic factor (BDNF) Bifrontal oscillatory currents, 25 Bipolar disorder (BD), 92, 225 clinical trials, mania, 240 left DLPFC, 240 mood stabilizer medications, 240 Blood-oxygenation level-dependent (BOLD), 114, 186 DeoxyHb, 172 OxyHb, 172 resting functional connectivity, 172–173 resting-state fMRI, 172–178 task-based fMRI, 173–185 Brain-derived neurotrophic factor (BDNF), 200, 236 Brain oscillations AC stimulation, 22 animal and human studies, 22 tACS, 23, 38 Brain stimulation neuropsychiatry (see Neuropsychiatry) techniques, 359 Brain–machine interface systems (BCIs), 163 Broca’s homologous area, 322 C Cannabinoids, 284 Cardiff anomalous perceptions scale (CAPS), 248 Cathodal tDCS, 274, 296, 297 Central post-stroke pain (CPSP), 324 © Springer International Publishing Switzerland 2016 A Brunoni et al (eds.), Transcranial Direct Current Stimulation in Neuropsychiatric Disorders, DOI 10.1007/978-3-319-33967-2 405 Index 406 Cerebellar/spinal DC stimulation, 228 Cerebellar tDCS (ctDCS) brain plasticity, 227 cerebellum, 224 cognitive improvement, 224 computational modeling, 225 electrode montages, 225 euthymic BD patients, 225 noninvasive tool, 224 open-label pilot study, 225 PSQI, 225 psychiatric and neurological disorders, 224 psychiatric patients, 225 Purkinje cells, 224 rehabilitation, 228 spinal DC, 227 spinal polarization, 227 Cerebellum, 224 Cerebral spinal fluid (CSF), 49–50 Chronic migraine (CM), 307 Cochrane meta-analysis, 322 Cognition, 274 Cognitive behavioral therapy (CBT), 266 Cognitive control therapy (CCT), 238 Cognitive enhancement abilities, 368 athletic performance, 369 behavioral impulse control, 365 brain stimulation, 366 character autonomy, 373, 374 brain stimulation, 372 conceptual framework, 373 DBS, 372 emotional challenges, 372 issues, 372 self-enhancement, 372, 373 situational context vs personality, 373 sports and fatigue, 373 clinical applications, 365, 368 DIY community, 368 justice, 372 language, 365 learning and memory, 365 lie detection, 366 manipulation, 367 NIBS, 365 response inhibition, 365 self-interest with social values, 366 stimulation, 365 technologies, 366 visuospatial processing, 366 working memory, 365 Cognitive functions, 256–260 Compassionate treatment, 386, 389 Concurrent acquisition, 170 CONEP See also National Ethics Committee (CONEP) Constraint-induced movement therapy (CIMT), 316 Continuous performance task (CPT), 111 Co-registration, 158, 160 Cortical excitability, 294, 295 acute change, 34 inhibition, 95 MDD, 91 OCD, 91 sustained change, 34–35 TMS, 89 Cortical inhibition See Psychiatric disorders Cortical oscillations, 202, 203, 209 Cortical silent period (CSP) contralateral motor cortex, 87 GABAB receptor-mediated inhibitory neurotransmission, 88 Cortico-cortical connectivity, 86 CPT See Continuous performance task (CPT) Craving, 282–283 Creatine, 190 CSP See Cortical silent period (CSP) Cyberball task, 147 D DBS See Deep brain stimulation (DBS) DC stimulation (DCS), 294 Deep brain stimulation (DBS), 59, 212, 266 Deoxygenated haemoglobin (DeoxyHb), 171 Design and methodology, tDCS active control condition, 396 blinding, 396 electrodes and contact medium, 397–398 location, 398 placement, 398–399 monitoring functional effects approaches, 400 cognitive, 400 critical review, 401 guidance, 401 MRI, 401 neuroimaging tools, 400 risk, 401 viscosity electrode gel, 401 online and offline protocols, 395–396 participant screening, 396–397 protocol intensity, 394–395 safety/adverse events and monitoring, 399–400 sham, 396 stimulator selection, 399 Diffusion tensor imaging (DTI), 52 Direct current stimulation (DCS), 68 Discomfort, 344, 346 Disorders of consciousness (DOC) amantadine, 332 clinical management, 331 cortical and subcortical brain areas, 337 CRS-R, 333 deep brain stimulation, 333 definition, 330–331 Index diagnostic tool, 335–336 long-term effects, 336–337 neuroimaging acquisition, 337 neuronal correlates, 335 neurophysiology and neuroimaging techniques, 331 pharmacological agents, 332 prefrontal cortex, 333 zolpidem, 332, 333 DLPFC See Dorsolateral prefrontal cortex (DLPFC) Dorsal anterior cingulate cortex (dACC), 269 Dorsolateral prefrontal cortex (DLPFC), 104, 144, 162, 224, 234, 268, 323 Dysphagia, 323 E ECT See Electroconvulsive therapy (ECT) EEG See Electroencephalography (EEG) Electric fields, 197–198 Electric fish De Compositionibus Medicamentorum, 4, dietary health properties, Greco-Roman period, headache, therapeutic application, Electric therapy, Electrical current distribution, 303 Electrical current flow, 303 Electroconvulsive therapy (ECT), 48, 359 mental illness, 13 schizophrenia, 13 Electrodes preparation and contact medium, 397–398 locations, 398 placement, 398–399 Electroencephalography (EEG), 108, 154, 156, 158, 204 brain oscillations, 93 psychiatric disorders, 93–94 tDCS advantages, 155–157 BCIs, 163 behavioural studies, 162 bipolar montage, 160 brain stimulation, 159 DLPFC, 163 EEG, 155, 156, 161 electrical current, 160 functional connectivity, 159 multimodal association, 154–155 neuromodulatory effects, 159 non-invasive brain stimulation, 154 solid foundations, 154 spatial and temporal resolution, 159 TMS, 93 Electrostatic machines See Volta’s pile Electrotherapy device, 49 Emotional face processing, 145–146 Emotional memory encoding and retrieval, 144–145 Emotional regulation DLPFC, 146 mood and anxiety disorders, 147 407 physical pain thresholds, 146 SCR, 146 tDCS studies, 146 Emotions definition, 144 regulation processes, 144, 146 tDCS, 144 Epilepsy anodal tDCS, 295, 296 cathodal tDCS, 295, 296 clinical seizures, 294 in vitro model, 295 