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Nghiên cứu thành phần hóa học và hoạt tính gây độc của loài sao biển Culcita novaeguineae Muller Troschel. 1842 và Pentaceraster gracilis (Lutken. 1871) ở Việt NamNghiên cứu thành phần hóa học và hoạt tính gây độc của loài sao biển Culcita novaeguineae Muller Troschel. 1842 và Pentaceraster gracilis (Lutken. 1871) ở Việt NamNghiên cứu thành phần hóa học và hoạt tính gây độc của loài sao biển Culcita novaeguineae Muller Troschel. 1842 và Pentaceraster gracilis (Lutken. 1871) ở Việt NamNghiên cứu thành phần hóa học và hoạt tính gây độc của loài sao biển Culcita novaeguineae Muller Troschel. 1842 và Pentaceraster gracilis (Lutken. 1871) ở Việt NamNghiên cứu thành phần hóa học và hoạt tính gây độc của loài sao biển Culcita novaeguineae Muller Troschel. 1842 và Pentaceraster gracilis (Lutken. 1871) ở Việt NamNghiên cứu thành phần hóa học và hoạt tính gây độc của loài sao biển Culcita novaeguineae Muller Troschel. 1842 và Pentaceraster gracilis (Lutken. 1871) ở Việt NamNghiên cứu thành phần hóa học và hoạt tính gây độc của loài sao biển Culcita novaeguineae Muller Troschel. 1842 và Pentaceraster gracilis (Lutken. 1871) ở Việt Nam
1 CULCITA NOVAEGUINEAE MÜLLER & TROSCHEL, 1842 VÀ PENTACERASTER GRACILIS (LUTKEN, 1871) 2018 CULCITA NOVAEGUINEAE MÜLLER & TROSCHEL, 1842 VÀ PENTACERASTER GRACILIS (LUTKEN, 1871) N 2018 i VS 2018 ii - -15 ,m -18 VS - , TS N tác tra , TS iii i iii ii v vi 2 24 24 I.2 Tình 26 26 Archaster typicus batheri 28 Asteropsis carinifera 29 Astropecten polyacanthus 30 Astropecten monacanthus 31 Protoreaster nodosus 31 iv 32 Acanthaster planci ckia laevigata 32 Anthenea aspera 33 35 35 37 37 38 II.2.2 38 40 Culcita novaeguineae 40 Pentaceraster gracilis 42 43 46 Culcita novaeguineae 46 IV.2 X Pentaceraster gracilis 93 124 125 127 DA 129 130 v 49 57 61 66 72 B 77 82 86 92 94 100 106 110 114 119 123 Gi Pentaceraster gracilis 50 Culcita novaeguineae 126 vi Hình III.1.a C novaeguineae Hình III.1.b n CH2Cl2 40 C novaeguineae 41 Hình III.2 P gracilis Hình IV.1.1.a Hình IV.1.1.b -ESI- Hình IV.1.1.c Hình IV.1.1.d 13 H- 42 CN1 46 CN1 46 CN1 DMSO-d6 pyridine-d5 C- 47 47 CN1 Hình IV.1.1.e CN1 48 Hình IV.1.1.f CN1 50 Hình IV.1.1.g 51 CN1 Hình IV.1.1.h 51 CN1 Hình IV.1.1.i CN1 Hình IV.1.1.j 53 CN1 Hình IV.1.2.a 54 CN2 Hình IV.1.2.b Hình IV.1.2.c 13 HC- 52 CN2 54 CN2 55 Hình IV.1.2.d CN2 56 Hình IV.1.2.e CN2 56 Hình IV.1.2.f Hình IV.1.3.a H- 59 CN3 Hình IV.1.3.b 59 CN3 Hình IV.1.3.c Hình IV.1.3.d 56 CN2 13 C- 59 CN3 60 CN3 Hình IV.1.3.e CN3 60 Hình IV.1.3.f CN3 60 Hình IV.1.3.g CN3 62 Hình