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Int. J. Med. Sci. 2010, 7 http://www.medsci.org 213IInntteerrnnaattiioonnaall JJoouurrnnaall ooff MMeeddiiccaall SScciieenncceess 2010; 7(4):213-223 © Ivyspring International Publisher. All rights reserved Research Paper Extension of the PNA world by functionalized PNA monomers eligible can-didates for inverse Diels Alder Click Chemistry Manfred Wiessler1, Waldemar Waldeck2, Ruediger Pipkorn3, Christian Kliem1, Peter Lorenz1, Heinz Fleischhacker1, Manuel Hafner4, and Klaus Braun1 1. German Cancer Research Center, Dept. of Imaging and Radiooncology, INF 280, D-69120 Heidelberg, Germany 2. German Cancer Research Center, Division of Biophysics of Macromolecules, INF 580, D-69120 Heidelberg, Germany 3. German Cancer Research Center, Central Peptide Synthesis Unit, INF 580, D-69120 Heidelberg, Germany 4. Mannheim University of Applied Sciences, Department of Biotechnology, Paul-Wittsack-Straße 10, D-68163 Mannheim, Germany Corresponding author: Dr. Klaus Braun, Im Neuenheimer Feld 280, German Cancer Research Center, Dep. Of Medical Physics in Radiology, D-69120 Heidelberg, Germany. Tel. No.: +49 6221 42 2495; Fax No.: +49 6221 42 3326; E-mail: k.braun@dkfz.de Received: 2010.03.10; Accepted: 2010.06.22; Published: 2010.06.27 Abstract Progress in genome research led to new perspectives in diagnostic applications and to new promising therapies. On account of their specificity and sensitivity, nucleic acids (DNA/RNA) increasingly are in the focus of the scientific interest. While nucleic acids were a target of therapeutic interventions up to now, they could serve as excellent tools in the future, being highly sequence-specific in molecular diagnostics. Examples for imaging modalities are the representation of metabolic processes (Molecular Imaging) and customized therapeutic ap-proaches (“Targeted Therapy”). In the individualized medicine nucleic acids could play a key role; this requires new properties of the nucleic acids, such as stability. Due to evolutionary reasons natural nucleic acids are substrates for nucleases and therefore suitable only to a limited extent as a drug. To use DNA as an excellent drug, modifications are required leading e.g. to a peptide nucleic acid (PNA). Here we show that an easy substitution of nucleobases by functional molecules with different reactivity like the Reppe anhydride and pentenoic acid derivatives is feasible. These derivatives allow an independent multi-ligation of functionalized compounds, e.g. pharmacologically active ones together with imaging components, leading to local concentrations sufficient for therapy and diagnostics at the same time. The high chemical stability and ease of synthesis could enhance nucleic chemistry applications and qualify PNA as a favourite for delivery. This system is not restricted to medicament material, but appropriate for the development of new and highly efficient drugs for a sustainable pharmacy. Key words: Click Chemistry; Diels Alder Reactioninvers (DARinv); Peptide Nucleic Acid (PNA); PNA building block functionalization Introduction Open questions in the world of nucleic acids are areas for improvement of the hypotheses concerning the origin of the life and the crucial genetic building blocks. The search for simpler precursor molecules leads to the peptide nucleic acid world (PNA).[1-3] At present PNA finds increasing interest in the scientific community. This manuscript does not intend to an-swer questions concerning the greater plausibility of PNA Cộng Hoà Xã Hội Chủ Nghĩa Việt Nam Độc lập – Tự – Hạnh phúc o0o -Bình Dương, ngày 30 tháng 06 năm 2017 TỜ TRÌNH Danh sách ứng cử viên bầu vào BKS NK 2016-2021 - Kính gửi: ĐẠI HỘI ĐỒNG CỔ ĐÔNG THƯỜNG NIÊN 2017 Căn Luật Doanh nghiệp Việt Nam; Căn Điều lệ Công ty cổ phần Beton 6.; Căn Nội dung chương trình Hội đồng quản trị gởi cho cổ đông (kèm thư mời) việc đề cử, ứng cử ứng cử viên bầu vào BKS nhiệm kỳ 2016-2021; Tính đến hết ngày 27/06/2017, hồ sơ đề cử / ứng cử, Hội đồng quản trị thống trình Đại hội đồng cổ đông thông qua danh sách ứng viên bầu bổ sung cho BKS nhiệm kỳ 2016-2021 sau: Bà NGUYỄN THỊ HỒNG NGÂN Sinh năm: 1985 Nguyên quán: Hải Phòng Quốc tịch: VIỆT NAM Trình