in vivo experiments, 297 neuromodulation, 293–294 preclinical study, 295–297 randomized sham controlled study, 294 refractory focal epilepsy, 294 seizure suppression, 295 tDCS, 294 EPSPs See Excitatory postsynaptic potentials (EPSPs) ERD See Event-related desynchronization (ERD) Erythema, 345 Event-related desynchronization (ERD), 205 Event-related potentials (ERP), 73, 159, 269 Excitatory postsynaptic currents (EPSCs), 296 Excitatory postsynaptic potentials (EPSPs), 90 Exposure therapy, 269 F Facial emotion identification test (FEIT), 259 Faradic current, 11, 12 FDA See Food and Drug Administration (FDA) Feasibility See Home-based tDCS Fibromyalgia, 305–307 Finite element method, 52 fMRI See Functional magnetic resonance imaging (fMRI) Focality, 32, 33 Food and Drug Administration (FDA) classification, 384 definition, 384 premarket and postmarket approvals, 384, 385 Frontal tDCS catatonic symptoms, 256 negative symptoms, 254–256 Fronto-cingulo-striatal (FCS), 234 Frontotemporal dementia, 279 Frontotemporal tDCS See Auditory verbal hallucinations Functional connectivity, 37, 38, 41 Functional magnetic resonance imaging (fMRI), 53, 155, 171, 206, 283 G GABA See Gamma-aminobutyric acid (GABA) GABAA receptor, 296 Galvanic current, 9–11 Gamma-aminobutyric acid (GABA), 189–191 cortical excitability and neuroplasticity, 87 IPSPs, 87 408 Gamma-aminobutyric acid (GABA) (cont.) LICI and CSP, 88 neurophysiological mechanisms, 87 receptor-mediated inhibitory neurotransmission, 88 Glutamate, 189 Graphical User Interface (GUI), 56 Greco-Roman period, H HD-tDCS See High-definition tDCS (HD-tDCS) Headache, 344, 345 Head circumference, 388 Hemispheric Asymmetry Reduction in Older Adults (HAROLD), 126 High-definition-tDCS (HD-tDCS), 32, 202, 302 Hippocampus, 269 H-MRS brain’s endogenous neurochemicals, 187 GABA, 189–190 glutamate, 189 LTP-like process, 187 MRS, 187, 189 NAA and creatine, 190 Home-based tDCS antidepressant effects of brain stimulation techniques, 359 device and equipment design bifrontal montage, 353 clinician-administered stimulation, 353 electrode montage, 353 electrode placement, 353, 354 electrode sponges, 354 headset, 353 internet, 354 minimal manufacturing standards, 354 performance, 353 regulatory requirements, 353 safety features, 353 sham stimulation, 354 standardised procedure, 354 United States Federal Drug Agency, 354 ECT, 359 efficacy, 358 feasibility and efficacy, 359 monitoring, 356 neuromodulation techniques, 352 patient selection and contraindications, 354–355 safety administration, 357 guidelines, 357 list of standard safety precautions, 357 low risk procedure, 357 patient’s treatment diary, 357 planning, 358 self-administration, 353, 358 suitability, 352 technology and operation, 352 therapy, 358 Index TMS, 352, 359 tolerability, 358 training and credentialing checking, 355 competency in tDCS administration, 355 electrode placement and scalp contact, 355 maintenance, 355 procedural checklist, 356 process, 356 satisfactory completion, 356 working knowledge, tDCS principles, 355 training procedures and real-time supervision, 358 treatment option, 359 treatment period, 358 I IAT See Implicit association test (IAT) ICF See Intracortical facilitation (ICF) IFC See Inferior frontal cortex (IFC) IFG See Inferior gyrus (IFG) Implicit association test (IAT), 148 Implicit prejudice, 148 In vitro DCS data, 296 Incremental polarization, 76 Independent component analysis (ICA), 172 Inferior frontal cortex (IFC), 114, 150 Inferior frontal gyrus (IFG), 145 Inferior gyrus (IFG), 114 Infinite parameter space, 192 Inhibitory postsynaptic potentials (IPSPs), 87 Institutional Review Board (IRB), 385 Instrumental frequency injection, 158 Inter-trial phase coherence (ITPC), 208 Intracortical facilitation (ICF) EPSPs, 90 N-methyl-D-aspartate receptor antagonists, 90 OCD, 90 Intraparietal sulcus (IPS), 115 Iontophoresis devices, 386 IPS See Intraparietal sulcus (IPS) IPSPs See Inhibitory postsynaptic potentials (IPSPs) IRB See Institutional Review Board (IRB) Itching, 344, 345 ITPC See Inter-trial phase coherence (ITPC) L Laser-evoked potentials (LEPs), 205, 227 LCMV See Linearly constrained minimum variance (LCMV) LEPs See Laser-evoked potentials (LEPs) Lewy body dementia, 276, 278 Linearly constrained minimum variance (LCMV), 209 Long-interval cortical inhibition (LICI) DLPFC, 88 GABAB receptor-mediated inhibitory neurotransmission, 88 Long-term potentiation (LTP), 200 Index LORETA See Low-resolution brain electromagnetic tomography (LORETA) Low-resolution brain electromagnetic tomography (LORETA), 286 LTP-like processes, 187 LTP See Long-term potentiation (LTP) M Magnetic resonance imaging (MRI), 170, 187 Magnetic resonance spectroscopy (MRS), 186–187 Magnetoencephalography (MEG), 205 Major depressive disorder (MDD) amygdala and hippocampus, 234 cognitive-executive pathway, 234 cortical and subcortical brain activities, 234 discrete neural networks, 234 FCS, 234 novel therapeutic strategies, 234 pro-inflammatory cytokines, 236 symptoms, 233 tDCS, 235 and TMS, 91–92 TRD, 234 MATRICS consensus cognitive battery (MCCB), 259 Mayer–Salovey–Caruso emotional intelligence test (MSCEIT), 259 MDD See Major depressive disorder (MDD) Medial prefrontal cortex (MPFC), 149 Medial temporal lobe (MTL), 111 Medical device FDA, 384–385 tDCS, 389 MEG See Magnetoencephalography (MEG) Membrane polarization, 76 MEP See Motor-evoked potential (MEP) Meta-plasticity, 76 Methodology See Design and methodology, tDCS μ-opioid receptor (MOR), 304 Migraine headache, 307–308 Mild cognitive impairment (MCI), 275, 278 Minimally conscious