TICH /r^ pHAil -" ta HolKHoA HocxYIHUAT TicH HoA, ri uAsrNH HocutTltAm ,'/lili'iZ 4V-5,l' ,ffi9" VIETNAMANALYTICAL SCIENCES SOCIEry I.SSN - 086 - 3224 T r 13 2GCr8 Tap cht phan ticlLHoa, Lf ud'Sinh lzoc'Tdp 13,36 2120A8 SODANXUAr roNGHqPru|loT AROYLHYDRAZON 2,s-DI HYDROXIAXETOPHENON D6'ntoiLsoan 26 - 11 ' 2007 Vu NIinh TAn, Pham Vin Nhi6u, Vir Phtlong Li6n KJrca Hod lrcc,Dai ltoc Kh.oa ltoc Ttt Nliin, loral Dai hoc Qu6lcgta Hd l'lAi SUMMARY | SYNTHESiS OF SOME 2,5.DIH\DROXYACETOPHENONE ARO\'L HYDRAZONE DERIRATIVES nirit i cac Sotne 2,5-diltydroxyacetoplter.rone aroyl |rydrcLzone deriratiues haue been prepared by tlrc acids witlt ltydrazidesof substit.utedbenzo.ic condensationof' 2,5- dilrydr"oxyacetoplLenone t by IR, H-NMR and MS spectroscopies Tlrc structure of theseproducts hauebeen'd.etermined (;\l()l kha : tin ,rl CO ntor rollg i vor '1inir f{1tc', iow D6 gop phdnkhdcphuchdu quathiet liai dn noi chungva trongc6ngnghiOp mon kim loai gd-v" An mon kim loai gay ton thdt to lol ciro n6n sirn xudt, che vdn chuy6nvir cdtgifr sin phim br6n ; , l kinh te thegioi, Theoddnhgrd cua Lien hop qu6c ddu mo n6i ndng.chungt6i ti6n hanht6nghop va (LiNDP),in rtroukin loai lam ton thdttoi 3o/ott\ttg nghi6ncuukhi ndnguc ch6dn monciranQt s6 din : : ,^,,^ sin phirn quocgia (GNP) Boi vay"ngll€n cuu ve xuat 2,j -drhydroxiaxetophenon aroylhydrazou kiroa Niri duoc cic kirn loai dd iriort va bao v6 dn Congrrinh [.2.4] clio bi6t v€ nanguc cl.:6 hocquantarnfu iau.Co nhrdupliuongphdpbaov'0 in nronkim loai cua niQts6 din xu6t iiydrazon, chong in mou krm lo4r n|uug phuong phap su cirngniru rn6i tuongquangifracdutmc phdntu io'i dungcic chit uc ch6 in rnon duoc su dung sornva ning irc chd in mon kirn loai cuachungbang ptrOUienhon ca phuolg phdptinh hod.hocluo-ngtu.Crichydrazon Vi€t Nam li nuoc co hiu nhi6t doi, 6m bo duoc t6ng ho.pbing phin ung ngung tu cua qua kinl mort frinh ln bidn dai, la moi lruolg d6 th6 vdi hydrazitcria axit benzoicth6 axetophenon loai xay Vo'i sLrphat tri6n cua ndn kinh t6 qudc tuorrgung.Trongc6ngtrinh ndychirngtoi t6ngho p dan,nrrocta su dung kinr loarngay cangnii€u lvl0t nrot s6 din xu6t 2,5-dihydroxiaxetophenon aroyl frong nhrtng lTnli ruc ma nuoc ta phai su du.ng hy&azon(goi tit hydrazon)tuong t.u,rrhungdi hr vd cdc axit iienzoicchuanh6mtir6 o nhidu chit trc ch6 dn rnon li cong nghiep kJrai hydroquinon cacvi tri o-.m-.vaparatheoso duoiday tliacva loc diu congnghr€pch€ bi€n diu mo r rtd oiu ' l OH OH I ;\r-c=o 1 \ v -,- j, , + i l C H' C.H.on _+t H2N-NH=_{*e)_ -H,o o (I) (llr*) I A",r- \ il -lJ IO H C=N NH -C i,"" { ,) 1r \ /n { ) (tIIlr) Trr-,ngdc' R : o-CH3,p-CH:, tn-OH, p-OH JJ io l NH:8,9I ( iH) OH' :12,59( H) ,I OHb:1 1,17(H) l ,Cr ,C4H :7,84( 2H ) , ,C oH:6,97 (1H),C2,,C6,-H :7,7 5(2H), q i| 9t H f /-\ i li I \ vT l t h v C3,,C5,- H:6,75( 2H) ,CH3u' :2,4( 3H ) , t ' CH3b:2,4(3H) II ? D H OH l c )\' NH;8,89(1l{),OHu: 12,57(lH), 2'=13'., ,o"n -c - N- NH -{-1-'l i // o lr-\ cH, o o 6'*= I ^ / \' J ll Ii | | ,t \ t:) ^ NH:8,90( 1H),OH':I 2,63(1H), d o -i Tt A a OH l t / ,J ; ll rl oYa | -a -tr1 - r1\ n_-r- r-rrar - 1^ \ I Y r | il cH, ' -\3' '/ \\ \ ,c tY-orl //4' o'Lu, UN -J I I l I I I _l C O H bI:0 , 9 (H ) , O H ' : , 2H()i , C3,Ca-H:7,83(2H),C6-H:6,96(1H), C:,,Cs,H:6,74(2H), C2',C6'-H:6,88(2H), CH3:2,39(3 H) h t C3,Ca-H:1,34(2H),C6-H :6.97(lH), C:,,Cs,H:7,00(2H), C a',C6'-H :7,29(2H), CH3:2,4(3H) h ilt O H b :11 ,I ( H ) ,O H ' : , ( H ) ptrot