độ chuyên môn: Cử nhân luật Chức vụ nay: Thành viên BKS HBG Ông TRẦN TIẾN ĐẠT Năm sinh: 1974 Nguyên quán: Thừa Thiên - Huế Quốc tịch: VIỆT NAM Trình độ chuyên môn: Kỹ sư xây dựng Chức vụ nay: Thành viên BKS HBG Kính trình đại hội thông qua./ TM HỘI ĐỒNG QUẢN TRỊ CHỦ TỊCH (Đã ký) TRẦN VĂN CẦU Công ty Cổ Phần Beton Tầng – Tòa nhà Hưng Bình, 406 Ung Văn Khiêm, Phường 25, Quận Bình Thạnh, TP.HCM T: (84.8) 3899.8100 - F: (84.8) 3510.6222 - www.beton6.com P.1/1 I.Revision: play tennis play soccer watch TV read a book play volleyball play video games II. New words: 1.to play badminton 2. to do aerobics II. New words: 3. to swim II. New words: 4.to play table tennis II. New words:c 5.to jog II. New words: 6.to skip II. New words: Checking: 1 ASI-ACCREDITATION SERVICES INTERNATIONAL GmbH ASI-REP-54-SCS-2006-Michigan DNR (Public Summary) Charles-de-Gaulle-Str. 5 ● 53113 Bonn, Germany ● Tel.: +49 - 228 - 367 66 0 ● info@accreditation-services.com FSC Annual Surveillance of SCS for 2006 Forest Management Audit to Michigan Department of Natural Resources, USA (SCS-FM/COC-090N) Date of audit: 23-27 October 2006 Public Summary, prepared by ASI based on the final ASI audit report. NAME DATE Report drafted by: Hans Joachim Droste 02 July 2007 Reviewed by ASI: Hubert de Bonafos 02 July 2007 Reviewed by local expert: Bill Wilkinson 04 July 2007 Reviewed by CAB: Robert Hrubes 08 July 2007 Finalized by ASI: Hans Joachim Droste 09 July 2007 Report last updated: FSC Chain of Custody Surveillance Audit of SCS for 2006: Michigan DNR ASI-REP-54-SCS-2006-Michigan DNR (Public Summary) 2 Credits The authors would like to thank Dr Robert Hrubes from SCS and his team as well as Denis Nezich, Mike Paluda, and Larry Pedersen from MI DNR and their staff for preparing and making the arrangements that made this audit possible and efficient. 1 Background The operation audited by SCS Name of operation Michigan Department of Natural Resources (MI DNR) Type of certificate Single FM with multiple FMUs Total area 3.75 million acres Type of management State-owned temperate natural and semi-natural forests Name of contact person Dennis Nezich Address 1990 US-41, South Marquette, MI 49855 Country USA Phone number 906-228-6501 Fax number 517-373-2443 URL www.michigan.gov/dnr E-mail address nezichd@michigan.gov Brief description of the operation The Michigan Department of Natural Resources (MI DNR) is responsible for the management of the Michigan state forestlands on an area of 1.6 Mio ha (about 21% of the state’s timberland). DNR also provides guidance and planning information for working with private landowners, environmental regulators, and other governmental agencies to achieve landscape and habitat goals for natural resources management. The areas managed by the DNR within the State Forest System are largely non- contiguous tracts of forest that are scattered throughout the landscapes of the Northern Lower Peninsula of Michigan and all of Upper Peninsula of Michigan. Over half (51.6%) of DNR-owned forestland is located in the Northern Lower Peninsula ecoregion. The Eastern Upper Peninsula and Western Upper Peninsula ecoregions contain 26.5% and 21.9% of forestland respectively. In contrast to the statewide landscape, the largest DNR community type is aspen (22 percent), followed by northern hardwoods (13 percent), jack pine (9 percent), red pine (7 percent), mixed swamp conifers (6 percent), oak (6 percent), and cedar swamp (6 percent) The long range trend in Michigan is towards more mature forests with incrementally increasing average tree diameters. More information about MI DNR can be obtained from their website at www.michigan.gov/dnr. The website also includes a pubic version of the management plan. FSC Chain of Custody Surveillance Audit of SCS for 2006: Michigan DNR ASI-REP-54-SCS-2006-Michigan DNR (Public Summary) 3 The certification history Pre-audit 25-29 October 2004 Main audit: 18-30 September 2005 Date of certificate issue 31 December 2005 “Special audit” March 2006 Date of 1st surveillance 23-27 LIST OF TOOLS FOR PACKAGE INTEGRITY CHECKING No Tool name Tetra Pak part No 90243‐0110 Usage Measuring Instrument Splice Test Pliers 78073‐0101 For TS tear down test Leak