state (MCS), 330 MNI See Montreal Neurological Institute (MNI) Montage selection, 396 Montgomery and Asberg Depression Rating Scale (MADRS), 225 Montreal Neurological Institute (MNI), 209 Motor cortex, 32, 33 Motor cortex stimulation (MCS), 301 Motor-evoked potential (MEP), 204 amplitude, 89 TMS, 86 Motor function, 317, 318 Motor recovery acute stroke therapies, 316 anodal/cathodal TDCS, 317 cortical epidural stimulation, 318 corticospinal integrity, 318 inter-hemispheric rivalry theory, 316 409 meta-analysis, 317, 319–320 somatosensory stimulation, 317 TDCS, 316, 321 trans-cranial induction, 317 unilateral vs bilateral TDCS, 317 upper limb impairments, 317 Motor threshold, 89 MTL See Medial temporal lobe (MTL) Multimodal association approach, 155 Mu-opioid receptors, 305 N N-Acetylaspartic acid (NAA), 190 nAChRs See Nicotinic cholinergic receptors (nAChRs) National Ethics Committee (CONEP), 389 National Health Surveillance Agency (ANVISA), 389 Negative symptoms, 254–256 Neurodegenerative cognitive disorders AD, 274, 275, 277, 278 Lewy body dementia, 275, 276, 278 Parkinson’s disease, 276, 278 Neuroethics capacity of tDCS, 374 challenges, 370 conditions, 375 DIY users, 374 implications, 375 neurodiversity, 374 non-medical, 374 normal and pathological mental functioning, 375 pharmacological self-enhancement, 375 polypharmacy, 375 qualitative impact, 374 risk of tDCS misuse, 375 self-treatment, 375 Neuroimaging, 192, 305, 307 Neuromodulation, 49, 293, 352, 370 home-based tDCS (see Home-based tDCS) technologies, 368 Neuropathic pains, 308–309 Neurophysiological effects, 388 Neuroplasticity, 30 Neuropsychiatry ADHD, 367 anodal DLPFC stimulation, 367 applications, 364 bio-psycho-social health, 369 brain stimulation, 364 clinical and cognitive enhancement, 364 clinical intervention, 364 cognitive (see Cognitive enhancement) cognitive constructs, 368 depression and chronic pain, 367 ethical challenges, 370 ethics (see Neuroethics) mechanism of tDCS, 375 neuromodulation technologies, 368 neurorehabilitation application, 368 410 Neuropsychiatry (cont.) noninvasive brain stimulation, 364 optimistic, 364 personality-dependent effects, 367 post-stroke neurorehabilitation, 368 problematic behaviors, 367 PTSD, 367 safety, 370–372 scientific challenges anodal/cathodal stimulation, 369 behavioral and cortical excitability effects, 369 cognition, 369 drugs, 370 initial dogma, 369 limitations, 370 medications, 370 stimulation parameters, 369 tDCS mechanisms, 369 social and cultural consequences, 376 society, 364 spinal cord injury, 367 surgery, 364 Nicotinic cholinergic receptors (nAChRs), 283 NMDA See N-methyl-D-aspartate (NMDA) NMDA-dependent long-term depression (LTD), 296 NMDA receptor channels, 35, 36 NMDA receptors, 200 N-methyl-D-aspartate (NMDA), 91, 296 Non-invasive brain stimulation (NIBS), 246, 266, 316 neuroimaging techniques, 41 neuromodulators, 41 neurophysiological recordings, 41 tACS anodal/cathodal stimulation, 38 brain oscillation, 38 cognition and behaviour, 39, 41 physiological effects, 38–39 tDCS cortical excitability (see Cortical excitability) cranial foraminae and fissures, 30 current intensity/density, 31 electrode current direction, 31–32 electrode position/configuration, 31–32 inter-regional effects, 37–38 neurophysiological effect, 30 pharmacology, 35–37 physiological effects, 33 sensorimotor cortex, 30 stimulation duration/interval, 32–33 Noninvasive neuromodulatory therapies, 301 Nonsignificant risk device, 385 O Obsessive-compulsive disorder (OCD), 225 cathodal tDCS, 267 DLPFC, 266 GABAB, 91 NMDA, 91 Index OFC, 266 open-label pilot study, 267 pre-SMA, 267 Yale-Brown Obsessive Compulsive Scale scores, 267 Obsessive Compulsive Drinking Scale (OCDS), 285 OCD See Obsessive-compulsive disorder (OCD) OCD visual analog scale (OCD-VAS), 225 OFC See Orbitofrontal cortex (OFC) Off-label program, 386, 387, 389 Open-label pilot study, 267 Orbitofrontal cortex (OFC), 225, 266, 282 Oscillatory tDCS, 24 Oxygenated haemoglobin (OxyHb), 171 P Pain syndromes active and sham stimulation, 302 anterior cingulate cortex, 304 categorization, 300 central and peripheral sensitization, 300 computational models, 302 dysfunctional mechanisms, 301 electrical brain stimulation, 301 HD-tDCS, 302 intracortical inhibition, 300 M1-SO, 302 MCS, 301 mu-opioid system, 304 neuromodulatory technique, 304 neuroplasticity, 303 nociception, 300 noninvasive neuromodulatory therapies, 301 noxious stimulus, 300 tDCS, 301 Paired-pulse facilitation (PPF), 200 Parkinson’s disease, 276, 278 Patient and participant screening, tDCS electrodes place, 397 medication, 397 neuropsychiatric and neurological conditions, 397 sessions, 396 stimulation parameters, 396 therapeutic interventions, 397 PCA See Principal component analysis (PCA) Pharmacology neuromodulators, 35 nicotinic receptors, 36 serotonin, 36 Phase-locking value (PLV), 209 Phosphorus MR spectroscopy (31P MRS) ATP and phosphocreatine, 190 tDCS and MRS, 190–192 Pittsburgh Sleep Quality Index (PSQI), 225 Planum temporale (PT), 111 Plasticity motor cortex, 86 SCZ, 97 TMS, 86 Index PLV See Phase-locking value (PLV) Point of subjective equality (PSE), 133 Positive and negative syndrome scale (PANSS), 248 Positron emission tomography (PET), 155 Post hoc subgroup analysis, 318 Posterior parietal cortex (PPC), 104 Post-stroke depression (PSD), 324 Post-stroke impairment syndromes, 316 Post-traumatic stress disorder (PTSD) ERP, 269 exposure therapy, 269 PPC See Posterior parietal cortex (PPC) PPF See Paired-pulse facilitation (PPF) Principal component analysis (PCA), 208 PSE See Point of