IV.1.3.h CN3 Hình IV.1.3.i 63 CN3 Hình IV.1.3.j CN3 Hình IV.1.4.a CN4 Hình IV.1.4.b Hình IV.1.4.c 13 HC- 62 64 64 CN4 64 CN4 65 Hình IV.1.4.d CN4 65 Hình IV.1.4.e CN4 65 vii Hình IV.1.4.f 67 CN4 Hình IV.1.4.g 67 CN4 Hình IV.1.4.h 67 CN4 Hình IV.1.4.i - 68 CN4 Hình IV.1.5.a 68 CN5 Hình IV.1.5.b Hình IV.1.5.c 13 HC- CN5 69 CN5 69 Hình IV.1.5.d CN5 70 Hình IV.1.5.e CN5 70 Hình IV.1.5.f CN5 Hình IV.1.5.g 71 CN5 Hình IV.1.5.h Hình IV.1.5.i - CN5 71 CN5 73 Hình IV.1.6.a 73 CN6 Hình IV.1.6.b Hình IV.1.6.c 13 HC- 70 CN6 74 CN6 74 Hình IV.1.6.d CN6 74 Hình IV.1.6.e CN6 75 Hình IV.1.6.f CN6 Hình IV.1.6.g 75 CN6 Hình IV.1.6.h Hình IV.1.6.i - CN6 76 CN6 78 Hình IV.1.7.a 78 CN7 Hình IV.1.7.b Hình IV.1.7.c 13 HC- 75 CN7 78 CN7 79 Hình IV.1.7.d CN7 79 Hình IV.1.7.e CN7 80 Hình IV.1.7.f 81 CN7 Hình IV.1.7.g CN7 Hình IV.1.7.h Hình IV.1.7.i - CN7 81 CN7 83 Hình IV.1.8.a CN8 Hình IV.1.8.b Hình IV.1.8.c 13 HC- 81 83 CN8 83 CN8 84 Hình IV.1.8.d CN8 84 Hình IV.1.8.e CN8 85 viii Hình IV.1.8.f 85 CN8 Hình IV.1.8.g CN8 Hình IV.1.8.h Hình IV.1.8.i - CN8 87 CN8 87 Hình IV.1.9.a 88 CN9 Hình IV.1.9.b Hình IV.1.9.c 13 HC- 85 CN9 88 CN9 89 Hình IV.1.9.d CN9 89 Hình IV.1.9.e CN9 89 Hình IV.1.9.f CN9 Hình IV.1.9.g 90 CN9 Hình IV.1.9.h Hình IV.1.9.i - CN9 91 CN9 91 Hình IV.1.9.j Hình IV.2.1.a H- 93 PG2 Hình IV.2.1.b Hình IV.2.1.c 92 CN9 93 PG2 13 C- 90 96 PG2 Hình IV.2.1.d PG2 96 Hình IV.2.1.e PG2 96 Hình IV.2.1.f 97 PG2 Hình IV.2.1.g 97 PG2 Hình IV.2.2.a 98 PG1 Hình IV.2.2.b Hình IV.2.2.c 13 HC- PG1 98 PG1 99 Hình IV.2.2.d PG1 99 Hình IV.2.2.e PG1 99 Hình IV.2.2.f PG1 101 Hình IV.2.2.g 102 PG1 Hình IV.2.3.a Hình IV.2.3.b HR-ESI- Hình IV.2.3.c Hình IV.2.3.d 13 HC- PG3 102 PG3 102 103 PG3 103 PG3 Hình IV.2.3.e PG3 104 Hình IV.2.3.f PG3 105 Hình IV.2.3.g Hình IV.2.3.h PG3 PG3 105 105 125 IV.4 HepG2 (gan) SK- s Culcita novaeguineae C novaeguineae CN5 CN8 CN1 CN4 CN9 IC50> 100 µM CN5 1,59 µM), MCF7 (IC50 = 33,96 LNCaP (IC50 = 31,80 1,47 µM) SK-Mel2 (IC50 = 32,99 (IC50 = 32,66 dòng HepG2 (IC50 = 75,01 4,11 µM 3,05 µM halityloside B (CN7) 2,65 µM), MCF7 IC50 = 39,68 2,65 µM) KB (IC50 = 44,37 (IC50 = 39,99 SK-Mel2 (IC50 = 50,09 (IC50 = 80,22 1,57 µM), KB 3,00 µM 4,06 µM 3,67 µM culcitoside C5 (CN6) halityloside A (CN8 MCF7, KB SK- 50 2,84 µM 48,59 (IC50 > 100 µM) dòng HepG2 Pentaceraster gracilis P gracilis PG1 LNCaP (IC50 = 39,75 3,34 µM), KB (IC50 = 36,53 0,78 µM), HepG2 (IC50 = 16,75 0,69 µM) SK-Mel2 (IC50 = 19,44 MCF7 (IC50 = 47,34 7,01 µM IC50 = 86,57 HepG2 (IC50 = 79,69 1,45 µM) 3,14 µM) SK-Mel2 (IC50 = 96,77 2,19 µM), 4,07 µM) khơng 126 IC50> 100 µM PG2 PG6 50> 100 µM C