Detection Fluid 90298‐0026 For Red Ink test (1 bottle = litter) Measuring Instrument Zonoscope 90243‐0203 Magnifying lenses Disposable Syringe PEAK supplier Scale Lupe 10X, Zoom Lupe 816, Scale Lupe 10X, Light Lupe 15X, please contact PEAK supplier directly Any supplier For checking LS/SA heating zone and scratches on internal surfaces of packaging material For TS Dissolved evaluation and Heating Pattern of Dissolved samples Needle 0.4-0.5mm Photo For Conductivity test For Red Ink Injection to Airgap (for LS/SA Strip testing) Tetra Pak Vietnam JSC Floor 14, Metrololitan Building, 235 Dong Khoi, District 1, HoChiMinh city, Vietnam Tel: +84 8257100 - Fax: +84 8257 101 - Website: www.tetrapak.com Page of LIST OF OTHER TOOLS No Tool name Tetra Pak part No 90337‐0007 Usage Areometer, 27000200 TEST APPARATUS 90298‐0030 For Hydrogen Peroxide residue test (1 tube = 100 test strips) Scissors & Cutter Any supplier For cutting the package sharply (TS tear down test, Dissolving test, Conductivity test, ) Water tray Any supplier For Conductivity test (with salt solution 1.0%) Pipettes Any supplier For Red Ink Dye test Photo For Hydrogen Peroxide Concentration check Tetra Pak Vietnam JSC Floor 14, Metrololitan Building, 235 Dong Khoi, District 1, HoChiMinh city, Vietnam Tel: +84 8257100 - Fax: +84 8257 101 - Website: www.tetrapak.com Page of MINISTRY OF FINANCE - SOCIALIST REPUBLIC OF VIETNAM Independence - Freedom - Happiness No 304/2016/TT-BTC Ha Noi, November 15, 2016 CIRCULAR ON PROMULGATION OF LIST OF PRICES FOR AUTOMOBILES AND MOTORBIKES ON WHICH REGISTRATION FEES ARE IMPOSED Pursuant to the Law on Tax administration No 78/2006/QH11 dated November 29, 2006 by the National Assembly; the Law on amendments to a number of articles of the Law on Tax administration No 21/2012/QH13 dated November 20, 2012 by the National Assembly and the guiding decrees thereof; Pursuant to the Law on Fees and Charges No 97/2015/QH13 dated November 25, 2015; Pursuant to the Decree No 140/2016/ND-CP dated October 10, 2016 by the Government providing guidance on registration fees; Pursuant to the Decree No 177/2013/ND-CP dated November 14, 2013 by the Government detailing and guiding the implementation of a number of articles of the Law on Pricing; the Decree No 149/2016/ND-CP dated November 11, 2016 amending and supplementing a number of articles of the Decree No 177/2013/ND-CP dated November 14, 2013 by the Government detailing and guiding the implementation of a number of articles of the Law on Pricing; Pursuant to Decree No 215/2013/ND-CP dated December 23, 2013 by the Government defining the functions, tasks, entitlements and organizational structure of the Ministry of Finance; At the request of the Director of the General Department of Taxation, The Minister of Finance hereby promulgates the List of prices for automobiles and motorbikes on which registration fees are imposed as follows: Article Scope of regulation This Circular promulgates the List of prices for new properties on which registration fees are imposed (hereinafter referred to as the “Price list”), including: a) Two-wheeled and three-wheeled motorbikes, mopeds (including electric motorbikes) and similar vehicles, collectively referred to as motorbikes, and their chassis and bodywork, the replacement of which is subject to registration with competent authorities; b) Automobiles, trailer trucks or semi-trailer trucks and similar vehicles, collectively referred to as automobiles, and their chassis and bodywork which are replaced and subject to registration with competent authorities Prices for used automobiles and motorbikes upon which registration fees are imposed are specified in the Circular No 301/2016/TT-BTC dated November 15, 2016 by the Minister of Finance Article Regulated entities Any organization or individual having an automobile or motorbike on which registration fee is imposed upon its registration with a competent authority Any enterprise manufacturing and/or trading in domestic automobiles and/or motorbikes; enterprise trading in imported automobiles and/or motorbikes Tax authorities of all levels and relevant organizations and individuals Article Prices on which registration fees are imposed