subjective equality (PSE) Psychiatric disorders BD, 92 GABAergic inhibitory deficits, 90 MDD, 91–92 novel psychopharmacological, 92 OCD, 91 SCZ, 90–91 somatic treatments, 92 Psychotic symptom rating scale (PSYRATS), 248 PT See Planum temporale (PT) Q Quasi-uniform assumption, 70–72 R Randomized sham controlled study, 294 Regulatory FDA, 384–385 NIBS (see Noninvasive brain stimulation (NIBS)) tDCS (see Transcranial direct current stimulation (tDCS)) Rehabilitation, 316, 321, 331, 334, 337 Remote supervision, 352, 355 Repetitive transcranial magnetic stimulation (rTMS), 316 Repetitive transorbital alternating current stimulation (rtACS), 25 Reproducibility, tDCS, 394, 397 Resting-state networks (RSNs), 172, 173 Reward pathway, 282, 283, 287 RSN strength, 179 rtACS See Repetitive transorbital alternating current stimulation (rtACS) S Safety cognition abilities, 370 arithmetic decision making efficiency, 371 automaticity, 371 control, 371 degradation, 371 411 DIY stimulation, 371 IQ testing, 371 long-term changes, 371 mental trade-offs, 371 risk, 370 therapeutic stimulation, 372 working memory, 371 dorsolateral prefrontal cortex, 348 neurologic malformations/brain neoplasias, 348 neuron-specific enolase, 346 neuropsychiatric samples, 347 neurosurgical procedures, 348 noninvasive brain stimulation, 348 skin damage, 347 tDS erythema, 399 extracephalic reference electrode, 400 modern protocols, 399 risk, 400 skin lesions/burns, 400 tolerability, 399 SAI See Short latency afferent inhibition (SAI) Schizophrenia (SCZ) classification, 246 clozapine, 91 cognitive remediation therapy, 261 depression, 261 frontotemporal electrode montage, 246 GABAergic deficits, 90 left prefrontal region, 246 motor cortex excitability, 261 NIBS techniques, 246 optimizing tDCS parameters, 260 symptoms, 246 tDCS, 246, 247, 260 transcranial electric stimulation, 260–261 SCR See Skin conductance response (SCR) SCZ See Schizophrenia (SCZ) Seizure, 344, 346, 347 Selective serotonin re-uptake inhibitors (SSRIs), 36, 266 Self-administered treatment, 359 SEPs See Somatosensory-evoked potentials (SEPs) Sequential acquisition, 170 Serotonin reuptake transporter (SERT), 235 Serotonin transporter genetic polymorphism (SLC6A4), 235 Short-interval cortical inhibition (SICI) GABAA receptors, 88 motor cortex, 92 Short-interval intracortical facilitation (SICF), 90 Short intracortical inhibition (SICI), 227 Short latency afferent inhibition (SAI), 89 Short-term memory (STM), 118 SICF See Short-interval intracortical facilitation (SICF) SICI See Short-interval cortical inhibition (SICI) Skin erythema, 345 lesions, 347 reddening, 345 412 Skin conductance response (SCR), 146 Sleep oscillations, 212 Slow oscillations (SO) anesthesia, 215 cortical slices, 213 effects of DC, 213 electric fields, 213–215 natural sleep and anesthesia, 213 UP and DOWN states, 213 Social decision-making, 148, 149 Social neuroscience implicit prejudice, 148 perspective taking, 149–150 social decision-making, 148, 149 Somatosensory-evoked potentials (SEPs), 205 Spasticity, 324 Speech language therapy, 321 Spinal cord, 226–227 Spinal cord injury (SCI), 227 SSRIs See Selective serotonin re-uptake inhibitors (SSRIs) STM See Short-term memory (STM) Stress, 78 Striatum, 282 Stroke brain activity/plasticity, 316 cognitive decline, 323 conventional rehabilitative approach, 316 definition, 315 impairments, 315 neuroimaging techniques, 316 re-learning process, 316 TDCS, 316 Substance-use disorders (SUD) chronic disorders, 282 cognitive functions, 287 craving, 282–283 decision-making process and impulsivity, 287 definition, 282 DLPFC, 282 dopamine, 282 dopaminergic pathway, 289 frontal cortical activity, 287 hippocampus, 282 mesocortical pathway, 289 OFC, 282 tDCS, 282, 287, 288 Supra-spinal level, 227 Synaptic plasticity, 75–76 T Task activation networks, 173 TCI See Transcallosal inhibition (TCI) tDCS See Transcranial direct current stimulation (tDCS) Temporomandibular disorder (TMD), 302 Temporoparietal junction (TPJ), 149 tES–EEG technical aspects, 157–159 Tingling, 344, 345 Index TMS See Transcranial magnetic stimulation (TMS) Tobacco-use disorder (TUD), 283–284 Tolerability acceptability, 346 adverse effects skin reddening, 345 transcranial direct current stimulation, 344 Torpedo fish, Transcallosal inhibition (TCI), 89 Transcranial alternating current stimulation (tACS) and oscillations, 77 and tDCS anisotropy in skull, 51 assessment of safety, 57 boost oscillating activity, 50 in brain, 50 clinical guidelines, 58 computational models, 53, 58 cortical electric field, 61 CSF, 54 dose optimization, 57 electric field intensity, 56 electrode montages, 62 electrodes, 51 forward modeling, 55 methods and protocols, 50–53 noninvasive neuromodulation, 51 optimization, 56 rational protocol/guideline, 60 simulation predictions, 55 single subject analysis, 55 stimulation, 48 susceptible populations, 58–63 technical features, 55 transcranial current flow, 52 vulnerable populations, 51 Transcranial direct current stimulation (tDCS), 48, 282, 364, 394–396 AB, 133 ameliorates depressive symptoms, 235 anodal and cathodal, 14, 15 antidepressant effects, 236 ANVISA, 389 application, 389 attention, 109–112 AUD, 285–286 behavioural and electrophysiological outcomes, 130 cannabinoids, 284 citalopram, 236 classification, 385 clinical evidence follow-up studies, 239 meta-analyses, 239, 240 open-label studies, 237 SELECT-TDCS trial, 239 sham-controlled and randomized clinical trial, 237, 238 clinical practice, 385–386 COMT gene, 134 Index COMT polymorphisms, 236 CONEP, 389 conventional electrode placement, 170, 