novaeguineae P gracilis 50 dòng IC50 LNCaP µM) MCF7 KB HepG2 SK-Mel2 C novaeguineae S CN1 >100 >100 >100 >100 >100 CN2 >100 >100 >100 >100 >100 CN3 >100 >100 >100 >100 >100 CN4 >100 >100 >100 >100 >100 CN5 31,80 1,59 33,96 1,57 32,66 1,47 75,01 4,11 32,99 3,05 CN6 57,08 1,81 62,95 2,96 92,04 2,84 >100 89,76 2,47 CN7 39,68 2,65 39,99 2,65 44,37 3,00 80,22 3,67 50,09 4,06 CN8 48,59 2,30 51,61 2,70 70,70 3,56 >100 73,99 3,10 CN9 >100 >100 >100 >100 >100 P gracilis S PG1 39,75 3,34 47,34 7,01 36,53 0,78 16,75 0,69 19,44 1,45 PG2 >100 >100 >100 >100 >100 PG3 >100 >100 >100 >100 >100 PG4 >100 >100 >100 >100 >100 PG5 >100 >100 >100 >100 >100 PG6 >100 >100 >100 >100 >100 PG7 86,57 2,19 >100 >100 79,69 3,14 96,77 4,07 Elipticinea 1,99 0,16 1,95 0,12 2,07 0,12 1,71 0,16 2,15 0,24 a 127 Culcita novaeguineae Pentaceraster gracilis ó0 t C novaeguineae ( P gracilis ( ) 07 có ) Culcita novaeguineae (Müller & Troschel, 1842): Novaeguinoside E ; Natri -[(O- -D-fucopyranosyl-(l 2)-O- -D-galactopyranosyl-(l [ -D-quinovopyranosyl-(l 2)]-O- -D-xylopyranosyl-(l 4)-O- 3)-O- -D-quino vopyranosyl)-oxy]-5 -pregn-9(11)-ene-20-one-3 -yl-sulfate (CN2); Linckoside B (CN3); Halityloside E (CN4); Halityloside D (CN5); Culcitoside C5 (CN6); Halityloside B (CN7); Halityloside A (CN8); -cholestane-3 ,6 ,7 ,8 ,15 ,16 ,26-heptol (CN9); Pentaceraster gracilis (Lutken, 1871): Maculatoside (PG1); Protoreasteroside (PG2); Pentaceroside A ; Pentaceroside B ; Nodososide (PG5); (5 ,25S)-Cholestane-3 ,6 ,8,15 ,16 ,26-hexol-3-O-[(2-O-methyl)- -D-xy lopyranoside] (PG6); -Cholestane-3 ,6 ,7 ,8 ,15 ,16 ,26-heptol (PG7) 128 C novaeguineae có sa glycoside P gracilis polyhydroxy steroid in vitro HepG2 (gan) SKCulcita novaeguineae (Müller & Troschel, 1842): H CN5 LNCaP, MCF7, KB SK-Mel2 HepG2 halityloside B (CN7) MCF7 KB SK-Mel2 HepG2 culcitoside C5 (CN6) halityloside A (CN8 MCF7, KB SK50 2,84 µM 48,59 (IC50 > 100 µM) dòng HepG2 Pentaceraster gracilis (Lutken, 1871) H PG1 LNCaP, KB, HepG2 SK-Mel2 MCF7 , HepG2 SK-Mel2 (IC50 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Anthenea aspera 33 35 35 37 37 38 II.2.2 38 40 Culcita novaeguineae 40 Pentaceraster gracilis 42 43 46 Culcita novaeguineae 46 IV.2 X Pentaceraster gracilis 93 124 125 127 DA 129 130 v 49 57 61...1 CULCITA NOVAEGUINEAE MÜLLER & TROSCHEL, 1842 VÀ PENTACERASTER GRACILIS (LUTKEN, 1871) N 2018 i VS 2018 ii - -15 ,m -18 VS - , TS N tác... 100 106 110 114 119 123 Gi Pentaceraster gracilis 50 Culcita novaeguineae 126 vi Hình III.1.a C novaeguineae Hình III.1.b n CH2Cl2 40 C novaeguineae 41 Hình III.2 P gracilis Hình IV.1.1.a Hình