171 cortical excitability and neuroplasticity, 235 density, 134 design (see Design and methodology, tDCS) devices, 386–387 DLPFC, 146, 283 EEG, 133 electric fish, 4, electrodes, 15 emotion studies DLPFC, 144 emotion regulation, 146, 147 emotional prosody, 145 face processing, 145–146 fear conditioning, 147 memory encoding and retrieval, 144–145 social pain, 147 excitability effects, 394 gender-dependent effects, 134 genetic polymorphisms, 133 guidance, 394 healthy older adults, 126–130 and 1H-MRS protocol, 306 hyperpolarization, 14 intensity, 394 and inter-individual factors, 130–132 inverted-U-shaped relationship, 134 language, 112–115 learning and memory anterior temporal lobe, 125 DLPFC, 124 HD-tDCS, 124 hemisphere, 125 parietal and temporal cortices, 125 parietal cortex, 124 REM and non-REM sleep, 125 STM, 118 MRI, 170–171 neurocognitive effects, 130 neuroimaging techniques, 170 neuropsychiatry (see Neuropsychiatry) neuropsychological disorders, 16 noninvasive brain stimulation, 394 noninvasive technique, 16 NSR, 385 numerical cognition, 115–118 pregnancy, 388 pre-synaptic SERT, 235 PSE, 133 psychiatric disorders, 170 scalp anodal currents, 14 SCR, 146 sertraline, 236 social decision-making, 148 social interactions, 143, 148 social neuroscience (see Social neuroscience) stimulant-use disorders, 286–287 413 TMS, 170 trials, major depression, 239 TUD, 283–284 unipolar vs bipolar depressed patients, 240 val/val homozygous, 134 variability, 394 VSTM, 130 Transcranial electric stimulation (tES) ACS/DCS, 69 addiction, 78 Alzheimer’s disease, 78 biomarkers, 73 brain oscillation, 22–23 brain stimulation, 69 cellular and network mechanisms, 200 clinical applications, 24–25 clinical protocols, 68–69 computational forward models, 201, 202 computational neural models, 202–203 cortical modulation, 23 DCS, 68 depolarizing/hyperpolarizing effect, 21 electric fields, 197–200 electrical field distribution, 203 electrode, 68 functional connectivity application, 211 BOLD, 211 brain, 211 cortico-striatal and thalamo-cortical circuits, 212 MEA, 211 micro-scale level, 211 network, 210 neuronal activity, 211 neuroplasticity, 210 noninvasive brain stimulation techniques, 211, 212 semiparametric method, 211 hippocampus and neocortex, 196 human brain artifact templates, 208 EEG activity/motor-evoked potentials, 207 electricity and brain activity, 204 electrophysiological changes, 208 electrotherapy, 204 IAF, 207 LCMV, 209 local field potentials and EEG oscillations, 207 mechanism, 206–207, 209–210 neurophysiology, 204–206 noninvasive electrical brain stimulation, 207 phasic modulation, 209 psychiatric disorders, 204 TMS, 204 hypothesis-driven approaches, 26 mechanisms, 196 motivation, animal research, 68 network effects, 76–77 network oscillations and electric fields, 198–199 neurological and psychiatric disorders, 196 Index 414 Transcranial electric stimulation (tES) (cont.) neuronal polarization, 73–75 neurophysiological measurements, 204 noninvasive electrophysiology and imaging studies, 196 noninvasive and inexpensive methods, 77 PD, 22 quasi-uniform assumption, 70–72 safety concerns, 72–73 stress, 78 synaptic plasticity, 75–76 and tDCS mechanisms, 72 and Oscillations, 77 oscillatory, 24 protocols, 74 tES, 22 tRNS, 23, 24 types, 196 Transcranial magnetic stimulation (TMS), 73, 115, 148, 170, 204 applications, 86–87 brain stimulation cortical excitability/inhibition, 95 TBS, 95, 96 tDCS, 96 CSP, 87, 88 EEG, 93, 94 ICF, 89, 90 LICI, 88 MEP, 89 motor threshold, 89 neuropsychiatric disorders (see Psychiatric disorders) noninvasive neurophysiological tool, 85 SAI, 89 SICF, 90 SICI, 88 TCI, 89 Transcranial random noise stimulation (tRNS), 260 application, 23 endogenous noise, 24 physiological mechanisms, 24 Transcutaneous spinal direct current stimulation (tsDCS), 226 TRD See Treatment-resistant depression (TRD) Treatment-resistant depression (TRD), 234 tRNS See Transcranial random noise stimulation (tRNS) TUD See Tobacco-use disorder (TUD) U Ultimatum game (UG), 148 V Vegetative state, 330 Ventrolateral prefrontal cortex (VLPFC), 147 Ventro-medial prefrontal cortex (vmPFC), 234, 269 VEPs See Visual-evoked potentials (VEPs) Visual-evoked potentials (VEPs), 205 Visual short-term memory task (VSTM), 130 Visuospatial neglect, 321 VLPFC See Ventrolateral prefrontal cortex (VLPFC) Volta’s pile artificial electric energy, brain stimulation, 12 ECT, 10, 13, 14 electric therapy, electrotherapeutic applications, faradic current, 12 galvanic current, 9, 10 hypochondriasis, hysterical aphonia, 10 phosphenes, psychiatric and neurological diseases, 11 sleep-inducing effect, 13 vasodilation, 11 VSTM See Visual short-term memory task (VSTM) W White and gray matter proportion, 388 Working memory (WM) anodal and cathodal, 109 brain region, 109 cognitive abilities, 104 DLPFC, 104 EEG, 108 effects, tDCS, 104–107 PPC, 104 real-world application, 108 World Health Organization, 315 Y Yale–Brown Obsessive and Compulsive Scale score (Y-BOCS), 225, 267 Z Zolpidem, 333 .. .Transcranial Direct Current Stimulation in Neuropsychiatric Disorders André Brunoni • Michael Nitsche Colleen Loo Editors Transcranial Direct Current Stimulation in Neuropsychiatric Disorders. .. convinced that Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: Clinical Principles and Management will be a captivating bedside book for many researchers in the field—us included... maximum safety in the application of electrical current These original 13 scientists used ordinary alternating current propagated in sine waves and in measured intensity as a means of producing convulsive

Ngày đăng: 14/05/2018, 13:25

Từ khóa liên quan

Mục lục

  • Foreword

    • References

  • Preface

  • Contents

  • Contributors

  • Part I: Introduction and Mechanisms of Action

    • 1: Historical Aspects of Transcranial Electric Stimulation

      • The First Clinical-Therapeutic Electrical Applications: The Electric Fish

      • Transcranial Electrical Stimulation: From Electrostatic Machines to Volta’s Pile

      • The Reappraisal of Transcranial Direct Current Stimulation (tDCS) from 1960 Onward

      • Concluding Remarks

      • References

    • 2: The New Modalities of Transcranial Electric Stimulation: tACS, tRNS, and Other Approaches

      • Introduction

      • tACS: Intrusion with Brain Oscillation

      • Modulating the Activity of the Human Brain Using tACS

      • Using tACS on Another Way: tRNS

      • Other Types of Oscillatory tES: Oscillating Transcranial Direct Current Stimulation (o-DCS)

        • Clinical Applications

      • Conclusions

      • References

    • 3: Physiology of Transcranial Direct and Alternating Current Stimulation

      • Introduction

      • tDCS

        • tDCS Protocols and Effects

          • Current Intensity/Density

          • Electrode Position/Configuration/Current Direction

          • Stimulation Duration/Interval

        • tDCS Physiology

          • Regional Effects of tDCS

            • Acute Change of Cortical Excitability

            • Sustained Change of Cortical Excitability and Activity

            • Pharmacology of tDCS

            • tDCS Effect on Cortical Regions Other Than M1

          • Inter-regional Effects of tDCS

      • tACS

        • tACS Protocols and Effects

          • Physiological Effects of tACS

          • tACS Effects on Cognition and Behaviour

      • General Remarks

      • References

    • 4: Computer-Based Models of tDCS and tACS

      • Overview of Computational Models of Noninvasive Neuromodulation

      • Methods and Protocols in the Generation of Computational Forward Models of tDCS/tACS

      • Pitfalls and Challenges in the Application and Interpretation of Computational Model Predictions

      • Use of Computational Models in Clinical Practice: Consideration for Efficacy

      • Use of Computational Models in Clinical Practice: Consideration for Safety

      • Use of Computational Models in Clinical Practice: Consideration for Individual Dose Titration

      • Example Results of Computational Analysis in Susceptible Populations

      • Conclusion

      • References

    • 5: Animal Studies in the Field of Transcranial Electric Stimulation

      • Experimental Design of tDCS and tACS Animal Studies

        • Classification of Animal Studies and Relevance to Clinical Protocols

        • tDCS and tACS Dose

        • The Quasi-Uniform Assumption

        • Translation from Animal Studies to Clinical Applications: The Importance of Intensity

        • Safety Concerns

        • Relating Biomarkers from Animal Models to Humans

      • Neuronal Polarization

        • Polarity-Specific Effects for DCS and Implications for ACS

        • Quantifying Neuronal Polarization with Coupling Constants

      • Synaptic Plasticity

      • Network Effects

        • tDCS and Oscillations

        • tACS and Oscillations

      • Applications to Clinical Pathologies

        • Addiction

        • Alzheimer’s Disease

        • Chronic Stress

      • Prospects for Animal Research in tDCS/tACS Informing Ongoing Human Trials

      • References

    • 6: Cortical Inhibition and Excitation in Neuropsychiatric Disorders Using Transcranial Magnetic Stimulation

      • Introduction

      • Applications of TMS

        • Importance of GABA

      • Inhibitory TMS Paradigms

        • Cortical Silent Period and Long-­Interval Cortical Inhibition

        • Short-Interval Cortical Inhibition

        • Transcallosal Inhibition

        • Short Latency Afferent Inhibition

      • Excitatory TMS Paradigms

        • MEP Amplitude

        • Motor Threshold

        • Intracortical Facilitation

        • Short-Interval Intracortical Facilitation

      • Inhibitory Neurotransmission in Psychiatric Disorders

        • Inhibitory Impairments in Patients with Schizophrenia

        • Cortical Excitability in OCD Patients

        • TMS and MDD Patients

        • TMS in Patients with Bipolar Disorder

        • Clinical Implications

      • Use of EEG

        • TMS Combined with EEG

        • Application of Combined TMS and EEG in Psychiatric Disorders

      • Clinical Applications of Brain Stimulation

        • Repetitive TMS

        • Theta Burst Stimulation

        • Transcranial Direct Current Stimulation

        • Concluding Remarks

      • Discussion and Conclusions

      • References

    • 7: Neurocognitive Effects of tDCS in the Healthy Brain

      • Introduction

        • Effects of tDCS on Working Memory

        • Effects of tDCS on Attention

        • Effects of tDCS on Language

        • Effects of tDCS on Numerical Cognition

        • Effects of tDCS on Learning and Memory

        • Neurocognitive Effects of tDCS in Healthy Older Adults

      • Inter-individual Differences in the Context of tDCS Outcomes

      • Conclusions

      • References

    • 8: Transcranial Direct Current Stimulation in Social and Emotion Research

      • Introduction

        • tDCS on Emotion Studies

          • Emotional Memory Encoding and Retrieval

          • Emotional Prosody

          • Emotional Face Processing

          • Emotion Regulation

          • Social Pain

          • Fear Conditioning

        • Social Neuroscience

          • Implicit Prejudice

          • Social Decision-Making

          • Perspective Taking

      • Conclusions

      • References

    • 9: Multimodal Association of tDCS with Electroencephalography

      • Introduction: A Brief Picture of the Present State of Research

      • Principles of Multimodal Association

      • Advantages of Combining tES with Other Methods

      • tES–EEG Technical Aspects

      • tDCS–EEG in Studying Cortical Excitability, Connectivity and Plasticity

      • Multimodal Imaging as a Diagnostic/Prognostic Tool in Neuropsychiatric Disorders

      • Conclusions and Final Remarks

      • References

    • 10: tDCS and Magnetic Resonance Imaging

      • Introduction

      • Combining tDCS and MRI

      • Functional Magnetic Resonance Imaging

      • BOLD Functional MRI

        • Resting-State fMRI

          • tDCS Has Significant, but Somewhat Unclear, Effects on Resting Functional Connectivity

          • tDCS as a Potential Tool to Understand the Basis of Resting Functional Connectivity

        • Task-Based fMRI

          • Studies in Healthy Controls

      • Arterial Spin Labelling

      • Magnetic Resonance Spectroscopy

      • 1H-MRS

        • Neurochemicals of Interest

          • Glutamate

          • GABA

          • N-Acetylaspartate Acid and Creatine

      • 31P-MRS

        • Combining tDCS with MRS

      • Conclusions and Future Directions

      • References

    • 11: Target Engagement with Transcranial Current Stimulation

      • Mechanistic Insights from Animal Studies

        • Effect of Electric Fields on Individual Neurons

        • Interactions of Network Oscillations and Electric Fields

        • Outlasting Effects of Electric Fields

        • Interaction of Cellular and Network Mechanisms

      • Computational Models

        • Forward Models

        • Computational Neural Models

        • Future Directions

      • Effects of Weak Electric Fields on the Human Brain

        • Neurophysiology of tDCS in Humans

        • Mechanisms of tDCS in Humans

        • Neurophysiology of tACS in Humans

        • Mechanism of tACS in Humans

      • Probing Functional Connectivity with tES

      • Application of tES to Sleep Oscillations

        • Mechanisms of Slow Oscillations

        • Modulating the Slow Oscillation with Weak Electric Fields

        • Anesthesia as a Tool to Study Slow Oscillations

      • Outlook

      • References

    • 12: Cerebellar and Spinal tDCS

      • Cerebellar Transcranial Direct Current Stimulation: Technique’s Overview and Clinical Applications

      • Transcutaneous Spinal Direct Current Stimulation: Technique’s Overview

      • Mechanisms of Action

        • Putative Mechanisms of Action at a Spinal Level

        • Putative Mechanisms of Action at a Supra-Spinal Level

      • Perspective on Clinical Studies

      • Why Should Psychiatrists Be Interested in Cerebellar/Spinal DC Stimulation?

      • References

  • Part II: Applications of tDCS in Neuropsychiatric Disorders

    • 13: Mood Disorders

      • Major Depressive Disorder

        • Introduction

      • Technical Aspects of Using tDCS in Major Depression

      • Mechanisms of Action

      • Clinical Evidence

        • Open-Label Studies

        • Randomized, Sham-Controlled Trials

        • Follow-Up Studies

        • Meta-Analyses

      • Bipolar Disorder

      • Discussion

      • References

    • 14: Schizophrenia

      • Introduction

      • Effects of Frontotemporal tDCS on Auditory Verbal Hallucinations

        • Effects of Frontotemporal tDCS on Other Symptoms

        • Predictive Markers of Response to Frontotemporal tDCS on Auditory Verbal Hallucinations

        • Brain Correlates of the Effects of Frontotemporal tDCS on Auditory Verbal Hallucinations

      • Effects of Frontal tDCS on Negative Symptoms and Other Symptoms of Schizophrenia

        • Brain Correlates of the Effects of Frontal tDCS on Negative Symptoms

        • Effects of Frontal tDCS on Other Symptoms

      • Effects of TDCS on Cognitive Functions

      • Safety of Using tDCS for Treating Schizophrenia

      • Optimizing tDCS Efficacy on Symptoms of Schizophrenia

        • Optimizing tDCS Parameters

        • Other Modalities of Transcranial Electric Stimulation in Schizophrenia

        • Combining tDCS with Other Approaches

      • Conclusion

      • References

    • 15: OCD, Anxiety Disorders, and PTSD

      • Introduction

        • OCD

      • tDCS in Anxiety Disorders

      • tDCS in PTSD

      • Conclusion

      • References

    • 16: Neurodegenerative Cognitive Disorders

      • Alzheimer’s Dementia

      • Lewy Bodies Dementia and Parkinson’s Disease

      • Conclusions and Future Directions

      • References

    • 17: Impulsivity and Substance-Use Disorders

      • Introduction

      • Neural Substrates of Substance-Use Disorders

      • Neural Substrates of Craving

      • The Use of tDCS Applied to DLPFC in SUD

        • Tobacco-Use Disorder (TUD)

        • Cannabis-Use Disorders

        • Alcohol-Use Disorders (AUD)

        • Stimulant-Use Disorders

      • Discussion and Conclusion

      • References

    • 18: Epilepsy

      • Introduction

        • Introduction: Neuromodulation in Epilepsy

        • tDCS in Epilepsy

      • Clinical Studies

      • Preclinical Studies

      • Conclusion

      • References

    • 19: Pain Syndromes

      • Introduction

      • Effects and Putative Mechanisms of tDCS in Different Chronic Pain Syndromes

        • Fibromyalgia

        • Migraine Headache

        • Neuropathic Pains

      • Concluding Remarks

      • References

    • 20: Stroke

      • Motor Recovery

      • Visuospatial Neglect

      • Aphasia

      • Dysphagia

      • Cognitive Decline

      • Spasticity

      • Post-stroke Depression

      • Central Post-stroke Pain

      • Conclusions

      • References

    • 21: Transcranial Direct Current Stimulation in Disorders of Consciousness

      • Introduction

        • Definition of Disorders of Consciousness (DOC)

        • Current Treatment and Limitations in Patients with Disorders of Consciousness (DOC)

      • tDCS in Disorders of Consciousness (DOC)

        • Pilot Studies

        • Neuronal Correlates of tDCS in DOC

        • tDCS as a Diagnostic Tool

        • Long-Term Effects

      • Conclusions and Future Directions

      • References

  • Part III: The Clinical Use of tDCS

    • 22: Safety and Tolerability

      • Introduction

      • Tolerability

        • Common Adverse Effects

          • Skin Reddening

        • Parameters Associated with Adverse Effects

        • Acceptability in Clinical Trials

      • Safety

        • Serious Adverse Effects

        • Skin Lesions

        • Safety in Neuropsychiatric Samples

        • Functional Impairment

      • Contraindications

      • Conclusion

      • References

    • 23: Home-Based tDCS: Design, Feasibility and Safety Considerations

      • Introduction

      • tDCS Suitability for Home Use

      • Device and Equipment Design

      • Patient Selection and Contraindications

      • Training and Credentialing

      • Ongoing Monitoring and Oversight

      • Patient Safety

      • Home-Based tDCS Studies

      • Further Approaches Using Home-�Based tDCS

      • References

    • 24: Ethical Aspects of tDCS Use in Neuropsychiatry and the Risk of Misuse

      • Introduction: Is tDCS Hope or Hype?

      • The Promise of tDCS

        • tDCS as a Cognitive Neuroscience Tool

        • tDCS as a Clinical Intervention

        • tDCS to Enhance Normal Cognition

      • The Perils of tDCS

        • Scientific Challenges

        • Ethical Challenges

        • Safety

        • Justice

        • Character

        • Autonomy

      • Ethical Considerations Pertaining to Neuropsychiatry

      • Conclusion

      • References

    • 25: Regulatory Aspects

      • Introduction

      • FDA Regulation of Medical Devices

      • tDCS in Research

      • tDCS in Clinical Practice

      • TDCS Devices

      • Considerations on Patient Selection

        • tDCS Candidates

        • tDCS in Pediatrics

        • tDCS in Pregnancy

      • Considerations on Application of tDCS

      • TDCS Experience in Other Countries

      • Conclusion

      • References

    • 26: Clinical Research and Methodological Aspects for tDCS Research

      • Introduction

      • Clinical/Research Trial Designs

        • Protocol Intensity/Duration/Repetition

        • Methodological Aspects of Online and Offline Protocols

        • Blinding, Sham, and Active Control

      • Patient/Participant Screening

      • Electrodes and Contact Medium

      • Electrode Location

      • Electrode Placement

      • tDCS Stimulator Selection

      • Assessment of Safety/Adverse Events and Monitoring During Stimulation

      • Monitoring Functional Effects of tDCS

      • Concluding Remarks

      • References

  • Index

Tài liệu cùng người dùng

  • Đang cập nhật ...

Tài liệu liên quan